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Diana N. J. Lockwood - One of the best experts on this subject based on the ideXlab platform.
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Immuno-staining in skin biopsies for CD68, TNF-α, TGF-β and iNOS.*
2013Co-Authors: Diana N. J. Lockwood, Lavanya Suneetha, Karuna Devi Sagili, Meher Vani Chaduvula, Ismail Mohammed, Wim Van Brakel, W. C. Smith, Peter Nicholls, Sujai SuneethaAbstract:*Figures are rounded to 1 decimal place.**Borderline Tuberculoid Leprosy;***Borderline lepromatous Leprosy;†Lepromatous Leprosy;‡Reversal reaction.§Erythema Nodosum Leprosum;∥The following molecules were assessed as marker for TIR in skin biopsies: CD68+ (sensitivity 82%, specificity 52%), TNF-α (sensitivity 59%, specificity 80%), iNOS (sensitivity 58%, specificity 69%) and TGF-β (sensitivity 88%, specificity 57%).
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Immuno-staining in nerve biopsies for CD68, TNF-α, TGF-β and iNOS.*
2013Co-Authors: Diana N. J. Lockwood, Lavanya Suneetha, Karuna Devi Sagili, Meher Vani Chaduvula, Ismail Mohammed, Wim Van Brakel, W. C. Smith, Peter Nicholls, Sujai SuneethaAbstract:*Percentages rounded to nearest integer because of small numbers.**Borderline Tuberculoid Leprosy;***Borderline lepromatous Leprosy;†Lepromatous Leprosy;‡Reversal reaction.
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Categories of indeterminate Leprosy found on skin biopsy examination.
2012Co-Authors: Diana N. J. Lockwood, Wim Van Brakel, Peter Nicholls, Cairns W. S. Smith, Loretta Das, Pramila Barkataki, Sujai SuneethaAbstract:*No significant lesion;**Indeterminate;†Resolved;‡Borderline lepromatous Leprosy;§Pure Neural;∥Borderline Tuberculoid Leprosy.
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Comparison of clinical diagnoses and histological skin biopsy diagnoses at registration.
2012Co-Authors: Diana N. J. Lockwood, Wim Van Brakel, Peter Nicholls, Cairns W. S. Smith, Loretta Das, Pramila Barkataki, Sujai SuneethaAbstract:*Borderline Tuberculoid Leprosy;**Borderline lepromatous Leprosy;†Lepromatous Leprosy;‡Indeterminate Leprosy;§No significant lesion;∥Borderline Borderline Leprosy;#Pure Neural Leprosy.
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expression of cc and cxc chemokines and chemokine receptors in human Leprosy skin lesions
Clinical and Experimental Immunology, 2003Co-Authors: A A Kirkaldy, A C Musonda, S Khanolkharyoung, Sujai Suneetha, Diana N. J. LockwoodAbstract:We have investigated the expression of chemokines and their receptors in Leprosy skin lesions using immunohistochemistry. Skin biopsies from 25 Leprosy patients across the Leprosy spectrum, 11 patients undergoing type I reversal reactions and four normal donors were immunostained by ABC peroxidase method using antibodies against CC and CXC chemokines and their receptors. Using an in situ hybridization technique we have also studied the expression of monocyte chemoattractant protein 1 (MCP-1), RANTES and interleukin (IL)-8 chemokines mRNA in Leprosy skin lesions. Chemokines and receptor expression was detected in all Leprosy skin biopsies. Expression of CC chemokines MCP-1 (P < 0.01) and RANTES (P < 0.01) were elevated significantly in Borderline Tuberculoid Leprosy in reversal reaction compared to non-reactional Borderline Tuberculoid Leprosy, but there was no difference in the expression of IL-8 chemokine. Surprisingly, there was no significant difference in the expression of CC (CCR2 and CCR5) and CXC (CXCR2) chemokine receptors across the Leprosy spectrum. Similarly, there was no significant difference in the expression of mRNA for MCP-1, regulated upon activation normal T cell expressed and secreted (RANTES) and IL-8 chemokines. Here, the presence of a neutrophil chemoattractant IL-8 in Leprosy lesions, which do not contain neutrophils, suggests strongly a role of IL-8 as a monocyte and lymphocyte recruiter in Leprosy lesions. These results suggest that the chemokines and their receptors, which are known to chemoattract T lymphocytes and macrophages, are involved in assembling the cellular infiltrate found in lesions across the Leprosy spectrum.
Jianyu Zhu - One of the best experts on this subject based on the ideXlab platform.
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a rare case of type 1 Leprosy reactions following tetanus infection in a Borderline Tuberculoid Leprosy patient and a literature review
Infectious Diseases of Poverty, 2018Co-Authors: Chao Shi, Zhichun Jing, Degang Yang, Jianyu ZhuAbstract:Type 1 Leprosy reaction, also known as “reversal reaction”, is related to cellular immune responses to Mycobacterium leprae antigens. The risk factors that trigger type 1 Leprosy reactions are poorly understood. Leprosy with concurrent tetanus is rare, and there are no publicly available reports of a Leprosy patient infected with tetanus that induced type 1 Leprosy reactions. A 56-year-old Chinese Han female presented to our hospital with symptoms of erythematous plaques and pain over her left upper limb for 2 days and foreign object sensation in her throat for 3 days. The patient had a 6-year history of Leprosy. Type 1 Leprosy reactions were initially considered, followed by treatment with methylprednisolone. Two days later, the patient’s symptoms were aggravated, with neck muscle tension and difficulty in opening her mouth, and the erythematous plaques had spread over most of her left upper limb. After further careful examinations, we confirmed the diagnosis of tetanus with concurrent type 1 Leprosy reactions. The patient was given anti-tetanus treatment for 12 days and anti-Leprosy reaction treatment for 4 months; the diseases were eventually controlled. This report suggests that tetanus infection may be a trigger for type 1 Leprosy reactions.
Chao Shi - One of the best experts on this subject based on the ideXlab platform.
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a rare case of type 1 Leprosy reactions following tetanus infection in a Borderline Tuberculoid Leprosy patient and a literature review
Infectious Diseases of Poverty, 2018Co-Authors: Chao Shi, Zhichun Jing, Degang Yang, Jianyu ZhuAbstract:Type 1 Leprosy reaction, also known as “reversal reaction”, is related to cellular immune responses to Mycobacterium leprae antigens. The risk factors that trigger type 1 Leprosy reactions are poorly understood. Leprosy with concurrent tetanus is rare, and there are no publicly available reports of a Leprosy patient infected with tetanus that induced type 1 Leprosy reactions. A 56-year-old Chinese Han female presented to our hospital with symptoms of erythematous plaques and pain over her left upper limb for 2 days and foreign object sensation in her throat for 3 days. The patient had a 6-year history of Leprosy. Type 1 Leprosy reactions were initially considered, followed by treatment with methylprednisolone. Two days later, the patient’s symptoms were aggravated, with neck muscle tension and difficulty in opening her mouth, and the erythematous plaques had spread over most of her left upper limb. After further careful examinations, we confirmed the diagnosis of tetanus with concurrent type 1 Leprosy reactions. The patient was given anti-tetanus treatment for 12 days and anti-Leprosy reaction treatment for 4 months; the diseases were eventually controlled. This report suggests that tetanus infection may be a trigger for type 1 Leprosy reactions.
Milton Cury Filho - One of the best experts on this subject based on the ideXlab platform.
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Surgical treatment of type I neuritis in a teenage boy with Borderline Tuberculoid Leprosy
Revista da Sociedade Brasileira de Medicina Tropical, 2015Co-Authors: Christiane Salgado Sette, Milton Cury Filho, Patrick Alexander Wachholz, Paula Yoshiko Masuda, Renata Borges Fortes Da Costa Figueira, Cleverson Teixeira Soares, Jaison Antônio BarretoAbstract:Exacerbation of the immune response against Mycobacterium leprae can lead to neuritis, which is commonly treated via immunosuppression with corticosteroids. Early neurolysis may be performed concurrently, especially in young patients with a risk of functional sequelae. We report the case of a young patient experienced intense pain in the left elbow one year after the treatment of Tuberculoid-Tuberculoid Leprosy. The pain was associated with paresthesias in the ulnar edge and left ulnar claw. After evaluation, the diagnosis was changed to Borderline Tuberculoid Leprosy accompanied with neuritis of the left ulnar nerve. Early neurolysis resulted in rapid reduction of the pain and recovery of motor function.
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Borderline Tuberculoid Leprosy associated with primary cutaneous histoplasmosis
Anais brasileiros de dermatologia, 2012Co-Authors: Carolina Ribas Do Nascimento, Ronita Rocelina Carvalhal Silva Soares, Antônio Carlos Ceribelli Martelli, Maria Izilda Andrade, Milton Cury FilhoAbstract:We describe a case of Borderline Tuberculoid Leprosy associated with primary cutaneous histoplasmosis in a patient who presented at our hospital with skin lesions and joint complaints.
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Borderline Tuberculoid Leprosy associated with primary cutaneous histoplasmosis hanseniase dimorfa Tuberculoide associada a histoplasmose cutânea primaria
2012Co-Authors: Ronita Rocelina Carvalhal, Maria Izilda Andrade, Silva Soares, Antônio Carlos, Ceribelli Martelli, Milton Cury FilhoAbstract:Abstract: We describe a case of Borderline Tuberculoid Leprosy associated with primary cutaneous his-toplasmosis in a patient who presented at our hospital with skin lesions and joint complaints.Keywords: Granuloma; Histoplasmosis; Leprosy Resumo: Descrevemos um caso de hanseniase dimorfa Tuberculoide associada a histoplasmose cutâneaprimaria em um paciente que procurou nosso hospital com lesoes dermatologicas e queixas articulares.Palavras-chave: Granuloma; Hanseniase; Histoplasmose Received on 29.09.2010.Approved by the Advisory Board and accepted for publication on 08.11.2010 . * Study performed at the Lauro de Souza Lima Institute (ILSL), Bauru (SP), Brazil. Conflict of interest: None / Conflito de interesse: Nenhum Financial funding: None / Suporte financeiro: Nenhum 1 Dermatologist, studying for Master´s Degree in Clinical Medicine/Dermatology at the Federal University of Rio Grande do Sul ( UFRGS), Porto Alegre (RS), Brazil. 2 Dermatologist in private practice, Cruzeiro (SP), Brazil.
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Borderline Tuberculoid Leprosy associated with primary cutaneous histoplasmosis Hanseníase dimorfa Tuberculoide associada à histoplasmose cutânea primária
Sociedade Brasileira de Dermatologia, 2012Co-Authors: Carolina Ribas Do Nascimento, Ronita Rocelina Carvalhal Silva Soares, Antônio Carlos Ceribelli Martelli, Maria Izilda Andrade, Milton Cury FilhoAbstract:We describe a case of Borderline Tuberculoid Leprosy associated with primary cutaneous histoplasmosis in a patient who presented at our hospital with skin lesions and joint complaints.Descrevemos um caso de hanseníase dimorfa Tuberculoide associada à histoplasmose cutânea primária em um paciente que procurou nosso hospital com lesões dermatológicas e queixas articulares
Indira Nath - One of the best experts on this subject based on the ideXlab platform.
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Gene expression (Mean (ΔCt ± SD) of selected cytokines, signaling molecules and transcription factors associated with FOXP3+Treg and iTreg cells in skin lesions and M.leprae stimulated PBMC respectively in Leprosy patients and healthy subjects.
2014Co-Authors: Chaman Saini, Venkatesh Ramesh, Indira NathAbstract:p≤0.05 was considered as significant using Mann Whitney two tailed, non parametric test. Abbreviations: LL: lepromatous Leprosy, BT: Borderline Tuberculoid Leprosy. N: skin from normal subjects undergoing cosmetic surgery. HC: healthy household contacts. Figures in parenthesis indicate number of subjects studied. Skin:a BT vs LL p
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Mean pg/ml ± SD and range of cytokines in culture supernatants of 48 hr MLSA stimulated PBMC from TT/BT and LL patients.
2013Co-Authors: Chaman Saini, V. Ramesh, Indira NathAbstract:BT; Borderline Tuberculoid Leprosy respectively, LL; polar lepromatous Leprosy, as per Ridley Jopling classification [2] MLSA: heat killed sonicated armadillo derived M.leprae antigens.**p
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Mean Δ ct ± SD of cytokines (negative regulator of Th17 cells differentiation) of 48 hr MLSA stimulated PBMC and skin from BT, LL patients and healthy contacts.
2013Co-Authors: Chaman Saini, V. Ramesh, Indira NathAbstract:BT: Borderline Tuberculoid Leprosy, LL: polar lepromatous Leprosy, as per Ridley Jopling classification [2], HC; healthy contacts exposed to Leprosy patients to 1–2 years.*; p
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Clinical characteristics of freshly diagnosed, untreated Leprosy patients and healthy contacts of patients and healthy skin (from cosmetic surgery) included in study.
2013Co-Authors: Chaman Saini, V. Ramesh, Indira NathAbstract:BT: Borderline Tuberculoid Leprosy, LL: polar lepromatous Leprosy, as per Ridley Jopling classification [2], HC; healthy contacts exposed to Leprosy patients to 1–2 years. BI: Bacillary Index (mean of six lesional sites). M; male, F; female. Healthy skin; patients undergoing cosmetic surgery for burns were also included as controls.