The Experts below are selected from a list of 20142 Experts worldwide ranked by ideXlab platform
Jeremy M Crook - One of the best experts on this subject based on the ideXlab platform.
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a 3d printed graphene electrode device for enhanced and scalable stem cell culture osteoinduction and tissue building
Materials & Design, 2021Co-Authors: Xiao Liu, Jeremy M Crook, Gordon G WallaceAbstract:Abstract Bone related diseases and disorders increasingly impact human health. Electrical stimulation (ES) has been shown to promote osteogenesis and healing of bone defects. Graphene, is an electrically conductive and Biocompatible Material with good mechanical properties (strength with flexibility), and therefore shows significant promise as a cell-compatible electrode for ES. Graphene-based scaffolds may therefore be used for 3D cell and tissue support, including 3D osteoinduction. We have fabricated 3D graphene electrode structures to provide ES to human adipose stem cells (ADSCs). The assemblies support ADSC growth and differentiation, with ES augmenting proliferation and osteogenesis. Our findings expand our previous work on developing graphene-based cell culture platforms for bone engineering, demonstrating their adaptability and amalgamation for more scalable and high throughput stem cell maintenance, osteoinduction and tissue building. Furthermore, the devices have the potential to be employed for a variety of other cells and tissues for research and therapeutics, including regenerative medicine.
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a 3d printed graphene electrode device for enhanced and scalable stem cell culture osteoinduction and tissue building
Materials & Design, 2021Co-Authors: Xiao Liu, Jeremy M Crook, Gordon G WallaceAbstract:Abstract Bone related diseases and disorders increasingly impact human health principally due to prolonged life expectancy and increasing obesity. Electrical stimulation (ES) has been shown to promote osteogenesis and healing of bone defects. Graphene, is an electrically conductive and Biocompatible Material with good mechanical properties (strength with flexibility), and therefore shows significant promise as a cell-compatible electrode for ES. Graphene-based scaffolds may therefore be used for 3D cell and tissue support, including 3D osteoinduction. We have fabricated 3D graphene electrode structures to provide ES to human adipose stem cells (ADSCs). The assemblies support ADSC growth and differentiation, with ES augmenting proliferation and osteogenesis. Our findings expand our previous work on developing graphene-based cell culture platforms for bone engineering, demonstrating their adaptability and amalgamation for more scalable and high throughput stem cell maintenance, osteoinduction and tissue building. Furthermore, the devices have the potential to be employed for a variety of other cells and tissues for research and therapeutics, including regenerative medicine.
Gordon G Wallace - One of the best experts on this subject based on the ideXlab platform.
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a 3d printed graphene electrode device for enhanced and scalable stem cell culture osteoinduction and tissue building
Materials & Design, 2021Co-Authors: Xiao Liu, Jeremy M Crook, Gordon G WallaceAbstract:Abstract Bone related diseases and disorders increasingly impact human health. Electrical stimulation (ES) has been shown to promote osteogenesis and healing of bone defects. Graphene, is an electrically conductive and Biocompatible Material with good mechanical properties (strength with flexibility), and therefore shows significant promise as a cell-compatible electrode for ES. Graphene-based scaffolds may therefore be used for 3D cell and tissue support, including 3D osteoinduction. We have fabricated 3D graphene electrode structures to provide ES to human adipose stem cells (ADSCs). The assemblies support ADSC growth and differentiation, with ES augmenting proliferation and osteogenesis. Our findings expand our previous work on developing graphene-based cell culture platforms for bone engineering, demonstrating their adaptability and amalgamation for more scalable and high throughput stem cell maintenance, osteoinduction and tissue building. Furthermore, the devices have the potential to be employed for a variety of other cells and tissues for research and therapeutics, including regenerative medicine.
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a 3d printed graphene electrode device for enhanced and scalable stem cell culture osteoinduction and tissue building
Materials & Design, 2021Co-Authors: Xiao Liu, Jeremy M Crook, Gordon G WallaceAbstract:Abstract Bone related diseases and disorders increasingly impact human health principally due to prolonged life expectancy and increasing obesity. Electrical stimulation (ES) has been shown to promote osteogenesis and healing of bone defects. Graphene, is an electrically conductive and Biocompatible Material with good mechanical properties (strength with flexibility), and therefore shows significant promise as a cell-compatible electrode for ES. Graphene-based scaffolds may therefore be used for 3D cell and tissue support, including 3D osteoinduction. We have fabricated 3D graphene electrode structures to provide ES to human adipose stem cells (ADSCs). The assemblies support ADSC growth and differentiation, with ES augmenting proliferation and osteogenesis. Our findings expand our previous work on developing graphene-based cell culture platforms for bone engineering, demonstrating their adaptability and amalgamation for more scalable and high throughput stem cell maintenance, osteoinduction and tissue building. Furthermore, the devices have the potential to be employed for a variety of other cells and tissues for research and therapeutics, including regenerative medicine.
Xiao Liu - One of the best experts on this subject based on the ideXlab platform.
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a 3d printed graphene electrode device for enhanced and scalable stem cell culture osteoinduction and tissue building
Materials & Design, 2021Co-Authors: Xiao Liu, Jeremy M Crook, Gordon G WallaceAbstract:Abstract Bone related diseases and disorders increasingly impact human health. Electrical stimulation (ES) has been shown to promote osteogenesis and healing of bone defects. Graphene, is an electrically conductive and Biocompatible Material with good mechanical properties (strength with flexibility), and therefore shows significant promise as a cell-compatible electrode for ES. Graphene-based scaffolds may therefore be used for 3D cell and tissue support, including 3D osteoinduction. We have fabricated 3D graphene electrode structures to provide ES to human adipose stem cells (ADSCs). The assemblies support ADSC growth and differentiation, with ES augmenting proliferation and osteogenesis. Our findings expand our previous work on developing graphene-based cell culture platforms for bone engineering, demonstrating their adaptability and amalgamation for more scalable and high throughput stem cell maintenance, osteoinduction and tissue building. Furthermore, the devices have the potential to be employed for a variety of other cells and tissues for research and therapeutics, including regenerative medicine.
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a 3d printed graphene electrode device for enhanced and scalable stem cell culture osteoinduction and tissue building
Materials & Design, 2021Co-Authors: Xiao Liu, Jeremy M Crook, Gordon G WallaceAbstract:Abstract Bone related diseases and disorders increasingly impact human health principally due to prolonged life expectancy and increasing obesity. Electrical stimulation (ES) has been shown to promote osteogenesis and healing of bone defects. Graphene, is an electrically conductive and Biocompatible Material with good mechanical properties (strength with flexibility), and therefore shows significant promise as a cell-compatible electrode for ES. Graphene-based scaffolds may therefore be used for 3D cell and tissue support, including 3D osteoinduction. We have fabricated 3D graphene electrode structures to provide ES to human adipose stem cells (ADSCs). The assemblies support ADSC growth and differentiation, with ES augmenting proliferation and osteogenesis. Our findings expand our previous work on developing graphene-based cell culture platforms for bone engineering, demonstrating their adaptability and amalgamation for more scalable and high throughput stem cell maintenance, osteoinduction and tissue building. Furthermore, the devices have the potential to be employed for a variety of other cells and tissues for research and therapeutics, including regenerative medicine.
Cameron G Mcdougall - One of the best experts on this subject based on the ideXlab platform.
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preliminary investigation of calcium alginate gel as a Biocompatible Material for endovascular aneurysm embolization in vivo
Neurosurgery, 2007Co-Authors: T Becker, Mark C Preul, William D Bichard, Daryl R Kipke, Cameron G McdougallAbstract:Objective We sought to expand our assessment of calcium alginate as an embolic agent in an aneurysm model in swine that survived from 30 to 90 days. The objective of this study was to assess the biocompatibility and stability of calcium alginate in aneurysms in vivo. Methods Ten models were created from a venous pouch sutured to the carotid artery, simulating flow to a side-wall aneurysm. Eight swine received complete embolizations, and two were less than 50% embolized to be used as controls. Alginate and calcium chloride were injected from concentric-tube microcatheters to form a mass that filled the aneurysm pouch. Results Angiography and histology verified complete aneurysm occlusion and neck healing up to 90 days in eight swine. Both control animal aneurysms ruptured within 8 days. No animals showed evidence of downstream calcium alginate gel propagation. A minor bioactive response to the alginate gel was noted at 30 days, and fibrous tissue grew over the aneurysm orifice, sealing off the defect. No degenerative or inflammatory response was observed. At 90 days, moderate fibrous tissue surrounded the alginate. Tissue growth across the aneurysm neck remained complete and stable with no signs of neointimal growth into the parent vessel. Conclusion Calcium alginate was an effective endovascular occlusion Material that filled the aneurysm and provided an effective template for tissue growth across the aneurysm neck after 30 days and up to 90 days. Complete filling of the aneurysm with calcium alginate ensures stability, biocompatibility, and optimal healing for up to 90 days in swine.
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calcium alginate gel as a Biocompatible Material for endovascular arteriovenous malformation embolization six month results in an animal model
Neurosurgery, 2005Co-Authors: T Becker, Mark C Preul, William D Bichard, Daryl R Kipke, Cameron G McdougallAbstract:OBJECTIVE: We sought to expand our assessment of calcium alginate as an embolic agent in an animal model of a cerebral arteriovenous malformation (AVM). The objective of this study was to assess the long-term biocompatibility and stability of calcium alginate in AVM swine models that survived from 1 to 6 months. METHODS: The swine model included a carotid-jugular anastomosis to redirect flow to the rete mirabile (RM), thereby simulating flow to an AVM. Alginate and the reactive component, calcium chloride, were injected from double-lumen or concentric-tube microcatheters to form an occlusion of the RM feeding vessel and the inferior portion of the RM. RESULTS: Angiography and histology verified complete occlusion of the RM feeding vessel for up to 6 months in eight of nine swine. Blood flow remained open to the superior portion of the RM and the circle of Willis. No evidence of downstream calcium alginate gel was seen in the follow-up angiograms or the histological preparations of the circle of Willis. A minor bioactive response to the alginate gel was noted at 1 month, yet no degenerative or inflammatory response was seen. At 6 months, there was moderate fibrous tissue around the alginate, which further sealed off flow to the embolized areas of the RM. CONCLUSION: Over a period of 6 months, calcium alginate was an effective endovascular occlusion Material that blocked blood flow to the inferior portion of the RM. The chronic AVM model verified the long-term stability and biocompatibility of calcium alginate.
T Becker - One of the best experts on this subject based on the ideXlab platform.
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preliminary investigation of calcium alginate gel as a Biocompatible Material for endovascular aneurysm embolization in vivo
Neurosurgery, 2007Co-Authors: T Becker, Mark C Preul, William D Bichard, Daryl R Kipke, Cameron G McdougallAbstract:Objective We sought to expand our assessment of calcium alginate as an embolic agent in an aneurysm model in swine that survived from 30 to 90 days. The objective of this study was to assess the biocompatibility and stability of calcium alginate in aneurysms in vivo. Methods Ten models were created from a venous pouch sutured to the carotid artery, simulating flow to a side-wall aneurysm. Eight swine received complete embolizations, and two were less than 50% embolized to be used as controls. Alginate and calcium chloride were injected from concentric-tube microcatheters to form a mass that filled the aneurysm pouch. Results Angiography and histology verified complete aneurysm occlusion and neck healing up to 90 days in eight swine. Both control animal aneurysms ruptured within 8 days. No animals showed evidence of downstream calcium alginate gel propagation. A minor bioactive response to the alginate gel was noted at 30 days, and fibrous tissue grew over the aneurysm orifice, sealing off the defect. No degenerative or inflammatory response was observed. At 90 days, moderate fibrous tissue surrounded the alginate. Tissue growth across the aneurysm neck remained complete and stable with no signs of neointimal growth into the parent vessel. Conclusion Calcium alginate was an effective endovascular occlusion Material that filled the aneurysm and provided an effective template for tissue growth across the aneurysm neck after 30 days and up to 90 days. Complete filling of the aneurysm with calcium alginate ensures stability, biocompatibility, and optimal healing for up to 90 days in swine.
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calcium alginate gel as a Biocompatible Material for endovascular arteriovenous malformation embolization six month results in an animal model
Neurosurgery, 2005Co-Authors: T Becker, Mark C Preul, William D Bichard, Daryl R Kipke, Cameron G McdougallAbstract:OBJECTIVE: We sought to expand our assessment of calcium alginate as an embolic agent in an animal model of a cerebral arteriovenous malformation (AVM). The objective of this study was to assess the long-term biocompatibility and stability of calcium alginate in AVM swine models that survived from 1 to 6 months. METHODS: The swine model included a carotid-jugular anastomosis to redirect flow to the rete mirabile (RM), thereby simulating flow to an AVM. Alginate and the reactive component, calcium chloride, were injected from double-lumen or concentric-tube microcatheters to form an occlusion of the RM feeding vessel and the inferior portion of the RM. RESULTS: Angiography and histology verified complete occlusion of the RM feeding vessel for up to 6 months in eight of nine swine. Blood flow remained open to the superior portion of the RM and the circle of Willis. No evidence of downstream calcium alginate gel was seen in the follow-up angiograms or the histological preparations of the circle of Willis. A minor bioactive response to the alginate gel was noted at 1 month, yet no degenerative or inflammatory response was seen. At 6 months, there was moderate fibrous tissue around the alginate, which further sealed off flow to the embolized areas of the RM. CONCLUSION: Over a period of 6 months, calcium alginate was an effective endovascular occlusion Material that blocked blood flow to the inferior portion of the RM. The chronic AVM model verified the long-term stability and biocompatibility of calcium alginate.