The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform

Christopher Barnerkowollik - One of the best experts on this subject based on the ideXlab platform.

Sébastien Perrier - One of the best experts on this subject based on the ideXlab platform.

Vincent M Rotello - One of the best experts on this subject based on the ideXlab platform.

  • gold nanoparticle platforms as drug and Biomacromolecule delivery systems
    Journal of Controlled Release, 2010
    Co-Authors: Bradley Duncan, Chaekyu Kim, Vincent M Rotello
    Abstract:

    Gold nanoparticles (AuNPs) are a suitable platform for development of efficient delivery systems. AuNPs can be easily synthesized, functionalized, and are biocompatible. The tunability of the AuNP monolayer allows for complete control of surface properties for targeting and stability/release using these nanocarriers. This review will discuss several delivery strategies utilizing AuNPs.

  • the Biomacromolecule nanoparticle interface
    Nano Today, 2007
    Co-Authors: Changcheng You, Apiwat Chompoosor, Vincent M Rotello
    Abstract:

    The wide variety of core materials, coupled with the ability to engineer their surface properties, make monolayer-protected nanoparticles (NPs) excellent scaffolds for targeting Biomacromolecules. In this review, we focus on recent advances in NP-Biomacromolecule interactions, highlighting the control of Biomacromolecule structure and function through engineered interactions with NP surfaces.

  • engineering the nanoparticle Biomacromolecule interface
    Journal of Materials Chemistry, 2006
    Co-Authors: Changcheng You, Ayush Verma, Vincent M Rotello
    Abstract:

    Monolayer-protected nanoparticles feature tunable size, surface functionality and core material, providing scaffolds for targeting Biomacromolecules. This review highlights recent advances in nanoparticle-Biomacromolecule interactions, focusing on two key areas: (1) The modulation of structure and function of Biomacromolecules through engineered interactions with nanoparticle surfaces: (2) The use of Biomacromolecules as building blocks for nanostructured materials.

  • surface recognition of Biomacromolecules using nanoparticle receptors
    Chemical Communications, 2005
    Co-Authors: Ayush Verma, Vincent M Rotello
    Abstract:

    Nanoparticles present a versatile scaffold to target Biomacromolecule surfaces via complementary interactions. This review highlights some unique features of nanoparticles that make them particularly attractive resources for biomacromolecular recognition, and displays their use in modulation of structure and function of Biomacromolecules.

  • Biomacromolecule surface recognition using nanoparticle receptors
    Supramolecular Chemistry, 2005
    Co-Authors: Rochelle R Arvizo, Ayush Verma, Vincent M Rotello
    Abstract:

    Biomacromolecule surface recognition is an important factor in regulating cellular processes. Nanometer-scale mixed monolayer-protected clusters (MMPCs) provide scaffolds for creating receptors targeting biomacromolecular surfaces. Unique features of nanoparticles that make them particularly attractive resources for biomacromolecular recognition and their use in modification of structure and function of Biomacromolecules are illustrated in this review.

Alessandro Casnati - One of the best experts on this subject based on the ideXlab platform.

  • Biomacromolecule Recognition by Calixarene Macrocycles
    Comprehensive Supramolecular Chemistry II, 2017
    Co-Authors: Laura Baldini, Alessandro Casnati, Francesco Sansone
    Abstract:

    After having been extensively studied as a receptor for small guests (both neutral and charged), the last 20 years have witnessed the progressive use of the calixarene macrocycle as a ligand for the recognition of large Biomacromolecules. Thanks to the easy functionalization of both rims, to the multivalent nature of the scaffold, and to the possibility of controlling its three-dimensional shape and conformation, a number of calixarene derivatives able to selectively interact with proteins (including specific areas of a protein surface or an active site) or with nucleic acids have been reported. This review critically covers the results obtained in the field of Biomacromolecule recognition by calixarene derivatives, giving a special emphasis to those examples where the interaction with the target leads to a specific and potentially medically relevant activity, such as protein inhibition, disruption of protein–protein interactions, and gene delivery.

  • correction moulding calixarenes for Biomacromolecule targeting
    Chemical Communications, 2015
    Co-Authors: Marta Giuliani, Francesco Sansone, Ilaria Morbioli, Alessandro Casnati
    Abstract:

    Correction for 'Moulding calixarenes for Biomacromolecule targeting' by Marta Giuliani et al., Chem. Commun., 2015, 51, 14140-14159.

  • Moulding calixarenes for Biomacromolecule targeting
    Chemical Communications, 2015
    Co-Authors: Marta Giuliani, Francesco Sansone, Ilaria Morbioli, Alessandro Casnati
    Abstract:

    After their successful use as a preorganized platform for the preparation of receptors for metal ions and small neutral molecules over the last 15 years, calixarenes are enjoying a renaissance of popularity as scaffolds for ligands that are able to efficiently and selectively target macromolecules such as proteins/enzymes, nucleic acids and lipids. This feature article summarizes the peculiar factors characterizing the calixarene structure and properties, as well as outlines the main rules that can be used to turn such macrocycles into efficient and successful ligands for these classes of Biomacromolecules. Factors that affect the multivalent properties of calixarenes, such as the size, conformation and stereochemical presentation of binding groups or their amphiphilicity and hybrid character, are described in detail with the use of a few selected examples from the literature. Perspectives and applications of these ligands in bionanotechnology and nanomedicine, such as protein sensing and inhibition, gene-delivery, targeted drug-delivery and cell imaging, are also discussed.

Christian J Doonan - One of the best experts on this subject based on the ideXlab platform.

  • control of structure topology and spatial distribution of Biomacromolecules in protein zif 8 biocomposites
    Chemistry of Materials, 2018
    Co-Authors: Weibin Liang, Raffaele Ricco, Natasha K Maddigan, Robert P Dickinson, Christopher J Sumby, Stephen G Bell, Paolo Falcaro, Christian J Doonan
    Abstract:

    The protective capacity and applications of biomimetically mineralized Biomacromolecule zeolitic imidazolate framework (ZIF) composites are likely dependent on the localization of the biomolecule and the topology of the mineralized ZIF coating. Herein, we identify reaction conditions to reliably yield the porous ZIF-8 sodalite topology (high ZIF-8 precursor concentrations; high 2-methylimidazole:Zn2+ ratios) in preference to other more dense phases. Furthermore, protocols to universally prepare biocomposites with a range of Biomacromolecules are canvassed. Through the use of fluorophore-tagged proteins and confocal laser scanning microscopy (CLSM), we further establish the positioning of biomolecules within ZIF-8 crystals. CLSM reveals subsurface localization with fluorescein-tagged bovine serum albumin (BSA) or full encapsulation with rhodamine B-tagged BSA. These observations allowed us to demonstrate that core–shell ZIF-8 growth strategies afford complete encapsulation with varying thicknesses of poten...

  • biomimetic mineralization of metal organic frameworks as protective coatings for Biomacromolecules
    Nature Communications, 2015
    Co-Authors: Kang Liang, Raffaele Ricco, Stephen G Bell, Cara M Doherty, Mark J Styles, Nigel Kirby, Stephen T Mudie, David N Haylock, Anita J Hill, Christian J Doonan
    Abstract:

    Robust Biomacromolecules could be used for a wide range of biotechnological applications. Here the authors report a biomimetic mineralization process, in which biomolecules are encapsulated within metal-organic frameworks, and their stability is subsequently increased without significant bioactivity loss.