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Siegfried Trattnig - One of the best experts on this subject based on the ideXlab platform.
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state of the art mr imaging after knee Cartilage Repair surgery
Radiology, 2015Co-Authors: Ali Guermazi, Mats Brittberg, Frank W Roemer, Hamza Alizai, Carl S Winalski, Goetz Welsch, Siegfried TrattnigAbstract:The combination of MR imaging–based morphologic and compositional imaging plays an integral role in the assessment of Cartilage Repair tissue and its integration to native tissues after Cartilage Repair surgery.
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state of the art mr imaging after knee Cartilage Repair surgery
Radiology, 2015Co-Authors: Ali Guermazi, Mats Brittberg, Goetz H Welsch, Frank W Roemer, Hamza Alizai, Carl S Winalski, Siegfried TrattnigAbstract:Cartilage injuries are common, especially in athletes. Because these injuries frequently affect young patients, and they have the potential to progress to osteoarthritis, treatment to alleviate symptoms and delay joint degeneration is warranted. A number of surgical techniques are available to treat focal chondral defects, including marrow stimulation, osteochondral auto- and allografting, and autologous chondrocyte implantation. Although arthroscopy is considered the standard of reference for the evaluation of Cartilage before and after Repair, it is invasive with associated morbidity and cannot adequately depict the deep Cartilage layer and underlying bone. Magnetic resonance (MR) imaging provides unparalleled noninvasive assessment of the Repair site and all other joint tissues. MR observation of Cartilage Repair tissue is a well-established semiquantitative scoring system for Repair tissue that has primarily been used in clinical research studies. The Cartilage Repair osteoarthritis knee score (CROAKS) optimizes comprehensive morphologic assessment of the knee joint after Cartilage Repair. Furthermore, quantitative, compositional MR imaging measurements (eg, T2, T2*, T1ρ), delayed gadolinium-enhanced MR imaging of Cartilage (dGEMRIC), and sodium imaging are available for biochemical assessment. These quantitative MR imaging techniques help assess collagen content and orientation, water content, and glycosaminoglycan and/or proteoglycan content both in the Repair tissue as it matures and in the "native" Cartilage. In this review, the authors discuss the principles of state-of-the-art morphologic and compositional MR imaging techniques for imaging of Cartilage Repair and their application to longitudinal studies.
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Cartilage Repair surgery outcome evaluation by using noninvasive Cartilage biomarkers based on quantitative mri techniques
BioMed Research International, 2014Co-Authors: Pia M Jungmann, Siegfried Trattnig, Dimitrios C Karampinos, Thomas Baum, Ernst J Rummeny, Jan S Bauer, Benjamin Erdle, Thomas M Link, Xiaojuan Li, Klaus WoertlerAbstract:Background. New quantitative magnetic resonance imaging (MRI) techniques are increasingly applied as outcome measures after Cartilage Repair. Objective. To review the current literature on the use of quantitative MRI biomarkers for evaluation of Cartilage Repair at the knee and ankle. Methods. Using PubMed literature research, studies on biochemical, quantitative MR imaging of Cartilage Repair were identified and reviewed. Results. Quantitative MR biomarkers detect early degeneration of articular Cartilage, mainly represented by an increasing water content, collagen disruption, and proteoglycan loss. Recently, feasibility of biochemical MR imaging of Cartilage Repair tissue and surrounding Cartilage was demonstrated. Ultrastructural properties of the tissue after different Repair procedures resulted in differences in imaging characteristics. T2 mapping, T1rho mapping, delayed gadolinium-enhanced MRI of Cartilage (dGEMRIC), and diffusion weighted imaging (DWI) are applicable on most clinical 1.5 T and 3 T MR scanners. Currently, a standard of reference is difficult to define and knowledge is limited concerning correlation of clinical and MR findings. The lack of histological correlations complicates the identification of the exact tissue composition. Conclusions. A multimodal approach combining several quantitative MRI techniques in addition to morphological and clinical evaluation might be promising. Further investigations are required to demonstrate the potential for outcome evaluation after Cartilage Repair.
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is magnetic resonance imaging reliable in predicting clinical outcome after articular Cartilage Repair of the knee a systematic review and meta analysis
American Journal of Sports Medicine, 2013Co-Authors: Tommy S. De Windt, Mats Brittberg, Goetz H Welsch, Stefan Marlovits, Lucienne A Vonk, Daniel B.f. Saris, Siegfried TrattnigAbstract:Background: While MRI can provide a detailed morphological evaluation after articular Cartilage Repair, its additional value in determining clinical outcome has yet to be determined. Purpose: To evaluate the correlation between MRI and clinical outcome after Cartilage Repair and to identify parameters that are most important in determining clinical outcome. Study Design: Systematic review and meta-analysis. Methods: A systematic search was performed in Embase, MEDLINE, and the Cochrane Collaboration. Articles were screened for relevance and appraised for quality. Guidelines in the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) Statement were used. Chi-square tests were performed to find variables that could determine correlation between clinical and radiological parameters. Results: A total of 32 articles (total number of patients, 1019) were included. A majority (81%) were case series or cohort studies that used similar standardized MRI techniques. The mean Coleman score was 63 (range, 42-96). For the majority of MRI parameters, limited or no correlation was found. Nine studies (28%) found a correlation between clinical outcome and the composite magnetic resonance observation of Cartilage Repair tissue (MOCART) or Henderson score and 7 (22%) with defect fill. In 5 studies, a weak to moderate correlation was found between clinical outcome and the T2 index (mean Pearson coefficient r = .53). Conclusion: Strong evidence to determine whether morphological MRI is reliable in predicting clinical outcome after Cartilage Repair is lacking. Future research aiming specifically at clinical sensitivity of advanced morphological and biochemical MRI techniques after articular Cartilage Repair could be of great importance to the field.
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evaluation of Cartilage Repair tissue after matrix associated autologous chondrocyte transplantation using a hyaluronic based or a collagen based scaffold with morphological mocart scoring and biochemical t2 mapping preliminary results
American Journal of Sports Medicine, 2010Co-Authors: Goetz H Welsch, Stefan Marlovits, Tallal C Mamisch, Lukas Zak, M Blanke, Alexander Olk, Siegfried TrattnigAbstract:BackgroundIn Cartilage Repair, bioregenerative approaches using tissue engineering techniques have tried to achieve a close resemblance to hyaline Cartilage, which might be visualized using advanced magnetic resonance imaging.PurposeTo compare Cartilage Repair tissue at the femoral condyle noninvasively after matrix-associated autologous chondrocyte transplantation using Hyalograft C, a hyaluronic-based scaffold, to Cartilage Repair tissue after transplantation using CaReS, a collagen-based scaffold, with magnetic resonance imaging using morphologic scoring and T2 mapping.Study DesignCohort study; Level of evidence, 3.MethodsTwenty patients after matrix-associated autologous chondrocyte transplantation (Hyalograft C, n = 10; CaReS, n = 10) underwent 3-T magnetic resonance imaging 24 months after surgery. Groups were matched by age and defect size/localization. For clinical outcome, the Brittberg score was assessed. Morphologic analysis was applied using the magnetic resonance observation of Cartilage repa...
Daniel B.f. Saris - One of the best experts on this subject based on the ideXlab platform.
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arthroscopic airbrush assisted cell spraying for Cartilage Repair design development and characterization of custom made arthroscopic spray nozzles
Tissue Engineering Part C-methods, 2017Co-Authors: Koen Dijkstra, Lucienne A Vonk, Jan Hendriks, Daniel B.f. Saris, Marcel KarperienAbstract:Introduction: Airbrush-assisted cell spraying would facilitate fully arthroscopic filling of Cartilage defects, thereby providing a minimally invasive procedure for Cartilage Repair. This study pro...
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a vision on the future of articular Cartilage Repair
European Cells & Materials, 2014Co-Authors: Magali Cucchiarini, Koon M Wong, Daniel B.f. Saris, Martin J Stoddart, Peter J. RoughleyAbstract:: An AO Foundation (Davos, Switzerland) sponsored workshop "Cell Therapy in Cartilage Repair" from the Symposium "Where Science meets Clinics" (September 5-7, 2013, Davos) gathered leaders from medicine, science, industry, and regulatory organisations to debate the vision of cell therapy in articular Cartilage Repair and the measures that could be taken to narrow the gap between vision and current practice. Cell-based therapy is already in clinical use to enhance the Repair of Cartilage lesions, with procedures such as microfracture and articular chondrocyte implantation. However, even though long term follow up is good from a clinical perspective and some of the most rigorous randomised controlled trials in the regenerative medicine/orthopaedics field show beneficial effect, none of these options have proved successful in restoring the original articular Cartilage structure and functionality in patients so far. With the remarkable recent advances in experimental research in cell biology (new sources for chondrocytes, stem cells), molecular biology (growth factors, genes), biomaterials, biomechanics, and translational science, a combined effort between scientists and clinicians with broad expertise may allow development of an improved cell therapy for Cartilage Repair. This position paper describes the current state of the art in the field to help define a procedure adapted to the clinical situation for upcoming translation in the patient.
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is magnetic resonance imaging reliable in predicting clinical outcome after articular Cartilage Repair of the knee a systematic review and meta analysis
American Journal of Sports Medicine, 2013Co-Authors: Tommy S. De Windt, Mats Brittberg, Goetz H Welsch, Stefan Marlovits, Lucienne A Vonk, Daniel B.f. Saris, Siegfried TrattnigAbstract:Background: While MRI can provide a detailed morphological evaluation after articular Cartilage Repair, its additional value in determining clinical outcome has yet to be determined. Purpose: To evaluate the correlation between MRI and clinical outcome after Cartilage Repair and to identify parameters that are most important in determining clinical outcome. Study Design: Systematic review and meta-analysis. Methods: A systematic search was performed in Embase, MEDLINE, and the Cochrane Collaboration. Articles were screened for relevance and appraised for quality. Guidelines in the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) Statement were used. Chi-square tests were performed to find variables that could determine correlation between clinical and radiological parameters. Results: A total of 32 articles (total number of patients, 1019) were included. A majority (81%) were case series or cohort studies that used similar standardized MRI techniques. The mean Coleman score was 63 (range, 42-96). For the majority of MRI parameters, limited or no correlation was found. Nine studies (28%) found a correlation between clinical outcome and the composite magnetic resonance observation of Cartilage Repair tissue (MOCART) or Henderson score and 7 (22%) with defect fill. In 5 studies, a weak to moderate correlation was found between clinical outcome and the T2 index (mean Pearson coefficient r = .53). Conclusion: Strong evidence to determine whether morphological MRI is reliable in predicting clinical outcome after Cartilage Repair is lacking. Future research aiming specifically at clinical sensitivity of advanced morphological and biochemical MRI techniques after articular Cartilage Repair could be of great importance to the field.
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international Cartilage Repair society icrs recommended guidelines for histological endpoints for Cartilage Repair studies in animal models and clinical trials
Cartilage, 2011Co-Authors: Caroline D Hoemann, Pierre Mainilvarlet, Daniel B.f. Saris, Rita A Kandel, Sally Roberts, Laura B Creemers, Stephane Methot, Anthony P Hollander, Michael D BuschmannAbstract:Cartilage Repair strategies aim to resurface a lesion with osteochondral tissue resembling native Cartilage, but a variety of Repair tissues are usually observed. Histology is an important structural outcome that could serve as an interim measure of efficacy in randomized controlled clinical studies. The purpose of this article is to propose guidelines for standardized histoprocessing and unbiased evaluation of animal tissues and human biopsies. Methods were compiled from a literature review, and illustrative data were added. In animal models, treatments are usually administered to acute defects created in healthy tissues, and the entire joint can be analyzed at multiple postoperative time points. In human clinical therapy, treatments are applied to developed lesions, and biopsies are obtained, usually from a subset of patients, at a specific time point. In striving to standardize evaluation of structural endpoints in Cartilage Repair studies, 5 variables should be controlled: 1) location of biopsy/sample section, 2) timing of biopsy/sample recovery, 3) histoprocessing, 4) staining, and 5) blinded evaluation with a proper control group. Histological scores, quantitative histomorphometry of Repair tissue thickness, percentage of tissue staining for collagens and glycosaminoglycan, polarized light microscopy for collagen fibril organization, and subchondral bone integration/structure are all relevant outcome measures that can be collected and used to assess the efficacy of novel therapeutics. Standardized histology methods could improve statistical analyses, help interpret and validate noninvasive imaging outcomes, and permit cross-comparison between studies. Currently, there are no suitable substitutes for histology in evaluating Repair tissue quality and cartilaginous character.
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guidelines for the design and conduct of clinical studies in knee articular Cartilage Repair international Cartilage Repair society recommendations based on current scientific evidence and standards of clinical care
Cartilage, 2011Co-Authors: Kai Mithoefer, Matthew Shive, Wilfried Dalemans, David W Levine, Jonas Ranstam, Kenneth Zaslav, Daniel B.f. Saris, Jack Farr, Brian J. Cole, Mats BrittbergAbstract:Objective:To summarize current clinical research practice and develop methodological standards for objective scientific evaluation of knee Cartilage Repair procedures and products.Design:A comprehensive literature review was performed of high-level original studies providing information relevant for the design of clinical studies on articular Cartilage Repair in the knee. Analysis of Cartilage Repair publications and synopses of ongoing trials were used to identify important criteria for the design, reporting, and interpretation of studies in this field.Results:Current literature reflects the methodological limitations of the scientific evidence available for articular Cartilage Repair. However, clinical trial databases of ongoing trials document a trend suggesting improved study designs and clinical evaluation methodology. Based on the current scientific information and standards of clinical care, detailed methodological recommendations were developed for the statistical study design, patient recruitment...
Jun-young Chung - One of the best experts on this subject based on the ideXlab platform.
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single stage cell based Cartilage Repair in a rabbit model cell tracking and in vivo chondrogenesis of human umbilical cord blood derived mesenchymal stem cells and hyaluronic acid hydrogel composite
Osteoarthritis and Cartilage, 2017Co-Authors: Y B Park, J A Kim, W J Han, J Rhim, H J Lee, K J Kim, Y G Park, Jun-young ChungAbstract:Summary Objective Human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) have gained popularity as a promising cell source for regenerative medicine, but limited in vivo studies have reported Cartilage Repair. In addition, the roles of MSCs in Cartilage Repair are not well-understood. The purpose of this study was to investigate the feasibility of transplanting hUCB-MSCs and hyaluronic acid (HA) hydrogel composite to Repair articular Cartilage defects in a rabbit model and determine whether the transplanted cells persisted or disappeared from the defect site. Design Osteochondral defects were created in the trochlear grooves of the knees. The hUCB-MSCs and HA composite was transplanted into the defect of experimental knees. Control knees were transplanted by HA or left untreated. Animals were sacrificed at 8 and 16 weeks post-transplantation and additionally at 2 and 4 weeks to evaluate the fate of transplanted cells. The Repair tissues were evaluated by gross, histological and immunohistochemical analysis. Results Transplanting hUCB-MSCs and HA composite resulted in overall superior Cartilage Repair tissue with better quality than HA alone or no treatment. Cellular architecture and collagen arrangement at 16 weeks were similar to those of surrounding normal articular Cartilage tissue. Histological scores also revealed that Cartilage Repair in experimental knees was better than that in control knees. Immunohistochemical analysis with anti-human nuclear antibody confirmed that the transplanted MSCs disappeared gradually over time. Conclusion Transplanting hUCB-MSCs and HA composite promote Cartilage Repair and interactions between hUCB-MSCs and host cells initiated by paracrine action may play an important role in Cartilage Repair.
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effect of transplanting various concentrations of a composite of human umbilical cord blood derived mesenchymal stem cells and hyaluronic acid hydrogel on articular Cartilage Repair in a rabbit model
PLOS ONE, 2016Co-Authors: Yongbeom Park, Jun-young Chung, J Rhim, Jina Kim, Yonggeun Park, Hanjun LeeAbstract:Background Mesenchymal stem cells (MSCs) are known to have therapeutic potential for Cartilage Repair. However, the optimal concentration of MSCs for Cartilage Repair remains unclear. Therefore, we aimed to explore the feasibility of Cartilage Repair by human umbilical cord blood-derived MSCs (hUCB-MSCs) and to determine the optimal concentrations of the MSCs in a rabbit model. Methods Osteochondral defects were created in the trochlear groove of femur in 55 rabbits. Four experimental groups (11 rabbits/group) were treated by transplanting the composite of hUCB-MSCs and HA with various MSCs concentrations (0.1, 0.5, 1.0, and 1.5 x 107 cells/ml). One control group was left untreated. At 4, 8, and 16 weeks post-transplantation, the degree of Cartilage Repair was evaluated grossly and histologically. Findings Overall, transplanting hUCB-MSCs and HA hydrogel resulted in Cartilage Repair tissue with better quality than the control without transplantation (P = 0.015 in 0.1, P = 0.004 in 0.5, P = 0.004 in 1.0, P = 0.132 in 1.5 x 107 cells/ml). Interestingly, high cell concentration of hUCB-MSCs (1.5×107 cells/ml) was inferior to low cell concentrations (0.1, 0.5, and 1.0 x 107 cells/ml) in Cartilage Repair (P = 0.394,P = 0.041, P = 0.699, respectively). The 0.5 x 107 cells/ml group showed the highest Cartilage Repair score at 4, 8 and 16 weeks post transplantation, and followed by 0.1x107 cells/ml group or 1.0 x 107 cell/ml group. Conclusions The results of this study suggest that transplantation of the composite of hUCB-MSCs and HA is beneficial for Cartilage Repair. In addition, this study shows that optimal MSC concentration needs to be determined for better Cartilage Repair.
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comparison of articular Cartilage Repair with different hydrogel human umbilical cord blood derived mesenchymal stem cell composites in a rat model
Stem Cell Research & Therapy, 2014Co-Authors: Jun-young Chung, Chulwon Ha, Minjung Song, Yongbeom ParkAbstract:Introduction The present work was designed to explore the feasibility and efficacy of articular Cartilage Repair using composites of human umbilical cord blood derived mesenchymal stem cells (hUCB-MSCs) and four different hydrogels in a rat model.
Stefan Marlovits - One of the best experts on this subject based on the ideXlab platform.
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is magnetic resonance imaging reliable in predicting clinical outcome after articular Cartilage Repair of the knee a systematic review and meta analysis
American Journal of Sports Medicine, 2013Co-Authors: Tommy S. De Windt, Mats Brittberg, Goetz H Welsch, Stefan Marlovits, Lucienne A Vonk, Daniel B.f. Saris, Siegfried TrattnigAbstract:Background: While MRI can provide a detailed morphological evaluation after articular Cartilage Repair, its additional value in determining clinical outcome has yet to be determined. Purpose: To evaluate the correlation between MRI and clinical outcome after Cartilage Repair and to identify parameters that are most important in determining clinical outcome. Study Design: Systematic review and meta-analysis. Methods: A systematic search was performed in Embase, MEDLINE, and the Cochrane Collaboration. Articles were screened for relevance and appraised for quality. Guidelines in the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) Statement were used. Chi-square tests were performed to find variables that could determine correlation between clinical and radiological parameters. Results: A total of 32 articles (total number of patients, 1019) were included. A majority (81%) were case series or cohort studies that used similar standardized MRI techniques. The mean Coleman score was 63 (range, 42-96). For the majority of MRI parameters, limited or no correlation was found. Nine studies (28%) found a correlation between clinical outcome and the composite magnetic resonance observation of Cartilage Repair tissue (MOCART) or Henderson score and 7 (22%) with defect fill. In 5 studies, a weak to moderate correlation was found between clinical outcome and the T2 index (mean Pearson coefficient r = .53). Conclusion: Strong evidence to determine whether morphological MRI is reliable in predicting clinical outcome after Cartilage Repair is lacking. Future research aiming specifically at clinical sensitivity of advanced morphological and biochemical MRI techniques after articular Cartilage Repair could be of great importance to the field.
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evaluation of Cartilage Repair tissue after matrix associated autologous chondrocyte transplantation using a hyaluronic based or a collagen based scaffold with morphological mocart scoring and biochemical t2 mapping preliminary results
American Journal of Sports Medicine, 2010Co-Authors: Goetz H Welsch, Stefan Marlovits, Tallal C Mamisch, Lukas Zak, M Blanke, Alexander Olk, Siegfried TrattnigAbstract:BackgroundIn Cartilage Repair, bioregenerative approaches using tissue engineering techniques have tried to achieve a close resemblance to hyaline Cartilage, which might be visualized using advanced magnetic resonance imaging.PurposeTo compare Cartilage Repair tissue at the femoral condyle noninvasively after matrix-associated autologous chondrocyte transplantation using Hyalograft C, a hyaluronic-based scaffold, to Cartilage Repair tissue after transplantation using CaReS, a collagen-based scaffold, with magnetic resonance imaging using morphologic scoring and T2 mapping.Study DesignCohort study; Level of evidence, 3.MethodsTwenty patients after matrix-associated autologous chondrocyte transplantation (Hyalograft C, n = 10; CaReS, n = 10) underwent 3-T magnetic resonance imaging 24 months after surgery. Groups were matched by age and defect size/localization. For clinical outcome, the Brittberg score was assessed. Morphologic analysis was applied using the magnetic resonance observation of Cartilage repa...
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quantitative t2 mapping during follow up after matrix associated autologous chondrocyte transplantation mact full thickness and zonal evaluation to visualize the maturation of Cartilage Repair tissue
Journal of Orthopaedic Research, 2009Co-Authors: Goetz H Welsch, Stefan Marlovits, Tallal C Mamisch, C Glaser, Klaus M Friedrich, Friedrich F Hennig, Erich Salomonowitz, Siegfried TrattnigAbstract:The purpose of this article was to evaluate the potential of in vivo zonal T2-mapping as a noninvasive tool in the longitudinal visualization of Cartilage Repair tissue maturation after matrix-associated autologous chondrocyte transplantation (MACT). Fifteen patients were treated with MACT and evaluated cross-sectionally, with a baseline MRI at a follow-up of 19.7 +/- 12.1 months after Cartilage transplantation surgery of the knee. In the same 15 patients, 12 months later (31.7 +/- 12.0 months after surgery), a longitudinal 1-year follow-up MRI was obtained. MRI was performed on a 3 Tesla MR scanner; morphological evaluation was performed using a double-echo steady-state sequence; T2 maps were calculated from a multiecho, spin-echo sequence. Quantitative mean (full-thickness) and zonal (deep and superficial) T2 values were calculated in the Cartilage Repair area and in control Cartilage sites. A statistical analysis of variance was performed. Full-tickness T2 values showed no significant difference between sites of healthy Cartilage and Cartilage Repair tissue (p 0.05); however, during the 1-year follow-up, a significant zonal stratification could be observed (p < 0.05). Morphological evaluation showed no significant difference between the baseline and the 1-year follow-up MRI. T2 mapping seems to be more sensitive in revealing changes in the Repair tissue compared to morphological MRI. In vivo zonal T2 assessment may be sensitive enough to characterize the maturation of Cartilage Repair tissue.
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magnetization transfer contrast and t2 mapping in the evaluation of Cartilage Repair tissue with 3t mri
Journal of Magnetic Resonance Imaging, 2008Co-Authors: Goetz H Welsch, Stefan Marlovits, Siegfried Trattnig, K Scheffler, Pavol Szomonanyi, S Quirbach, Stephan Domayer, Oliver Bieri, Tallal C MamischAbstract:PURPOSE: To use magnetization transfer (MT) imaging in the visualization of healthy articular Cartilage and Cartilage Repair tissue after different Cartilage Repair procedures, and to assess global as well as zonal values and compare the results to T2-relaxation. MATERIALS AND METHODS: Thirty-four patients (17 after microfracture [MFX] and 17 after matrix-associated autologous Cartilage transplantation [MACT]) were examined with 3T MRI. The MT ratio (MTR) was calculated from measurements with and without MT contrast. T2-values were evaluated using a multiecho, spin-echo approach. Global (full thickness of Cartilage) and zonal (deep and superficial aspect) region-of-interest assessment of Cartilage Repair tissue and normal-appearing Cartilage was performed. RESULTS: In patients after MFX and MACT, the global MTR of Cartilage Repair tissue was significantly lower compared to healthy Cartilage. In contrast, using T2, Cartilage Repair tissue showed significantly lower T2 values only after MFX, whereas after MACT, global T2 values were comparable to healthy Cartilage. For zonal evaluation, MTR and T2 showed a significant stratification within healthy Cartilage, and T2 additionally within Cartilage Repair tissue after MACT. CONCLUSION: MT imaging is capable and sensitive in the detection of differences between healthy Cartilage and areas of Cartilage Repair and might be an additional tool in biochemical Cartilage imaging. For both MTR and T2 mapping, zonal assessment is desirable.
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matrix based autologous chondrocyte implantation for Cartilage Repair noninvasive monitoring by high resolution magnetic resonance imaging
Magnetic Resonance Imaging, 2005Co-Authors: Siegfried Trattnig, Vilmos Vecsei, Ahmed Bassalamah, Katja Pinker, Christina Plank, Stefan MarlovitsAbstract:Abstract Objective Monitoring of articular Cartilage Repair after matrix-associated autologous chondrocyte implantation (MACI) by a new grading and point-scale system based on noninvasive Cartilage-specific magnetic resonance imaging (MRI) protocol. Patients and Methods In 20 patients, postoperative high-resolution MRI follow-up examinations at 4, 12, 24 and 52 weeks after matrix-based ACI for Cartilage Repair were initiated. The Repair tissue was described with separate variables: degree of defect Repair in width and length, surface, structure and signal intensity of the Repair tissue, and status of the subchondral lamina and bone. For these variables, a grading system with point-scale evaluation was applied, and the mean average values were calculated for every follow-up MR exam of each patient. Results In 10 patients, an incomplete filling of the defect improved to complete filling (6 patients) or less incomplete (4 patients) filling of the defect. Three cases of implant hypertrophy returned to normal within 1 year. Complete filling of the defect by Repair tissue was found in 2 patients from the beginning. Integration was complete in 10 cases. Improvement of incomplete to complete integration was found in 3 patients. The signal intensity of the implant developed to native Cartilage signal in 13 patients. The mean average values increased from the 4th to the 52nd week in 17 of 20 patients and decreased in 3 of 20 patients. Conclusion High-resolution MRI provides a noninvasive tool for monitoring the development of Cartilage Repair tissue in MACI over time and helps to differentiate abnormal Repair tissue from a normal maturation process.
Yongbeom Park - One of the best experts on this subject based on the ideXlab platform.
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intra articular mesenchymal stem cells in osteoarthritis of the knee a systematic review of clinical outcomes and evidence of Cartilage Repair
Arthroscopy, 2019Co-Authors: Chulwon Ha, Yongbeom ParkAbstract:Purpose To provide a systematic review of the clinical literature reporting the efficacy of mesenchymal stem cells (MSCs) in terms of clinical outcomes including pain and function and Cartilage Repair in patients with osteoarthritis. Methods We systematically reviewed any studies investigating clinical outcomes and Cartilage Repair after the clinical application of cell populations containing MSCs in human subjects with knee osteoarthritis through MEDLINE, EMBASE, the Cochrane Library, CINAHL, Web of Science, and Scopus. Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. Studies with a level of evidence of IV or V were excluded. Methodological quality was assessed using the Modified Coleman Methodology Score. Clinical outcomes were assessed using clinical scores, and Cartilage Repair was assessed using magnetic resonance imaging and second-look arthroscopy findings. Results A total of 17 studies that met the criteria of 50 full-text studies were included in this review, with 6 randomized controlled trials, 8 prospective observational studies, and 3 retrospective case-control studies. Among 17 studies, 8 studies used bone marrow–derived MSCs, 6 used adipose tissue–derived stromal vascular fraction, 2 used adipose tissue–derived MSCs, and 1 used umbilical cord blood–derived MSCs. All studies except 2 reported significantly better clinical outcomes in the MSC group or improved clinical outcomes at final follow-up. In terms of Cartilage Repair, 9 of 11 studies reported improvement of the Cartilage state on magnetic resonance imaging, and 6 of 7 studies reported Repaired tissue on second-look arthroscopy. The mean Modified Coleman Methodology Score was 55.5 ± 15.5 (range, 28-74). Conclusions Intra-articular MSCs provide improvements in pain and function in knee osteoarthritis at short-term follow-up ( Level of Evidence Level III; systematic review of level I, II, and III studies.
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effect of transplanting various concentrations of a composite of human umbilical cord blood derived mesenchymal stem cells and hyaluronic acid hydrogel on articular Cartilage Repair in a rabbit model
PLOS ONE, 2016Co-Authors: Yongbeom Park, Jun-young Chung, J Rhim, Jina Kim, Yonggeun Park, Hanjun LeeAbstract:Background Mesenchymal stem cells (MSCs) are known to have therapeutic potential for Cartilage Repair. However, the optimal concentration of MSCs for Cartilage Repair remains unclear. Therefore, we aimed to explore the feasibility of Cartilage Repair by human umbilical cord blood-derived MSCs (hUCB-MSCs) and to determine the optimal concentrations of the MSCs in a rabbit model. Methods Osteochondral defects were created in the trochlear groove of femur in 55 rabbits. Four experimental groups (11 rabbits/group) were treated by transplanting the composite of hUCB-MSCs and HA with various MSCs concentrations (0.1, 0.5, 1.0, and 1.5 x 107 cells/ml). One control group was left untreated. At 4, 8, and 16 weeks post-transplantation, the degree of Cartilage Repair was evaluated grossly and histologically. Findings Overall, transplanting hUCB-MSCs and HA hydrogel resulted in Cartilage Repair tissue with better quality than the control without transplantation (P = 0.015 in 0.1, P = 0.004 in 0.5, P = 0.004 in 1.0, P = 0.132 in 1.5 x 107 cells/ml). Interestingly, high cell concentration of hUCB-MSCs (1.5×107 cells/ml) was inferior to low cell concentrations (0.1, 0.5, and 1.0 x 107 cells/ml) in Cartilage Repair (P = 0.394,P = 0.041, P = 0.699, respectively). The 0.5 x 107 cells/ml group showed the highest Cartilage Repair score at 4, 8 and 16 weeks post transplantation, and followed by 0.1x107 cells/ml group or 1.0 x 107 cell/ml group. Conclusions The results of this study suggest that transplantation of the composite of hUCB-MSCs and HA is beneficial for Cartilage Repair. In addition, this study shows that optimal MSC concentration needs to be determined for better Cartilage Repair.
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comparison of articular Cartilage Repair with different hydrogel human umbilical cord blood derived mesenchymal stem cell composites in a rat model
Stem Cell Research & Therapy, 2014Co-Authors: Jun-young Chung, Chulwon Ha, Minjung Song, Yongbeom ParkAbstract:Introduction The present work was designed to explore the feasibility and efficacy of articular Cartilage Repair using composites of human umbilical cord blood derived mesenchymal stem cells (hUCB-MSCs) and four different hydrogels in a rat model.