The Experts below are selected from a list of 317781 Experts worldwide ranked by ideXlab platform
Chang You Gao - One of the best experts on this subject based on the ideXlab platform.
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Gradient biomaterials and their influences on Cell Migration
Interface Focus, 2012Co-Authors: Jindan Wu, Tanchen Ren, Huaping Tan, Lulu Han, Zhengwei Mao, Chang You GaoAbstract:Cell Migration participates in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. The Cells specifically migrate to destiny sites induced by the gradually varying concentration (gradient) of soluble signal factors and the ligands bound with the extraCellular matrix in the body during a wound healing process. Therefore, regulation of the Cell Migration behaviours is of paramount importance in regenerative medicine. One important way is to create a microenvironment that mimics the in vivo Cellular and tissue complexity by incorporating physical, chemical and biological signal gradients into engineered biomaterials. In this review, the gradients existing in vivo and their influences on Cell Migration are briefly described. Recent developments in the fabrication of gradient biomaterials for controlling Cellular behaviours, especially the Cell Migration, are summarized, highlighting the importance of the intrinsic driving mechanism for tissue regeneration and the design principle of complicated and advanced tissue regenerative materials. The potential uses of the gradient biomaterials in regenerative medicine are introduced. The current and future trends in gradient biomaterials and programmed Cell Migration in terms of the long-term goals of tissue regeneration are prospected.
Sylvia E. Le Dévédec - One of the best experts on this subject based on the ideXlab platform.
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Community standards for open Cell Migration data
GigaScience, 2020Co-Authors: Alejandra Gonzalez-beltran, Paola Masuzzo, Peter Friedl, Christophe Ampe, Gert Jan Bakker, Sébastien Besson, Robert H. Eibl, Matthias Gunzer, Mark Kittisopikul, Sylvia E. Le DévédecAbstract:Cell Migration research has become a high-content field. However, the quantitative information encapsulated in these complex and high-dimensional datasets is not fully exploited owing to the diversity of experimental protocols and non-standardized output formats. In addition, typically the datasets are not open for reuse. Making the data open and Findable, Accessible, Interoperable, and Reusable (FAIR) will enable meta-analysis, data integration, and data mining. Standardized data formats and controlled vocabularies are essential for building a suitable infrastructure for that purpose but are not available in the Cell Migration domain. We here present standardization efforts by the Cell Migration Standardisation Organisation (CMSO), an open community-driven organization to facilitate the development of standards for Cell Migration data. This work will foster the development of improved algorithms and tools and enable secondary analysis of public datasets, ultimately unlocking new knowledge of the complex biological process of Cell Migration.
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Community Standards for Open Cell Migration Data
2019Co-Authors: Alejandra Gonzalez-beltran, Paola Masuzzo, Peter Friedl, Christophe Ampe, Gert Jan Bakker, Sébastien Besson, Robert H. Eibl, Matthias Gunzer, Mark Kittisopikul, Sylvia E. Le DévédecAbstract:Cell Migration research has become a high-content field. However, the quantitative information encapsulated in these complex and high-dimensional datasets is not fully exploited due to the diversity of experimental protocols and non-standardised output formats. In addition, typically the datasets are not open for reuse. Making the data open and Findable, Accessible, Interoperable, and Reusable (FAIR) will enable meta-analysis, data integration, and data mining. Standardised data formats and controlled vocabularies are essential for building a suitable infrastructure for that purpose but are not available in the Cell Migration domain. We here present standardisation efforts by the Cell Migration Standardisation Organization, CMSO, an open community-driven organisation to facilitate the development of standards for Cell Migration data. This work will foster the development of improved algorithms and tools, and enable secondary analysis of public datasets, ultimately unlocking new knowledge of the complex biological process of Cell Migration.
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Systems microscopy approaches to understand cancer Cell Migration and metastasis
Cellular and Molecular Life Sciences, 2010Co-Authors: Sylvia E. Le Dévédec, Hans Bont, Veerander Ghotra, Hoa Truong, Erik H. Danen, Fons Verbeek, Bob WaterAbstract:Cell Migration is essential in a number of processes, including wound healing, angiogenesis and cancer metastasis. Especially, invasion of cancer Cells in the surrounding tissue is a crucial step that requires increased Cell motility. Cell Migration is a well-orchestrated process that involves the continuous formation and disassembly of matrix adhesions. Those structural anchor points interact with the extra-Cellular matrix and also participate in adhesion-dependent signalling. Although these processes are essential for cancer metastasis, little is known about the molecular mechanisms that regulate adhesion dynamics during tumour Cell Migration. In this review, we provide an overview of recent advanced imaging strategies together with quantitative image analysis that can be implemented to understand the dynamics of matrix adhesions and its molecular components in relation to tumour Cell Migration. This dynamic Cell imaging together with multiparametric image analysis will help in understanding the molecular mechanisms that define cancer Cell Migration.
Paola Masuzzo - One of the best experts on this subject based on the ideXlab platform.
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Community standards for open Cell Migration data
GigaScience, 2020Co-Authors: Alejandra Gonzalez-beltran, Paola Masuzzo, Peter Friedl, Christophe Ampe, Gert Jan Bakker, Sébastien Besson, Robert H. Eibl, Matthias Gunzer, Mark Kittisopikul, Sylvia E. Le DévédecAbstract:Cell Migration research has become a high-content field. However, the quantitative information encapsulated in these complex and high-dimensional datasets is not fully exploited owing to the diversity of experimental protocols and non-standardized output formats. In addition, typically the datasets are not open for reuse. Making the data open and Findable, Accessible, Interoperable, and Reusable (FAIR) will enable meta-analysis, data integration, and data mining. Standardized data formats and controlled vocabularies are essential for building a suitable infrastructure for that purpose but are not available in the Cell Migration domain. We here present standardization efforts by the Cell Migration Standardisation Organisation (CMSO), an open community-driven organization to facilitate the development of standards for Cell Migration data. This work will foster the development of improved algorithms and tools and enable secondary analysis of public datasets, ultimately unlocking new knowledge of the complex biological process of Cell Migration.
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Community Standards for Open Cell Migration Data
2019Co-Authors: Alejandra Gonzalez-beltran, Paola Masuzzo, Peter Friedl, Christophe Ampe, Gert Jan Bakker, Sébastien Besson, Robert H. Eibl, Matthias Gunzer, Mark Kittisopikul, Sylvia E. Le DévédecAbstract:Cell Migration research has become a high-content field. However, the quantitative information encapsulated in these complex and high-dimensional datasets is not fully exploited due to the diversity of experimental protocols and non-standardised output formats. In addition, typically the datasets are not open for reuse. Making the data open and Findable, Accessible, Interoperable, and Reusable (FAIR) will enable meta-analysis, data integration, and data mining. Standardised data formats and controlled vocabularies are essential for building a suitable infrastructure for that purpose but are not available in the Cell Migration domain. We here present standardisation efforts by the Cell Migration Standardisation Organization, CMSO, an open community-driven organisation to facilitate the development of standards for Cell Migration data. This work will foster the development of improved algorithms and tools, and enable secondary analysis of public datasets, ultimately unlocking new knowledge of the complex biological process of Cell Migration.
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Taking Aim at Moving Targets in Computational Cell Migration
Trends in cell biology, 2015Co-Authors: Paola Masuzzo, Christophe Ampe, Marleen Van Troys, Lennart MartensAbstract:Cell Migration is central to the development and maintenance of multiCellular organisms. Fundamental understanding of Cell Migration can, for example, direct novel therapeutic strategies to control invasive tumor Cells. However, the study of Cell Migration yields an overabundance of experimental data that require demanding processing and analysis for results extraction. Computational methods and tools have therefore become essential in the quantification and modeling of Cell Migration data. We review computational approaches for the key tasks in the quantification of in vitro Cell Migration: image pre-processing, motion estimation and feature extraction. Moreover, we summarize the current state-of-the-art for in silico modeling of Cell Migration. Finally, we provide a list of available software tools for Cell Migration to assist researchers in choosing the most appropriate solution for their needs.
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an open data ecosystem for Cell Migration research
Trends in Cell Biology, 2015Co-Authors: Paola Masuzzo, Lennart MartensAbstract:Cell Migration research has recently become both a high content and a high throughput field thanks to technological, computational, and methodological advances. Simultaneously, however, urgent bioinformatics needs regarding data management, standardization, and dissemination have emerged. To address these concerns, we propose to establish an open data ecosystem for Cell Migration research.
Peter Friedl - One of the best experts on this subject based on the ideXlab platform.
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Community standards for open Cell Migration data
GigaScience, 2020Co-Authors: Alejandra Gonzalez-beltran, Paola Masuzzo, Peter Friedl, Christophe Ampe, Gert Jan Bakker, Sébastien Besson, Robert H. Eibl, Matthias Gunzer, Mark Kittisopikul, Sylvia E. Le DévédecAbstract:Cell Migration research has become a high-content field. However, the quantitative information encapsulated in these complex and high-dimensional datasets is not fully exploited owing to the diversity of experimental protocols and non-standardized output formats. In addition, typically the datasets are not open for reuse. Making the data open and Findable, Accessible, Interoperable, and Reusable (FAIR) will enable meta-analysis, data integration, and data mining. Standardized data formats and controlled vocabularies are essential for building a suitable infrastructure for that purpose but are not available in the Cell Migration domain. We here present standardization efforts by the Cell Migration Standardisation Organisation (CMSO), an open community-driven organization to facilitate the development of standards for Cell Migration data. This work will foster the development of improved algorithms and tools and enable secondary analysis of public datasets, ultimately unlocking new knowledge of the complex biological process of Cell Migration.
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Community Standards for Open Cell Migration Data
2019Co-Authors: Alejandra Gonzalez-beltran, Paola Masuzzo, Peter Friedl, Christophe Ampe, Gert Jan Bakker, Sébastien Besson, Robert H. Eibl, Matthias Gunzer, Mark Kittisopikul, Sylvia E. Le DévédecAbstract:Cell Migration research has become a high-content field. However, the quantitative information encapsulated in these complex and high-dimensional datasets is not fully exploited due to the diversity of experimental protocols and non-standardised output formats. In addition, typically the datasets are not open for reuse. Making the data open and Findable, Accessible, Interoperable, and Reusable (FAIR) will enable meta-analysis, data integration, and data mining. Standardised data formats and controlled vocabularies are essential for building a suitable infrastructure for that purpose but are not available in the Cell Migration domain. We here present standardisation efforts by the Cell Migration Standardisation Organization, CMSO, an open community-driven organisation to facilitate the development of standards for Cell Migration data. This work will foster the development of improved algorithms and tools, and enable secondary analysis of public datasets, ultimately unlocking new knowledge of the complex biological process of Cell Migration.
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New dimensions in Cell Migration.
Nature reviews. Molecular cell biology, 2012Co-Authors: Peter Friedl, Erik Sahai, Stephen J. Weiss, Kenneth M. YamadaAbstract:Studies of Cell Migration in three-dimensional (3D) Cell culture systems and in vivo have revealed several differences when compared with Cell Migration in two dimensions, including their morphology and mechanical and signalling control. Here, researchers assess the contribution of 3D models to our understanding of Cell Migration, both in terms of the mechanisms used to drive single Cell and collective Cell Migration and how migrating Cells respond to a changing environment in vivo.
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nuclear mechanics during Cell Migration
Current Opinion in Cell Biology, 2011Co-Authors: Peter Friedl, Katarina Wolf, Jan LammerdingAbstract:During Cell Migration, the movement of the nucleus must be coordinated with the cytoskeletal dynamics at the leading edge and trailing end, and, as a result, undergoes complex changes in position and shape, which in turn affects Cell polarity, shape, and Migration efficiency. We here describe the steps of nuclear positioning and deformation during Cell polarization and Migration, focusing on Migration through three-dimensional matrices. We discuss molecular components that govern nuclear shape and stiffness, and review how nuclear dynamics are connected to and controlled by the actin, tubulin and intermediate cytoskeleton-based Migration machinery and how this regulation is altered in pathological conditions. Understanding the regulation of nuclear biomechanics has important implications for Cell Migration during tissue regeneration, immune defence and cancer.
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Mechanisms of collective Cell Migration at a glance.
Journal of Cell Science, 2009Co-Authors: Olga Ilina, Peter FriedlAbstract:This article is part of a Minifocus on collective Cell Migration. For further reading, please see related articles: `Wound repair at a glance' by Tanya Shaw and Paul Martin ( J. Cell Sci. 122 , [3209-3213][1]) and `Collective Cell Migration in development' by Cornelis Weijer ( J. Cell Sci. 122 , [
Jindan Wu - One of the best experts on this subject based on the ideXlab platform.
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Gradient biomaterials and their influences on Cell Migration
Interface Focus, 2012Co-Authors: Jindan Wu, Tanchen Ren, Huaping Tan, Lulu Han, Zhengwei Mao, Chang You GaoAbstract:Cell Migration participates in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. The Cells specifically migrate to destiny sites induced by the gradually varying concentration (gradient) of soluble signal factors and the ligands bound with the extraCellular matrix in the body during a wound healing process. Therefore, regulation of the Cell Migration behaviours is of paramount importance in regenerative medicine. One important way is to create a microenvironment that mimics the in vivo Cellular and tissue complexity by incorporating physical, chemical and biological signal gradients into engineered biomaterials. In this review, the gradients existing in vivo and their influences on Cell Migration are briefly described. Recent developments in the fabrication of gradient biomaterials for controlling Cellular behaviours, especially the Cell Migration, are summarized, highlighting the importance of the intrinsic driving mechanism for tissue regeneration and the design principle of complicated and advanced tissue regenerative materials. The potential uses of the gradient biomaterials in regenerative medicine are introduced. The current and future trends in gradient biomaterials and programmed Cell Migration in terms of the long-term goals of tissue regeneration are prospected.