The Experts below are selected from a list of 37233 Experts worldwide ranked by ideXlab platform

N Selvamurugan - One of the best experts on this subject based on the ideXlab platform.

  • biocomposites containing natural polymers and hydroxyapatite for Bone Tissue Engineering
    International Journal of Biological Macromolecules, 2010
    Co-Authors: Maddela Swetha, Kolli Sahithi, A Moorthi, N Srinivasan, Kumarasamy Ramasamy, N Selvamurugan
    Abstract:

    Bone Tissue Engineering is an alternative strategy to generate Bone utilizing a combination of biomaterials and cells. Biomaterials that mimic the structure and composition of Bone Tissues at nanoscale are important for the development of Bone Tissue Engineering applications. Natural or biopolymer-based composites containing chitin, chitosan, or collagen have advantages such as biocompatibility, biodegradability that are essential for Bone Tissue Engineering. The inclusion of nanoparticles of hydroxyapatite (one of the most widely used bioceramic materials) into the biopolymer matrix improves the mechanical properties and incorporates the nanotopographic features that mimic the nanostructure of Bone. This review summarizes the recent work on the development of biocomposites containing natural polymers with hydroxyapatite particles suitable for use in Bone defects/Bone regeneration.

Yu-shik Hwang - One of the best experts on this subject based on the ideXlab platform.

  • Stem cells in Bone Tissue Engineering.
    Biomedical Materials, 2010
    Co-Authors: Jeong Min Seong, Byung-chul Kim, Anathathios Mantalaris, Il Keun Kwon, Jae Hong Park, Yu-shik Hwang
    Abstract:

    Bone Tissue Engineering has been one of the most promising areas of research, providing a potential clinical application to cure Bone defects. Recently, various stem cells including embryonic stem cells (ESCs), Bone marrow-derived mesenchymal stem cells (BM-MSCs), umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs), adipose Tissue-derived stem cells (ADSCs), muscle-derived stem cells (MDSCs) and dental pulp stem cells (DPSCs) have received extensive attention in the field of Bone Tissue Engineering due to their distinct biological capability to differentiate into osteogenic lineages. The application of these stem cells to Bone Tissue Engineering requires inducing in vitro differentiation of these cells into Bone forming cells, osteoblasts. For this purpose, efficient in vitro differentiation towards osteogenic lineage requires the development of well-defined and proficient protocols. This would reduce the likelihood of spontaneous differentiation into divergent lineages and increase the available cell source for application to Bone Tissue Engineering therapies. This review provides a critical examination of the various experimental strategies that could be used to direct the differentiation of ESC, BM-MSC, UCB-MSC, ADSC, MDSC and DPSC towards osteogenic lineages and their potential applications in Tissue Engineering, particularly in the regeneration of Bone.

  • Stem cells in Bone Tissue Engineering.
    Biomedical Materials, 2010
    Co-Authors: Jeong Min Seong, Byung-chul Kim, Anathathios Mantalaris, Il Keun Kwon, Jae Hong Park, Yu-shik Hwang
    Abstract:

    Bone Tissue Engineering has been one of the most promising areas of research, providing a potential clinical application to cure Bone defects. Recently, various stem cells including embryonic stem cells (ESCs), Bone marrow-derived mesenchymal stem cells (BM-MSCs), umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs), adipose Tissue-derived stem cells (ADSCs), muscle-derived stem cells (MDSCs) and dental pulp stem cells (DPSCs) have received extensive attention in the field of Bone Tissue Engineering due to their distinct biological capability to differentiate into osteogenic lineages. The application of these stem cells to Bone Tissue Engineering requires inducing in vitro differentiation of these cells into Bone forming cells, osteoblasts. For this purpose, efficient in vitro differentiation towards osteogenic lineage requires the development of well-defined and proficient protocols. This would reduce the likelihood of spontaneous differentiation into divergent lineages and increase the available cell source for application to Bone Tissue Engineering therapies. This review provides a critical examination of the various experimental strategies that could be used to direct the differentiation of ESC, BM-MSC, UCB-MSC, ADSC, MDSC and DPSC towards osteogenic lineages and their potential applications in Tissue Engineering, particularly in the regeneration of Bone.

Aldo Roberto Boccaccini - One of the best experts on this subject based on the ideXlab platform.

  • Nanofiber composites in Bone Tissue Engineering
    Nanofiber Composites for Biomedical Applications, 2017
    Co-Authors: Liliana Liverani, Judith A. Roether, Aldo Roberto Boccaccini
    Abstract:

    Abstract The present chapter is concerned with the use of nanofibers composites for Bone Tissue Engineering applications. In particular, an overview about the topic with the definitions of the most used terms is provided in the first part of the book chapter. The remaining part of the chapter is focused on the biomimetic approach at the basis of the development of nanofiber composites for Bone Tissue Engineering, as well as the selection of the organic phase as the filler, and new trends in the electrospinning process and the integration of the electrospinning technique with other scaffolds fabrication techniques. The chapter ends with a section devoted to the results of the in vivo tests performed on these nanofiber composites for Bone Tissue Engineering applications.

  • Bioactive Glass-Based Scaffolds for Bone Tissue Engineering
    Advances in Biochemical Engineering \ Biotechnology, 2011
    Co-Authors: Julia Will, Lc Lutz-christian Gerhardt, Aldo Roberto Boccaccini
    Abstract:

    Originally developed to fill and restore Bone defects, bioactive glasses are currently also being intensively investigated for Bone Tissue Engineering applications. In this chapter, we review and discuss current knowledge on porous Bone Tissue Engineering scaffolds made from bioactive silicate glasses. A brief historical review and the fundamental requirements in the field of Bone Tissue Engineering scaffolds will be presented, followed by a detailed overview of recent developments in bioactive glass-based scaffolds. In addition, the effects of ionic dissolution products of bioactive glasses on osteogenesis and angiogenic properties of scaffolds are briefly addressed. Finally, promising areas of future research and requirements for the advancement of the field are highlighted and discussed.

  • Bioactive Glass and Glass-Ceramic Scaffolds for Bone Tissue Engineering
    Materials, 2010
    Co-Authors: Lutz-christian Gerhardt, Aldo Roberto Boccaccini
    Abstract:

    Traditionally, bioactive glasses have been used to fill and restore Bone defects. More recently, this category of biomaterials has become an emerging research field for Bone Tissue Engineering applications. Here, we review and discuss current knowledge on porous Bone Tissue Engineering scaffolds on the basis of melt-derived bioactive silicate glass compositions and relevant composite structures. Starting with an excerpt on the history of bioactive glasses, as well as on fundamental requirements for Bone Tissue Engineering scaffolds, a detailed overview on recent developments of bioactive glass and glass-ceramic scaffolds will be given, including a summary of common fabrication methods and a discussion on the microstructural-mechanical properties of scaffolds in relation to human Bone (structure-property and structure-function relationship). In addition, ion release effects of bioactive glasses concerning osteogenic and angiogenic responses are addressed. Finally, areas of future research are highlighted in this review.

Jeong Min Seong - One of the best experts on this subject based on the ideXlab platform.

  • Stem cells in Bone Tissue Engineering.
    Biomedical Materials, 2010
    Co-Authors: Jeong Min Seong, Byung-chul Kim, Anathathios Mantalaris, Il Keun Kwon, Jae Hong Park, Yu-shik Hwang
    Abstract:

    Bone Tissue Engineering has been one of the most promising areas of research, providing a potential clinical application to cure Bone defects. Recently, various stem cells including embryonic stem cells (ESCs), Bone marrow-derived mesenchymal stem cells (BM-MSCs), umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs), adipose Tissue-derived stem cells (ADSCs), muscle-derived stem cells (MDSCs) and dental pulp stem cells (DPSCs) have received extensive attention in the field of Bone Tissue Engineering due to their distinct biological capability to differentiate into osteogenic lineages. The application of these stem cells to Bone Tissue Engineering requires inducing in vitro differentiation of these cells into Bone forming cells, osteoblasts. For this purpose, efficient in vitro differentiation towards osteogenic lineage requires the development of well-defined and proficient protocols. This would reduce the likelihood of spontaneous differentiation into divergent lineages and increase the available cell source for application to Bone Tissue Engineering therapies. This review provides a critical examination of the various experimental strategies that could be used to direct the differentiation of ESC, BM-MSC, UCB-MSC, ADSC, MDSC and DPSC towards osteogenic lineages and their potential applications in Tissue Engineering, particularly in the regeneration of Bone.

  • Stem cells in Bone Tissue Engineering.
    Biomedical Materials, 2010
    Co-Authors: Jeong Min Seong, Byung-chul Kim, Anathathios Mantalaris, Il Keun Kwon, Jae Hong Park, Yu-shik Hwang
    Abstract:

    Bone Tissue Engineering has been one of the most promising areas of research, providing a potential clinical application to cure Bone defects. Recently, various stem cells including embryonic stem cells (ESCs), Bone marrow-derived mesenchymal stem cells (BM-MSCs), umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs), adipose Tissue-derived stem cells (ADSCs), muscle-derived stem cells (MDSCs) and dental pulp stem cells (DPSCs) have received extensive attention in the field of Bone Tissue Engineering due to their distinct biological capability to differentiate into osteogenic lineages. The application of these stem cells to Bone Tissue Engineering requires inducing in vitro differentiation of these cells into Bone forming cells, osteoblasts. For this purpose, efficient in vitro differentiation towards osteogenic lineage requires the development of well-defined and proficient protocols. This would reduce the likelihood of spontaneous differentiation into divergent lineages and increase the available cell source for application to Bone Tissue Engineering therapies. This review provides a critical examination of the various experimental strategies that could be used to direct the differentiation of ESC, BM-MSC, UCB-MSC, ADSC, MDSC and DPSC towards osteogenic lineages and their potential applications in Tissue Engineering, particularly in the regeneration of Bone.

Cato T. Laurencin - One of the best experts on this subject based on the ideXlab platform.

  • Bone Tissue Engineering
    Biomaterials Science, 2012
    Co-Authors: Justin L. Brown, Sangamesh G. Kumbar, Cato T. Laurencin
    Abstract:

    Abstract This chapter explores efforts in Bone Tissue Engineering. It begins with a discussion of fundamental Bone biology and moves through the current and historic efforts for strategies to repair or regenerate Bone Tissue. Finally, this chapter discusses how an understanding of cell biology can advance future strategies for Bone Tissue Engineering applications to generate or regenerate Bone Tissue.

  • Bone Tissue Engineering: recent advances and challenges.
    Crit Rev Biomed Eng, 2012
    Co-Authors: Amir Amini, Cato T. Laurencin, S P Nukavarapu
    Abstract:

    The worldwide incidence of Bone disorders and conditions has trended steeply upward and is expected to double by 2020, especially in populations where aging is coupled with increased obesity and poor physical activity. Engineered Bone Tissue has been viewed as a potential alternative to the conventional use of Bone grafts, due to their limitless supply and no disease transmission. However, Bone Tissue Engineering practices have not proceeded to clinical practice due to several limitations or challenges. Bone Tissue Engineering aims to induce new functional Bone regeneration via the synergistic combination of biomaterials, cells, and factor therapy. In this review, we discuss the fundamentals of Bone Tissue Engineering, highlighting the current state of this field. Further, we review the recent advances of biomaterial and cell-based research, as well as approaches used to enhance Bone regeneration. Specifically, we discuss widely investigated biomaterial scaffolds, micro- and nano-structural properties of these scaffolds, and the incorporation of biomimetic properties and/or growth factors. In addition, we examine various cellular approaches, including the use of mesenchymal stem cells (MSCs), embryonic stem cells (ESCs), adult stem cells, induced pluripotent stem cells (iPSCs), and platelet-rich plasma (PRP), and their clinical application strengths and limitations. We conclude by overviewing the challenges that face the Bone Tissue Engineering field, such as the lack of sufficient vascularization at the defect site, and the research aimed at functional Bone Tissue Engineering. These challenges will drive future research in the field.

  • Nanostructured Scaffolds for Bone Tissue Engineering
    Active Implants and Scaffolds for Tissue Regeneration, 2011
    Co-Authors: John C. Igwe, Cato T. Laurencin, Ami Amini, Paiyz E. Mikael, S P Nukavarapu
    Abstract:

    The field of Tissue Engineering is an emerging discipline that applies basic principles of life sciences and Engineering for the repair and restoration of human Tissues and organs. Among many Tissue types, Bone has attracted much attention since it is the second most transplanted Tissue in clinics. Bone is a complex Tissue where organic and inorganic components interact to maintain an appropriate physio-chemical balance to allow for its cellular and structural functions. Treating Bone loss via Tissue Engineering approach requires the design, fabrication and characterization of biodegradable scaffolds that display similar characteristics as the Bone. Scaffolds for Bone Tissue Engineering should have nano/micro structural features similar to the Bone extracellular matrix to mimic the Bone environment and support the Bone cell adhesion, proliferation and differentiation. This chapter mainly focuses on the 3D nanostructured scaffold fabrication techniques and the scaffold characterization for in vitro and in vivo Bone Tissue Engineering. Further, the chapter highlights the various effects of nanofeatures on Bone forming cell performance, as well the signaling cascades induced by nanotopography.