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Hans-peter Fuehrer - One of the best experts on this subject based on the ideXlab platform.
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An overview of the host spectrum and distribution of Calodium hepaticum (syn. Capillaria Hepatica): part 2—Mammalia (excluding Muroidea)
Parasitology Research, 2014Co-Authors: Hans-peter FuehrerAbstract:Calodium hepaticum (syn. Capillaria Hepatica ) is a globally distributed zoonotic nematode with low host specificity and a high affinity to the liver. Although murid rodents are the main definite hosts, various other mammals can be affected with hepatic Capillariasis: non-murid rodents, Insectivora, Chiroptera, Lagomorpha, Artiodactyla, Perissodactyla, Hyracoidea, Marsupialia, Carnivora, and Primates. Overall, more than 180 mammalian species (including humans) are known as suitable hosts of this pathogen. This review gives an overview of the distribution and host spectrum of C. hepaticum in non-Muroidean mammals in wildlife and zoos as well as in domesticated and laboratory animals. Furthermore, the role of spurious infections in animals and the dissemination of C. hepaticum by mammalian and non-mammalian animals are summarized.
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An overview of the host spectrum and distribution of Calodium hepaticum (syn. Capillaria Hepatica): part 1—Muroidea
Parasitology Research, 2014Co-Authors: Hans-peter FuehrerAbstract:Calodium hepaticum (syn. Capillaria Hepatica ) is a worldwide-distributed species of zoonotic nematodes with a high affinity to the liver. Several rodent species of the superfamily Muroidea serve as main hosts for this pathogen. C. hepaticum has been found in Muroidean hosts in more than 60 countries in Europe; North, Central, and South America; Asia; Africa; and Oceania. C. hepaticum was documented in more than 90 Muroidean rodent species (Murinae, Deomyinae, Arvicolinae, Neotominae, Cricetinae, Sigmodontinae, Gerbillinae, and Cricetomyinae). Globally, the Norway rat ( Rattus norvegicus ) seems to be the main host species for this nematode. However, locally high prevalences (above 50 %) have also been observed in several other synanthropic (commensal and non-commensal) Muroidea species (e.g., Rattus tanezumi , Ondatra zibethicus , Apodemus sylvaticus ). This review gives an overview of the distribution and host spectrum of C. hepaticum in Muroidea host species.
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Capillaria Hepatica in man—an overview of hepatic capillariosis and spurious infections
Parasitology Research, 2011Co-Authors: Hans-peter Fuehrer, Petra Igel, Herbert AuerAbstract:Capillaria Hepatica (syn. for Calodium hepaticum ) is a zoonotic nematode parasitizing in the livers of rodents as main hosts and in numerous other mammals including humans. It is the causative agent of the rare conditions of hepatic capillariosis and spurious C. Hepatica infections in humans. In this review, 163 reported cases of infestations with this parasite (72 reports of hepatic capillariosis, 13 serologically confirmed infestations and 78 observations of spurious infections) are summarized with an overview on the distribution, symptoms, pathology, diagnosis, serology and therapy of this rare human pathogen.
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Capillaria Hepatica in man an overview of hepatic capillariosis and spurious infections
Parasitology Research, 2011Co-Authors: Hans-peter Fuehrer, Petra Igel, Herbert AuerAbstract:Capillaria Hepatica (syn. for Calodium hepaticum) is a zoonotic nematode parasitizing in the livers of rodents as main hosts and in numerous other mammals including humans. It is the causative agent of the rare conditions of hepatic capillariosis and spurious C. Hepatica infections in humans. In this review, 163 reported cases of infestations with this parasite (72 reports of hepatic capillariosis, 13 serologically confirmed infestations and 78 observations of spurious infections) are summarized with an overview on the distribution, symptoms, pathology, diagnosis, serology and therapy of this rare human pathogen.
Herbert Auer - One of the best experts on this subject based on the ideXlab platform.
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Capillaria Hepatica in man—an overview of hepatic capillariosis and spurious infections
Parasitology Research, 2011Co-Authors: Hans-peter Fuehrer, Petra Igel, Herbert AuerAbstract:Capillaria Hepatica (syn. for Calodium hepaticum ) is a zoonotic nematode parasitizing in the livers of rodents as main hosts and in numerous other mammals including humans. It is the causative agent of the rare conditions of hepatic capillariosis and spurious C. Hepatica infections in humans. In this review, 163 reported cases of infestations with this parasite (72 reports of hepatic capillariosis, 13 serologically confirmed infestations and 78 observations of spurious infections) are summarized with an overview on the distribution, symptoms, pathology, diagnosis, serology and therapy of this rare human pathogen.
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Capillaria Hepatica in man an overview of hepatic capillariosis and spurious infections
Parasitology Research, 2011Co-Authors: Hans-peter Fuehrer, Petra Igel, Herbert AuerAbstract:Capillaria Hepatica (syn. for Calodium hepaticum) is a zoonotic nematode parasitizing in the livers of rodents as main hosts and in numerous other mammals including humans. It is the causative agent of the rare conditions of hepatic capillariosis and spurious C. Hepatica infections in humans. In this review, 163 reported cases of infestations with this parasite (72 reports of hepatic capillariosis, 13 serologically confirmed infestations and 78 observations of spurious infections) are summarized with an overview on the distribution, symptoms, pathology, diagnosis, serology and therapy of this rare human pathogen.
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serological detection of Capillaria Hepatica by indirect immunofluorescence assay
Journal of Clinical Microbiology, 2000Co-Authors: Martina Junckervoss, Heinrich Prosl, Helga Lussy, Ulrike Enzenberg, Herbert Auer, Norbert NowotnyAbstract:In this paper, a serological assay for the detection of antibodies to Capillaria Hepatica, a zoonotic parasite, is described. In the past, the only way of detecting Capillaria Hepatica was to perform a liver biopsy. The indirect immunofluorescence (IIF) assay, based on liver sections of naturally infected mice and human serum samples, is suitable for detecting early stages of human infections and for screening purposes. No cross-reactivity with other parasitic infections was detected. We have applied the IIF assay to serum samples of 60 employees of the Zoological Garden of Vienna, Schonbrunn, Austria, and found one positive and one questionable sample.
Zilton A Andrade - One of the best experts on this subject based on the ideXlab platform.
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dynamics of Capillaria Hepatica induced hepatic septal fibrosis in rats
Revista Da Sociedade Brasileira De Medicina Tropical, 2010Co-Authors: Lidiane Gaban, Márcia Maria De Souza, Cleber Douglas Lucinio Ramos, Aryon De Almeida Barbosa, Zilton A AndradeAbstract:INTRODUCTION: The pathogenesis of septal hepatic fibrosis, induced in rats by Capillaria Hepatica infection, was studied with the aid of a large collection of stored paraffin blocks, representative of the different evolutive phases of fibrosis which appeared in 100% of infected rats. METHODS: Studies were conducted involving histology, immunohistochemistry, immunofluorescence and morphometric methods, in order to observe the dynamic behavior of the cellular and matrix components of fibrosis, over a one year period of evolution. RESULTS: Observation verified that septal fibrosis originates from several portal spaces simultaneously. Its origin and progression involve blood vessel proliferation (angiogenesis), multiplication of actin-positive cells (pericytes and myofibroblasts) and progressive collagen deposition. By the end of 4-5 months, a progressive decrease in all these components was observed, when signs of regression of septal fibrosis became more evident over time. CONCLUSIONS: Besides indicating the fundamental role played by angiogenesis in the pathogenesis of fibrosis, these morphological data concerning the dynamics of this C. Hepatica experimental model proved to be adequate for future investigations regarding the functional aspects of fibrosis induction, progression and regression.
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Capillaria Hepatica induced septal fibrosis in rats a contribution to the study of liver fibrogenesis
Revista Da Sociedade Brasileira De Medicina Tropical, 2010Co-Authors: Valter Lucas Chaves Barbosa, Zilton A AndradeAbstract:INTRODUCTION: Septal fibrosis of the liver regularly develops in rats infected with the nematode Capillaria Hepatica. Curative treatment of the infection prevents the development of septal fibrosis when intervention occurs up to postinfection day (PID) 15, but not later. The present investigation aimed to demonstrate which parasitic factors are present when the process of septal fibrosis can no longer be prevented by curative treatment. METHODS: Wistar rats were infected with 600 embryonated eggs of C. Hepatica administered by gavage and treated with ivermectin and mebendazole in separate groups at PIDs 10, 12, 15, 17 or 20. Rats from each group and their nontreated controls, were killed and examined 40 days after the end of treatment. RESULTS: Findings by PID 15 were compatible with the stage of complete maturation of infection, when worms and eggs were fully developed and a complex host-parasite multifocal necroinflammatory reaction showed greater intensity, but with no signs of septal fibrosis, which appeared from PID 17 onward. CONCLUSIONS: Since the worms spontaneously died by PID 15, not only septal fibrosis production, but also its maintenance and further development appeared dependent on the presence of eggs, which were the only parasitic factor remaining thereafter.
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role of partial hepatectomy on Capillaria Hepatica induced hepatic fibrosis in rats
Revista Da Sociedade Brasileira De Medicina Tropical, 2007Co-Authors: Carolina Cincura Silva Santos, Zaira Onofrenunes, Zilton A AndradeAbstract:Sabe-se que a fibrose Hepatica pode sofrer uma reducao em sequencia uma hepatectomia parcial, uma vez que o parenquima hepatico se regenera muito rapido, mas nao o excesso de tecido fibroso. O presente trabalho avalia esta hipotese ao observar como se comporta a fibrose septal sistematizada induzida pela Capillaria Hepatica no rato, apos infeccao de 30 ou 90 dias de duracao, em animais submetidos a hepatectomia parcial. Os resultados revelaram que a fibrose em si mesma nao foi afetada na sua morfologia, mas a sua quantidade relativa apareceu diminuida significativamente no campo microscopico como consequencia do aumento da massa de tecido hepatico pos-regeneracao.
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role of partial hepatectomy on Capillaria Hepatica induced hepatic fibrosis in rats papel da hepatectomia parcial sobre a fibrose septal do figado induzida pela Capillaria Hepatica em ratos
2007Co-Authors: Carolina Cincura Silva Santos, Zaira Onofrenunes, Zilton A AndradeAbstract:It is known that hepatic fibrosis may regress following partial hepatectomy, since the hepatic parenchyma regenerates very rapidly, but not the excess of fibrous tissue. The present study evaluated this hypothesis by observing the behavior of systematized septal fibrosis induced by either 30 or 90-day-old Capillaria Hepatica infection, in rats subjected to partial hepatectomy. The results revealed that the morphology of the fibrosis was unaffected, but its relative quantity within the microscope field appeared significantly decreased, as a consequence of the increased liver tissue mass following regeneration.
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Capillaria Hepatica in rats focal parasitic hepatic lesions and septal fibrosis run independent courses
Memorias Do Instituto Oswaldo Cruz, 2006Co-Authors: Ana Thereza Gomes, Liliane M Cunha, Carla Guimaraes Bastos, Bruno Frederico Medrado, Barbara C A Assis, Zilton A AndradeAbstract:Capillaria Hepatica causes two main lesions in the liver of rats: multifocal chronic inflammation, directly related to the presence of disintegrating parasites and their eggs, and a process of systematized septal fibrosis. The comparative behavior of these two lesions was investigated in rats experimentally infected with 600 embryonated eggs, following either corticosteroid treatment or specific antigenic stimulation, in an attempt to understand the relationship between these two lesions, and the pathogenesis of septal fibrosis. The two treatments differently modified the morphological aspects of the focal parasitic-related lesions, but did not interfere with the presentation of diffuse septal fibrosis, although a mild decrease in the degree of fibrosis occurred in corticoid-treated animals. These findings indicate that although the two lesions are C. Hepatica induced, they are under different pathogenetic control, the induction of septal fibrosis being triggered during early infection to follow an independent pathway.
Petra Igel - One of the best experts on this subject based on the ideXlab platform.
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Capillaria Hepatica in man—an overview of hepatic capillariosis and spurious infections
Parasitology Research, 2011Co-Authors: Hans-peter Fuehrer, Petra Igel, Herbert AuerAbstract:Capillaria Hepatica (syn. for Calodium hepaticum ) is a zoonotic nematode parasitizing in the livers of rodents as main hosts and in numerous other mammals including humans. It is the causative agent of the rare conditions of hepatic capillariosis and spurious C. Hepatica infections in humans. In this review, 163 reported cases of infestations with this parasite (72 reports of hepatic capillariosis, 13 serologically confirmed infestations and 78 observations of spurious infections) are summarized with an overview on the distribution, symptoms, pathology, diagnosis, serology and therapy of this rare human pathogen.
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Capillaria Hepatica in man an overview of hepatic capillariosis and spurious infections
Parasitology Research, 2011Co-Authors: Hans-peter Fuehrer, Petra Igel, Herbert AuerAbstract:Capillaria Hepatica (syn. for Calodium hepaticum) is a zoonotic nematode parasitizing in the livers of rodents as main hosts and in numerous other mammals including humans. It is the causative agent of the rare conditions of hepatic capillariosis and spurious C. Hepatica infections in humans. In this review, 163 reported cases of infestations with this parasite (72 reports of hepatic capillariosis, 13 serologically confirmed infestations and 78 observations of spurious infections) are summarized with an overview on the distribution, symptoms, pathology, diagnosis, serology and therapy of this rare human pathogen.
Márcia Maria De Souza - One of the best experts on this subject based on the ideXlab platform.
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Capillaria Hepatica-induced hepatic fibrosis in rats: paradoxical effect of repeated infections Fibrose do fígado e Capillaria Hepatica em ratos: efeito paradoxal nas infecções repetidas
2020Co-Authors: Ludmila Oliveira, Márcia Maria De Souza, Zilton De Araújo AndradeAbstract:Multiple exposures to parasitic agents are considered an important factor in the genesis of the most severe forms of the diseases they cause. Capillaria Hepatica-induced septal fibrosis of the liver in rats usually runs without signs of portal hypertension or hepatic failure. After determining the hepatic profile of 15 animals during the course of a single infection, we submitted 20 rats to multiple Capillaria Hepatica infections to determine whether repeated exposures would augment fibrosis production, transforming septal hepatic fibrosis into a true cirrhosis. Ten single-infection rats served as controls. A total of 5 exposures, with 45-day intervals, were made. Histological changes were followed by means of surgical liver biopsies, collected prior to infection and to each re-infection. Functional changes were minimal and transient. Although a slight recrudescence of fibrosis was observed after the first two re-infections and when the single-infected control group was re-infected at the end of the experiment, subsequent re-infections failed to increase the amount of fibrosis. On the contrary, there occurred quantitative and qualitative evidence of collagen degradation and suppression of parasite development. These paradoxical results are in keeping with the hypothesis that a complex immunological modulation participates in the mechanism of hepatic fibrosis induced by Capillaria Hepatica infection in rats.
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study of the prevalence of Capillaria Hepatica in humans and rodents in an urban area of the city of porto velho rondonia brazil
Revista Do Instituto De Medicina Tropical De Sao Paulo, 2015Co-Authors: Elierson Jose Gomes Da Rocha, Márcia Maria De Souza, Sergio De Almeida Basano, Eduardo Resende Honda, Marcio Botelho De Castro, Edson Moleta Colodel, Jessica Carolinne Damasceno E Silva, Lauro Prado Barros, Elisa Sousa Rodrigues, Luis Marcelo Aranha CamargoAbstract:Introducao: Capilariase Hepatica e causada pela Capillaria Hepatica (syn. Calodium hepaticum) (Bancroft, 1893), Travassos, 1915 (Nematoda, Trichinelloidea, Capillariidae), sendo uma zoonose comum entre roedores, porem rara em humanos. Setenta e dois casos humanos foram relatados na literatura mundial desde o primeiro caso descrito por MACARTHUR em 192417,27. O objetivo desse estudo e determinar a prevalencia da Capillaria Hepatica em humanos e roedores de area urbana da cidade de Porto Velho, capital de Rondonia, Brasil. Metodo: Apos realizar um censo da area, 490 moradores foram aleatoriamente selecionados e assinaram termo de consentimento, foram colhidas amostras de sangue para testar anticorpos anti-Capillaria Hepatica. Simultaneamente, ratos foram capturados para determinacao da prevalencia deste parasita atraves do exame histopatologico em cortes de figado. Resultados: Foi encontrada entre humanos prevalencia de 1,8% de positividade para anticorpos especificos em diluicao de 1:150, indicando exposicao aos ovos do parasito; 0,8% desses tambem deram testes positivos quando seus soros sofreram diluicao de 1:400, indicando infeccao verdadeira. Nos ratos, a prevalencia foi de 2%. Conclusao: A prevalencia encontrada para o parasito entre homens e roedores foi baixa. Enquanto a prevalencia encontrada entre humanos esteve dentro dos limites encontrados na literatura, a prevalencia entre roedores foi bem menor.
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dynamics of Capillaria Hepatica induced hepatic septal fibrosis in rats
Revista Da Sociedade Brasileira De Medicina Tropical, 2010Co-Authors: Lidiane Gaban, Márcia Maria De Souza, Cleber Douglas Lucinio Ramos, Aryon De Almeida Barbosa, Zilton A AndradeAbstract:INTRODUCTION: The pathogenesis of septal hepatic fibrosis, induced in rats by Capillaria Hepatica infection, was studied with the aid of a large collection of stored paraffin blocks, representative of the different evolutive phases of fibrosis which appeared in 100% of infected rats. METHODS: Studies were conducted involving histology, immunohistochemistry, immunofluorescence and morphometric methods, in order to observe the dynamic behavior of the cellular and matrix components of fibrosis, over a one year period of evolution. RESULTS: Observation verified that septal fibrosis originates from several portal spaces simultaneously. Its origin and progression involve blood vessel proliferation (angiogenesis), multiplication of actin-positive cells (pericytes and myofibroblasts) and progressive collagen deposition. By the end of 4-5 months, a progressive decrease in all these components was observed, when signs of regression of septal fibrosis became more evident over time. CONCLUSIONS: Besides indicating the fundamental role played by angiogenesis in the pathogenesis of fibrosis, these morphological data concerning the dynamics of this C. Hepatica experimental model proved to be adequate for future investigations regarding the functional aspects of fibrosis induction, progression and regression.
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Capillariaisis trichurida trichinellidae Capillaria Hepatica in the brazilian amazon low pathogenicity low infectivity and a novel mode of transmission
Parasites & Vectors, 2010Co-Authors: Luis Marcelo Aranha Camargo, Juliana De Souza Almeida Aranha Camargo, Luana Janaina Souza Vera, Pedro Di Tarique Crispim Barreto, Eudes Kang Tourinho, Márcia Maria De SouzaAbstract:Background Human Capillariasis caused by Capillaria Hepatica (syn. Calodium hepaticum) is a rare disease with no more than 40 cases registered around the world. Classically, the disease has severe symptoms that mimic acute hepatitis. Natural reservoirs of C. Hepatica are urban rodents (Mus musculus and Rattus novergicus) that harbor their eggs in the liver. After examining the feces of 6 riverine inhabitants (Rio Preto area, 8° 03'S and 62° 53' W to 8° 14'S and 62° 52'W) of the State of Rondonia, Brazil, and identifying C. Hepatica eggs in their feces, the authors decided to investigate the real dimension of these findings by looking for two positive signals.
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Capillaria Hepatica induced hepatic fibrosis in rats paradoxical effect of repeated infections
Revista Da Sociedade Brasileira De Medicina Tropical, 2004Co-Authors: Ludmila Oliveira, Márcia Maria De Souza, Zilton A AndradeAbstract:Multiple exposures to parasitic agents are considered an important factor in the genesis of the most severe forms of the diseases they cause. Capillaria Hepatica-induced septal fibrosis of the liver in rats usually runs without signs of portal hypertension or hepatic failure. After determining the hepatic profile of 15 animals during the course of a single infection, we submitted 20 rats to multiple Capillaria Hepatica infections to determine whether repeated exposures would augment fibrosis production, transforming septal hepatic fibrosis into a true cirrhosis. Ten single-infection rats served as controls. A total of 5 exposures, with 45-day intervals, were made. Histological changes were followed by means of surgical liver biopsies, collected prior to infection and to each re-infection. Functional changes were minimal and transient. Although a slight recrudescence of fibrosis was observed after the first two re-infections and when the single-infected control group was re-infected at the end of the experiment, subsequent re-infections failed to increase the amount of fibrosis. On the contrary, there occurred quantitative and qualitative evidence of collagen degradation and suppression of parasite development. These paradoxical results are in keeping with the hypothesis that a complex immunological modulation participates in the mechanism of hepatic fibrosis induced by Capillaria Hepatica infection in rats.
