Biomedical Imaging

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Andrew F. Laine - One of the best experts on this subject based on the ideXlab platform.

  • In the Spotlight: Biomedical Imaging
    IEEE Reviews in Biomedical Engineering, 2013
    Co-Authors: Andrew F. Laine
    Abstract:

    In this spotlight, advances in four topics in Biomedical Imaging are described. This does not begin to cover all of the advances in the field, but include topics that remain the most compelling in terms of mortality (cardiovascular disease) and increasing concern (Chronic Obstructive Pulmonary Disease, (COPD)). We also report on some very exciting progress in making methods of MR spectroscopy more reliable and robust, thus suitable for wider clinical use. Finally, we describe recent developments in nuclear and molecular Imaging related to diagnosis and treatment of cancer.

  • In the Spotlight: Biomedical Imaging
    IEEE Reviews in Biomedical Engineering, 2008
    Co-Authors: Andrew F. Laine
    Abstract:

    This article reviews some of the more recent advances and trends in the area of Biomedical Imaging. Real-time multimodality Imaging and image-guided interventions are presented as well as other fast growing areas of interdisciplinary research and development. Segmentation, registration and spatial-temporal integration in medical image processing are also discussed.

B.e. Bouma - One of the best experts on this subject based on the ideXlab platform.

Brett E Bouma - One of the best experts on this subject based on the ideXlab platform.

  • dual modality fluorescence and full field optical coherence microscopy for Biomedical Imaging applications
    Biomedical Optics Express, 2012
    Co-Authors: Egidijus Auksorius, Yaron Bromberg, Rūta Motiejūnaitė, Alberto Pieretti, Emmanuel Coron, Jorge Aranda, Allan M Goldstein, Brett E Bouma, Andrius Kazlauskas, Guillermo J Tearney
    Abstract:

    Full-field optical coherence microscopy (FFOCM) is a high-resolution interferometric technique that is particularly attractive for Biomedical Imaging. Here we show that combining it with structured illumination fluorescence microscopy on one platform can increase its versatility since it enables co-localized registration of optically sectioned reflectance and fluorescence images. To demonstrate the potential of this dual modality, a fixed and labeled mouse retina was imaged. Results showed that both techniques can provide complementary information and therefore the system could potentially be useful for Biomedical Imaging applications.

  • numerical study of wavelength swept semiconductor ring lasers the role of refractive index nonlinearities in semiconductor optical amplifiers and implications for Biomedical Imaging applications
    Optics Letters, 2006
    Co-Authors: A Bilenca, Guillermo J Tearney, Brett E Bouma
    Abstract:

    Recent results have demonstrated unprecedented wavelength-tuning speed and repetition rate performance of semiconductor ring lasers incorporating scanning filters. However, several unique operational characteristics of these lasers have not been adequately explained, and the lack of an accurate model has hindered optimization. We numerically investigated the characteristics of these sources, using a semiconductor optical amplifier (SOA) traveling-wave Langevin model, and found good agreement with experimental measurements. In particular, we explored the role of the SOA refractive-index nonlinearities in determining the intracavity frequency-shift-broadening and the emitted power dependence on scan speed and direction. Our model predicts both continuous-wave and pulse operation and shows a universal relationship between the output power of lasers that have different cavity lengths and the filter peak frequency shift per round trip, therefore revealing the advantage of short cavities for high-speed Biomedical Imaging.

X S Xie - One of the best experts on this subject based on the ideXlab platform.

  • Stimulated Raman scattering microscopy for Biomedical Imaging
    Multiphoton Microscopy in the Biomedical Sciences Ix, 2009
    Co-Authors: Wei Min, Jing X Kang, Christian W. Freudiger, Sijia Lu, Chengwei He, X S Xie
    Abstract:

    Label-free chemical contrast is highly desirable in Biomedical Imaging. Spontaneous Raman microscopy provides specific vibrational signatures of chemical bonds, but is often hindered by low sensitivity. Here we report a 3D multi-photon vibrational Imaging technique based on stimulated Raman scattering (SRS). The sensitivity of SRS is significantly greater than that of spontaneous Raman scattering, and is further enhanced by high-frequency (MHz) phase-sensitive detection. SRS microscopy has a major advantage over previous coherent Raman techniques in that it offers background-free and easily interpretable chemical contrast. We show a variety of Biomedical applications, such as differentiating distributions of omega-3 fatty acids and saturated lipids in living cells, Imaging of brain and skin tissues based on intrinsic lipid contrast.

  • Label-Free Biomedical Imaging with High Sensitivity by Stimulated Raman Scattering Microscopy
    Science, 2008
    Co-Authors: Christian W. Freudiger, Jason C Tsai, Jing X Kang, Sijia Lu, Gary R. Holtom, Wei Min, Brian G Saar, Chengwei He, X S Xie
    Abstract:

    Label-free chemical contrast is highly desirable in Biomedical Imaging. Spontaneous Raman microscopy provides specific vibrational signatures of chemical bonds, but is often hindered by low sensitivity. Here we report a three-dimensional multiphoton vibrational Imaging technique based on stimulated Raman scattering (SRS). The sensitivity of SRS Imaging is significantly greater than that of spontaneous Raman microscopy, which is achieved by implementing high-frequency (megahertz) phase-sensitive detection. SRS microscopy has a major advantage over previous coherent Raman techniques in that it offers background-free and readily interpretable chemical contrast. We show a variety of Biomedical applications, such as differentiating distributions of omega-3 fatty acids and saturated lipids in living cells, Imaging of brain and skin tissues based on intrinsic lipid contrast, and monitoring drug delivery through the epidermis.

  • Label-Free Biomedical Imaging with High Sensitivity by Stimulated Raman Scattering Microscopy\r10.1126/science.1165758
    Science, 2008
    Co-Authors: Christian W. Freudiger, Jason C Tsai, Jing X Kang, Sijia Lu, Gary R. Holtom, Wei Min, Brian G Saar, Chengwei He, X S Xie
    Abstract:

    Label-free chemical contrast is highly desirable in Biomedical Imaging. Spontaneous Raman microscopy provides specific vibrational signatures of chemical bonds, but is often hindered by low sensitivity. Here we report a three-dimensional multiphoton vibrational Imaging technique based on stimulated Raman scattering (SRS). The sensitivity of SRS Imaging is significantly greater than that of spontaneous Raman microscopy, which is achieved by implementing high-frequency (megahertz) phase-sensitive detection. SRS microscopy has a major advantage over previous coherent Raman techniques in that it offers background-free and readily interpretable chemical contrast. We show a variety of Biomedical applications, such as differentiating distributions of omega-3 fatty acids and saturated lipids in living cells, Imaging of brain and skin tissues based on intrinsic lipid contrast, and monitoring drug delivery through the epidermis.

William R Hendee - One of the best experts on this subject based on the ideXlab platform.

  • Biomedical Imaging Techniques
    The Optics Encyclopedia, 2007
    Co-Authors: William R Hendee
    Abstract:

    Biomedical images are used extensively for noninvasive exploration of the internal anatomy, physiology, and metabolism of patients suffering from virtually every disease and injury known to humankind. These images are a prototypical example of “high-tech” medicine and are produced in many different ways, from receipt of X rays transmitted through the patient to detection of radio-frequency signals emitted from tissues subjected to intense magnetic fields. In the past three decades, major advances in medical Imaging have occurred, including X-ray and emission-computed tomography, real-time, gray-scale and Doppler ultrasound Imaging, computer and digital projection radiography, and magnetic resonance Imaging. Several additional Imaging techniques are under exploration, including laser optical Imaging, electrical impedance tomography, infrared and microwave thermography, acoustothermometry, and electrical and magnetic source Imaging. Whether these or a completely new Imaging technique may emerge as a significant Imaging modality remains to be seen. In the meantime, additional applications of existing medical Imaging methods continue to be identified, such as the use of functional magnetic resonance and emission-computed tomography for planning and monitoring radiation treatments for cancer. Keywords: Biomedical Imaging; projection Imaging; emission Imaging; reflection Imaging; digital Imaging; Imaging in radiation therapy; new Imaging modalities; image detail

  • Biomedical Imaging Research Opportunities Workshop III: A White Paper
    Annals of Biomedical Engineering, 2006
    Co-Authors: William R Hendee, G. Scott Gazelle
    Abstract:

    The third Biomedical Imaging Research Opportunities Workshop (BIROW III) was held on March 11–12, 2005, in Bethesda, MD. The workshop addressed four areas of Imaging that present opportunities for research and development: Multimodality Image-Guided Therapy, Imaging Informatics, Imaging Cell Trafficking, and Technology Improvement and Commercialization. The first three areas were individually addressed in their own plenary sessions, followed by audience discussions that explored research opportunities and challenges. This paper synthesizes these discussions into a strategy for future research directions in Biomedical Imaging.

  • Opportunities and challenges for the National Institute of Biomedical Imaging and Bioengineering.
    Radiology, 2003
    Co-Authors: William R Hendee
    Abstract:

    On December 29, 2000, President Clinton signed the National Institute of Biomedical Imaging and Bioengineering (NIBIB) Establishment Act (Public Law No. 106-580), following passage of the Act by the House of Representatives in September 2000 and by the Senate in early December 2000. With the President’s signature, NIBIB was created as a new resource for support of extramural research in Biomedical Imaging, bioengineering, and bioinformatics. This event was the product of many years of work within the diagnostic Imaging community, joined in the late 1990s by the bioengineering community. Pivotal organizations in this collaborative effort were the Academy of Radiology Research, or ARR, which was supported by its 25 organizational members, and the American Institute of Medical and Biological Engineering, or AIMBE, which was supported by its 16 scientific societies (1). With the aid of internal and external consultants, a mission statement was crafted for the new institute (2): The mission of the National Institute of Biomedical Imaging and Bioengineering is to promote fundamental discoveries, design and development, and translation and assessment of technological capabilities in Biomedical Imaging and bioengineering, enabled by relevant areas of information science, physics, chemistry, mathematics, materials science, and computer sciences. The Institute plans, conducts, fosters and supports an integrated and coordinated program of research and research training that can be applied to a broad spectrum of biological processes, disorders and diseases and across organ systems. The Institute coordinates with the Biomedical Imaging and bioengineering programs of other agencies and NIH [National Institutes of Health] institutes to support Imaging and engineering research with potential medical applications, and facilitates the transfer of such technologies to medical applications.

  • the national institute of Biomedical Imaging and bioengineering history status and potential impact
    Radiology, 2002
    Co-Authors: William R Hendee, Shu Chien, Douglas C Maynard, Donna J Dean
    Abstract:

    In December 2000, President Clinton signed legislation establishing the National Institute of Biomedical Imaging and Bioengineering (NIBIB). This action was the result of a multidecade effort of the Biomedical Imaging and engineering communities to gain increased recognition for Biomedical Imaging and engineering research within the National Institutes of Health and to enhance the impact of these disciplines on the health and well-being of people worldwide. Beginning in January 2001, several activities were initiated to form NIBIB into a real asset for researchers in Biomedical Imaging and engineering. These activities reflect a recognition that research in Biomedical Imaging and bioengineering has the potential of positively influencing research in many other Biomedical disciplines, as well as directly affecting the welfare of people everywhere. This potential impact is discussed in this report, together with the history and present status of the formation of NIBIB.

  • the national institute of Biomedical Imaging and bioengineering history status and potential impact
    Annals of Biomedical Engineering, 2002
    Co-Authors: William R Hendee, Shu Chien, Douglas C Maynard, Donna J Dean
    Abstract:

    This paper describes the history, current status, and objectives and potential impact of the new National Institute of Biomedical Imaging and Bioengineering (NIBIB). Three of the authors (Hendee, Chien, and Maynard) have been involved over several years in the effort to raise the identity of Biomedical Imaging and bioengineering at the National Institutes of Health. The fourth author (Dean) is the Acting Director of the newly formed NIBIB. These individuals have an extensive collective knowledge of the events that led to formation of the NIBIB, and are intimately involved in shaping its objectives and implementation strategy. This special report provides a historical record of activities leading to establishment of the NIBIB, and an accounting of present and potential advances in Biomedical engineering and Imaging that will be facilitated and enhanced by NIBIB. The National Institute of Biomedical Imaging and Bioengineering represents a “coming of age” of Biomedical engineering and Imaging, and offers great potential to expand the research frontiers of these disciplines to unparalleled heights. © 2002 Biomedical Engineering Society. PAC2002: 8762+n, 8759-e, 0178+p, 0165+g, 8761-c

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