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Jiang Chang – One of the best experts on this subject based on the ideXlab platform.

  • silicate Bioceramics from soft tissue regeneration to tumor therapy
    Journal of Materials Chemistry B, 2019
    Co-Authors: Qingqing Yu, Jiang Chang, Chengtie Wu

    Abstract:

    Great efforts have been devoted to exploiting silicate Bioceramics for various applications in soft tissue regeneration, owing to their excellent bioactivity. Based on the inherent ability of silicate Bioceramics to repair tissue, bioactive ions are easily incorporated into silicate Bioceramics to endow them with extra biological properties, such as enhanced angiogenesis, antibiosis, enhanced osteogenesis, and antitumor effect, which significantly expands the application of multifunctional silicate Bioceramics. Furthermore, silicate nanoBioceramics with unique structures have been widely employed for tumor therapy. In recent years, the novel applications of silicate Bioceramics for both tissue regeneration and tumor therapy have substantially grown. Eliminating the skin tumors first and then repairing the skin wounds has been widely investigated by our groups, which might shed some light on treating other soft tissue tumor or tumor-induced defects. This review first describes the recent advances made in the development of silicate Bioceramics as therapeutic platforms for soft tissue regeneration. We then highlight the major silicate nanoBioceramics used for tumor therapy. Silicate Bioceramics for both soft tissue regeneration and tumor therapy are further emphasized. Finally, challenges and future directions of silicate Bioceramics stepping into the clinics are discussed. This review will inspire researchers to create the efficient and functional silicate Bioceramics needed for regeneration and tumor therapy of other tissues.

  • in vivo evaluation of the subchronic systemic toxicity of akermanite Bioceramic for bone regeneration following iso standard methods
    RSC Advances, 2019
    Co-Authors: Yanling Zhou, Zhiguang Hua, Haibo Zhu, Ying Zhou, Peiji Wang, Jiang Chang

    Abstract:

    Although the akermanite (Ca2MgSi2O7) Bioceramic has been confirmed to possess favorable osteogenic activity, until now little was known about its in vivo subchronic systemic toxicity, which is important for determining the biocompatibility and the clinical applications of the material in bone implants. In this study, the subchronic systemic toxicity of akermanite Bioceramic was for the first time investigated according to well-accepted ISO standard methods. Following the method, healthy adult Wistar rats were injected with certain amounts of extracts of akermanite Bioceramic that was intended to simulate the ionic product during the degradation of the material when implanted into the body. At day 28 after injection, the general body conditions, blood cytology, blood biochemistry and histology of all important organs of the rats were examined. The results showed that there was no significant difference in the hemoglobin concentration, red blood cell count, platelet count and white blood cell count between the rats with injection of akermanite Bioceramic extracts and the saline control. The indicators of liver function, including aspartate aminotransferase and alkaline phosphatase, and kidney function, including blood urea nitrogen and creatinine, did not show significant difference between the two groups (P > 0.05). In addition, the results of histological examination showed that the extract of akermanite Bioceramic did not cause any pathological changes to important organs such as the heart, liver and kidneys. These findings demonstrated that the ionic product derived from the degradation of akermanite Bioceramic did not cause in vivo subchronic systemic toxicity. The results of the current study provided more strengthened evidence for the biosafety of akermanite Bioceramic and suggest that this material with desirable biocompatibility may be a potential candidate for orthopedic clinical applications.

  • 3d printed Bioceramic scaffolds from bone tissue engineering to tumor therapy
    Acta Biomaterialia, 2018
    Co-Authors: Chu Feng, Jiang Chang

    Abstract:

    Abstract Toward the aim of personalized treatment, three-dimensional (3D) printing technology has been widely used in bone tissue engineering owing to its advantage of a fast, precise, and controllable fabrication process. Conventional Bioceramic scaffolds are mainly used for bone tissue engineering; however, there has been a significant change in the application of Bioceramic scaffolds during the past several years. Therefore, this review focuses on 3D-printed Bioceramic scaffolds with different compositions and hierarchical structures (macro, micro, and nano scales), and their effects on the mechanical, degradation, permeability, and biological properties. Further, this review highlights 3D-printed Bioceramic scaffolds for applications extending from bone tissue regeneration to bone tumor therapy. This review emphasizes recent developments in functional 3D-printed Bioceramic scaffolds with the ability to be used for both tumor therapy and bone tissue regeneration. Considering the challenges in bone tumor therapy, these functional Bioceramic scaffolds have a great potential in repairing bone defects induced by surgery and kill the possibly residual tumor cells to achieve bone tumor therapy. Finally, a brief perspective regarding future directions in this field was also provided. The review not only gives a summary of the research developments in Bioceramic science but also offers a new therapy strategy by extending multifunctions of traditional biomaterials toward a specific disease. Statement of significance This review outlines the development tendency of 3D-printed Bioceramic scaffolds for applications ranging from bone tissue regeneration to bone tumor therapy. Conventional Bioceramic scaffolds are mainly used for bone tissue engineering; however, there has been a significant change in the application of Bioceramic scaffolds during the past several years. Therefore, this review focuses on 3D-printed Bioceramic scaffolds with different compositions and hierarchical structures (macro, micro, and nano scales), and their effects on the mechanical, degradation, permeability, and biological properties. Further, this review highlights 3D-printed Bioceramic scaffolds for applications extending from bone tissue regeneration to bone tumor therapy. This review emphasizes recent developments in the functional 3D-printed Bioceramic scaffolds with the ability to be used for both bone tumor therapy and bone tissue regeneration.

Chengtie Wu – One of the best experts on this subject based on the ideXlab platform.

  • silicate Bioceramics from soft tissue regeneration to tumor therapy
    Journal of Materials Chemistry B, 2019
    Co-Authors: Qingqing Yu, Jiang Chang, Chengtie Wu

    Abstract:

    Great efforts have been devoted to exploiting silicate Bioceramics for various applications in soft tissue regeneration, owing to their excellent bioactivity. Based on the inherent ability of silicate Bioceramics to repair tissue, bioactive ions are easily incorporated into silicate Bioceramics to endow them with extra biological properties, such as enhanced angiogenesis, antibiosis, enhanced osteogenesis, and antitumor effect, which significantly expands the application of multifunctional silicate Bioceramics. Furthermore, silicate nanoBioceramics with unique structures have been widely employed for tumor therapy. In recent years, the novel applications of silicate Bioceramics for both tissue regeneration and tumor therapy have substantially grown. Eliminating the skin tumors first and then repairing the skin wounds has been widely investigated by our groups, which might shed some light on treating other soft tissue tumor or tumor-induced defects. This review first describes the recent advances made in the development of silicate Bioceramics as therapeutic platforms for soft tissue regeneration. We then highlight the major silicate nanoBioceramics used for tumor therapy. Silicate Bioceramics for both soft tissue regeneration and tumor therapy are further emphasized. Finally, challenges and future directions of silicate Bioceramics stepping into the clinics are discussed. This review will inspire researchers to create the efficient and functional silicate Bioceramics needed for regeneration and tumor therapy of other tissues.

  • the synergistic effects of sr and si bioactive ions on osteogenesis osteoclastogenesis and angiogenesis for osteoporotic bone regeneration
    Acta Biomaterialia, 2017
    Co-Authors: Jiang Chang, Chengtie Wu, Lingyong Jiang, Bing Fang

    Abstract:

    Abstract Bioactive ions released from Bioceramics play important roles in bone regeneration; however, it is unclear how each ionic composition in complex Bioceramics exerts its specific effect on bone regeneration. The aim of this study is to elucidate the functional effects of Sr and Si ions in Bioceramics on the regeneration of osteoporotic bone. A model Bioceramic with Sr- and Si-containing components (SMS) was successfully fabricated and the effects of ionic products from SMS Bioceramics on the osteogenic, osteoclastic and angiogenic differentiation of rBMSCs-OVX and RANKL-induced osteoclasts were investigated. The results showed that SMS Bioceramics could enhance ALP activity and expression of Col 1, OCN, Runx2, and angiogenic factors including VEGF and Ang-1. SMS Bioceramics not only rebalanced the OPG/RANKL ratio of rBMSCs-OVX at early stage, but also repressed RANKL-induced osteoclast formation and expression of TRAP, DC-STAMP, V-ATPase a3, and NFATc1. The synergistic effects of Sr and Si ions were further investigated as compared with those of similar concentrations of Sr and Si ions alone. Sr and Si ions possessed synergistic effects on osteogenesis, osteoclastogenesis, and angiogenesis, attributed to the dominant effects of Sr ions on enhancing angiogenesis and repressing osteoclastogenesis, and the dominant effects of Si ions on stimulating osteogenesis. The in vivo study using critical-size mandibular defects of OVX rat models showed that SMS Bioceramics could significantly enhance bone formation and mineralization compared with β-TCP Bioceramics. Our results are the first to elucidate the specific effect of each ion from Bioceramics on osteogenesis, osteoclastogenesis and angiogenesis for osteoporotic bone regeneration, paving the way for the design of functional biomaterials with complex compositions for tissue engineering and regenerative medicine. Statement of significance Bioactive ions released from Bioceramics play important roles for bone regeneration; however, it is unclear how each of ionic compositions in complex Bioceramics exerts its specific effect on bone regeneration. The aim of present study is to elucidate the functional effects of Sr and Si ions in complex Bioceramics on the regeneration of osteoporotic bone. A model Bioceramic with Sr and Si-containing components (SMS) was successfully fabricated and the effects of ionic products from SMS Bioceramics on the osteogenic, osteoclastic and angiogenic differentiation of rBMSCs-OVX and RANKL-induced osteoclasts were investigated. The results showed that SMS Bioceramics could enhance ALP activity and expression of Col 1, OCN, Runx2 and angiogenic factors including VEGF and Ang-1. SMS Bioceramics not only rebalanced the ratio of OPG/RANKL of OVX-BMSCs at early stage, but also repressed RANKL-induced osteoclast formation and expression of TRAP, DC-STAMP, V-ATPase a3, and NFATc1. The synergistic effects of Sr and Si ions were further investigated as compared with the similar concentration of Sr and Si ions alone. It was found that Sr and Si ions possessed synergistic effects on osteogenesis, osteoclastogenesis and angiogenesis, attributed to the dominant effects of Sr ions on enhancing angiogenesis and repressing osteoclastogenesis, and the dominant effects of Si ions on stimulating osteogenesis. The in vivo study using critical-size mandibular defects of OVX rat models showed that SMS Bioceramics could significantly enhance bone formation and mineralization as compared with β-TCP Bioceramics. It is suggested that SMS Bioceramics may be a promising biomaterial for osteoporotic bone regeneration. To our knowledge, this is the first time to elucidate the specific effect of each ion from Bioceramics on osteogenesis, osteoclastogenesis and angiogenesis for osteoporotic bone regeneration, paving the way to design functional biomaterials with complex compositions for tissue engineering and regenerative medicine.

  • a 3d printed scaffold with mos2 nanosheets for tumor therapy and tissue regeneration
    Npg Asia Materials, 2017
    Co-Authors: Xiaocheng Wang, Tao Li, Dong Zhai, Chuan Jiang, Jiang Chang-wei, Jinwu Wang, Chengtie Wu

    Abstract:

    The treatment of malignant bone tumors is a significant clinical challenge because it requires the simultaneous removal of tumor tissues and regeneration of bone defects, and bifunctional three-dimensional (3D) scaffolds that function in both tumor therapy and tissue regeneration are expected to address this need. In this study, novel bifunctional scaffolds (MS-AKT scaffolds) were successfully fabricated by combining a 3D printing technique with a hydrothermal method. During the hydrothermal process, MoS2 nanosheets were grown in situ on the strut surface of Bioceramic scaffolds, endowing them with photothermal therapeutic potential. Under near-infrared (NIR) irradiation, the temperature of the MS-AKT scaffolds rapidly increased and was effectively modulated by varying the MoS2 content, scaffold sizes and laser power densities. The photothermal temperature significantly decreased the viability of osteosarcoma cells and breast cancer cells and inhibited tumor growth in vivo. Moreover, the MS-AKT scaffolds supported the attachment, proliferation and osteogenic differentiation of bone mesenchymal stem cells and induced bone regeneration in vivo. This bifunctional scaffold, which treats the tumor and facilitates bone growth, offers a promising clinical strategy to treat tumor-induced bone defects. This proof-of-concept study demonstrates the feasibility of localized tumor therapy and tissue regeneration in diverse tissue engineering applications using multifunctional biomaterials. Molybdenum disulfide (MoS2) nanosheets grown on a Bioceramic scaffold are promising for improved treatment of malignant bone tumours. Treating malignant bone tumours is challenging as it requires removing tumour tissues while simultaneously regenerating bone defects. Current treatments combine surgery, chemotherapy and radiotherapy, which can result in incomplete removal of tumour cells, large bone defects and other harmful side effects. Now, Chengtie Wu of the Shanghai Institute of Ceramics, China, and co-workers have used hydrothermal processing to grow MoS2 nanosheets on three-dimensional printed Bioceramic scaffolds. The photothermal properties of these nanosheets can be used to generate heating in the vicinity of tumours, thereby inhibiting their growth, while the scaffolds provide support for bone regeneration. The bifunctional scaffold potentially could be used to clinically treat tumour-induced bone defects. A bifunctional scaffold was successfully prepared by in situ growth of MoS2 nanosheets on the 3D-printed Bioceramic scaffolds via a facile hydrothermal process. The prepared scaffolds exhibit an excellent capability for both tumor therapy and tissue regeneration, offering a promising clinical strategy for effective treatment of tumor-induced tissue defects.

Dong Zhai – One of the best experts on this subject based on the ideXlab platform.

  • a 3d printed scaffold with mos2 nanosheets for tumor therapy and tissue regeneration
    Npg Asia Materials, 2017
    Co-Authors: Xiaocheng Wang, Tao Li, Dong Zhai, Chuan Jiang, Jiang Chang-wei, Jinwu Wang, Chengtie Wu

    Abstract:

    The treatment of malignant bone tumors is a significant clinical challenge because it requires the simultaneous removal of tumor tissues and regeneration of bone defects, and bifunctional three-dimensional (3D) scaffolds that function in both tumor therapy and tissue regeneration are expected to address this need. In this study, novel bifunctional scaffolds (MS-AKT scaffolds) were successfully fabricated by combining a 3D printing technique with a hydrothermal method. During the hydrothermal process, MoS2 nanosheets were grown in situ on the strut surface of Bioceramic scaffolds, endowing them with photothermal therapeutic potential. Under near-infrared (NIR) irradiation, the temperature of the MS-AKT scaffolds rapidly increased and was effectively modulated by varying the MoS2 content, scaffold sizes and laser power densities. The photothermal temperature significantly decreased the viability of osteosarcoma cells and breast cancer cells and inhibited tumor growth in vivo. Moreover, the MS-AKT scaffolds supported the attachment, proliferation and osteogenic differentiation of bone mesenchymal stem cells and induced bone regeneration in vivo. This bifunctional scaffold, which treats the tumor and facilitates bone growth, offers a promising clinical strategy to treat tumor-induced bone defects. This proof-of-concept study demonstrates the feasibility of localized tumor therapy and tissue regeneration in diverse tissue engineering applications using multifunctional biomaterials. Molybdenum disulfide (MoS2) nanosheets grown on a Bioceramic scaffold are promising for improved treatment of malignant bone tumours. Treating malignant bone tumours is challenging as it requires removing tumour tissues while simultaneously regenerating bone defects. Current treatments combine surgery, chemotherapy and radiotherapy, which can result in incomplete removal of tumour cells, large bone defects and other harmful side effects. Now, Chengtie Wu of the Shanghai Institute of Ceramics, China, and co-workers have used hydrothermal processing to grow MoS2 nanosheets on three-dimensional printed Bioceramic scaffolds. The photothermal properties of these nanosheets can be used to generate heating in the vicinity of tumours, thereby inhibiting their growth, while the scaffolds provide support for bone regeneration. The bifunctional scaffold potentially could be used to clinically treat tumour-induced bone defects. A bifunctional scaffold was successfully prepared by in situ growth of MoS2 nanosheets on the 3D-printed Bioceramic scaffolds via a facile hydrothermal process. The prepared scaffolds exhibit an excellent capability for both tumor therapy and tissue regeneration, offering a promising clinical strategy for effective treatment of tumor-induced tissue defects.

  • 3d plotting of highly uniform sr5 po4 2sio4 Bioceramic scaffolds for bone tissue engineering
    Journal of Materials Chemistry B, 2016
    Co-Authors: Huiying Zhu, Dong Zhai, Yali Zhang, Zhiguang Hua, Jiang Chang

    Abstract:

    Bioceramics play an important role in bone regeneration. However, it is challenging to design Bioceramic scaffolds with suitable ionic components and beneficial osteo/angio-stimulation ability for enhanced bone regeneration. In this study, we successfully synthesized a pure-phase Sr5(PO4)2SiO4 (SPS) bioactive ceramic through a solid-state reaction method and further prepared highly uniform SPS Bioceramic scaffolds with controlled macropore sizes and mechanical strength by a 3D-plotting technique, and the biological responses of rabbit bone marrow stromal cells (rBMSCs) and human umbilical vein endothelial cells (HUVECs) after culturing with different concentrations of SPS extracts and porous scaffolds were systematically studied. The results showed that the ionic products from SPS Bioceramics significantly stimulated the proliferation, alkaline phosphate (ALP) activity and osteogenesis-related gene expression (Runx2, ALP, OCN, OPN) of rBMSCs as well as the proliferation and angiogenesis-related gene expression (VEGF, KDR, eNOS, HIF 1α) of HUVECs. 3D-plotted SPS scaffolds could effectively support the attachment and proliferation of both rBMSCs and HUVECs, and the proliferation rates of the two kinds of cells in SPS scaffolds were distinctively higher than those in β-tricalcium phosphate (β-TCP) scaffolds prepared by the same method. In addition, the compressive strength of SPS scaffolds could be well controlled in the range 8–30 MPa when their pore size varied from 100 to 300 μm, which was significantly higher than those of β-TCP scaffolds with similar pore sizes (∼1.5 times). Our results demonstrated that 3D-plotted SPS Bioceramic scaffolds with such a specific ionic combination and high mechanical strength as well as good degradability possessed the ability to stimulate both osteogenic and angiogenic differentiation of tissue cells, indicating that they might be promising biomaterials for bone tissue engineering.

  • hierarchical Bioceramic scaffolds with 3d plotted macropores and mussel inspired surface nanolayers for stimulating osteogenesis
    Nanoscale, 2016
    Co-Authors: Dong Zhai, Lunguo Xia, Ing Fang, Shiyi Che, Jiang Chang

    Abstract:

    The hierarchical structure of biomaterials plays an important role in the process of tissue reconstruction and regeneration. 3D-plotted scaffolds have been widely used for bone tissue engineering due to their controlled macropore structure and mechanical properties. However, the lack of micro- or nano-structures on the strut surface of 3D-plotted scaffolds, especially for Bioceramic scaffolds, limits their biological activity. Inspired by the adhesive versatility of mussels and the active ion-chelating capacity of polydopamine, we set out to prepare a hierarchical Bioceramic scaffold with controlled macropores and mussel-inspired surface nanolayers by combining the 3D-plotting technique with the polydopamine/apatite hybrid strategy in order to synergistically accelerate the osteogenesis and angiogenesis. β-Tricalcium phosphate (TCP) scaffolds were firstly 3D-plotted and then treated in dopamine–Tris/HCl and dopamine–SBF solutions to obtain TCP-DOPA-Tris and TCP-DOPA-SBF scaffolds, respectively. It was found that polydopamine/apatite hybrid nanolayers were formed on the surface of both TCP-DOPA-Tris and TCP-DOPA-SBF scaffolds and TCP-DOPA-SBF scaffolds induced apatite mineralization for the second time during the cell culture. As compared to TCP scaffolds, both TCP-DOPA-Tris and TCP-DOPA-SBF scaffolds significantly promoted the osteogenesis of bone marrow stromal cells (BMSCs) as well as the angiogenesis of human umbilical vein endothelial cells (HUVECs), and the TCP-DOPA-SBF group presented the highest in vitro osteogenic/angiogenic activity among the three groups. Furthermore, both TCP-DOPA-Tris and TCP-DOPA-SBF scaffolds significantly improved the formation of new bone in vivo as compared to TCP scaffolds without a nanostructured surface. Our results suggest that the utilization of a mussel-inspired Ca, P-chelated polydopamine nanolayer on 3D-plotted Bioceramic scaffolds is a viable and effective strategy to construct a hierarchical structure for synergistically accelerating osteogenesis.