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Jiping Chen - One of the best experts on this subject based on the ideXlab platform.

  • the dose effect of dansyl chloride on the derivative products of Bisphenols and its application for the determination of Bisphenols in human serum by high performance liquid chromatography tandem mass spectrometry
    Journal of Separation Science, 2021
    Co-Authors: Cuicui Guo, Xueqin Zhao, Jing Jin, Longxing Wang, Dongqin Tan, Jiping Chen
    Abstract:

    Human exposure to Bisphenols has rarely been reported. The most important challenges in this regard are the sensitivity and accuracy of the analytical methods employed. Dansyl chloride derivatization prior to high-performance liquid chromatography-tandem mass spectrometry has been prevalently employed to improve sensitivity. However, the dose effect of the derivatization reagent on the reaction products is not well understood, especially for reactants with two or more active groups. This study investigated the mass ratio of dansyl chloride to Bisphenols and found the mass ratio played a vital role in changing the composition of derivatives; further, the optimal ratio for obtaining di-substituted derivatives was confirmed. Under optimal conditions, solid-phase extraction followed by dansyl chloride derivatization coupled with high-performance liquid chromatography-tandem mass spectrometry was used to detect eight Bisphenols in human serum samples. The method detection limits of the eight Bisphenols were 0.025-0.28 ng/mL, and the recoveries were 72.9-121.7% by spiking Bisphenols (2, 5, and 20 ng/mL) into bovine serum. The detection frequencies of Bisphenol A and Bisphenol F in 73 serum samples obtained from children from Guangzhou were 41.1% and 71.2%, respectively, while the detection frequencies of other Bisphenols were below 20%. The concentrations of Bisphenol A and Bisphenol F were < 0.28-8.0 ng/mL and < 0.028-7.6 ng/mL, respectively.

  • determination of nine Bisphenols in sewage and sludge using dummy molecularly imprinted solid phase extraction coupled with liquid chromatography tandem mass spectrometry
    Journal of Chromatography A, 2018
    Co-Authors: Xiaoli Sun, Junyu Peng, Muhua Wang, Jincheng Wang, Chunlan Tang, Luoxing Yang, Hua Lei, Xueli Wang, Jiping Chen
    Abstract:

    Abstract This paper describes the determination of Bisphenol A (BPA), Bisphenol S (BPS), Bisphenol F (BPF), Bisphenol E (BPE), Bisphenol B (BPB), Bisphenol AF (BPAF), Bisphenol AP (BPAP), Bisphenol Z (BPZ) and tetrabromoBisphenol A (TBBPA) in sewage and sludge samples. A highly class-selective dummy molecularly imprinted polymer was used for solid phase extraction (SPE) and clean-up of the samples. Bisphenols was quantified by high-performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS). The developed method had acceptable recoveries (43.6–101%), precision (RSDs: 1.5–15%) and matrix effects (−6.7 to 28%). The method limits of quantitation (MLOQs) for nine Bisphenols in sewage and sludge samples were 0.0007–16.3 ng L−1 and 0.0004–8.28 ng g−1 dry weight (dw), respectively. The method was applied to a survey of a municipal wastewater treatment plant (WWTP) in Dalian. All of the tested Bisphenols, except BPB and BPZ, were presented in the analyzed samples. BPA, BPS, and BPF with the concentrations 412, 109 and 66.4 ng L−1 in the WWTP influent, respectively, were the predominant Bisphenols. The results demonstrated that BPS and BPF have become the most frequently used substitutes of BPA.

  • preparation of dummy imprinted polymers by pickering emulsion polymerization for the selective determination of seven Bisphenols from sediment samples
    IEEE Journal of Solid-state Circuits, 2016
    Co-Authors: Xiaoli Sun, Hao Sun, Jiajia Yang, Chaonan Huang, Xiangdong Zhang, Jiping Chen
    Abstract:

    The dummy molecularly imprinted polymers were prepared by Pickering emulsion polymerization. 4,4'-(1-Phenylethylidene) Bisphenol was selected as the dummy template to avoid the leakage of the target Bisphenols. The microsphere particles were characterized by scanning electron microscopy and nitrogen adsorption-desorption measurements, demonstrating that the regular-shaped and medium-sized particles (40-70 μm) were obtained with a specific surface area of 355.759 m(2) /g and a total pore volume of 0.561 cm(3) /g. The molecular imprinting properties of the particles were evaluated by static adsorption and chromatographic evaluation experiments. The association constant and maximum adsorption amount of Bisphenol A were 0.115 mmol/L and 3.327 μmol/g using Scatchard analysis. The microsphere particles were then used as a solid-phase extraction sorbent for selective extraction of seven Bisphenols. The method of dummy molecularly imprinted solid-phase extraction coupled with high-performance liquid chromatography and diode array detection was successfully established for the extraction and determination of seven Bisphenols from environmental sediment samples with method detection limits of 0.6-1.1 ng/g. Good recoveries (75.5-105.2%) for sediment samples at two spiking levels (500 and 250 ng/g) and reproducibility (RSDs < 7.7%, n = 3) were obtained.

  • molecularly imprinted polymer microspheres prepared by pickering emulsion polymerization for selective solid phase extraction of eight Bisphenols from human urine samples
    Analytica Chimica Acta, 2015
    Co-Authors: Jiajia Yang, Xiaoli Sun, Jincheng Wang, Hao Sun, Chaonan Huang, Rong Cao, Jiping Chen
    Abstract:

    The Bisphenol A (BPA) imprinted polymer microspheres were prepared by simple Pickering emulsion polymerization. Compared to traditional bulk polymerization, both high yields of polymer and good control of particle sizes were achieved. The characterization results of scanning electron microscopy and nitrogen adsorption-desorption measurements showed that the obtained molecularly imprinted polymer microsphere (MIPMS) particles possessed regular spherical shape, narrow diameter distribution (30-60 μm), a specific surface area (S(BET)) of 281.26 m(2) g(-1) and a total pore volume (V(t)) of 0.459 cm(3) g(-1). Good specific adsorption capacity for BPA was obtained in the sorption experiment and good class selectivity for BPA and its seven structural analogs (Bisphenol F, Bisphenol B, Bisphenol E, Bisphenol AF, Bisphenol S, Bisphenol AP and Bisphenol Z) was demonstrated by the chromatographic evaluation experiment. The MIPMS as solid-phase extraction (SPE) packing material was then evaluated for extraction and clean-up of these Bisphenols (BPs) from human urine samples. An accurate and sensitive analytical method based on the MIPMS-SPE coupled with HPLC-DAD has been successfully established for simultaneous determination of eight BPs from human urine samples with detection limits of 1.2-2.2 ng mL(-1). The recoveries of BPs for urine samples at two spiking levels (100 and 500 ng mL(-1) for each BP) were in the range of 81.3-106.7% with RSD values below 8.3%.

Thomas Wenzl - One of the best experts on this subject based on the ideXlab platform.

  • determination of Bisphenols in beverages by mixed mode solid phase extraction and liquid chromatography coupled to tandem mass spectrometry
    Journal of Chromatography A, 2015
    Co-Authors: Jorge Regueiro, Thomas Wenzl
    Abstract:

    Facing growing restrictions on the use of Bisphenol A in food contact materials, several Bisphenol analogs are arising as major alternatives to replace this chemical in most of its applications. This work reports a simple and robust method based on mixed-mode solid-phase extraction and stable-isotope dilution liquid chromatography-tandem mass spectrometry for the analysis of Bisphenol A and its main analogs - Bisphenol S, 4,4'-sulfonylbis(2-methylphenol), Bisphenol F, Bisphenol E, Bisphenol B, Bisphenol Z, Bisphenol AF, Bisphenol AP, tetrabromoBisphenol A and Bisphenol P - in alcoholic and non-alcoholic beverages. Mixed-mode solid-phase extraction, combining cationic exchange and reversed-phase mechanisms, was optimized to provide a selective extraction and purification of the target analytes. Derivatization of Bisphenols with pyridine-3-sulfonyl chloride allowed increasing their ionization efficiency by electrospray ionization. Validation of the proposed method was performed in terms of selectivity, matrix effects, linearity, precision, measurement uncertainty, trueness and limits of detection. Satisfactory repeatability and intermediate precision were obtained; the related relative standard deviations were ≤9% and ≤12%, respectively. The relative expanded uncertainty (k=2) was below 20% for all Bisphenol analogs and the trueness of the method was demonstrated by recovery experiments. Limits of detection (LOD) ranged from 1.6ngL(-1) to 27.9ngL(-1) for all compounds. Finally, several canned and non-canned beverages were analyzed to demonstrate the applicability of the method. Only Bisphenol A and three Bisphenol F isomers were detected in any of the samples. Bisphenol A concentration ranged from Bisphenol F varied from Bisphenol F and 2,4'-Bisphenol F were reported for the first time in beverages, at concentration levels up to 0.12 and 0.51μgL(-1), respectively.

  • development and validation of a stable isotope dilution liquid chromatography tandem mass spectrometry method for the determination of Bisphenols in ready made meals
    Journal of Chromatography A, 2015
    Co-Authors: Jorge Regueiro, Thomas Wenzl
    Abstract:

    Due to their growing consumption, ready-made meals are a major dietary component for many people in today's society, representing an important potential route of human exposure to several food contaminants. The recent restrictions in the use of Bisphenol A have led the plastic industry to look for alternative chemicals, most of them belonging to the same family of p,p'-Bisphenols. The aim of the current work was to develop and validate a method based on stable-isotope dilution liquid chromatography-tandem mass spectrometry for the analysis of Bisphenol A and its main analogs - Bisphenol S, 4,4'-sulfonylbis(2-methylphenol), Bisphenol F, Bisphenol E, Bisphenol B, Bisphenol Z, Bisphenol AF, Bisphenol AP, tetrabromoBisphenol A and Bisphenol P - in solid foodstuffs, and particularly in ready-made meals. Extraction was carried out by ultrasound-assisted extraction after sample disruption with sand. A selective solid-phase extraction procedure was then applied to reduce potential matrix interferences. Derivatization of Bisphenols with pyridine-3-sulfonyl chloride increased their ionization efficiency by electrospray ionization. Validation of the proposed method was performed in terms of selectivity, matrix effects, linearity, precision, measurement uncertainty, trueness and limits of detection. Satisfactory repeatability and intermediate precision were obtained; the related relative standard deviations were ≤7.8% and ≤10%, respectively. The relative expanded uncertainty (k=2) was below 17% for all Bisphenol analogs and the trueness of the method was demonstrated by spike recovery experiments. Low limits of detection, in the range from 0.025μgkg(-1) to 0.140μgkg(-1), were obtained for all compounds. To demonstrate the applicability of the proposed method, it was eventually applied to several ready-made meals purchased from different supermarkets in Belgium.

Jorge Regueiro - One of the best experts on this subject based on the ideXlab platform.

  • determination of Bisphenols in beverages by mixed mode solid phase extraction and liquid chromatography coupled to tandem mass spectrometry
    Journal of Chromatography A, 2015
    Co-Authors: Jorge Regueiro, Thomas Wenzl
    Abstract:

    Facing growing restrictions on the use of Bisphenol A in food contact materials, several Bisphenol analogs are arising as major alternatives to replace this chemical in most of its applications. This work reports a simple and robust method based on mixed-mode solid-phase extraction and stable-isotope dilution liquid chromatography-tandem mass spectrometry for the analysis of Bisphenol A and its main analogs - Bisphenol S, 4,4'-sulfonylbis(2-methylphenol), Bisphenol F, Bisphenol E, Bisphenol B, Bisphenol Z, Bisphenol AF, Bisphenol AP, tetrabromoBisphenol A and Bisphenol P - in alcoholic and non-alcoholic beverages. Mixed-mode solid-phase extraction, combining cationic exchange and reversed-phase mechanisms, was optimized to provide a selective extraction and purification of the target analytes. Derivatization of Bisphenols with pyridine-3-sulfonyl chloride allowed increasing their ionization efficiency by electrospray ionization. Validation of the proposed method was performed in terms of selectivity, matrix effects, linearity, precision, measurement uncertainty, trueness and limits of detection. Satisfactory repeatability and intermediate precision were obtained; the related relative standard deviations were ≤9% and ≤12%, respectively. The relative expanded uncertainty (k=2) was below 20% for all Bisphenol analogs and the trueness of the method was demonstrated by recovery experiments. Limits of detection (LOD) ranged from 1.6ngL(-1) to 27.9ngL(-1) for all compounds. Finally, several canned and non-canned beverages were analyzed to demonstrate the applicability of the method. Only Bisphenol A and three Bisphenol F isomers were detected in any of the samples. Bisphenol A concentration ranged from Bisphenol F varied from Bisphenol F and 2,4'-Bisphenol F were reported for the first time in beverages, at concentration levels up to 0.12 and 0.51μgL(-1), respectively.

  • development and validation of a stable isotope dilution liquid chromatography tandem mass spectrometry method for the determination of Bisphenols in ready made meals
    Journal of Chromatography A, 2015
    Co-Authors: Jorge Regueiro, Thomas Wenzl
    Abstract:

    Due to their growing consumption, ready-made meals are a major dietary component for many people in today's society, representing an important potential route of human exposure to several food contaminants. The recent restrictions in the use of Bisphenol A have led the plastic industry to look for alternative chemicals, most of them belonging to the same family of p,p'-Bisphenols. The aim of the current work was to develop and validate a method based on stable-isotope dilution liquid chromatography-tandem mass spectrometry for the analysis of Bisphenol A and its main analogs - Bisphenol S, 4,4'-sulfonylbis(2-methylphenol), Bisphenol F, Bisphenol E, Bisphenol B, Bisphenol Z, Bisphenol AF, Bisphenol AP, tetrabromoBisphenol A and Bisphenol P - in solid foodstuffs, and particularly in ready-made meals. Extraction was carried out by ultrasound-assisted extraction after sample disruption with sand. A selective solid-phase extraction procedure was then applied to reduce potential matrix interferences. Derivatization of Bisphenols with pyridine-3-sulfonyl chloride increased their ionization efficiency by electrospray ionization. Validation of the proposed method was performed in terms of selectivity, matrix effects, linearity, precision, measurement uncertainty, trueness and limits of detection. Satisfactory repeatability and intermediate precision were obtained; the related relative standard deviations were ≤7.8% and ≤10%, respectively. The relative expanded uncertainty (k=2) was below 17% for all Bisphenol analogs and the trueness of the method was demonstrated by spike recovery experiments. Low limits of detection, in the range from 0.025μgkg(-1) to 0.140μgkg(-1), were obtained for all compounds. To demonstrate the applicability of the proposed method, it was eventually applied to several ready-made meals purchased from different supermarkets in Belgium.

Xiaoli Sun - One of the best experts on this subject based on the ideXlab platform.

  • determination of nine Bisphenols in sewage and sludge using dummy molecularly imprinted solid phase extraction coupled with liquid chromatography tandem mass spectrometry
    Journal of Chromatography A, 2018
    Co-Authors: Xiaoli Sun, Junyu Peng, Muhua Wang, Jincheng Wang, Chunlan Tang, Luoxing Yang, Hua Lei, Xueli Wang, Jiping Chen
    Abstract:

    Abstract This paper describes the determination of Bisphenol A (BPA), Bisphenol S (BPS), Bisphenol F (BPF), Bisphenol E (BPE), Bisphenol B (BPB), Bisphenol AF (BPAF), Bisphenol AP (BPAP), Bisphenol Z (BPZ) and tetrabromoBisphenol A (TBBPA) in sewage and sludge samples. A highly class-selective dummy molecularly imprinted polymer was used for solid phase extraction (SPE) and clean-up of the samples. Bisphenols was quantified by high-performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS). The developed method had acceptable recoveries (43.6–101%), precision (RSDs: 1.5–15%) and matrix effects (−6.7 to 28%). The method limits of quantitation (MLOQs) for nine Bisphenols in sewage and sludge samples were 0.0007–16.3 ng L−1 and 0.0004–8.28 ng g−1 dry weight (dw), respectively. The method was applied to a survey of a municipal wastewater treatment plant (WWTP) in Dalian. All of the tested Bisphenols, except BPB and BPZ, were presented in the analyzed samples. BPA, BPS, and BPF with the concentrations 412, 109 and 66.4 ng L−1 in the WWTP influent, respectively, were the predominant Bisphenols. The results demonstrated that BPS and BPF have become the most frequently used substitutes of BPA.

  • preparation of dummy imprinted polymers by pickering emulsion polymerization for the selective determination of seven Bisphenols from sediment samples
    IEEE Journal of Solid-state Circuits, 2016
    Co-Authors: Xiaoli Sun, Hao Sun, Jiajia Yang, Chaonan Huang, Xiangdong Zhang, Jiping Chen
    Abstract:

    The dummy molecularly imprinted polymers were prepared by Pickering emulsion polymerization. 4,4'-(1-Phenylethylidene) Bisphenol was selected as the dummy template to avoid the leakage of the target Bisphenols. The microsphere particles were characterized by scanning electron microscopy and nitrogen adsorption-desorption measurements, demonstrating that the regular-shaped and medium-sized particles (40-70 μm) were obtained with a specific surface area of 355.759 m(2) /g and a total pore volume of 0.561 cm(3) /g. The molecular imprinting properties of the particles were evaluated by static adsorption and chromatographic evaluation experiments. The association constant and maximum adsorption amount of Bisphenol A were 0.115 mmol/L and 3.327 μmol/g using Scatchard analysis. The microsphere particles were then used as a solid-phase extraction sorbent for selective extraction of seven Bisphenols. The method of dummy molecularly imprinted solid-phase extraction coupled with high-performance liquid chromatography and diode array detection was successfully established for the extraction and determination of seven Bisphenols from environmental sediment samples with method detection limits of 0.6-1.1 ng/g. Good recoveries (75.5-105.2%) for sediment samples at two spiking levels (500 and 250 ng/g) and reproducibility (RSDs < 7.7%, n = 3) were obtained.

  • molecularly imprinted polymer microspheres prepared by pickering emulsion polymerization for selective solid phase extraction of eight Bisphenols from human urine samples
    Analytica Chimica Acta, 2015
    Co-Authors: Jiajia Yang, Xiaoli Sun, Jincheng Wang, Hao Sun, Chaonan Huang, Rong Cao, Jiping Chen
    Abstract:

    The Bisphenol A (BPA) imprinted polymer microspheres were prepared by simple Pickering emulsion polymerization. Compared to traditional bulk polymerization, both high yields of polymer and good control of particle sizes were achieved. The characterization results of scanning electron microscopy and nitrogen adsorption-desorption measurements showed that the obtained molecularly imprinted polymer microsphere (MIPMS) particles possessed regular spherical shape, narrow diameter distribution (30-60 μm), a specific surface area (S(BET)) of 281.26 m(2) g(-1) and a total pore volume (V(t)) of 0.459 cm(3) g(-1). Good specific adsorption capacity for BPA was obtained in the sorption experiment and good class selectivity for BPA and its seven structural analogs (Bisphenol F, Bisphenol B, Bisphenol E, Bisphenol AF, Bisphenol S, Bisphenol AP and Bisphenol Z) was demonstrated by the chromatographic evaluation experiment. The MIPMS as solid-phase extraction (SPE) packing material was then evaluated for extraction and clean-up of these Bisphenols (BPs) from human urine samples. An accurate and sensitive analytical method based on the MIPMS-SPE coupled with HPLC-DAD has been successfully established for simultaneous determination of eight BPs from human urine samples with detection limits of 1.2-2.2 ng mL(-1). The recoveries of BPs for urine samples at two spiking levels (100 and 500 ng mL(-1) for each BP) were in the range of 81.3-106.7% with RSD values below 8.3%.

Alexandros G Asimakopoulos - One of the best experts on this subject based on the ideXlab platform.

  • Occurrence of Bisphenols and Benzophenone UV Filters in White-Tailed Eagles (Haliaeetus albicilla) from Smøla, Norway.
    Toxics, 2021
    Co-Authors: Bernat Oró-nolla, Alexandros G Asimakopoulos, Silvia Lacorte, Kristine Vike-jonas, Susana González, Torgeir Nygård, Veerle L.b. Jaspers
    Abstract:

    There is a growing concern about the occurrence of Bisphenols and benzophenone UV filters in natural ecosystems, while data are limited regarding their actual occurrence in wildlife species, especially in raptors. In this study, concentrations of Bisphenol and benzophenone UV filter analogues were determined in liver tissue samples (n = 38) from white-tailed eagles (Haliaeetus albicilla) that were found dead in Smola (2006–2018), which is a Norwegian municipality that holds one of the densest breeding populations of white-tailed eagles in Europe. Bisphenol AF (BPAF; a fluorinated analogue) was the most ubiquitous contaminant since it was detected in 32 liver samples at concentrations ranging from 1.08 to 6.68 ng/g wet weight (w.w.), followed by Bisphenol A (BPA, mean 10.4 ng/g w.w.), benzophenone-1 (BzP-1, mean 3.24 ng/g w.w.), and 4-hydroxybenzophenone (4-OH-BzP, mean 0.62 ng/g w.w.). The concentrations found in livers suggested that white-tailed eagles potentially accumulate Bisphenols and benzophenone UV filters, which raises concern, as these plastic and personal care product-related emerging contaminants can show endocrine-disrupting properties. The high detection frequency of the fluorinated BPAF warrants further attention as other fluorinated compounds have proven to be extremely persistent and potentially harmful to wildlife.

  • association of urinary Bisphenols during pregnancy with maternal cord blood and childhood thyroid function
    Environment International, 2021
    Co-Authors: Arash Derakhshan, Elise M Philips, Akhgar Ghassabian, Susana Santos, Alexandros G Asimakopoulos, Andreas Kortenkamp, Vincent W V Jaddoe, Leonardo Trasande, Robin P Peeters
    Abstract:

    Abstract Background Most pregnant women are exposed to Bisphenols, a group of chemicals that can interfere with various components of the thyroid system. Objectives To investigate the association of maternal urinary Bisphenol concentrations during pregnancy with maternal, newborn and early childhood thyroid function. Methods This study was embedded in Generation R, a prospective, population-based birth cohort (Rotterdam, the Netherlands). Maternal urine samples were analyzed for eight Bisphenols at early ( 25 weeks) pregnancy. Maternal serum thyroid stimulating hormone (TSH), free thyroxine (FT4) and total thyroxine (TT4) were measured in early pregnancy and child TSH and FT4 were measured in cord blood and childhood. Results The final study population comprised 1,267 mothers, 853 newborns and 882 children. Of the eight Bisphenols measured, only Bisphenol A (BPA) was detected in >50% of samples at all three time-points and Bisphenol S (BPS) at the first time-point. There was no association of BPA or the Bisphenol molar sum with maternal thyroid function. Higher BPS concentrations were associated with a higher maternal TT4 (β [95% CI] per 1 (natural-log) unit increase: 0.97 [0.03 to 1.91]) but there was no association with TSH or FT4. Furthermore, higher BPS was associated with an attenuation of the association between maternal FT4 and TSH (Pinteraction = 0.001). There was no association of early or mid-pregnancy BPA or early pregnancy BPS with cord blood or childhood TSH and FT4. A higher late pregnancy maternal BPA exposure was associated with a higher TSH in female newborns (Pinteraction = 0.06) and a higher FT4 during childhood in males (Pinteraction = 0.08). Discussion Our findings show that exposure to Bisphenols may interfere with the thyroid system during pregnancy. Furthermore, the potential developmental toxicity of exposure to Bisphenols during pregnancy could affect the thyroid system in the offspring in a sex-specific manner.

  • Maternal Bisphenol urine concentrations, fetal growth and adverse birth outcomes
    'Springer Science and Business Media LLC', 2021
    Co-Authors: C.m. Sol, Alexandros G Asimakopoulos, Vincent W V Jaddoe, Leonardo Trasande, Em Philips, Kurunthachalam Kannan, C. Van Zwol - Janssens, Maria Pilar Martinez-moral, S.m. Moreira Da Silva Santos
    Abstract:

    Background: Exposure to Bisphenols may affect fetal growth and development. The trimester-specific effects of Bisphenols on repeated measures of fetal growth remain unknown. Our objective was to assess the associations of maternal Bisphenol urine concentrations with fetal growth measures and birth outcomes and identify potential critical exposure periods. Methods: In a population-based prospective cohort study among 1379 pregnant women, we measured maternal Bisphenol A, S and F urine concentrations in the first, second and third trimester. Fetal head circumference, length and weight were measured in the second and third trimester by ultrasound and at birth. Results: An interquartile range increase in maternal pregnancy-averaged Bisphenol S concentrations was associated with larger fetal head circumference (difference 0.18 (95% confidence interval (CI) 0.01 to 0.34) standard deviation scores (SDS), p-value< 0.05) across pregnancy. When focusing on specific critical exposure periods, any detection of first trimester Bisphenol S was associated with larger second and third trimester fetal head circumference (difference 0.15 (95% CI 0.05 to 0.26) and 0.12 (95% CI 0.02 to 0.23) SDS, respectively) and fetal weight (difference 0.12 (95% CI 0.02 to 0.22) and 0.16 (95% CI 0.06 to 0.26) SDS, respectively). The other Bisphenols were not consistently associated with fetal growth outcomes. Any detection of Bisphenol S and Bisphenol F in first trimester was also associated with a lower risk of being born small size for gestational age (Odds Ratio 0.56 (95% CI 0.38 to 0.74) and 0.55 (95% CI 0.36 to 0.85), respectively). Bisphenols were not associated with risk of preterm birth. Conclusions: Higher maternal Bisphenol S urine concentrations, especially in the first trimester, seem to be related with larger fetal head circumference, higher weight and a lower risk of being small size for gestational age at birth.

  • fetal phthalates and Bisphenols and childhood lipid and glucose metabolism a population based prospective cohort study
    Environment International, 2020
    Co-Authors: Susana Santos, Alexandros G Asimakopoulos, Chalana M Sol, Liesbeth Duijts, Mariapilar Martinezmoral
    Abstract:

    Abstract Background and aims Fetal exposure to endocrine disruptors such as phthalates and Bisphenols may lead to developmental metabolic adaptations. We examined associations of maternal phthalate and Bisphenol urine concentrations during pregnancy with lipids, insulin, and glucose concentrations at school age. Methods In a population-based, prospective cohort study among 757 mother–child pairs, we measured maternal phthalate and Bisphenol urine concentrations in first, second and third trimester of pregnancy. We measured non-fasting lipids, glucose and insulin blood concentrations of their children at a mean age of 9.7 (standard deviation 0.2) years. Analyses were performed for boys and girls separately. Results An interquartile range (IQR) higher natural log transformed third trimester maternal urine phthalic acid concentration was associated with a 0.20 (95% confidence interval (CI) 0.07–0.34) standard deviation score (SDS) higher triglycerides concentration among boys. Maternal Bisphenol urine concentrations were not associated with non-fasting lipid concentrations during childhood. An IQR higher natural log transformed second trimester maternal high molecular weight phthalates (HMWP) and di-2-ethylhexylphthalate (DEHP) urine concentration were associated with a 0.19 (95% CI 0.31–0.07) respectively 0.18 (95% CI 0.31–0.06) SDS lower glucose concentration among boys. An IQR higher natural log transformed third trimester maternal Bisphenol F urine concentration was associated with a 0.22 (95% CI 0.35–0.09) SDS lower non-fasting insulin concentration among boys. Conclusions Our results suggest potential persisting sex specific effects of fetal exposure to phthalates and Bisphenols on childhood lipid concentrations and glucose metabolism. Future studies are needed for replication and exploring underlying mechanisms.

  • Association of urinary Bisphenols during pregnancy with maternal, cord blood and childhood thyroid function
    'Elsevier BV', 2020
    Co-Authors: Derakhshan A, Santos S., Kannan K., Trasande L., Alexandros G Asimakopoulos, Em Philips, Ghassabian A, Kortenkamp A, Jaddoe Vwv, Rp Peeters
    Abstract:

    © 2020 The Authors Background: Most pregnant women are exposed to Bisphenols, a group of chemicals that can interfere with various components of the thyroid system. Objectives: To investigate the association of maternal urinary Bisphenol concentrations during pregnancy with maternal, newborn and early childhood thyroid function. Methods: This study was embedded in Generation R, a prospective, population-based birth cohort (Rotterdam, the Netherlands). Maternal urine samples were analyzed for eight Bisphenols at early (25 weeks) pregnancy. Maternal serum thyroid stimulating hormone (TSH), free thyroxine (FT4) and total thyroxine (TT4) were measured in early pregnancy and child TSH and FT4 were measured in cord blood and childhood. Results: The final study population comprised 1,267 mothers, 853 newborns and 882 children. Of the eight Bisphenols measured, only Bisphenol A (BPA) was detected in >50% of samples at all three time-points and Bisphenol S (BPS) at the first time-point. There was no association of BPA or the Bisphenol molar sum with maternal thyroid function. Higher BPS concentrations were associated with a higher maternal TT4 (β [95% CI] per 1 (natural-log) unit increase: 0.97 [0.03 to 1.91]) but there was no association with TSH or FT4. Furthermore, higher BPS was associated with an attenuation of the association between maternal FT4 and TSH (Pinteraction = 0.001). There was no association of early or mid-pregnancy BPA or early pregnancy BPS with cord blood or childhood TSH and FT4. A higher late pregnancy maternal BPA exposure was associated with a higher TSH in female newborns (Pinteraction = 0.06) and a higher FT4 during childhood in males (Pinteraction = 0.08). Discussion: Our findings show that exposure to Bisphenols may interfere with the thyroid system during pregnancy. Furthermore, the potential developmental toxicity of exposure to Bisphenols during pregnancy could affect the thyroid system in the offspring in a sex-specific manner.grant RO1ES022972 and RO1ES029779-01 from the National Institutes of Health, USA