The Experts below are selected from a list of 33831 Experts worldwide ranked by ideXlab platform
A J Mackay - One of the best experts on this subject based on the ideXlab platform.
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variation in lung function and alterations in cardiac Structure and function analysis of the uk biobank Cardiovascular magnetic resonance imaging substudy
PLOS ONE, 2018Co-Authors: Ross J Thomson, Nay Aung, Mihir M Sanghvi, Jose Miguel Paiva, Aaron M Lee, Filip Zemrak, Kenneth Fung, Paul E Pfeffer, A J MackayAbstract:Background Reduced lung function is common and associated with increased Cardiovascular morbidity and mortality, even in asymptomatic individuals without diagnosed respiratory disease. Previous studies have identified relationships between lung function and Cardiovascular Structure in individuals with pulmonary disease, but the relationships in those free from diagnosed cardiorespiratory disease have not been fully explored. Methods UK Biobank is a prospective cohort study of community participants in the United Kingdom. Individuals self-reported demographics and co-morbidities, and a subset underwent Cardiovascular magnetic resonance (CMR) imaging and spirometry. CMR images were analysed to derive ventricular volumes and mass. The relationships between CMR-derived measures and spirometry and age were modelled with multivariable linear regression, taking account of the effects of possible confounders. Results Data were available for 4,975 individuals, and after exclusion of those with pre-existing cardiorespiratory disease and unacceptable spirometry, 1,406 were included in the analyses. In fully-adjusted multivariable linear models lower FEV1 and FVC were associated with smaller left ventricular end-diastolic (-5.21ml per standard deviation (SD) change in FEV1, -5.69ml per SD change in FVC), end-systolic (-2.34ml, -2.56ml) and stroke volumes (-2.85ml, -3.11ml); right ventricular end-diastolic (-5.62ml, -5.84ml), end-systolic (-2.47ml, -2.46ml) and stroke volumes (-3.13ml, -3.36ml); and with lower left ventricular mass (-2.29g, -2.46g). Changes of comparable magnitude and direction were observed per decade increase in age. Conclusions This study shows that reduced FEV1 and FVC are associated with smaller ventricular volumes and reduced ventricular mass. The changes seen per standard deviation change in FEV1 and FVC are comparable to one decade of ageing.
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variation in lung function and alterations in cardiac Structure and function analysis of the uk biobank Cardiovascular magnetic resonance imaging substudy
PLOS ONE, 2018Co-Authors: Ross J Thomson, Nay Aung, Mihir M Sanghvi, Jose Miguel Paiva, Filip Zemrak, Kenneth Fung, Paul E Pfeffer, A J Mackay, Tricia M Mckeever, Elena LukaschukAbstract:BACKGROUND: Reduced lung function is common and associated with increased Cardiovascular morbidity and mortality, even in asymptomatic individuals without diagnosed respiratory disease. Previous studies have identified relationships between lung function and Cardiovascular Structure in individuals with pulmonary disease, but the relationships in those free from diagnosed cardiorespiratory disease have not been fully explored. METHODS: UK Biobank is a prospective cohort study of community participants in the United Kingdom. Individuals self-reported demographics and co-morbidities, and a subset underwent Cardiovascular magnetic resonance (CMR) imaging and spirometry. CMR images were analysed to derive ventricular volumes and mass. The relationships between CMR-derived measures and spirometry and age were modelled with multivariable linear regression, taking account of the effects of possible confounders. RESULTS: Data were available for 4,975 individuals, and after exclusion of those with pre-existing cardiorespiratory disease and unacceptable spirometry, 1,406 were included in the analyses. In fully-adjusted multivariable linear models lower FEV1 and FVC were associated with smaller left ventricular end-diastolic (-5.21ml per standard deviation (SD) change in FEV1, -5.69ml per SD change in FVC), end-systolic (-2.34ml, -2.56ml) and stroke volumes (-2.85ml, -3.11ml); right ventricular end-diastolic (-5.62ml, -5.84ml), end-systolic (-2.47ml, -2.46ml) and stroke volumes (-3.13ml, -3.36ml); and with lower left ventricular mass (-2.29g, -2.46g). Changes of comparable magnitude and direction were observed per decade increase in age. CONCLUSIONS: This study shows that reduced FEV1 and FVC are associated with smaller ventricular volumes and reduced ventricular mass. The changes seen per standard deviation change in FEV1 and FVC are comparable to one decade of ageing.
Paul E Pfeffer - One of the best experts on this subject based on the ideXlab platform.
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variation in lung function and alterations in cardiac Structure and function analysis of the uk biobank Cardiovascular magnetic resonance imaging substudy
PLOS ONE, 2018Co-Authors: Ross J Thomson, Nay Aung, Mihir M Sanghvi, Jose Miguel Paiva, Aaron M Lee, Filip Zemrak, Kenneth Fung, Paul E Pfeffer, A J MackayAbstract:Background Reduced lung function is common and associated with increased Cardiovascular morbidity and mortality, even in asymptomatic individuals without diagnosed respiratory disease. Previous studies have identified relationships between lung function and Cardiovascular Structure in individuals with pulmonary disease, but the relationships in those free from diagnosed cardiorespiratory disease have not been fully explored. Methods UK Biobank is a prospective cohort study of community participants in the United Kingdom. Individuals self-reported demographics and co-morbidities, and a subset underwent Cardiovascular magnetic resonance (CMR) imaging and spirometry. CMR images were analysed to derive ventricular volumes and mass. The relationships between CMR-derived measures and spirometry and age were modelled with multivariable linear regression, taking account of the effects of possible confounders. Results Data were available for 4,975 individuals, and after exclusion of those with pre-existing cardiorespiratory disease and unacceptable spirometry, 1,406 were included in the analyses. In fully-adjusted multivariable linear models lower FEV1 and FVC were associated with smaller left ventricular end-diastolic (-5.21ml per standard deviation (SD) change in FEV1, -5.69ml per SD change in FVC), end-systolic (-2.34ml, -2.56ml) and stroke volumes (-2.85ml, -3.11ml); right ventricular end-diastolic (-5.62ml, -5.84ml), end-systolic (-2.47ml, -2.46ml) and stroke volumes (-3.13ml, -3.36ml); and with lower left ventricular mass (-2.29g, -2.46g). Changes of comparable magnitude and direction were observed per decade increase in age. Conclusions This study shows that reduced FEV1 and FVC are associated with smaller ventricular volumes and reduced ventricular mass. The changes seen per standard deviation change in FEV1 and FVC are comparable to one decade of ageing.
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variation in lung function and alterations in cardiac Structure and function analysis of the uk biobank Cardiovascular magnetic resonance imaging substudy
PLOS ONE, 2018Co-Authors: Ross J Thomson, Nay Aung, Mihir M Sanghvi, Jose Miguel Paiva, Filip Zemrak, Kenneth Fung, Paul E Pfeffer, A J Mackay, Tricia M Mckeever, Elena LukaschukAbstract:BACKGROUND: Reduced lung function is common and associated with increased Cardiovascular morbidity and mortality, even in asymptomatic individuals without diagnosed respiratory disease. Previous studies have identified relationships between lung function and Cardiovascular Structure in individuals with pulmonary disease, but the relationships in those free from diagnosed cardiorespiratory disease have not been fully explored. METHODS: UK Biobank is a prospective cohort study of community participants in the United Kingdom. Individuals self-reported demographics and co-morbidities, and a subset underwent Cardiovascular magnetic resonance (CMR) imaging and spirometry. CMR images were analysed to derive ventricular volumes and mass. The relationships between CMR-derived measures and spirometry and age were modelled with multivariable linear regression, taking account of the effects of possible confounders. RESULTS: Data were available for 4,975 individuals, and after exclusion of those with pre-existing cardiorespiratory disease and unacceptable spirometry, 1,406 were included in the analyses. In fully-adjusted multivariable linear models lower FEV1 and FVC were associated with smaller left ventricular end-diastolic (-5.21ml per standard deviation (SD) change in FEV1, -5.69ml per SD change in FVC), end-systolic (-2.34ml, -2.56ml) and stroke volumes (-2.85ml, -3.11ml); right ventricular end-diastolic (-5.62ml, -5.84ml), end-systolic (-2.47ml, -2.46ml) and stroke volumes (-3.13ml, -3.36ml); and with lower left ventricular mass (-2.29g, -2.46g). Changes of comparable magnitude and direction were observed per decade increase in age. CONCLUSIONS: This study shows that reduced FEV1 and FVC are associated with smaller ventricular volumes and reduced ventricular mass. The changes seen per standard deviation change in FEV1 and FVC are comparable to one decade of ageing.
Ross J Thomson - One of the best experts on this subject based on the ideXlab platform.
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variation in lung function and alterations in cardiac Structure and function analysis of the uk biobank Cardiovascular magnetic resonance imaging substudy
PLOS ONE, 2018Co-Authors: Ross J Thomson, Nay Aung, Mihir M Sanghvi, Jose Miguel Paiva, Aaron M Lee, Filip Zemrak, Kenneth Fung, Paul E Pfeffer, A J MackayAbstract:Background Reduced lung function is common and associated with increased Cardiovascular morbidity and mortality, even in asymptomatic individuals without diagnosed respiratory disease. Previous studies have identified relationships between lung function and Cardiovascular Structure in individuals with pulmonary disease, but the relationships in those free from diagnosed cardiorespiratory disease have not been fully explored. Methods UK Biobank is a prospective cohort study of community participants in the United Kingdom. Individuals self-reported demographics and co-morbidities, and a subset underwent Cardiovascular magnetic resonance (CMR) imaging and spirometry. CMR images were analysed to derive ventricular volumes and mass. The relationships between CMR-derived measures and spirometry and age were modelled with multivariable linear regression, taking account of the effects of possible confounders. Results Data were available for 4,975 individuals, and after exclusion of those with pre-existing cardiorespiratory disease and unacceptable spirometry, 1,406 were included in the analyses. In fully-adjusted multivariable linear models lower FEV1 and FVC were associated with smaller left ventricular end-diastolic (-5.21ml per standard deviation (SD) change in FEV1, -5.69ml per SD change in FVC), end-systolic (-2.34ml, -2.56ml) and stroke volumes (-2.85ml, -3.11ml); right ventricular end-diastolic (-5.62ml, -5.84ml), end-systolic (-2.47ml, -2.46ml) and stroke volumes (-3.13ml, -3.36ml); and with lower left ventricular mass (-2.29g, -2.46g). Changes of comparable magnitude and direction were observed per decade increase in age. Conclusions This study shows that reduced FEV1 and FVC are associated with smaller ventricular volumes and reduced ventricular mass. The changes seen per standard deviation change in FEV1 and FVC are comparable to one decade of ageing.
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variation in lung function and alterations in cardiac Structure and function analysis of the uk biobank Cardiovascular magnetic resonance imaging substudy
PLOS ONE, 2018Co-Authors: Ross J Thomson, Nay Aung, Mihir M Sanghvi, Jose Miguel Paiva, Filip Zemrak, Kenneth Fung, Paul E Pfeffer, A J Mackay, Tricia M Mckeever, Elena LukaschukAbstract:BACKGROUND: Reduced lung function is common and associated with increased Cardiovascular morbidity and mortality, even in asymptomatic individuals without diagnosed respiratory disease. Previous studies have identified relationships between lung function and Cardiovascular Structure in individuals with pulmonary disease, but the relationships in those free from diagnosed cardiorespiratory disease have not been fully explored. METHODS: UK Biobank is a prospective cohort study of community participants in the United Kingdom. Individuals self-reported demographics and co-morbidities, and a subset underwent Cardiovascular magnetic resonance (CMR) imaging and spirometry. CMR images were analysed to derive ventricular volumes and mass. The relationships between CMR-derived measures and spirometry and age were modelled with multivariable linear regression, taking account of the effects of possible confounders. RESULTS: Data were available for 4,975 individuals, and after exclusion of those with pre-existing cardiorespiratory disease and unacceptable spirometry, 1,406 were included in the analyses. In fully-adjusted multivariable linear models lower FEV1 and FVC were associated with smaller left ventricular end-diastolic (-5.21ml per standard deviation (SD) change in FEV1, -5.69ml per SD change in FVC), end-systolic (-2.34ml, -2.56ml) and stroke volumes (-2.85ml, -3.11ml); right ventricular end-diastolic (-5.62ml, -5.84ml), end-systolic (-2.47ml, -2.46ml) and stroke volumes (-3.13ml, -3.36ml); and with lower left ventricular mass (-2.29g, -2.46g). Changes of comparable magnitude and direction were observed per decade increase in age. CONCLUSIONS: This study shows that reduced FEV1 and FVC are associated with smaller ventricular volumes and reduced ventricular mass. The changes seen per standard deviation change in FEV1 and FVC are comparable to one decade of ageing.
Lohendran Baskaran - One of the best experts on this subject based on the ideXlab platform.
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automatic segmentation of multiple Cardiovascular Structures from cardiac computed tomography angiography images using deep learning
PLOS ONE, 2020Co-Authors: Lohendran Baskaran, Subhi J Alaref, Gabriel Maliakal, Benjamin C Lee, Jeong W Choi, Sang Eun Lee, Ji Min SungAbstract:Author(s): Baskaran, Lohendran; Al'Aref, Subhi J; Maliakal, Gabriel; Lee, Benjamin C; Xu, Zhuoran; Choi, Jeong W; Lee, Sang-Eun; Sung, Ji Min; Lin, Fay Y; Dunham, Simon; Mosadegh, Bobak; Kim, Yong-Jin; Gottlieb, Ilan; Lee, Byoung Kwon; Chun, Eun Ju; Cademartiri, Filippo; Maffei, Erica; Marques, Hugo; Shin, Sanghoon; Choi, Jung Hyun; Chinnaiyan, Kavitha; Hadamitzky, Martin; Conte, Edoardo; Andreini, Daniele; Pontone, Gianluca; Budoff, Matthew J; Leipsic, Jonathon A; Raff, Gilbert L; Virmani, Renu; Samady, Habib; Stone, Peter H; Berman, Daniel S; Narula, Jagat; Bax, Jeroen J; Chang, Hyuk-Jae; Min, James K; Shaw, Leslee J | Abstract: OBJECTIVES:To develop, demonstrate and evaluate an automated deep learning method for multiple Cardiovascular Structure segmentation. BACKGROUND:Segmentation of Cardiovascular images is resource-intensive. We design an automated deep learning method for the segmentation of multiple Structures from Coronary Computed Tomography Angiography (CCTA) images. METHODS:Images from a multicenter registry of patients that underwent clinically-indicated CCTA were used. The proximal ascending and descending aorta (PAA, DA), superior and inferior vena cavae (SVC, IVC), pulmonary artery (PA), coronary sinus (CS), right ventricular wall (RVW) and left atrial wall (LAW) were annotated as ground truth. The U-net-derived deep learning model was trained, validated and tested in a 70:20:10 split. RESULTS:The dataset comprised 206 patients, with 5.130 billion pixels. Mean age was 59.9 ± 9.4 yrs., and was 42.7% female. An overall median Dice score of 0.820 (0.782, 0.843) was achieved. Median Dice scores for PAA, DA, SVC, IVC, PA, CS, RVW and LAW were 0.969 (0.979, 0.988), 0.953 (0.955, 0.983), 0.937 (0.934, 0.965), 0.903 (0.897, 0.948), 0.775 (0.724, 0.925), 0.720 (0.642, 0.809), 0.685 (0.631, 0.761) and 0.625 (0.596, 0.749) respectively. Apart from the CS, there were no significant differences in performance between sexes or age groups. CONCLUSIONS:An automated deep learning model demonstrated segmentation of multiple Cardiovascular Structures from CCTA images with reasonable overall accuracy when evaluated on a pixel level.
Amil M Shah - One of the best experts on this subject based on the ideXlab platform.
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ideal Cardiovascular health during adult life and Cardiovascular Structure and function among the elderly
Circulation, 2015Co-Authors: Amil M Shah, Brian Claggett, Aaron R Folsom, Pamela L Lutsey, Christie M Ballantyne, Gerardo Heiss, Scott D SolomonAbstract:Background— A higher American Heart Association Cardiovascular health score (CVHS) predicts a lower incidence of Cardiovascular disease (CVD). However, the relationship of CVHS attainment through midlife to late life with CVD prevalence and Cardiovascular Structure and function in late life is not well described. Methods and Results— The following 6 ideal Cardiovascular health metrics were assessed in the Atherosclerosis Risk in Communities (ARIC) study participants at 5 examination visits between 1987 and 2013: nonsmoking, body mass index 2 , untreated total cholesterol Conclusions— Greater attainment of, and improvements in, ideal Cardiovascular health through midlife to late life are associated with lower CVD prevalence and better Cardiovascular Structure and function when elderly. These findings highlight the importance of consistent primordial and primary prevention efforts throughout midlife to late life as a potential intervention to decrease the burden of CVD among the elderly.
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abstract p124 ideal Cardiovascular health during adult life and Cardiovascular Structure and function among the elderly
Circulation, 2015Co-Authors: Amil M Shah, Brian Claggett, Aaron R Folsom, Pamela L Lutsey, Scott D SolomonAbstract:Introduction: The AHA has identified seven ideal Cardiovascular (CV) health metrics to target primary prevention of CV disease, including heart failure. The relationship between the consistent attainment of these metrics in adulthood and CV Structure and function in late-life is not well described. Hypothesis: We hypothesized that the greater number of ideal CV health metrics consistently achieved in adulthood will be associated with better cardiac and arterial function when elderly. Methods: The following six ideal CV health metrics were assessed in Atherosclerosis Risk in Communities (ARIC) study participants at 5 exam visits between 1987 and 2013 (visits 1-4 in 1987-98, visit 5 in 2011-13): nonsmoking, body mass index Results: At Visit 5, median age was 75.2 years (IQR 71.7, 79.7), 42% were male, and 21% black. At least 4 metrics were consistently attained in 6%, with 3, 2, 1, and 0 metrics consistently attained in 14%, 35%, 35%, and 12% respectively. Greater number of metrics consistently attained was associated with better LV Structure, systolic and diastolic function, less arterial stiffness, and lower NT-proBNP and high sensitivity troponin T at Visit 5 (Table). Conclusions: In this community-based cohort, greater number of ideal CV health metrics consistently attained over an approximately 26 year span was associated with better Cardiovascular Structure and function when elderly.
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association between renal function and Cardiovascular Structure and function in heart failure with preserved ejection fraction
European Heart Journal, 2014Co-Authors: Mauro Gori, Amil M Shah, Brian Claggett, Deepak K Gupta, Angela B S Santos, Elisabeth Kraigherkrainer, Burkert Pieske, Michele Senni, David M Charytan, Michael R ZileAbstract:Aim Renal dysfunction is a common comorbidity in patients with heart failure and preserved ejection fraction (HFpEF). We sought to determine whether renal dysfunction was associated with measures of Cardiovascular Structure/function in patients with HFpEF. Methods We studied 217 participants from the PARAMOUNT study with HFpEF who had echocardiography and measures of kidney function. We evaluated the relationships between renal dysfunction [estimated glomerular filtration rate (eGFR) >30 and <60 mL/min/1.73 m2 and/or albuminuria] and Cardiovascular Structure/function. Results The mean age of the study population was 71 years, 55% were women, 94% hypertensive, and 40% diabetic. Impairment of at least one parameter of kidney function was present in 62% of patients (16% only albuminuria, 23% only low eGFR, 23% both). Renal dysfunction was associated with abnormal LV geometry (defined as concentric hypertrophy, or eccentric hypertrophy, or concentric remodelling) (adjusted P = 0.048), lower midwall fractional shortening (MWFS) ( P = 0.009), and higher NT-proBNP ( P = 0.006). Compared with patients without renal dysfunction, those with low eGFR and no albuminuria had a higher prevalence of abnormal LV geometry ( P = 0.032) and lower MWFS ( P < 0.01), as opposed to those with only albuminuria. Conversely, albuminuria alone was associated with greater LV dimensions ( P < 0.05). Patients with combined renal impairment had mixed abnormalities (higher LV wall thicknesses, NT-proBNP; lower MWFS). Conclusion Renal dysfunction, as determined by both eGFR and albuminuria, is highly prevalent in HFpEF, and associated with cardiac remodelling and subtle systolic dysfunction. The observed differences in cardiac Structure/function between each type of renal damage suggest that both parameters of kidney function might play a distinct role in HFpEF.
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sex specific Cardiovascular Structure and function in heart failure with preserved ejection fraction
European Journal of Heart Failure, 2014Co-Authors: Mauro Gori, Amil M Shah, Brian Claggett, Carolyn S P Lam, Deepak K Gupta, Angela B S Santos, Susan Cheng, Michael R Zile, Elisabeth Kraigherkrainer, Burkert PieskeAbstract:Aims Women are more likely to develop heart failure with preserved ejection fraction (HFpEF) than men. We studied the relationship between sex and Cardiovascular Structure and function in patients with HFpEF. Methods and results The study included 279 participants from the PARAMOUNT study (57% women) with analysable baseline echocardiograms (mean age 71 years, 94% hypertensive, 38% diabetic). We assessed sex-based differences in baseline clinical characteristics and measures of Cardiovascular Structure/function. Coronary artery disease was less common in women than in men. Women were more obese and symptomatic, and less likely to have albuminuria. Women had higher indexed left ventricular (LV) wall thicknesses, worse diastolic function (lower E′, P = 0.002; higher E/E′, P < 0.001), while LV mass and LV volumes indexed for height2.7 were similar. Nonetheless, female sex was associated with a trend towards higher prevalence of abnormal LV geometry (defined as concentric hypertrophy, or eccentric hypertrophy, or concentric remodelling) at baseline (unadjusted P = 0.028, adjusted P = 0.056) and 12 weeks' follow up (unadjusted P = 0.001, adjusted P = 0.006), but not at 36 weeks' follow up (unadjusted P = 0.81, adjusted P = 0.99). Despite higher LV ejection fraction in women, global LV strain was similar between the sexes, while Tissue Doppler Imaging S′ mitral velocity was lower in women. Both LV diastolic and systolic stiffness were higher in women than men (P < 0.001), even adjusting for LV concentricity and clinical covariates. We observed no sex differences in systolic arterial–LV coupling, as women also had higher absolute arterial elastance compared with men, although this difference was not significant after adjusting for height2.7. Conclusion More pronounced diastolic dysfunction may contribute to the greater predisposition for HFpEF in women compared with men.