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Olav P. Van Der Jagt - One of the best experts on this subject based on the ideXlab platform.
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Effect of unfocused extracorporeal shockwave therapy on Bone Mineral Content of twelve distal forearms of postmenopausal women: a clinical pilot study.
Archives of Osteoporosis, 2019Co-Authors: Marianne K E Koolen, Harrie Weinans, Wolfgang Schaden, Moyo C. Kruyt, Fetullah Cumhur Oner, Olav P. Van Der JagtAbstract:Summary: Extracorporeal shockwave therapy showed a pronounced effect on Bone mass in previous animal studies. We showed in this pilot study that a single treatment with unfocused shockwave therapy in unselected patients does not show side effects. Although our study did not show any effect of shockwave on BMD, the limited sample size does not definitively exclude this and a study with 174 subjects per group would be needed to show an effect size of 0.3 with a power of 80%. Purpose: Unfocused extracorporeal shockwave therapy might stimulate Bone formation to reduce the fracture risk. In this study, we assessed the safety of unfocused extracorporeal shockwave therapy and its effects on Bone mass. Methods: A clinical pilot study with twelve female patients free of Bone disease undergoing elective surgery of the lower extremity or elective spinal surgery under general anesthesia received 3.000 electrohydraulic-generated unfocused extracorporeal shockwaves (energy flux density 0.3 mJ/mm2) to one distal forearm. The contralateral forearm served as a control. We examined the effect on Bone mass with the use of repeated dual energy X-ray absorptiometry measurements and we measured patient discomfort around the therapy. Results: No difference in Bone Mineral Content and density was measured 6 and 12 weeks after therapy. shockwave therapy occasionally caused transient erythema or mild hematoma, but no discomfort in daily life or (late) adverse events. Conclusions: Unfocused extracorporeal shockwave therapy is a safe treatment, but no increase in Bone mass on the forearm was found at 0.3 mJ/mm2 energy flux density. In this study, we were not able to demonstrate that a single treatment with unfocused shockwave therapy in unselected patients had any effect in terms of Bone Mineral density (BMD) or Bone Mineral Content (BMC). A power analysis indicated that 174 patients per group are required to show an effect size of 0.3 with a power of 80%.
Marianne K E Koolen - One of the best experts on this subject based on the ideXlab platform.
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Effect of unfocused extracorporeal shockwave therapy on Bone Mineral Content of twelve distal forearms of postmenopausal women: a clinical pilot study.
Archives of Osteoporosis, 2019Co-Authors: Marianne K E Koolen, Harrie Weinans, Wolfgang Schaden, Moyo C. Kruyt, Fetullah Cumhur Oner, Olav P. Van Der JagtAbstract:Summary: Extracorporeal shockwave therapy showed a pronounced effect on Bone mass in previous animal studies. We showed in this pilot study that a single treatment with unfocused shockwave therapy in unselected patients does not show side effects. Although our study did not show any effect of shockwave on BMD, the limited sample size does not definitively exclude this and a study with 174 subjects per group would be needed to show an effect size of 0.3 with a power of 80%. Purpose: Unfocused extracorporeal shockwave therapy might stimulate Bone formation to reduce the fracture risk. In this study, we assessed the safety of unfocused extracorporeal shockwave therapy and its effects on Bone mass. Methods: A clinical pilot study with twelve female patients free of Bone disease undergoing elective surgery of the lower extremity or elective spinal surgery under general anesthesia received 3.000 electrohydraulic-generated unfocused extracorporeal shockwaves (energy flux density 0.3 mJ/mm2) to one distal forearm. The contralateral forearm served as a control. We examined the effect on Bone mass with the use of repeated dual energy X-ray absorptiometry measurements and we measured patient discomfort around the therapy. Results: No difference in Bone Mineral Content and density was measured 6 and 12 weeks after therapy. shockwave therapy occasionally caused transient erythema or mild hematoma, but no discomfort in daily life or (late) adverse events. Conclusions: Unfocused extracorporeal shockwave therapy is a safe treatment, but no increase in Bone mass on the forearm was found at 0.3 mJ/mm2 energy flux density. In this study, we were not able to demonstrate that a single treatment with unfocused shockwave therapy in unselected patients had any effect in terms of Bone Mineral density (BMD) or Bone Mineral Content (BMC). A power analysis indicated that 174 patients per group are required to show an effect size of 0.3 with a power of 80%.
Dawn A Skelton - One of the best experts on this subject based on the ideXlab platform.
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the frequency of osteogenic activities and the pattern of intermittence between periods of physical activity and sedentary behaviour affects Bone Mineral Content the cross sectional nhanes study
BMC Public Health, 2014Co-Authors: Sebastien F M Chastin, Oleksii Mandrichenko, Dawn A SkeltonAbstract:Background Sedentary behaviours, defined as non exercising seated activities, have been shown to have deleterious effects on health. It has been hypothesised that too much sitting time can have a detrimental effect on Bone health in youth. The aim of this study is to test this hypothesis by exploring the association between objectively measured volume and patterns of time spent in sedentary behaviours, time spent in specific screen-based sedentary pursuits and Bone Mineral Content (BMC) accrual in youth.
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the frequency of osteogenic activities and the pattern of intermittence between periods of physical activity and sedentary behaviour affects Bone Mineral Content the cross sectional nhanes study
BMC Public Health, 2014Co-Authors: Sebastien F M Chastin, Oleksii Mandrichenko, Dawn A SkeltonAbstract:Sedentary behaviours, defined as non exercising seated activities, have been shown to have deleterious effects on health. It has been hypothesised that too much sitting time can have a detrimental effect on Bone health in youth. The aim of this study is to test this hypothesis by exploring the association between objectively measured volume and patterns of time spent in sedentary behaviours, time spent in specific screen-based sedentary pursuits and Bone Mineral Content (BMC) accrual in youth. NHANES 2005–2006 cycle data includes BMC of the femoral and spinal region via dual-energy X-ray absorptiometry (DEXA), assessment of physical activity and sedentary behaviour patterns through accelerometry, self reported time spent in screen based pursuits (watching TV and using a computer), and frequency of vigorous playtime and strengthening activities. Multiple regression analysis, stratified by gender was performed on N = 671 males and N = 677 females aged from 8 to 22 years. Time spent in screen-based sedentary behaviours is negatively associated with femoral BMC (males and females) and spinal BMC (females only) after correction for time spent in moderate and vigorous activity. Regression coefficients indicate that an additional hour per day of screen-based sitting corresponds to a difference of −0.77 g femoral BMC in females [95% CI: -1.31 to −0.22] and of −0.45 g femoral BMC in males [95% CI: -0.83 to −0.06]. This association is attenuated when self-reported engagement in regular (average 5 times per week) strengthening exercise (for males) and vigorous playing (for both males and females) is taken into account. Total sitting time and non screen-based sitting do not appear to have a negative association with BMC, whereas screen based sedentary time does. Patterns of intermittence between periods of sitting and moderate to vigorous activity appears to be positively associated with Bone health when activity is clustered in time and inter-spaced with long continuous bouts of sitting. Some specific sedentary pursuits (screen-based) are negatively associated with Bone health in youth. This association is specific to gender and anatomical area. This relationship between screen-based time and Bone health is independent of the total amount of physical activity measured objectively, but not independent of self-reported frequency of strengthening and vigorous play activities. The data clearly suggests that the frequency, rather than the volume, of osteogenic activities is important in counteracting the effect of sedentary behaviour on Bone health. The pattern of intermittence between sedentary periods and activity also plays a role in Bone accrual, with clustered short bouts of activity interspaced with long periods of sedentary behaviours appearing to be more beneficial than activities more evenly spread in time.
H Rico - One of the best experts on this subject based on the ideXlab platform.
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correlation of total body Bone Mineral Content determined by dual energy x ray absorptiometry with Bone Mineral density determined by peripheral quantitative computed tomography
Academic Radiology, 1995Co-Authors: M Revilla, L F Villa, Jose Luis Cardenas, E R Hernandez, H RicoAbstract:Rationale and Objectives. We sought to determine the value of peripheral quantitative computed tomography (pQCT) in measuring Bone Mineral density. Methods. In 50 healthy, eugonodal premenopausal women, we correlated measurements of total Bone Mineral Content (BMC TB ), made with dual-energy X-ray absorptiometry (DXA), and Bone Mineral density, determined by pQCT. Results. The partial correlations, adjusted for weight and age, between BMC TB and cortical Bone density, total Bone density, and trabecular Bone density were .71 ( p p p Conclusion. These results and the advantages of pQCT—providing precise Bone density determinations for trabecular and compact Bone separately, having a high spatial resolution that allows a “compartmental” analysis of Bone structure, having a low coefficient of variation, and having a minimal radiation dose (
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total and regional Bone Mineral Content in women treated with gnrh agonists
Calcified Tissue International, 1993Co-Authors: H Rico, F Arnanz, M Revilla, S Perera, M Iritia, L F Villa, I ArribasAbstract:Changes in Bone Mineral Content induced by GnRH agonists were investigated by measuring total body Bone Mineral Content (TBBM) and regional Bone Mineral Content (BMC) (arms, legs, trunk, pelvis) and densities with dual energy X-ray absorptiometry in 25 premenopausal women before and after a 6-month treatment with gonadotropin-releasing hormone (GnRH) agonists. Biological markers of Bone remodeling, estrogens, luteinizing hormone, and follicle-stimulating hormone were also measured. Weight and body mass index increased significantly after treatment (P<0.05), and TBBM, corrected for weight (TBBM/W), decreased (P<0.001). The changes in BMC that we observed ranged from +2.5% to -6.9%. The greatest decrease in regional BMC occurred in the trunk (4.4%, P<0.001), with TBBM decreasing by 2.1% (P<0.001). No significant changes were observed in the limbs. Tartrate-resistant acid phosphatase (TRAP) increased significantly after treatment (P<0.001) and a significant negative correlation between TRAP and TBBM (P<0.001) and between TRAP and estradiol (P<0.001) were observed before treatment. The lack of changes observed in the BMC of the limbs indicate that GnRH agonists cause a preferential loss of BMC in trunk osseous structures, a situation similar to that of the first years of menopause.
Babette S. Zemel - One of the best experts on this subject based on the ideXlab platform.
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Bone Mineral Content and density of the lumbar spine of infants and toddlers influence of age sex race growth and human milk feeding
Journal of Bone and Mineral Research, 2013Co-Authors: Heidi J. Kalkwarf, Babette S. Zemel, Kimberly Yolton, James E HeubiAbstract:Little is known about factors that affect Bone mass and density of infants and toddlers and the means to assess their Bone health owing to challenges in studying this population. The objectives of this study were to describe age, sex, race, growth, and human milk feeding effects on Bone Mineral Content (BMC) and areal density (aBMD) of the lumbar spine, and determine precision of BMC and aBMD measurements. We conducted a cross-sectional study of 307 healthy participants (63 black), ages 1 to 36 months. BMC and aBMD of the lumbar spine were measured by dual-energy X-ray absorptiometry. Duplicate scans were obtained on 76 participants for precision determination. Age-specific Z-scores for aBMD, weight, and length (BMDZ, WAZ, LAZ) were calculated. Information on human milk feeding duration was ascertained by questionnaire. Between ages 1 and 36 months, lumbar spine BMC increased about fivefold and aBMD increased twofold (p < 0.0001). BMC was greater (5.8%) in males than in females (p = 0.001), but there was no difference in aBMD (p = 0.37). There was no difference in BMC or aBMD between whites and blacks (p ≥ 0.16). WAZ and LAZ were positively associated with BMDZ (r = 0.34 and 0.24, p < 0.001). Duration of human milk feeding was negatively associated with BMDZ in infants <12 months of age (r = −0.42, p < 0.001). Precision of BMC and aBMD measurements was good, 2.20% and 1.84%, respectively. Dramatic increases in BMC and aBMD of the lumbar spine occur in the first 36 months of life. We provide age-specific values for aBMD of healthy infants and toddlers that can be used to evaluate Bone deficits. Future studies are needed to identify the age when sex and race differences in aBMD occur, and how best to account for delayed or accelerated growth in the context of Bone health assessment of infants and toddlers. © 2013 American Society for Bone and Mineral Research
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revised reference curves for Bone Mineral Content and areal Bone Mineral density according to age and sex for black and non black children results of the Bone Mineral density in childhood study
The Journal of Clinical Endocrinology and Metabolism, 2011Co-Authors: Babette S. Zemel, Joan M Lappe, Margaret M Frederick, John A Shepherd, Xangke Huang, Sharon E. Oberfield, Vicente Gilsanz, Ming Lu, Heidi J. Kalkwarf, Soroosh MahboubiAbstract:Context: Deficits in Bone acquisition during growth may increase fracture risk. Assessment of Bone health during childhood requires appropriate reference values relative to age, sex, and population ancestry to identify Bone deficits. Objective: The objective of this study was to provide revised and extended reference curves for Bone Mineral Content (BMC) and areal Bone Mineral density (aBMD) in children. Design: The Bone Mineral Density in Childhood Study was a multicenter longitudinal study with annual assessments for up to 7 yr. Setting: The study was conducted at five clinical centers in the United States. Participants: Two thousand fourteen healthy children (992 males, 22% African-Americans) aged 5–23 yr participated in the study. Intervention: There were no interventions. Main Outcome Measures: Reference percentiles for BMC and aBMD of the total body, lumbar spine, hip, and forearm were obtained using dual-energy x-ray absorptiometry for Black and non-Black children. Adjustment factors for height sta...
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Progressive Bone Mineral Content loss in children with intractable epilepsy treated with the ketogenic diet.
The American journal of clinical nutrition, 2008Co-Authors: A. G. Christina Bergqvist, Joan I. Schall, Virginia A. Stallings, Babette S. ZemelAbstract:BACKGROUND: The ketogenic diet (KD) is a high-fat, low-carbohydrate, and protein diet that effectively treats intractable epilepsy (IE).\n\nOBJECTIVE: The purpose of this study was to measure the change in Bone Mineral Content (BMC) in children with IE treated with the KD for 15 mo.\n\nDESIGN: Prepubertal children >or=5 y of age with IE were eligible. A 4:1 ketogenic diet was maintained for 15 mo, and whole-body and spine BMCs were measured with dual-energy X-ray absorptiometry. Z scores were generated by comparing the children with IE with a cohort of 847 healthy children. Other measurements included demographics, anthropometry, serum 25-hydroxyvitamin D (25-OHD), intact parathyroid hormone, electrolytes, and dietary intake. All measurements were performed at baseline and at 3, 6, 12, and 15 mo. Longitudinal mixed effects models were used to analyze change in BMC over time.\n\nRESULTS: Twenty-five children (9 girls, 16 boys) with IE [age (x +/- SD): 7.3 +/- 1.9 y] participated. Growth and Bone health status were suboptimal as were serum 25-OHD concentrations and dietary intake of calcium and vitamin D. Whole-body and spine BMC-for-age both declined by 0.6 z score/y and whole-body and spine BMC-for-height declined 0.7 z score/y and 0.4 z score/y, respectively. Height declined 0.5 z score/y. Body mass index (BMI; in kg/m(2)) z score, age, and ambulation were positive predictors of BMC, which declined sharply over 15 mo of KD treatment.\n\nCONCLUSION: Bone health in children with IE was poor, particularly for younger nonambulatory children with low BMI status. The KD resulted in progressive loss of BMC. The mechanism is unclear. Further studies are needed.
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the Bone Mineral density in childhood study Bone Mineral Content and density according to age sex and race
The Journal of Clinical Endocrinology and Metabolism, 2007Co-Authors: Heidi J. Kalkwarf, Joan M Lappe, Mary Horlick, Margaret M Frederick, Karen K Winer, Sharon E. Oberfield, Soroosh Mahboubi, Vicente Gilsanz, Babette S. Zemel, John A ShepherdAbstract:Context: Low Bone mass may increase risk of fracture. Several chronic medical conditions, medications, and lifestyle factors affect Bone Mineral accrual. Appropriate reference values are essential for identification of children with Bone deficits. Objective: Our objective was to establish reference curves for Bone Mineral Content (BMC) and density (BMD) in children. Design and Setting: The Bone Mineral Density in Childhood Study is an ongoing longitudinal study in which measurements are obtained annually at five clinical centers in the United States. Participants: Participants included 1554 healthy children (761 male, 793 female), ages 6–16 yr, of all ethnicities. Main Outcome Measures: Scans of the whole body, lumbar spine, hip, and forearm were obtained using dual-energy x-ray absorptiometry. Percentile curves based on three annual measurements were generated using the LMS statistical procedure. Results: BMC of the whole body and lumbar spine and BMD of the whole body, lumbar spine, total hip, femoral n...