The Experts below are selected from a list of 546 Experts worldwide ranked by ideXlab platform
Jeanyves Fagon - One of the best experts on this subject based on the ideXlab platform.
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candidemia and Candiduria in critically ill patients admitted to intensive care units in france incidence molecular diversity management and outcome
Intensive Care Medicine, 2008Co-Authors: Marieelisabeth Bougnoux, Guillaume Kac, Philippe Aegerter, Christophe Denfert, Jeanyves FagonAbstract:Objective To determine the concomitant incidence, molecular diversity, management and outcome of nosocomial candidemia and Candiduria in intensive care unit (ICU) patients in France.
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candidemia and Candiduria in critically ill patients admitted to intensive care units in france incidence molecular diversity management and outcome
Intensive Care Medicine, 2008Co-Authors: Marieelisabeth Bougnoux, Guillaume Kac, Philippe Aegerter, Christophe Denfert, Jeanyves FagonAbstract:To determine the concomitant incidence, molecular diversity, management and outcome of nosocomial candidemia and Candiduria in intensive care unit (ICU) patients in France. A 1-year prospective observational study in 24 adult ICUs. Two hundred and sixty-two patients with nosocomial candidemia and/or Candiduria. Blood and urine samples were collected when signs of sepsis were present. Antifungal susceptibility of Candida strains was determined; in addition, all blood and 72% of urine C. albicans isolates were analyzed by using multi-locus sequence type (MLST). The mean incidences of candidemia and Candiduria were 6.7 and 27.4/1000 admissions, respectively. Eight percent of candiduric patients developed candidemia with the same species. The mean interval between ICU admission and candidemia was 19.0 ± 2.9 days, and 17.2 ± 1.1 days for Candiduria. C. albicans and C. glabrata were isolated in 54.2% and 17% of blood and 66.5% and 21.6% of urine Candida-positive cultures, respectively. Fluconazole was the most frequently prescribed agent. In all candidemic patients, the prescribed curative antifungal agent was active in vitro against the responsible identified strain. Crude ICU mortality was 61.8% for candidemic and 31.3% for candiduric patients. Seventy-five percent of the patients were infected with a unique C. albicans strain; cross-transmission between seven patients was suggested in one hospital. Candidemia is late-onset ICU-acquired infection associated with high mortality. No difference in susceptibility and genetic background were found between blood and urine strains of Candida species.
Marieelisabeth Bougnoux - One of the best experts on this subject based on the ideXlab platform.
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candidemia and Candiduria in critically ill patients admitted to intensive care units in france incidence molecular diversity management and outcome
Intensive Care Medicine, 2008Co-Authors: Marieelisabeth Bougnoux, Guillaume Kac, Philippe Aegerter, Christophe Denfert, Jeanyves FagonAbstract:Objective To determine the concomitant incidence, molecular diversity, management and outcome of nosocomial candidemia and Candiduria in intensive care unit (ICU) patients in France.
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candidemia and Candiduria in critically ill patients admitted to intensive care units in france incidence molecular diversity management and outcome
Intensive Care Medicine, 2008Co-Authors: Marieelisabeth Bougnoux, Guillaume Kac, Philippe Aegerter, Christophe Denfert, Jeanyves FagonAbstract:To determine the concomitant incidence, molecular diversity, management and outcome of nosocomial candidemia and Candiduria in intensive care unit (ICU) patients in France. A 1-year prospective observational study in 24 adult ICUs. Two hundred and sixty-two patients with nosocomial candidemia and/or Candiduria. Blood and urine samples were collected when signs of sepsis were present. Antifungal susceptibility of Candida strains was determined; in addition, all blood and 72% of urine C. albicans isolates were analyzed by using multi-locus sequence type (MLST). The mean incidences of candidemia and Candiduria were 6.7 and 27.4/1000 admissions, respectively. Eight percent of candiduric patients developed candidemia with the same species. The mean interval between ICU admission and candidemia was 19.0 ± 2.9 days, and 17.2 ± 1.1 days for Candiduria. C. albicans and C. glabrata were isolated in 54.2% and 17% of blood and 66.5% and 21.6% of urine Candida-positive cultures, respectively. Fluconazole was the most frequently prescribed agent. In all candidemic patients, the prescribed curative antifungal agent was active in vitro against the responsible identified strain. Crude ICU mortality was 61.8% for candidemic and 31.3% for candiduric patients. Seventy-five percent of the patients were infected with a unique C. albicans strain; cross-transmission between seven patients was suggested in one hospital. Candidemia is late-onset ICU-acquired infection associated with high mortality. No difference in susceptibility and genetic background were found between blood and urine strains of Candida species.
Victor Silva - One of the best experts on this subject based on the ideXlab platform.
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nosocomial Candiduria in women undergoing urinary catheterization clonal relationship between strains isolated from vaginal tract and urine
Medical Mycology, 2007Co-Authors: Victor Silva, German Hermosilla, Claudia AbarcaAbstract:We determined the incidence of nosocomial Candiduria associated with indwelling urinary catheters in 42 women with and without Candida spp. vaginal colonization being treated in the intensive care unit (ICU). We established a relationship between strains initially isolated from the vaginal tract and those subsequently recovered from urine samples through the use of random amplified polymorphic DNA (RAPD). The overall incidence of nosocomial Candiduria in these patients was 21.4%. Vaginal colonization by Candida spp. was detected in 11 patients (26.2%) of whom 6 (54.5%) developed Candiduria. In comparison, only 3 (9.7%) cases of Candiduria were found in women who were not colonized by the yeast (RR: 4.4, 95% CI 1.61� 86.8, P� 0.005). The dendrogram obtained by RAPD using 14 primers showed that the strains isolated from vagina and urine samples in five women had high similarity values (SAB� 0.9) forming independent clusters. Our study suggests that women vaginally colonized by Candida spp. in an ICU setting have a high risk of acquiring nosocomial Candiduria and that strains isolated from both sites in a single patient may be genetically related.
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microbiological characteristics of yeasts isolated from urinary tracts of intensive care unit patients undergoing urinary catheterization
Journal of Clinical Microbiology, 1999Co-Authors: Naldy Febre, Arnaldo Lopes Colombo, Victor Silva, Eduardo Alexandrino Servolo Medeiros, Sergio Barsanti Wey, Olga FischmanAbstract:We studied 70 intensive care unit patients to determine the incidence of nosocomial Candiduria associated with indwelling urinary catheters and to assess microbiological characteristics of the yeasts. The yeasts were isolated, 13 of 17 in urine cultures and 4 of 17 in blood cultures, and colonization had occurred 3 days after the insertion of indwelling urinary catheters. For four strains the MICs of the antifungal drugs were high.
Carol A. Kauffman - One of the best experts on this subject based on the ideXlab platform.
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Candida Urinary Tract Infections—Diagnosis
2016Co-Authors: Carol A. Kauffman, Jack D Sobel, John F. Fisher, Cheryl A. NewmanAbstract:The finding of Candiduria in a patient with or without symptoms should be neither dismissed nor hastily treated, but requires a careful evaluation, which should proceed in a logical fashion. Symptoms ofCandida pyelonephritis, cystitis, prostatitis, or epididymo-orchitis are little different from those of the same infections produced by other pathogens. Candiduria occurring in critically ill patients should initially be regarded as a marker for the possibility of invasive candidiasis. The first step in evaluation is to verify funguria by repeating the urinalysis and urine culture. Pyuria is a nonspecific finding; the morphology of the offending yeast may allow separation of Candida glabrata from other species. Candida casts in the urine are indicative of renal candidiasis but are rarely seen. With respect to culture, colony counts have not proved to be diagnostically useful. In symptomatic or critically ill patients with Candiduria, ultrasonography of the kidneys and collecting systems is the preferred initial study. However, computed tomography (CT) is better able to discern pyelonephritis or perinephric abscess. The role of magnetic resonance imaging and renal scintigraphy is ill defined, and prudent physicians should consult with colleagues in the departments of radiology and urology to determine the optimal studies in candiduric patients who require in-depth evaluation. When yeastlike organisms are discovered in the urine, the major decision that must be made is whether or no
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diagnosis and management of fungal urinary tract infection
Infectious Disease Clinics of North America, 2014Co-Authors: Carol A. KauffmanAbstract:When the terms funguria or fungal urinary tract infection are used, most physicians are referring to Candiduria and urinary tract infections due to Candida species. Other fungi, including yeasts and molds can involve the kidney during the course of disseminated infection, but rarely cause symptoms referable to the urinary tract. Candida species appear to be unique in their ability to both colonize and cause invasive disease in the urinary tract. This overview focuses only on Candiduria and Candida urinary tract infection because they are common and many times present perplexing management issues.
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Candiduria a randomized double blind study of treatment with fluconazole and placebo
Clinical Infectious Diseases, 2000Co-Authors: Jack D Sobel, Carol A. Kauffman, David S Mckinsey, Marcus J Zervos, Jose A Vazquez, Adolf W Karchmer, Carolynn J Thomas, Helene Panzer, William E DismukesAbstract:: Management of Candiduria is limited by the lack of information about its natural history and lack of data from controlled studies on the efficacy of treating it with antimycotic agents. We compared fungal eradication rates among 316 consecutive candiduric (asymptomatic or minimally symptomatic) hospitalized patients treated with fluconazole (200 mg) or placebo daily for 14 days. In an intent-to-treat analysis, Candiduria cleared by day 14 in 79 (50%) of 159 receiving fluconazole and 46 (29%) of 157 receiving placebo (P<.001), with higher eradication rates among patients completing 14 days of therapy (P<.0001), including 33 (52%) of 64 catheterized and 42 (78%) of 54 noncatheterized patients. Pretreatment serum creatinine levels were inversely related to Candiduria eradication. Fluconazole initially produced high eradication rates, but cultures at 2 weeks revealed similar Candiduria rates among treated and untreated patients. Oral fluconazole was safe and effective for short-term eradication of Candiduria, especially following catheter removal. Long-term eradication rates were disappointing and not associated with clinical benefit.
Guillaume Kac - One of the best experts on this subject based on the ideXlab platform.
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candidemia and Candiduria in critically ill patients admitted to intensive care units in france incidence molecular diversity management and outcome
Intensive Care Medicine, 2008Co-Authors: Marieelisabeth Bougnoux, Guillaume Kac, Philippe Aegerter, Christophe Denfert, Jeanyves FagonAbstract:Objective To determine the concomitant incidence, molecular diversity, management and outcome of nosocomial candidemia and Candiduria in intensive care unit (ICU) patients in France.
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candidemia and Candiduria in critically ill patients admitted to intensive care units in france incidence molecular diversity management and outcome
Intensive Care Medicine, 2008Co-Authors: Marieelisabeth Bougnoux, Guillaume Kac, Philippe Aegerter, Christophe Denfert, Jeanyves FagonAbstract:To determine the concomitant incidence, molecular diversity, management and outcome of nosocomial candidemia and Candiduria in intensive care unit (ICU) patients in France. A 1-year prospective observational study in 24 adult ICUs. Two hundred and sixty-two patients with nosocomial candidemia and/or Candiduria. Blood and urine samples were collected when signs of sepsis were present. Antifungal susceptibility of Candida strains was determined; in addition, all blood and 72% of urine C. albicans isolates were analyzed by using multi-locus sequence type (MLST). The mean incidences of candidemia and Candiduria were 6.7 and 27.4/1000 admissions, respectively. Eight percent of candiduric patients developed candidemia with the same species. The mean interval between ICU admission and candidemia was 19.0 ± 2.9 days, and 17.2 ± 1.1 days for Candiduria. C. albicans and C. glabrata were isolated in 54.2% and 17% of blood and 66.5% and 21.6% of urine Candida-positive cultures, respectively. Fluconazole was the most frequently prescribed agent. In all candidemic patients, the prescribed curative antifungal agent was active in vitro against the responsible identified strain. Crude ICU mortality was 61.8% for candidemic and 31.3% for candiduric patients. Seventy-five percent of the patients were infected with a unique C. albicans strain; cross-transmission between seven patients was suggested in one hospital. Candidemia is late-onset ICU-acquired infection associated with high mortality. No difference in susceptibility and genetic background were found between blood and urine strains of Candida species.
