The Experts below are selected from a list of 6330 Experts worldwide ranked by ideXlab platform
J Chattopadhyaya - One of the best experts on this subject based on the ideXlab platform.
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carbocyclic c c bond formation intramolecular radical ring closure to yield diastereomerically pure 7 s me or 7 r me carba lna nucleotide analogs
Current protocols in human genetics, 2017Co-Authors: Oleksandr Plashkevych, Ram Shankar Upadhayaya, J ChattopadhyayaAbstract:: In light of the impressive gene-silencing properties of carba-LNA modified oligo DNA and RNA, both in antisense RNA and siRNA approaches, which have been confirmed as proof-of-concept for biochemical applications in post-transcriptional gene silencing, we envision the true potential of carba-LNA modifications to be revealed soon. Herein we provide detailed protocols for synthesis of carba-LNA-A, -G, -5-Me C, and -T nucleosides on a medium/large scale (gram scale), as well as important guidelines for incorporation of these modified carba-LNAs into DNA or RNA oligonucleotides. Creation of a stereoselective C-C bond during the 5-exo radical intramolecular cyclization involves trapping of a C2' radical intermediate intramolecularly by the vicinal double bond of a C4'-tethered ─CH2 -CH═CH2 group. All diastereomers of substituted carba-LNAs are now available in pure form. The present procedure allows carba-LNA to be commercialized for medicinal or biotechnological purposes. © 2017 by John Wiley & Sons, Inc.
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intramolecular free radical cyclization reactions on pentose sugars for the synthesis of carba lna and carba ena and the application of their modified oligonucleotides as potential rna targeted therapeutics
Chemical Reviews, 2012Co-Authors: Chuanzheng Zhou, J ChattopadhyayaAbstract:Intramolecular Free-Radical Cyclization Reactions on Pentose Sugars for the Synthesis of Carba-LNA and Carba-ENA and the Application of Their Modified Oligonucleotides as Potential RNA Targeted Therapeutics
Yuqing Zhao - One of the best experts on this subject based on the ideXlab platform.
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new antitumor compounds from Carya cathayensis
ChemInform, 2012Co-Authors: Wei Wu, Xiuli Bi, Kaiqing Zhang, Yuqing ZhaoAbstract:The new lignan (I), and three new phenolics, carayensin-A (II), carayensin-B (III), and carayensin-C (IV) are isolated from the shells along with 13 known constituents.
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new antitumor compounds from Carya cathayensis
Bioorganic & Medicinal Chemistry Letters, 2012Co-Authors: Wei Wu, Xiuli Bi, Kaiqing Zhang, Yuqing ZhaoAbstract:Abstract A new lignan (7R,8S,8′R)-4,4′,9-trihydroxy-7,9′-epoxy-8,8′-lignan, and three new phenolics, carayensin-A, carayensin-B, and carayensin-C, together with 13 known compounds were isolated from the shells of Carya cathayensis. Their chemical structures were established mainly by 1D and 2D NMR techniques and mass spectrometry. All the compounds were evaluated for cytotoxicity against several human tumor types including human colorectal cancer cell lines (HCT-116, HT-29), human lung cancer cell line (A549), and human breast cancer cell line (MCF-7). The compounds 1, 5, 6, and 16 are considered to be potential as antitumor agents, which could significantly inhibit the cancer cell growth in a dose-dependent manner.
Hugh D. Wilson - One of the best experts on this subject based on the ideXlab platform.
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Carya aquatica (Native) 2
2011Co-Authors: Hugh D. WilsonAbstract:Carya aquatica, Winter condition. Family Juglandaceae, Subclass Hamamelidae. Origin: Native.
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Carya ovata (Cultivated) 2
2011Co-Authors: Hugh D. WilsonAbstract:Carya ovata, Fruit with husk. Family Juglandaceae, Subclass Hamamelidae. Origin: Cultivated.
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Carya sp. (Native) 2
2011Co-Authors: Hugh D. WilsonAbstract:Carya sp. , Pistillate flower, past anthesis. Family Juglandaceae, Subclass Hamamelidae. Origin: Native.
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Carya texana (Native) 3
2011Co-Authors: Hugh D. WilsonAbstract:Carya texana , Nut surface with husk from side. Family Juglandaceae, Subclass Hamamelidae. Origin: Native.
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Carya cordiformis (Native) 2
2011Co-Authors: Hugh D. WilsonAbstract:Carya cordiformis, Growing shoot with terminal bud; collected by Amanda Neill. Family Juglandaceae, Subclass Hamamelidae. Origin: Native.
Wei Wu - One of the best experts on this subject based on the ideXlab platform.
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new antitumor compounds from Carya cathayensis
ChemInform, 2012Co-Authors: Wei Wu, Xiuli Bi, Kaiqing Zhang, Yuqing ZhaoAbstract:The new lignan (I), and three new phenolics, carayensin-A (II), carayensin-B (III), and carayensin-C (IV) are isolated from the shells along with 13 known constituents.
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new antitumor compounds from Carya cathayensis
Bioorganic & Medicinal Chemistry Letters, 2012Co-Authors: Wei Wu, Xiuli Bi, Kaiqing Zhang, Yuqing ZhaoAbstract:Abstract A new lignan (7R,8S,8′R)-4,4′,9-trihydroxy-7,9′-epoxy-8,8′-lignan, and three new phenolics, carayensin-A, carayensin-B, and carayensin-C, together with 13 known compounds were isolated from the shells of Carya cathayensis. Their chemical structures were established mainly by 1D and 2D NMR techniques and mass spectrometry. All the compounds were evaluated for cytotoxicity against several human tumor types including human colorectal cancer cell lines (HCT-116, HT-29), human lung cancer cell line (A549), and human breast cancer cell line (MCF-7). The compounds 1, 5, 6, and 16 are considered to be potential as antitumor agents, which could significantly inhibit the cancer cell growth in a dose-dependent manner.
Chen Shen - One of the best experts on this subject based on the ideXlab platform.
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the genomes of pecan and chinese hickory provide insights into Carya evolution and nut nutrition
GigaScience, 2019Co-Authors: Youjun Huang, Lihong Xiao, Zhongren Zhang, Rui Zhang, Zhengjia Wang, Chunying Huang, Ren Huang, Yumeng Luan, Jianhua Wang, Chen ShenAbstract:BACKGROUND: Pecan (Carya illinoinensis) and Chinese hickory (C. cathayensis) are important commercially cultivated nut trees in the genus Carya (Juglandaceae), with high nutritional value and substantial health benefits. RESULTS: We obtained >187.22 and 178.87 gigabases of sequence, and ∼288× and 248× genome coverage, to a pecan cultivar ("Pawnee") and a domesticated Chinese hickory landrace (ZAFU-1), respectively. The total assembly size is 651.31 megabases (Mb) for pecan and 706.43 Mb for Chinese hickory. Two genome duplication events before the divergence from walnut were found in these species. Gene family analysis highlighted key genes in biotic and abiotic tolerance, oil, polyphenols, essential amino acids, and B vitamins. Further analyses of reduced-coverage genome sequences of 16 Carya and 2 Juglans species provide additional phylogenetic perspective on crop wild relatives. CONCLUSIONS: Cooperative characterization of these valuable resources provides a window to their evolutionary development and a valuable foundation for future crop improvement.