The Experts below are selected from a list of 235731 Experts worldwide ranked by ideXlab platform
Richard D Boyce - One of the best experts on this subject based on the ideXlab platform.
-
a new data repository for pharmacokinetic natural product drug interactions from Chemical Characterization to clinical studies
Drug Metabolism and Disposition, 2020Co-Authors: Caroline M C Birerwilliams, Brandon T Gufford, Eric Chou, Marijanel Alilio, Sidney Vanalstine, Rachael E Morley, Jeannine S Mccune, Mary F Paine, Richard D BoyceAbstract:There are many gaps in scientific knowledge about the clinical significance of pharmacokinetic natural product-drug interactions (NPDIs) in which the NP is the precipitant and a conventional drug is the object. The National Center for Complimentary and Integrative Health created the Center of Excellence for NPDI Research (NaPDI Center) (www.napdi.org) to provide leadership and guidance on the study of pharmacokinetic NPDIs. A key contribution of the Center is the first user-friendly online repository that stores and links pharmacokinetic NPDI data across Chemical Characterization, metabolomics analyses, and pharmacokinetic in vitro and clinical experiments (repo.napdi.org). The design is expected to help researchers more easily arrive at a complete understanding of pharmacokinetic NPDI research on a particular NP. The repository will also facilitate multidisciplinary collaborations, as the repository links all of the experimental data for a given NP across the study types. The current work describes the design of the repository, standard operating procedures (SOPs) used to enter data, and pharmacokinetic NPDI data that have been entered to date. To illustrate the usefulness of the NaPDI Center repository, more details on two high-priority NPs, cannabis and kratom, are provided as case studies.
-
a new data repository for pharmacokinetic natural product drug interactions from Chemical Characterization to clinical studies
Drug Metabolism and Disposition, 2020Co-Authors: Caroline M C Birerwilliams, Brandon T Gufford, Eric Chou, Marijanel Alilio, Sidney Vanalstine, Rachael E Morley, Jeannine S Mccune, Mary F Paine, Richard D BoyceAbstract:There are many gaps in scientific knowledge about the clinical significance of pharmacokinetic natural product-drug interactions (NPDIs) in which the natural product (NP) is the precipitant and a conventional drug is the object. The National Center for Complimentary and Integrative Health created the Center of Excellence for NPDI Research (NaPDI Center) (www.napdi.org) to provide leadership and guidance on the study of pharmacokinetic NPDIs. A key contribution of the Center is the first user-friendly online repository that stores and links pharmacokinetic NPDI data across Chemical Characterization, metabolomics analyses, and pharmacokinetic in vitro and clinical experiments (repo.napdi.org). The design is expected to help researchers more easily arrive at a complete understanding of pharmacokinetic NPDI research on a particular NP. The repository will also facilitate multidisciplinary collaborations, as the repository links all of the experimental data for a given NP across the study types. The current work describes the design of the repository, standard operating procedures used to enter data, and pharmacokinetic NPDI data that have been entered to date. To illustrate the usefulness of the NaPDI Center repository, more details on two high-priority NPs, cannabis and kratom, are provided as case studies. SIGNIFICANCE STATEMENT: The data and knowledge resulting from natural product-drug interaction (NPDI) studies is distributed across a variety of information sources, rendering difficulties to find, access, and reuse. The Center of Excellence for NPDI Research addressed these difficulties by developing the first user-friendly online repository that stores data from in vitro and clinical pharmacokinetic NPDI experiments and links them with study data from Chemical Characterization and metabolomics analyses of natural products that are also stored in the repository.
Isabel C.f.r. Ferreira - One of the best experts on this subject based on the ideXlab platform.
-
melissa officinalis l decoctions as functional beverages a bioactive approach and Chemical Characterization
Food & Function, 2015Co-Authors: Marcio Carocho, Ricardo C. Calhelha, Celestino Santosbuelga, Lillian Barros, Marina Sokovic, Ana Ciric, Patricia Morales, Isabel C.f.r. FerreiraAbstract:Lemon balm (Melissa officinalis L.) is a member of the Lamiaceae family with a long story of human consumption. It has been consumed for decades, directly in food and as a decoction or an infusion for its medicinal purposes. In this manuscript, a detailed Chemical Characterization of the decoction of this plant is described, encompassing antimicrobial, antioxidant and antitumor activities. Rosmarinic acid and lithospermic acid A were the most abundant phenolic compounds. Quinic acid, fructose, glucose and γ-tocopherol were the most abundant within their groups of molecules. M. officinalis decoctions were active against a wide range of microorganisms, Pseudomonas aeruginosa and Salmonella typhimurium, and Penicillium funiculosum being the most sensitive bacteria and fungi, respectively. The growth inhibition of different human tumor cell lines (mainly MCF-7 and HepG2) was also observed, as also high free radical scavenging activity and reducing power. This manuscript highlights some beneficial effects of these functional beverages.
-
exploring the antioxidant potential of helichrysum stoechas l moench phenolic compounds for cosmetic applications Chemical Characterization microencapsulation and incorporation into a moisturizer
Industrial Crops and Products, 2014Co-Authors: Marisa Barroso, Ana Maria Carvalho, Celestino Santosbuelga, Montserrat Dueñas, Lillian Barros, Isabel Fernandes, Maria Filomena Barreiro, Isabel C.f.r. FerreiraAbstract:The present work explores the antioxidant potential of Helichrysum stoechas (L.) Moench phenolic compounds for cosmetic applications involving the following steps: Chemical Characterization, microencapsulation and incorporation into a moisturizer. Eighteen different phenolic compounds were identified in flowering aerial parts (decoction and hydroalcoholic extract), being 3,5-O-dicaffeoylquinic acid and myricetin O-acetylhexoside the most abundant phenolic acid and flavonoid, respectively. Comparatively to the decoction form, the hydroalcoholic extract presented both higher antioxidant activity and higher phenolic content, being its lyophilized form chosen to proceed with microencapsulation studies. Double emulsion/evaporation microencapsulation technique was applied to produce polycaprolactone based microspheres containing H. stoechas hydroalcoholic extract, which were then successfully incorporated into a moisturizer. The results obtained demonstrated the antioxidant potential of H. stoechas hydroalcoholic extract and the viability of its microencapsulation, thus opening new perspectives for the exploitation of these natural phenolic extracts in applications such as the cosmetic industry.
-
bioactivity and Chemical Characterization in hydrophilic and lipophilic compounds of chenopodium ambrosioides l
Journal of Functional Foods, 2013Co-Authors: Lillian Barros, Ana Maria Carvalho, Eliana Pereira, Ricardo C. Calhelha, Celestino Santosbuelga, Montserrat Dueñas, Isabel C.f.r. FerreiraAbstract:The bioactive properties (antioxidant and antitumour activities, and hepatotoxicity) of the infusion and methanolic extracts of Chenopodium ambrosioides L., a plant commonly used in Portuguese folk medicine, were compared. The Chemical composition in hydrophilic (sugars, organic acids and phenolic compounds) and lipophilic (fatty acids and tocopherols) fractions were determined. In general, the infusion revealed higher antioxidant activity, while the methanolic extract was the only one showing antitumour effects against colon, cervical and hepatocellular carcinoma cell lines. No toxicity in non-tumour cells was observed either for the infusion or the extract. The studied plant proved to be a good source of natural antioxidants and other bioactive compounds, which may have industrial use. As far as we know, this is the first detailed Chemical Characterization and bioactivity evaluation of C. ambrosioides methanolic extract and infusion.
Caroline M C Birerwilliams - One of the best experts on this subject based on the ideXlab platform.
-
a new data repository for pharmacokinetic natural product drug interactions from Chemical Characterization to clinical studies
Drug Metabolism and Disposition, 2020Co-Authors: Caroline M C Birerwilliams, Brandon T Gufford, Eric Chou, Marijanel Alilio, Sidney Vanalstine, Rachael E Morley, Jeannine S Mccune, Mary F Paine, Richard D BoyceAbstract:There are many gaps in scientific knowledge about the clinical significance of pharmacokinetic natural product-drug interactions (NPDIs) in which the NP is the precipitant and a conventional drug is the object. The National Center for Complimentary and Integrative Health created the Center of Excellence for NPDI Research (NaPDI Center) (www.napdi.org) to provide leadership and guidance on the study of pharmacokinetic NPDIs. A key contribution of the Center is the first user-friendly online repository that stores and links pharmacokinetic NPDI data across Chemical Characterization, metabolomics analyses, and pharmacokinetic in vitro and clinical experiments (repo.napdi.org). The design is expected to help researchers more easily arrive at a complete understanding of pharmacokinetic NPDI research on a particular NP. The repository will also facilitate multidisciplinary collaborations, as the repository links all of the experimental data for a given NP across the study types. The current work describes the design of the repository, standard operating procedures (SOPs) used to enter data, and pharmacokinetic NPDI data that have been entered to date. To illustrate the usefulness of the NaPDI Center repository, more details on two high-priority NPs, cannabis and kratom, are provided as case studies.
-
a new data repository for pharmacokinetic natural product drug interactions from Chemical Characterization to clinical studies
Drug Metabolism and Disposition, 2020Co-Authors: Caroline M C Birerwilliams, Brandon T Gufford, Eric Chou, Marijanel Alilio, Sidney Vanalstine, Rachael E Morley, Jeannine S Mccune, Mary F Paine, Richard D BoyceAbstract:There are many gaps in scientific knowledge about the clinical significance of pharmacokinetic natural product-drug interactions (NPDIs) in which the natural product (NP) is the precipitant and a conventional drug is the object. The National Center for Complimentary and Integrative Health created the Center of Excellence for NPDI Research (NaPDI Center) (www.napdi.org) to provide leadership and guidance on the study of pharmacokinetic NPDIs. A key contribution of the Center is the first user-friendly online repository that stores and links pharmacokinetic NPDI data across Chemical Characterization, metabolomics analyses, and pharmacokinetic in vitro and clinical experiments (repo.napdi.org). The design is expected to help researchers more easily arrive at a complete understanding of pharmacokinetic NPDI research on a particular NP. The repository will also facilitate multidisciplinary collaborations, as the repository links all of the experimental data for a given NP across the study types. The current work describes the design of the repository, standard operating procedures used to enter data, and pharmacokinetic NPDI data that have been entered to date. To illustrate the usefulness of the NaPDI Center repository, more details on two high-priority NPs, cannabis and kratom, are provided as case studies. SIGNIFICANCE STATEMENT: The data and knowledge resulting from natural product-drug interaction (NPDI) studies is distributed across a variety of information sources, rendering difficulties to find, access, and reuse. The Center of Excellence for NPDI Research addressed these difficulties by developing the first user-friendly online repository that stores data from in vitro and clinical pharmacokinetic NPDI experiments and links them with study data from Chemical Characterization and metabolomics analyses of natural products that are also stored in the repository.
Ulf Karsten - One of the best experts on this subject based on the ideXlab platform.
-
Chemical Characterization and quantification of the brown algal storage compound laminarin a new methodological approach
Journal of Applied Phycology, 2016Co-Authors: Angelika Graiff, Wolfgang Ruth, Udo Kragl, Ulf KarstenAbstract:The polysaccharide laminarin (β-1,3-glucan) is used as a long-term carbon storage compound in brown algae. This Chemical storage form of carbon enables perennial brown algae in seasonally fluctuating ecosystems to uncouple growth from photosynthesis, i.e., most of these plants grow as seasonal anticipators in winter based on remobilization of laminarin, while in summer, growth typically ceased to fill up the storage pool. Because of this high ecological relevance, a reliable and precise method for determination and quantification of laminarin is needed. Therefore, a simple, efficient, cold water extraction method coupled to a new quantitative liquid chromatography-mass spectrometrical method (LC-MS) was developed. Laminarin was determined in 9 out of 12 brown algal species, and its expected typical molar mass distribution of 2000–7000 Da was confirmed. Furthermore, laminarin consisted of a complex mixture of different Chemical forms, since 15 Chemical laminarin species with distinct molecular weights were measured in 9 species of brown algae. Differences in chain length and number of laminarin species seem to be species specific and hence may indicate some chemotaxonomic value. Laminarin concentrations in the algal tissues ranged from 0.03 to 0.86 % dry weight (DW). The direct Chemical Characterization and quantification of laminarin by LC-MS represents a powerful method to verify the bioChemical and ecological importance of laminarin for brown algae.
I Mondragon - One of the best experts on this subject based on the ideXlab platform.
-
physico Chemical Characterization of lignins from different sources for use in phenol formaldehyde resin synthesis
Bioresource Technology, 2007Co-Authors: Alvaro Tejado, J M Echeverria, C Pena, Jalel Labidi, I MondragonAbstract:During the last decades lignin has been investigated as a promising natural alternative to petroChemicals in phenol–formaldehyde (PF) resin production, due to their structural similarity. Physico-Chemical Characterization of three types of lignin, namely kraft pine lignin (L1), soda–anthraquinone flax lignin (L2), and ethanol–water wild tamarind lignin (L3) has been evaluated to determine which one is the most suitable Chemical structure for above purpose. Characterization has been performed using Fourier transform infrared spectroscopy (FT-IR) and proton nuclear magnetic resonance spectrometry ( 1 H NMR) to analyse the Chemical structure, gel permeation chromatography (GPC) for determining molecular weight (MW) and molecular weight distribution (MWD), differential scanning calorimetry (DSC) to measure the glass transition temperature and thermogravimetric analysis (TGA) to follow the thermal degradation. Both structural and thermal characteristics suggest that kraft pine lignin (L1) would be a better phenol (P) substitute in the synthesis of lignin–phenol–formaldehyde (LPF) resins, as it presents higher amounts of activated free ring positions, higher MW and higher thermal decomposition temperature. � 2006 Elsevier Ltd. All rights reserved.
-
physico Chemical Characterization of lignins from different sources for use in phenol formaldehyde resin synthesis
Bioresource Technology, 2007Co-Authors: Alvaro Tejado, J M Echeverria, C Pena, Jalel Labidi, I MondragonAbstract:During the last decades lignin has been investigated as a promising natural alternative to petroChemicals in phenol-formaldehyde (PF) resin production, due to their structural similarity. Physico-Chemical Characterization of three types of lignin, namely kraft pine lignin (L1), soda-anthraquinone flax lignin (L2), and ethanol-water wild tamarind lignin (L3) has been evaluated to determine which one is the most suitable Chemical structure for above purpose. Characterization has been performed using Fourier transform infrared spectroscopy (FT-IR) and proton nuclear magnetic resonance spectrometry ((1)H NMR) to analyse the Chemical structure, gel permeation chromatography (GPC) for determining molecular weight (MW) and molecular weight distribution (MWD), differential scanning calorimetry (DSC) to measure the glass transition temperature and thermogravimetric analysis (TGA) to follow the thermal degradation. Both structural and thermal characteristics suggest that kraft pine lignin (L1) would be a better phenol (P) substitute in the synthesis of lignin-phenol-formaldehyde (LPF) resins, as it presents higher amounts of activated free ring positions, higher MW and higher thermal decomposition temperature.