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Willem Oosterlinck - One of the best experts on this subject based on the ideXlab platform.

  • Diagnosis and localization of a complicated urinary tract infection in neurogenic Bladder Disease by tubular proteinuria and serum prostate specific antigen
    Spinal Cord, 1998
    Co-Authors: Karel Everaert, J. Vande Walle, Carson Oostra, M Van Laere, Joris R Delanghe, Willem Oosterlinck
    Abstract:

    Diagnosis and localization of a complicated urinary tract infection in neurogenic Bladder Disease by tubular proteinuria and serum prostate specific antigen

  • diagnosis and localization of a complicated urinary tract infection in neurogenic Bladder Disease by tubular proteinuria and serum prostate specific antigen
    Spinal Cord, 1998
    Co-Authors: Karel Everaert, Carson Oostra, M Van Laere, Vande J Walle, Joris R Delanghe, Willem Oosterlinck
    Abstract:

    Introduction: Urinary tract infection is the most frequent complication occurring in patients with spinal cord injuries and can cause renal failure and male infertility. We used the urinary a-1-microglobulin (a1Mg) as a marker for pyelonephritis and the serum prostate specific antigen (PSA) as a marker for prostatitis with reference to the currently available methods. The aim of our study is (1) to diAerentiate between upper (pyelonephritis) and lower urinary tract infection (cystitis, prostatitis) in neurogenic Bladder Disease, (2) to determine if high (438.58C) fever in a neurogenic Bladder Disease patient was due to urological (prostatitis, pyelonephritis) causes or not. Patients and methods: We evaluated 147 patients of whom 27 had acute pyelonephritis, 16 had prostatitis with fever, 13 had chronic pyelonephritis, 68 had cystitis; 23 were control patients of whom nine had fever (438.58C) and 14 did not. The diagnoses and localizations were made on the basis of clinical evidence, with a CT scan, urography, Bladder wash-out tests, and five glass-specimen tests. The urinary a1Mg was determined using latex enhanced immunonephelometry and the serum PSA was measured using RIA. Results: For the urinary a1Mg, the sensitivity is 96% and the specificity 93% for the diagnosis of acute pyelonephritis. The serum PSA has a sensitivity of 69% and specificity of 96% in the diagnosis of prostatitis. The urinary a1Mg has a sensitivity of 96% and a specificity of 56% and the serum PSA has a sensitivity of 68% and a specificity of 100% in the diAerential diagnosis of prostatitis and pyelonephritis. The best discriminative parameter between pyelonephritis and prostatitis was the urinary a1Mg/serum PSA ratio with a sensitivity of 92% and specificity of 88%. Conclusion: Upper-tract infection with fever can be diagnosed in neurogenic Bladder Disease by determining the urinary a1Mg. In male patients, the serum PSA should be determined to distinguish upper-tract infection from prostatitis. High fever does not significantly influence our parameters so that we can diAerentiate whether or not high fever is due to urological causes.

Kristene Whitmore - One of the best experts on this subject based on the ideXlab platform.

Maarten Albersen - One of the best experts on this subject based on the ideXlab platform.

  • Characterization of voiding function and structural Bladder changes in a rat model of neurogenic underactive Bladder Disease.
    Neurourology and urodynamics, 2018
    Co-Authors: Emmanuel Weyne, Karel Dewulf, Yves Deruyer, Roma Rietjens, Wouter Everaerts, Trinity J. Bivalacqua, Dirk De Ridder, Frank Van Der Aa, Maarten Albersen
    Abstract:

    OBJECTIVES To create an animal model for neurogenic underactive Bladder Disease (UAB) and identify markers to describe secondary myogenic changes in the Bladder wall. MATERIALS AND METHODS Male rats underwent either bilateral pelvic nerve injury or sham surgery. Four weeks after surgery functional evaluation was performed and tissue was harvested. Functional evaluation consisted of analysis of voiding pattern, 24-h urine collection in a metabolic cage, in vivo cystometry and in-vitro contractile function assessment. PCR and immunohistochemical localization of different smooth muscle cell and extracellular matrix markers was performed on Bladder strips. RESULTS After pelvic nerve injury, dry Bladder weight increased and voiding contractions were absent, resulting in overflow incontinence. In-vitro contractile response to carbachol was decreased. This was paired with an upregulation of synthetic smooth muscle cell (SMC) markers mRNA expression such as retinol binding protein 1 (RBP1), myosin 10 (MYH10) and osteopontin (OPN), and a downregulation of contractile SMC marker smoothelin (SMTL). The SMTL/OPN mRNA ratio was 50 times higher in sham Bladders compared to PNI Bladders. CONCLUSIONS The loss of in-vivo and in-vitro contractile function following pelvic nerve transection is characterized by a switch from a contractile to synthetic SMC phenotype, which is best characterized by the ratio SMTL/OPN mRNA expression. Modulating this phenotypical switch is a potential target for the development of UAB therapy. We suggest for the first time a set of markers that may be useful to evaluate therapeutic strategies on improvements in Bladder wall structure.

Karel Everaert - One of the best experts on this subject based on the ideXlab platform.

  • Diagnosis and localization of a complicated urinary tract infection in neurogenic Bladder Disease by tubular proteinuria and serum prostate specific antigen
    Spinal Cord, 1998
    Co-Authors: Karel Everaert, J. Vande Walle, Carson Oostra, M Van Laere, Joris R Delanghe, Willem Oosterlinck
    Abstract:

    Diagnosis and localization of a complicated urinary tract infection in neurogenic Bladder Disease by tubular proteinuria and serum prostate specific antigen

  • diagnosis and localization of a complicated urinary tract infection in neurogenic Bladder Disease by tubular proteinuria and serum prostate specific antigen
    Spinal Cord, 1998
    Co-Authors: Karel Everaert, Carson Oostra, M Van Laere, Vande J Walle, Joris R Delanghe, Willem Oosterlinck
    Abstract:

    Introduction: Urinary tract infection is the most frequent complication occurring in patients with spinal cord injuries and can cause renal failure and male infertility. We used the urinary a-1-microglobulin (a1Mg) as a marker for pyelonephritis and the serum prostate specific antigen (PSA) as a marker for prostatitis with reference to the currently available methods. The aim of our study is (1) to diAerentiate between upper (pyelonephritis) and lower urinary tract infection (cystitis, prostatitis) in neurogenic Bladder Disease, (2) to determine if high (438.58C) fever in a neurogenic Bladder Disease patient was due to urological (prostatitis, pyelonephritis) causes or not. Patients and methods: We evaluated 147 patients of whom 27 had acute pyelonephritis, 16 had prostatitis with fever, 13 had chronic pyelonephritis, 68 had cystitis; 23 were control patients of whom nine had fever (438.58C) and 14 did not. The diagnoses and localizations were made on the basis of clinical evidence, with a CT scan, urography, Bladder wash-out tests, and five glass-specimen tests. The urinary a1Mg was determined using latex enhanced immunonephelometry and the serum PSA was measured using RIA. Results: For the urinary a1Mg, the sensitivity is 96% and the specificity 93% for the diagnosis of acute pyelonephritis. The serum PSA has a sensitivity of 69% and specificity of 96% in the diagnosis of prostatitis. The urinary a1Mg has a sensitivity of 96% and a specificity of 56% and the serum PSA has a sensitivity of 68% and a specificity of 100% in the diAerential diagnosis of prostatitis and pyelonephritis. The best discriminative parameter between pyelonephritis and prostatitis was the urinary a1Mg/serum PSA ratio with a sensitivity of 92% and specificity of 88%. Conclusion: Upper-tract infection with fever can be diagnosed in neurogenic Bladder Disease by determining the urinary a1Mg. In male patients, the serum PSA should be determined to distinguish upper-tract infection from prostatitis. High fever does not significantly influence our parameters so that we can diAerentiate whether or not high fever is due to urological causes.

Yves L. Homsy - One of the best experts on this subject based on the ideXlab platform.

  • Dysfunctional voiding syndromes and vesicoureteral reflux
    Pediatric Nephrology, 1994
    Co-Authors: Yves L. Homsy
    Abstract:

    Micturition disorders simulating neurogenic Bladder Disease have been loosely termed “dysfunctional voiding”. No underlying neuropathy can be found. A variety of voiding disturbances have been identified since the early 1970s, each with its own characteristics and clinical relevance. We have classified voiding dysfunctions into mild, moderate and severe, according to their potential impact on the upper tracts. Bladder instability, the Hinman syndrome and the Ochoa syndrome are the only dysfunctional voiding syndromes that are associated with reflux or ureterovesical obstruction. Each syndrome is briefly described.