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Martyna Kandeferszerszen - One of the best experts on this subject based on the ideXlab platform.
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effect of steroidal and non steroidal anti inflammatory drugs in combination with long acting oxytetracycline on non specific immunity of calves suffering from enzootic Bronchopneumonia
Veterinary Microbiology, 2003Co-Authors: D Bednarek, Barbara Zdzisinska, M Kondracki, Martyna KandeferszerszenAbstract:Abstract The aim of this paper was to compare the effect of flumethasone and meloxicam in combination with oxytetracycline on clinical and immunological parameters of calves suffering from enzootic Bronchopneumonia. The study was performed on 30 Black-and-White Lowland Breed calves with clinical signs of enzootic Bronchopneumonia divided randomly into three equal groups and, respectively, treated with—Group I: oxytetracycline and meloxicam; Group II: oxytetracycline and flumethasone; Group III (control): oxytetracycline only. Treatment of calves with the combination of oxytetracycline and meloxicam (Group I) caused a significantly faster, in comparison to other groups, improvement in the clinical illness index score (CIIS: cough, nasal discharge, dyspnea, depression and anorexia) and a faster normalization of body temperature. A slow decrease in white blood cell (WBC) count, the number of neutrophils, MID (mixed number of monocytes, eosinophils and basophils) and in the individual number of monocytes (CD14/CD45 positive cells) was observed in Groups I and III. In the blood of the calves which received oxytetracycline and flumethasone (Group II), leukocytosis, neutrophilia and monocytosis with concomitant lymphopenia and a low number of T cells (CD2+) was observed. Moreover, the calves treated with flumethasone exhibited a decrease in gamma-globulin concentration, and phagocytic parameters. Both drugs, flumethasone and meloxicam slightly decreased tumor necrosis factor (TNF) but meloxicam slightly increased the levels of interferon (IFN) in sera and in bronchoalveolar lavages (BALs). These results suggest that the combination of meloxicam with an antibiotic in calves suffering from enzootic Bronchopneumonia is superior to the antibiotic alone and also to the combination of the antibiotic with flumethasone.
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alterations in peripheral blood leukocytes functions during enzootic Bronchopneumonia of calves effect of treatment with antibiotics and immunomodulators
Deutsche Tierarztliche Wochenschrift, 1998Co-Authors: D Bednarek, Barbara Zdzisinska, M Kondracki, Wojciech Rzeski, I Lokaj, Martyna KandeferszerszenAbstract:Twelve calves from over veal calf farm were divided into two groups: group I-6 calves which developed typical signs of enzootic Bronchopneumonia and group II-6 calves with no symptoms of the disease. Both groups of calves were compared with respect to changes in several hematological parameters. Some functions of peripheral blood leukocytes as random migration, phagocytic index, percent of phagocytic cells and percent of NBT positive cells were also scored. In addition, changes in serum levels of interferon (IFN) and tumor necrosis factor (TNF) and the ability of peripheral blood leukocytes (PBL) to produce IFN and TNF were quantitated by biological methods. On the day of diagnosis, in group I of calves a significant increase in the total serum protein concentration, hemoglobin content, red and white blood cells counts in comparison to control calves (group II) was observed. The increased number of NBT positive neutrophils and moderate levels of serum IFN and TNF correlated with elevated body temperature, breathing and heart rates. Calves with Bronchopneumonia (group I) after diagnosis of the disease were treated with Tylbian (tylosine derivative), Flumetazon (glucocorticoid), Emulselvet (immunomodulator), bromhexinum and sulphonamides. Seven days after the beginning of treatment with medicaments a significant improvement in clinical symptoms was observed, however, the ability of PBL to cytokine production increased significantly 2 weeks after beginning of treatment and correlated with significant increase in random migration of neutrophils and their phagocytic activity, measured by the percent of phagocytic cells. Unexpectedly, in control calves (group II), not exhibiting any symptoms of Bronchopneumonia at the beginning of experiment, high serum IFN titers were detected which decreased significantly during the first week of observation. In contrast to that the ability of PBL of control calves to produce IFN increased significantly within 3 weeks of observation. The correlations between the ability of PBL to produce cytokine and the development of clinical symptoms of Bronchopneumonia are discussed.
Kazuyuki Suzuki - One of the best experts on this subject based on the ideXlab platform.
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endotoxin activities in bronchoalveolar lavage fluids from calves with mycoplasma Bronchopneumonia
American Association of Bovine Practitioners Proceedings of the Annual Conference, 2016Co-Authors: Yasunobu Nishi, Kazuyuki Suzuki, Toshio Shimamori, T Tsukano, Masakazu Tsuchiya, Andrew J NiehausAbstract:The frequency and severity of complex bovine respiratory diseases have increased globally, and respiratory disease is currently regarded as the principle health problem and most economically important disease in young calves. Bovine mycoplasmas are often isolated from pneumonic lungs in combination with other pathogens such as Pasteurella multocida. The systemic complications and deleterious outcomes associated with Gram-negative infections have been attributed to the exaggerated inflammatory responses largely elicited by a highly pro-inflammatory component of the Gram-negative bacterial envelope known as endotoxin. To the best of our knowledge, comparative studies on the relationship between endotoxin activity in plasma and bronchoalveolar lavage fluids (BALF), and between endotoxin activity and Bronchopneumonia have not yet been performed in calves. Therefore, the aim of the present study was to determine plasma and/or BALF endotoxin activity in calves with Bronchopneumonia.
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profiles of serum amino acids to screen for catabolic and inflammation status in calves with mycoplasma Bronchopneumonia
American Association of Bovine Practitioners Proceedings of the Annual Conference, 2015Co-Authors: Kenji Tsukano, Kazuyuki Suzuki, Toshio Shimamori, Ayano Sato, Katsunori Kudo, Ryuji Asano, Tadaharu Ajito, Jeffrey LakritzAbstract:Amino acid metabolism in cancer cells is significantly altered compared with that of normal cells. These changes are also reflected in the plasma amino acid profiles of patients with various types of inflammatory disease in human. Our hypothesis is that serum amino acid profiles of calves with mycoplasma EffecBronchopneumonia will be similar to those in human disease due to the inflammation and generalized catabolic state of these animals. The aim of this study was to investigate the relationships with serum amino acid profiles, total amino acids (TAA), branched amino acid:aromatic amino acid (BCAA/AAA) ratio, branched chain amino acid to tyrosine ratio (BTR) and serine to phosphorserine ratio (SPR) in calves with lung inflammation associated with mycoplasma Bronchopneumonia. Receiver operative characteristic (ROC) curves was constructed to describe the performance of amino acid profiles in calves with mycoplasma Bronchopneumonia. These data may be useful diagnostically and prognostically in calves with Bronchopneumonia.
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profiles of serum amino acids to screen for catabolic and inflammation status in calves with mycoplasma Bronchopneumonia
Journal of Veterinary Medical Science, 2015Co-Authors: Kenji Tsukano, Kazuyuki Suzuki, Toshio Shimamori, Ayano Sato, Katsunori Kudo, Ryuji Asano, Tadaharu Ajito, Jeffrey LakritzAbstract:The aim of the present study was to investigate the relationships between serum amino acid profiles in normal and calves with Mycoplasma Bronchopneumonia. Serum free amino acid concentrations in serum obtained from 34 calves with or without Mycoplasma Bronchopneumonia were determined by high-performance liquid chromatography. The calves with Mycoplasma were characterized by significantly lower total amino acid and total essential amino acid concentrations and molar ratios of branched-chain amino acid (BCAA) to aromatic amino acid (BCAA/AAA) and BCAA to tyrosine (BTR), and by a significantly higher molar ratio of serine phosphorylation (SPR). The proposed diagnostic cutoffs for BCAA/AAA, BTR and SPR in serum based on ROC analysis for detection of catabolic states associated with Mycoplasma Bronchopneumonia were set at 0.85, respectively. Our results suggest that determining the profiles of amino acids, especially BTR and SPR, could provide useful diagnostic information in terms of predicting protein catabolism in Mycoplasma Bronchopneumonia.
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analysis of trace and major elements in bronchoalveolar lavage fluid of mycoplasma Bronchopneumonia in calves
Biological Trace Element Research, 2012Co-Authors: Kazuyuki Suzuki, Jeffrey Lakritz, Hidetoshi Higuchi, Hidetomo Iwano, K Sera, Masateru Koiwa, Kiyoshi TaguchiAbstract:The aim of this study was to evaluate the reliability and effectiveness of direct determination of trace and major element concentrations in bronchoalveolar lavage fluid samples from Holstein calves with Mycoplasma Bronchopneumonia (n = 21) and healthy controls (n = 20). The samples were obtained during bronchoscopy using a standard examination method. A total of 18 elements (aluminum, bromine, calcium, chlorine, chromium, copper, iron, potassium, magnesium, manganese, molybdenum, nickel, phosphorous, sulfur, silicon, strontium, titanium, and zinc) were detected by particle-induced X-ray emission. The average bromine, iron, potassium, magnesium, and phosphorous concentrations were higher in calves with Bronchopneumonia than in controls (p < 0.05). They were found to have higher amounts of calcium and zinc, and a higher zinc–copper ratio than that in healthy calves (p < 0.001). Based on the receiver operating characteristics curves, we propose a diagnostic cutoff point for zinc–copper ratio for identification of Mycoplasma pneumonia of 8.676. Our results indicate that assessment of the elemental composition of broncholaveolar lavage fluid is a promising diagnostic tool for Mycoplasma Bronchopneumonia.
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trace and major elements status in bronchoalveolar lavage fluid in dogs with or without Bronchopneumonia
Biological Trace Element Research, 2008Co-Authors: Kazuyuki Suzuki, K Sera, Yoshiki Yamaya, Noriko Kanzawa, Momoko Chiba, Ryuji AsanoAbstract:The aim of this study was to investigate the relationships between the Bronchopneumonia and mean concentrations of those trace elements in bronchoalveolar lavage fluid (BALF). Twenty-nine dogs were included this study (17 healthy dogs and 12 dogs with respiratory disease). Each BALF sample had been obtained during bronchoscope examination by use of a standardized method. The concentrations of Al, Br, Ca, Cu, Fe, K, Ni, P, Si, Sr and Zn in BALF were measured by the particle-induced X-ray emission method. We found no relationship between the Bronchopneumonia and the levels of elements in the BALF, except Ca, P and Zn. The dogs with respiratory disease were found to have a large amount of Ca and Zn, and a high Ca/P and Zn/Cu ratios in BALF compared to those without respiratory disease.
D Bednarek - One of the best experts on this subject based on the ideXlab platform.
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effect of steroidal and non steroidal anti inflammatory drugs in combination with long acting oxytetracycline on non specific immunity of calves suffering from enzootic Bronchopneumonia
Veterinary Microbiology, 2003Co-Authors: D Bednarek, Barbara Zdzisinska, M Kondracki, Martyna KandeferszerszenAbstract:Abstract The aim of this paper was to compare the effect of flumethasone and meloxicam in combination with oxytetracycline on clinical and immunological parameters of calves suffering from enzootic Bronchopneumonia. The study was performed on 30 Black-and-White Lowland Breed calves with clinical signs of enzootic Bronchopneumonia divided randomly into three equal groups and, respectively, treated with—Group I: oxytetracycline and meloxicam; Group II: oxytetracycline and flumethasone; Group III (control): oxytetracycline only. Treatment of calves with the combination of oxytetracycline and meloxicam (Group I) caused a significantly faster, in comparison to other groups, improvement in the clinical illness index score (CIIS: cough, nasal discharge, dyspnea, depression and anorexia) and a faster normalization of body temperature. A slow decrease in white blood cell (WBC) count, the number of neutrophils, MID (mixed number of monocytes, eosinophils and basophils) and in the individual number of monocytes (CD14/CD45 positive cells) was observed in Groups I and III. In the blood of the calves which received oxytetracycline and flumethasone (Group II), leukocytosis, neutrophilia and monocytosis with concomitant lymphopenia and a low number of T cells (CD2+) was observed. Moreover, the calves treated with flumethasone exhibited a decrease in gamma-globulin concentration, and phagocytic parameters. Both drugs, flumethasone and meloxicam slightly decreased tumor necrosis factor (TNF) but meloxicam slightly increased the levels of interferon (IFN) in sera and in bronchoalveolar lavages (BALs). These results suggest that the combination of meloxicam with an antibiotic in calves suffering from enzootic Bronchopneumonia is superior to the antibiotic alone and also to the combination of the antibiotic with flumethasone.
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alterations in peripheral blood leukocytes functions during enzootic Bronchopneumonia of calves effect of treatment with antibiotics and immunomodulators
Deutsche Tierarztliche Wochenschrift, 1998Co-Authors: D Bednarek, Barbara Zdzisinska, M Kondracki, Wojciech Rzeski, I Lokaj, Martyna KandeferszerszenAbstract:Twelve calves from over veal calf farm were divided into two groups: group I-6 calves which developed typical signs of enzootic Bronchopneumonia and group II-6 calves with no symptoms of the disease. Both groups of calves were compared with respect to changes in several hematological parameters. Some functions of peripheral blood leukocytes as random migration, phagocytic index, percent of phagocytic cells and percent of NBT positive cells were also scored. In addition, changes in serum levels of interferon (IFN) and tumor necrosis factor (TNF) and the ability of peripheral blood leukocytes (PBL) to produce IFN and TNF were quantitated by biological methods. On the day of diagnosis, in group I of calves a significant increase in the total serum protein concentration, hemoglobin content, red and white blood cells counts in comparison to control calves (group II) was observed. The increased number of NBT positive neutrophils and moderate levels of serum IFN and TNF correlated with elevated body temperature, breathing and heart rates. Calves with Bronchopneumonia (group I) after diagnosis of the disease were treated with Tylbian (tylosine derivative), Flumetazon (glucocorticoid), Emulselvet (immunomodulator), bromhexinum and sulphonamides. Seven days after the beginning of treatment with medicaments a significant improvement in clinical symptoms was observed, however, the ability of PBL to cytokine production increased significantly 2 weeks after beginning of treatment and correlated with significant increase in random migration of neutrophils and their phagocytic activity, measured by the percent of phagocytic cells. Unexpectedly, in control calves (group II), not exhibiting any symptoms of Bronchopneumonia at the beginning of experiment, high serum IFN titers were detected which decreased significantly during the first week of observation. In contrast to that the ability of PBL of control calves to produce IFN increased significantly within 3 weeks of observation. The correlations between the ability of PBL to produce cytokine and the development of clinical symptoms of Bronchopneumonia are discussed.
Nurhidayah Ikeu - One of the best experts on this subject based on the ideXlab platform.
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Perbedaan Penurunan Suhu Tubuh Anak Bronchopneumonia yang diberikan Kompres Hangat di Axilla dan Frontal
Universitas Padjadjaran, 2015Co-Authors: R Rahmawati, Fatimah Sari, Nurhidayah IkeuAbstract:Bronchopneumoniapada anak saat ini menjadi penyakit yang paling sering terjadi pada anak. Masalah keperawatan utama yang terjadi pada anak dengan pneumonia adalah terjadinya demam yang sangat berbahaya jika tidak ditangani dengan tepat. Tujuan penelitian untuk mengetahui perbedaan penurunan suhu tubuh pada anak demam dengan Bronchopneumonia yang diberikan intervensi kompres hangat di axilladan frontaldi Ruang Anak RS “X”. Desain yang digunakan dalam penelitian ini adalah kuasi eksperimen dengan rancangan pretest and posttest two group before after design. Sampel berjumlah 30 orang dengan usia 0–12 bulan, diambil secara purposivesampling. Alat ukur yang digunakan termometer digital. Analisis data dilakukan dengan dependent sample t testdan independent sample t test. Hasil penelitian menunjukkan rata-rata suhu tubuh pada anak demam dengan Bronchopneumoniasebelum diberikan intervensi kompres hangat di daerah axilla38,51ºC sedangkan di frontal38,34ºC. Rata- rata suhu tubuh setelah diberikan intervensi di axilla37,89ºC dan di frontal37,98ºC. Rata-rata penurunan suhu tubuh setelah diberikan intervensi di axilla0.62ºC sedangkan di daerah frontal0.36ºC (nilai p=0.000; α=0.05), sehingga dapat disimpulkan ada perbedaan yang signifikan antara pemberian kompres hangat di axilladan di frontalterhadap penurunan suhu tubuh pada anak demam. Saran berdasarkan hasil penelitian, pemberian kompres hangat di axilladapat dijadikan intervensi dalam menurunkan suhu tubuh anak yang mengalami demam. Kata kunci: Axilla, Bronchopneumonia, demam, frontal, kompres hangat AbstractBronchopneumonia is the most common diseases in children. The primary nursing problems occurred in children with Bronchopneumonia is fever. This could be danger if could not treated appropriately. The aimed of this study was to identified the differences between warm compress intervention in axilla and frontal to reduce fever in children with Bronchopneumonia in hospital X in Bandung. The method used in this study was quasi experiment with two group pre and post test design. Purposive sampling was used as sampling technique in this study, with 30 respondents were participated in this study. Data was analysed using dependent t test and independent t test. Result of this study showed the average of body temperature in febrile children with Bronchopneumonia before warm compress intervention in axilla is 38.51 º C , while in the frontal 38.34º C. The average of body temperature after a given intervention in the axilla is 37.89º C, while in the frontal is 37.98ºC. There was a significant temperature’s decreases between frontal and axilla after intervention (p = 0.000; α = 0.05). There was a significant difference between giving a warm compress in the axilla and in the frontal the decrease in body temperature in febrile children. Based on this study, it can be concluded axillary warm compress can be used as an effective intervention to reduce fever in children.Key words:Axilla, Bronchopneumonia, fever, frontal, warm compresse
Wallace T. Miller - One of the best experts on this subject based on the ideXlab platform.
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Lower Respiratory Tract Infection with Human Metapneumovirus: Chest CT Imaging Features and Comparison with Other Viruses
European Journal of Radiology, 2020Co-Authors: Lawrence A. Marinari, Madeline A. Danny, Scott A. Simpson, James E. Schmitt, Wallace T. MillerAbstract:Abstract Purpose Human metapneumovirus has been increasingly identified as a cause of lower respiratory tract infection in adults worldwide. The CT imaging features of human metapneumovirus in adults have not been characterized. The purpose of this paper is to determine the imaging features of human metapneumovirus and to compare them with features of other viruses. Methods Two clinicians retrospectively reviewed the medical records of 104 adults with lower respiratory tract infection due to human metapneumovirus at four hospitals in the northeast USA over 32 months. CT images were evaluated by two chest radiologists for airspace consolidation, bronchiectasis, bronchial wall thickening, ground-glass opacities, pleural effusion and tree-in-bud opacities and the dominant imaging pattern. Results for human metapneumovirus were compared with results previously reported for other viruses. Results Human metapneumovirus predominantly caused an airway-centric pattern (71-81/104, 68-77%) of infection characterized by bronchial wall thickening, tree-in-bud opacities, peri-bronchial consolidation and/or peri-bronchial ground-glass opacities. The airway-centric pattern has been previously reported with other paramyxoviridae (parainfluenza virus and respiratory syncytial virus). However, human metapneumovirus was significantly more likely (p = 0.03-0.001) to cause Bronchopneumonia (46-55%) than parainfluenza virus (17%) or respiratory syncytial virus (21%). Follow-up CT in 41 (39%) patients with hMPV revealed resolution of findings in 38/41 (91%). Conclusion The paramyxoviridae, including human metapneumovirus, are known to have a propensity to infect ciliated respiratory cells and we have demonstrated this leads to a propensity to cause bronchitis, bronchiolitis and Bronchopneumonia on CT scans. Of these, human metapneumovirus is most likely to cause Bronchopneumonia. Healthcare providers should consider human metapneumovirus as a cause of pneumonia on chest CT.
