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M M Gabriel - One of the best experts on this subject based on the ideXlab platform.
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a busca pela qualidade validacao metodologica na identificacao e quantificacao do Carbaril por espectrofotometriametria derivativa
Visão Acadêmica, 2002Co-Authors: C P Brescansin, P M C K Gabriel, Escorsin J Neto, M Lopes, M M GabrielAbstract:O Estado do Parana tem como principal atividade economica a agricultura, ocupando o primeiro lugar na producao nacional de milho, feijao, soja, trigo e aveia; e o segundo lugar na producao de mandioca e batata. Para garantir o sucesso de sua agricultura e necessario a utilizacao de uma grande quantidade de praguicidas, onde o Carbaril e um pesticida altamente utilizado nas plantacoes em todo o Estado, resultando muitas vezes, em quadros de intoxicacao pelo seu uso inadequado. Considerando a ampla utilizacao do Carbaril em todo o Estado do Parana, verificou-se a necessidade de se desenvolver metodologias passiveis de reproducao na sua identificacao e quantificacao como agente causador de inumeras intoxicacoes. Visando a qualidade da pesquisa a ser desenvolvida decidiu-se aplicar os principios da validacao metodologica que possui todo o seu embasamento em normas internacionais e sistemas de qualidade como a ISO /IEC 17025, salientando assim seus aspectos tecnicos e legais. Objetivando a qualidade no desenvolvimento desta pesquisa, apresentamos a primeira parte do protocolo de validacao composto pelo delineamento experimental que inclui a adequacao da metodologia as condicoes do laboratorio, os estudos relativos as propriedades fisico- quimicas e os dados toxicocineticos da substância em estudo, no caso o Carbaril utilizando o metodo de espectrofotometria derivativa. SEARCH FOR QUALITY: METHODOLOGICAL VALIDATION APPLIED TO THE IDENTIFICATION AND QUANTIFICATION OF CARBARYL BY DERIVATIVE SPECTROPHOTOMETRIC Abstract Agriculture is the main Parana States economic activity and it is the major national producer of maize, beans, soya beans, wheat and oat. It comes second on the production of manioc and potatoes. In order to guarantee the production of all these agricultural commodities it is necessary to use large quantities of pesticides. Carbaryl is one of the pesticides largely used all over the States agricultural land and the overexposure toCarbaryl or itsmisuse results in important cases of intoxication. Thus, it was suggested the development of a simple, reliable and reproducible analytical method for determining the presence of Carbaryl in biological material originated from those cases. In order to guarantee a high level of quality to this study, it was decided to apply to it the principles of the methodological validation. This paper presents the first part of the validation protocol, which comprehends: the experimental draft, the method adjustment to the laboratorys work conditions, the study of Carbaryls physicochemical properties and its toxicokinetic data. The method suggested is the derivative spectrophotometric.
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a busca pela qualidade validacao metodologica na identificacao e quantificacao do Carbaril por espectrofotometriametria derivativa search for quality methodological validation applied to the identification and quantification of carbaryl by derivative
2002Co-Authors: P M C K Gabriel, Escorsin J Neto, M Lopes, M M GabrielAbstract:Agriculture is the main Parana State’s economic activity and it is the major national producer of maize, beans, soya beans, wheat and oat. It comes second on the production of manioc and potatoes. In order to guarantee the production of all these agricultural commodities it is necessary to use large quantities of pesticides. Carbaryl is one of the pesticides largely used all over the State’s agricultural land and the overexposure to Carbaryl or its misuse results in important cases of intoxication. Thus, it was suggested the development of a simple, reliable and reproducible analytical method for determining the presence of Carbaryl in biological material originated from those cases. In order to guarantee a high level of quality to this study, it was decided to apply to it the principles of the methodological validation. This paper presents the first part of the validation protocol, which comprehends: the experimental draft, the method adjustment to the laboratory’s work conditions, the study of Carbaryl’s physicochemical properties and its toxicokinetic data. The method suggested is the derivative spectrophotometric
José Cola Zanuncio - One of the best experts on this subject based on the ideXlab platform.
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exposure to insecticides reduces populations of rhynchophorus palmarum in oil palm plantations with bud rot disease
Insects, 2019Co-Authors: Luis Carlos Martinez, Angelica Platarueda, Francisco Andres Rodriguezdimate, Juliana Mendonca Campos, Valdeir Celestino Dos Santos, Gabriela Da Silva Rolim, Flavio Lemes Fernandes, Wiane Meloni Silva, Carlos Frederico Wilcken, José Cola ZanuncioAbstract:The South American palm weevil (SAPW), Rhynchophorus palmarum Linnaeus (Coleoptera: Curculionidae) is the main pest of Elaeis guineensis and damages palm trees with bud rot disease in the Americas. The effects of six neurotoxic insecticides (abamectin, carbaryl, deltamethrin, fipronil, imidacloprid and spinosad) were evaluated against SAPW for toxicity, survival, reproduction, and mortality. Abamectin (LC50 = 0.33 mg mL−1), Carbaryl (LC50 = 0.24 mg mL−1), deltamethrin (LC50 = 0.17 mg mL−1), and fipronil (LC50 = 0.42 mg mL−1) were the most toxic to SAPW. Adult survival was 95% without exposure to insecticides, decreasing to 78–65% in insects treated with the LC25 and 49–35% in insects exposed to LC50. Sublethal doses of carbaryl, fipronil and imidacloprid showed significant effect on the reproduction of this insect. Mortality of SAPW populations caused by insecticides had similar effects in the laboratory and field conditions. The results suggest that carbaryl, deltamethrin, fipronil, and imidacloprid caused significantly higher mortality as compared to the control in SAPW and may be used to control its populations in oil palm trees where bud rot appears as the key disease for SAPW attraction and infestation.
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Insecticide selectivity to Supputius cincticeps (Stal) (Het., Pentatomidae) and its prey Spodoptera frugiperda (J. E. Smith) (Lep., Noctuidae)
Journal of Applied Entomology, 1998Co-Authors: José Cola Zanuncio, V. C. Batalha, Raul Narciso C. Guedes, Marcelo Coutinho PicançoAbstract:: The selectivity of malathion, carbaryl, permethrin, and deltamethrin to Supputius cincticeps (Stal) (Het., Pentatomidae) and its prey Spodoptera frugiperda (J. E. Smith) (Lep., Noctuidae) (fall armyworm) was evaluated using leaves dipped in insecticide dilutions. Based on LC50 values, malathion was the least toxic insecticide to the fall armyworm followed by carbaryl, permethrin and deltamethrin which was the most toxic compound to this insect pest. Malathion was also the least toxic insecticide to the predaceous bug S. cincticeps, while carbaryl and permethrin showed intermediate toxicity and deltamethrin was the most toxic insecticide to this species. Malathion and carbaryl were more toxic to the predator than to the fall armyworm showing low selectivity in favour of the first. However, the pyrethroids showed the opposite effect with deltamethrin being the most selective insecticide in favour of S. cincticeps. Nymphs of the fifth instar and adults of the predator were more tolerant to the pyrethroids than third-instar nymphs. The other insecticides showed similar toxicity to all three developmental stages of the predator. Resume Selectivite des insecticides pour Supputius cincticeps (Say) (Het., Pentatomidae) et sa proie Spodoptera furgiperda (J. E. Smith) (Lep., Noctuidae) La selectivite du mulathion. Carbaril. pennetrine et deltametrine pour Supputius cincticeps (Say) (Het., Pentatomidae) et sa proie Spodoptera frugiperda (J. E. Smith) (Lep., Noctuidae) (chenille du cornet) fut evaluee a l'aide de feuilles impregnees d'insecticides. Le malathion s'est avere l'insecticide le moins toxique pour la chenille du cornet, suivi du Carbaril. permetrine et deltametrine, cette derniere etant l'insecticidc le plus toxique pour cet insecte-fleau. base sur les valeurs du CL50. Le malathion a egalemenl ete l'insecticide le moins toxique pour la punaise predatrice S. cincticeps, alors que le Carbaril et la permetrine ont affiche une toxicite intermediaire et la deltametrine, une grande toxicite pour cette espece. Les insecticides malathion et Carbaril furent plus toxiques pour la punaise predatrice que pour la chenille du cornet, affichant une basse selectivite en faveur du premier. Toutefois, les pyretroides ont presente un effet contraire avec la deltametrine, celle-ci etant l'insecticide le plus selectif en faveur du S. cincticeps. Les nymphes du 5e stade et punaises adultes ont ete encore plus tolerantes aux pyretroides que les nymphes du 3o stade. Les autres insecticides ont revele une toxicite similaire pour les trois stades de developpement du predateur.
Josean Leite Pereira-barros - One of the best experts on this subject based on the ideXlab platform.
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AÇÃO DE ALGUNS PRODUTOS FITOSSANITÁRIOS PARA ADULTOS DE Trichogramma galloi Zucchi, 1988 (Hymenoptera: Trichogrammatidae) Action of some phytossanitary products for Trichogramma galloi Zucchi, 1988 (Hymenoptera: Trichogrammatidae) adults
Ciencia E Agrotecnologia, 2006Co-Authors: Sônia Maria Forti Broglio-micheletti, Adriano Jorge, Nunes Dos Santos, Josean Leite Pereira-barrosAbstract:RESUMOObjetivou-se com este trabalho avaliar em laboratorio, a 26±2°C; UR 60±10% e fotofase de 12 horas, a influencia doherbicida metribuzin 480 SC, do inseticida quimico Carbaril 480 SC, do fungo Metarhizium anisopliae (Metsch) Sorokin e dooleo emulsionavel de nim, Azadirachta indica A. Juss, sobre o parasitismo, a emergencia e a longevidade de Trichogrammagalloi Zucchi, 1988, criados em ovos de Diatraea saccharalis (Fabricius, 1794). Conduziu-se o ensaio utilizando-se 100posturas, obtidas em laboratorio, nas 24 horas apos a oviposicao, as quais foram tratadas por imersao e oferecidas aosparasitoides. O delineamento experimental foi inteiramente casualizado com dez tratamentos e dez repeticoes. O parasitismofoi prejudicado pelo nim nas concentracoes de 0,33; 0,53 e 1%, seguido pelo Carbaril a 4%, metribuzim a 2,14% e M. anisopliae(IPA 159E) a 0,4%. A emergencia do parasitoide foi reduzida quando se utilizou o Carbaril, M. anisopliae (IPA 159E) emetribuzim e, a longevidade foi afetada quando se empregou metribuzim e M. anisopliae (IPA 159E) com uma variacao mediamenor que 24 horas.Termos para indexacao: Produto fitossanitario, broca-da-cana-de-acucar, Trichogramma, Metarhizium anisopliae.ABSTRACTThe objective was to evaluate, in laboratory, at 26°C, UR 60±10% and 12 hours photophase, the influence of herbicidemetribuzin 480 SC, the chemical insecticide carbaryl 480 SC, the entomophatogen Metarhizium anisopliae (Metsch) Sorokin andemulsionable neem oil, Azadirachta indica A. Juss, on the parasitism, emergency and longevity of Trichogramma galloi Zucchi, 1988,reared in eggs of Diatraea saccharalis (Fabricius, 1794). The bioassay was conducted using one hundred postures, from laboratoryrearing, in the 24 hours after oviposition, which were treated by immersion and offered to the natural enemies. The experimentaldesign was entirely randomized with ten treatments and ten repetitions. The parasitism was harmed by neem in the concentrations(0.33, 0.53 and 1%), followed for carbaryl 4%, metribuzim 2.14% and M. anisopliae (IPA 159E) 0.4%. The emergency of theparasitoid was reduced for the treatments: carbaryl, M. anisopliae (IPA 159E) and metribuzim, and the longevity for metribuzim andM. anisopliae (IPA 159E) with an average variation lower that 24 hours.Index terms: Phytossanitary product, sugarcane borer, Trichogramma, Metarhizium anisopliae.(Recebido para publicacao em 9 de agosto de 2005 e aprovado 22 de maio de 2006)
P M C K Gabriel - One of the best experts on this subject based on the ideXlab platform.
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a busca pela qualidade validacao metodologica na identificacao e quantificacao do Carbaril por espectrofotometriametria derivativa
Visão Acadêmica, 2002Co-Authors: C P Brescansin, P M C K Gabriel, Escorsin J Neto, M Lopes, M M GabrielAbstract:O Estado do Parana tem como principal atividade economica a agricultura, ocupando o primeiro lugar na producao nacional de milho, feijao, soja, trigo e aveia; e o segundo lugar na producao de mandioca e batata. Para garantir o sucesso de sua agricultura e necessario a utilizacao de uma grande quantidade de praguicidas, onde o Carbaril e um pesticida altamente utilizado nas plantacoes em todo o Estado, resultando muitas vezes, em quadros de intoxicacao pelo seu uso inadequado. Considerando a ampla utilizacao do Carbaril em todo o Estado do Parana, verificou-se a necessidade de se desenvolver metodologias passiveis de reproducao na sua identificacao e quantificacao como agente causador de inumeras intoxicacoes. Visando a qualidade da pesquisa a ser desenvolvida decidiu-se aplicar os principios da validacao metodologica que possui todo o seu embasamento em normas internacionais e sistemas de qualidade como a ISO /IEC 17025, salientando assim seus aspectos tecnicos e legais. Objetivando a qualidade no desenvolvimento desta pesquisa, apresentamos a primeira parte do protocolo de validacao composto pelo delineamento experimental que inclui a adequacao da metodologia as condicoes do laboratorio, os estudos relativos as propriedades fisico- quimicas e os dados toxicocineticos da substância em estudo, no caso o Carbaril utilizando o metodo de espectrofotometria derivativa. SEARCH FOR QUALITY: METHODOLOGICAL VALIDATION APPLIED TO THE IDENTIFICATION AND QUANTIFICATION OF CARBARYL BY DERIVATIVE SPECTROPHOTOMETRIC Abstract Agriculture is the main Parana States economic activity and it is the major national producer of maize, beans, soya beans, wheat and oat. It comes second on the production of manioc and potatoes. In order to guarantee the production of all these agricultural commodities it is necessary to use large quantities of pesticides. Carbaryl is one of the pesticides largely used all over the States agricultural land and the overexposure toCarbaryl or itsmisuse results in important cases of intoxication. Thus, it was suggested the development of a simple, reliable and reproducible analytical method for determining the presence of Carbaryl in biological material originated from those cases. In order to guarantee a high level of quality to this study, it was decided to apply to it the principles of the methodological validation. This paper presents the first part of the validation protocol, which comprehends: the experimental draft, the method adjustment to the laboratorys work conditions, the study of Carbaryls physicochemical properties and its toxicokinetic data. The method suggested is the derivative spectrophotometric.
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a busca pela qualidade validacao metodologica na identificacao e quantificacao do Carbaril por espectrofotometriametria derivativa search for quality methodological validation applied to the identification and quantification of carbaryl by derivative
2002Co-Authors: P M C K Gabriel, Escorsin J Neto, M Lopes, M M GabrielAbstract:Agriculture is the main Parana State’s economic activity and it is the major national producer of maize, beans, soya beans, wheat and oat. It comes second on the production of manioc and potatoes. In order to guarantee the production of all these agricultural commodities it is necessary to use large quantities of pesticides. Carbaryl is one of the pesticides largely used all over the State’s agricultural land and the overexposure to Carbaryl or its misuse results in important cases of intoxication. Thus, it was suggested the development of a simple, reliable and reproducible analytical method for determining the presence of Carbaryl in biological material originated from those cases. In order to guarantee a high level of quality to this study, it was decided to apply to it the principles of the methodological validation. This paper presents the first part of the validation protocol, which comprehends: the experimental draft, the method adjustment to the laboratory’s work conditions, the study of Carbaryl’s physicochemical properties and its toxicokinetic data. The method suggested is the derivative spectrophotometric
Shigeyuki Kitamura - One of the best experts on this subject based on the ideXlab platform.
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in vitro metabolism of methiocarb and carbaryl in rats and its effect on their estrogenic and antiandrogenic activities
Environmental Toxicology and Pharmacology, 2016Co-Authors: Satoko Tange, Nariaki Fujimoto, Naoto Uramaru, Fung Fuh Wong, Kazumi Sugihara, Shigeru Ohta, Shigeyuki KitamuraAbstract:Abstract In this work, we examined the metabolism of the carbamate insecticides methiocarb and carbaryl by rat liver microsomes and plasma, and its effect on their endocrine-disrupting activities. Methiocarb and carbaryl were not enzymatically hydrolyzed by rat liver microsomes, but were hydrolyzed by rat plasma, mainly to methylthio-3,5-xylenol (MX) and 1-naphthol, respectively. When methiocarb was incubated with rat liver microsomes in the presence of NADPH, methiocarb sulfoxide was formed. The hydrolysis product, MX, was also oxidized to the sulfoxide, 3,5-dimethyl-4-(methylsulfinyl)phenol (SP), by rat liver microsomes in the presence of NADPH. These oxidase activities were catalyzed by cytochrome P450 and flavin-containing monooxygenase. Methiocarb and carbaryl both exhibited estrogen receptor α (ERα) and ERβ agonistic activity. MX and 1-naphthol showed similar activities, but methiocarb sulfoxide and SP showed markedly decreased activities. On the other hand, methiocarb and carbaryl exhibited potent antiandrogenic activity in the concentration range of 1 × 10 −6 –3 × 10 −5 M. Their hydrolysis products, MX, and 1-naphthol also showed high activity, equivalent to that of flutamide. However, methiocarb sulfoxide and SP showed relatively low activity. Thus, hydrolysis of methiocarb and carbaryl and oxidation of methiocarb to the sulfoxide markedly modified the estrogenic and antiandrogenic activities of methiocarb and carbaryl.