The Experts below are selected from a list of 2853 Experts worldwide ranked by ideXlab platform
Gordon G Wallace - One of the best experts on this subject based on the ideXlab platform.
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conductive tough hydrogel for Bioapplications
Macromolecular Bioscience, 2018Co-Authors: Mohammad Javadi, Qi Gu, Sina Naficy, Syamak Farajikhah, Jeremy M Crook, Gordon G Wallace, Stephen BeirneAbstract:: Biocompatible conductive tough hydrogels represent a new class of advanced materials combining the properties of tough hydrogels and biocompatible conductors. Here, a simple method, to achieve a self-assembled tough elastomeric composite structure that is biocompatible, conductive, and with high flexibility, is reported. The hydrogel comprises polyether-based liner polyurethane (PU), poly(3,4-ethylenedioxythiophene) (PEDOT) doped with poly(4-styrenesulfonate) (PSS), and liquid crystal graphene oxide (LCGO). The polyurethane hybrid composite (PUHC) containing the PEDOT:PSS, LCGO, and PU has a higher electrical conductivity (10×), tensile modulus (>1.6×), and yield strength (>1.56×) compared to respective control samples. Furthermore, the PUHC is biocompatible and can support human neural stem cell (NSC) growth and differentiation to neurons and supporting neuroglia. Moreover, the stimulation of PUHC enhances NSC differentiation with enhanced neuritogenesis compared to unstimulated cultures. A model describing the synergistic effects of the PUHC components and their influence on the uniformity, biocompatibility, and electromechanical properties of the hydrogel is presented.
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electrochemical properties of swnt ferritin composite for Bioapplications
Sensors and Actuators B-chemical, 2008Co-Authors: Kwang Min Shin, Gordon G WallaceAbstract:A functionalized single-wall carbon nanotube (SWNT), fabricated using an acid treatment, was used to prepare SWNT/ferritin composites. Different physical and chemical composites were synthesized on a glassy carbon electrode, and their structures and electrochemical properties were analyzed. The specific redox reaction due to ferritin appeared in both composites, but depended on the structure of the composite, which influenced the electrochemical properties. The redox reaction of ferritin was analyzed using fulfilled core, holoferritin, and coreless, apoferritin. From the electrochemical results, we confirmed that electron transfer through the ferritin shell is possible, and that the core of the ferritin facilitates electron transfer in the composites. The chemical composites showed a significant catalytic activity towards hydrogen peroxide, and the electrochemical results show that this type of composite has potential as biosensors and in Bioapplications.
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Electrochemical properties of SWNT/ferritin composite for Bioapplications
Sensors and Actuators B-chemical, 2008Co-Authors: Kwang Min Shin, Gordon G WallaceAbstract:A functionalized single-wall carbon nanotube (SWNT), fabricated using an acid treatment, was used to prepare SWNT/ferritin composites. Different physical and chemical composites were synthesized on a glassy carbon electrode, and their structures and electrochemical properties were analyzed. The specific redox reaction due to ferritin appeared in both composites, but depended on the structure of the composite, which influenced the electrochemical properties. The redox reaction of ferritin was analyzed using fulfilled core, holoferritin, and coreless, apoferritin. From the electrochemical results, we confirmed that electron transfer through the ferritin shell is possible, and that the core of the ferritin facilitates electron transfer in the composites. The chemical composites showed a significant catalytic activity towards hydrogen peroxide, and the electrochemical results show that this type of composite has potential as biosensors and in Bioapplications.
Yong Zhang - One of the best experts on this subject based on the ideXlab platform.
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micropatterning of polystyrene nanoparticles and its Bioapplications
Colloids and Surfaces B: Biointerfaces, 2005Co-Authors: Chun Wang, Yong ZhangAbstract:Micropatterning of biomolecules forms the basis of cell culture, biosensor and microarray technology. Currently, the most widely used techniques are photoresist lithography, soft lithography or using robots which all involve multi-step surface modification directly on a planar substrate. Here we report a method to pattern biomolecules through self-assembling polystyrene nanoparticles in arrayed microwells on a solid surface to form well-ordered patterning, followed by attaching biomolecules to the assembled nanoparticles. The formation of colloidal patterns depends on capillary force, surface wettability and physical confinement. This method can be used for micropatterning a variety of biomolecules such as protein and antibody.
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Micropatterning of polystyrene nanoparticles and its Bioapplications
Colloids and Surfaces B: Biointerfaces, 2005Co-Authors: Chun Wang, F. L. Yap, Yong ZhangAbstract:Micropatterning of biomolecules forms the basis of cell culture, biosensor and microarray technology. Currently, the most widely used techniques are photoresist lithography, soft lithography or using robots which all involve multi-step surface modification directly on a planar substrate. Here we report a method to pattern biomolecules through self-assembling polystyrene nanoparticles in arrayed microwells on a solid surface to form well-ordered patterning, followed by attaching biomolecules to the assembled nanoparticles. The formation of colloidal patterns depends on capillary force, surface wettability and physical confinement. This method can be used for micropatterning a variety of biomolecules such as protein and antibody. © 2005 Elsevier B.V. All rights reserved.
Meixiu Li - One of the best experts on this subject based on the ideXlab platform.
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π π stacking interaction a nondestructive and facile means in material engineering for Bioapplications
Crystal Growth & Design, 2018Co-Authors: Tao Chen, Meixiu LiAbstract:π–π stacking interactions, as a kind of attractive and nondestructive noncovalent interaction, have been widely explored for the applications in modern chemistry, molecular biology, and supramolecular armamentarium, among which their Bioapplications have attracted tremendous attention due to the unique advantages such as strong binding force, nondestructive fabrication process, and simple operation. Impressively, great achievements have been made in the area of nucleobase stacking, biosensing, controlled drug release, protein folding, molecular recognition, self-assembly, template-directed synthesis. etc. In this review, we first discuss the characterization, geometric configurations, and requirements for π–π stacking interactions, and then focus on their typical Bioapplications in material engineering in particular. At the end, the outlook for potential applications of π–π stacking interactions is also discussed.
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π–π Stacking Interaction: A Nondestructive and Facile Means in Material Engineering for Bioapplications
Crystal Growth & Design, 2018Co-Authors: Tao Chen, Meixiu LiAbstract:π–π stacking interactions, as a kind of attractive and nondestructive noncovalent interaction, have been widely explored for the applications in modern chemistry, molecular biology, and supramolecular armamentarium, among which their Bioapplications have attracted tremendous attention due to the unique advantages such as strong binding force, nondestructive fabrication process, and simple operation. Impressively, great achievements have been made in the area of nucleobase stacking, biosensing, controlled drug release, protein folding, molecular recognition, self-assembly, template-directed synthesis. etc. In this review, we first discuss the characterization, geometric configurations, and requirements for π–π stacking interactions, and then focus on their typical Bioapplications in material engineering in particular. At the end, the outlook for potential applications of π–π stacking interactions is also discussed.
Olga A. Shenderova - One of the best experts on this subject based on the ideXlab platform.
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detonation nanodiamond particles processing modification and Bioapplications
2010Co-Authors: Olga A. Shenderova, Suzanne A.ciftan HensAbstract:This chapter will detail the requirements of modern detonation nanodiamonds (DNDs) intended for biomedical applications, beginning with DND material preparations and followed by bio-related applications developed at International Technology Center. DNDs are one of the most commercially promising nanodiamonds with a primary particle size of 4–5 nm, produced by detonation of carbon-containing explosives. The structural diversity of DNDs will be described, which depend upon synthesis conditions, postsynthesis processes, and modifications. Bioapplications reviewed include ballistic delivery of bio-functionalized DND into cells, photoluminescent biolabeling, biotarget capturing and collection by electrophoretic manipulation of DNDs, and health care applications. DNDs are advantageous when compared with the other types of nanoparticles due to DND large scale synthesis, small primary particle size, facile surface functionalization, stable photoluminescence as well as biocompatibility. Currently, biotechnology applications have shown that NDs can be used for bioanalytical purposes such as protein purification or fluorescent biolabeling, while research is in the developing stages for DNDs applied as diagnostic probes, delivery vehicles, enterosorbents and advanced medical device applications.
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nanodiamond particles properties and perspectives for Bioapplications
Critical Reviews in Solid State and Materials Sciences, 2009Co-Authors: Amanda M. Schrand, Suzanne A.ciftan Hens, Olga A. ShenderovaAbstract:Nanodiamonds (NDs) are members of the diverse structural family of nanocarbons that includes many varieties based on synthesis conditions, post-synthesis processes, and modifications. First studied in detail beginning in the 1960s in Russia, NDs have now gained world-wide attention due to their inexpensive large-scale synthesis based on the detonation of carbon-containing explosives, small primary particle size (∼ 4 to 5 nm) with narrow size distribution, facile surface functionalization including bio-conjugation, as well as high biocompatibility. It is anticipated that the attractive properties of NDs will be exploited for the development of therapeutic agents for diagnostic probes, delivery vehicles, gene therapy, anti-viral and anti-bacterial treatments, tissue scaffolds, and novel medical devices such as nanorobots. Additionally, biotechnology applications have shown the prospective use of NDs for bioanalytical purposes, such as protein purification or fluorescent biolabeling. This review critically e...
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Nanodiamond particles: Properties and perspectives for Bioapplications
Critical Reviews in Solid State and Materials Sciences, 2009Co-Authors: Amanda M. Schrand, Suzanne A.ciftan Hens, Olga A. ShenderovaAbstract:Nanodiamonds (NDs) are members of the diverse structural family of nanocarbons that includes many varieties based on synthesis conditions, post-synthesis processes, and modifications. First studied in detail beginning in the 1960s in Russia, NDs have now gained world-wide attention due to their inexpensive large-scale synthesis based on the detonation of carbon-containing explosives, small primary particle size (? 4 to 5 nm) with narrow size distribution, facile surface functionalization including bio-conjugation, as well as high biocompatibility. It is anticipated that the attractive properties of NDs will be exploited for the development of therapeutic agents for diagnostic probes, delivery vehicles, gene therapy, anti-viral and anti-bacterial treatments, tissue scaffolds, and novel medical devices such as nanorobots. Additionally, biotechnology applications have shown the prospective use of NDs for bioanalytical purposes, such as protein purification or fluorescent biolabeling. This review critically examines the use of NDs for biomedical applications based on type (i.e., high-pressure high-temperature [HPHT], CVD diamond, detonation ND [DND]), post-synthesis processing and modifications, and resultant properties including bio-interfacing. The discussion focuses on nanodiamond material in the form of nanoparticles, while the biomedical uses of nanodiamond coatings and thin films are discussed rather briefly. Specific use of NDs in both non-conjugated and conjugated forms as enterosorbents or solid phase carriers for small molecules including lysozyme, vaccines, and drugs is also considered. The use of NDs as human anti-cancer agents and in health care products is already showing promising results for further development. The review concludes with a look to the future directions and challenges involved in maximizing the potential of these exciting little carbon-based gems in the fields of engineering, medicine, and biotechnology.
Fan Zhang - One of the best experts on this subject based on the ideXlab platform.
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Bioapplications and biotechnologies of upconversion nanoparticle based nanosensors
Analyst, 2016Co-Authors: Chengli Wang, Xiaomin Li, Fan ZhangAbstract:Upconversion nanoparticles (UCNPs), which can emit ultraviolet/visible (UV/Vis) light under near-infrared (NIR) excitation, are regarded as a new generation of nanoprobes because of their unique optical properties, including a virtually zero auto-fluorescence background for the improved signal-to-noise ratio, narrow emission bandwidths and high resistance to photo-bleaching. These properties make UCNPs promising candidates as luminescent bioprobes in biomedicine and biotechnology. In this review, we focus on the recent progress in the development of UCNP-based nanoprobes for biosensing. Firstly, as the FRET process is a widely used method for biosensing to improve the sensitivity, we summarize recent research studies about UCNP-based nanocomposites utilizing the FRET process for biosensing. Different energy acceptors (organic dyes, noble metal nanoparticles, carbon nanomaterials and semiconductor nanomaterials) with their own advantages and limitations are well summarized in this review. Secondly, since UCNPs have been utilized for the detection of different kinds of analytes, we introduce recent research studies about UCNPs for ions, gas molecules, biomolecules and thermal sensing. Finally, we highlight the typical detection techniques and UCNP based devices for Bioapplications.
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multifunctional upconversion magnetic hybrid nanostructured materials synthesis and Bioapplications
Theranostics, 2013Co-Authors: Xiaomin Li, Dongyuan Zhao, Fan ZhangAbstract:The combination of nanotechnology and biology has developed into an emerging research area: nano-biotechnology. Upconversion nanoparticles (UCNPs) have attracted a great deal of attention in Bioapplications due to their high chemical stability, low toxicity, and high signal-to-noise ratio. Magnetic nanoparticles (MNPs) are also well-established nanomaterials that offer controlled size, ability to be manipulated externally, and enhancement of contrast in magnetic resonance imaging (MRI). As a result, these nanoparticles could have many applications in biology and medicine, in- cluding protein purification, drug delivery, and medical imaging. Because of the potential benefits of multimodal functionality in biomedical applications, researchers would like to design and fabricate multifunctional upconversion-magnetic hybrid nanostructured materials. The hybrid nanostruc- tures, which combine UCNPs with MNPs, exhibit upconversion fluorescence alongside super- paramagnetism property. Such structures could provide a platform for enhanced bioimaging and controlled drug delivery. We expect that the combination of unique structural characteristics and integrated functions of multifunctional upconversion-magnetic nanoparticles will attract increasing research interest and could lead to new opportunities in nano-Bioapplications.
