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David Beighton - One of the best experts on this subject based on the ideXlab platform.
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The effect of Chlorhexidine Acetate/xylitol chewing gum on the plaque and gingival indices of elderly occupants in residential homes.
Journal of clinical periodontology, 2008Co-Authors: D Simons, Susan Brailsford, Edwina Kidd, David BeightonAbstract:Aim: A randomised, controlled, double-blind, clinical trial was conducted to investigate the effect of a Chlorhexidine Acetate/xylitol gum (ACHX) on the plaque and gingival indices of 111 elderly occupants in residential homes. A gum containing xylitol alone (X) and a no gum (N) group was included. Participants’ opinions about chewing gum were also investigated. Methods: Subjects chewed 2 pellets, for 15 min, 2× daily for 12 months. Results: In the ACHX group, the plaque and gingival indices significantly decreased (p
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the effect of Chlorhexidine Acetate xylitol chewing gum on the plaque and gingival indices of elderly occupants in residential homes
Journal of Clinical Periodontology, 2001Co-Authors: D Simons, Susan Brailsford, E A M Kidd, David BeightonAbstract:Aim: A randomised, controlled, double-blind, clinical trial was conducted to investigate the effect of a Chlorhexidine Acetate/xylitol gum (ACHX) on the plaque and gingival indices of 111 elderly occupants in residential homes. A gum containing xylitol alone (X) and a no gum (N) group was included. Participants’ opinions about chewing gum were also investigated. Methods: Subjects chewed 2 pellets, for 15 min, 2× daily for 12 months. Results: In the ACHX group, the plaque and gingival indices significantly decreased (p<0.001) over the 12 months. In the X group, only the plaque score significantly decreased (p<0.05) and in the N control group, both indices remained high and did not change significantly. The acceptance of both chewing gums was high but more participants in the ACHX group felt that the gum kept their mouth healthy (p<0.05). The effect of the ACHX gum on plaque and gingival indices was significantly greater than for the X gum. Conclusion: The long-term use of a Chlorhexidine Acetate/xylitol chewing gum may therefore support oral hygiene routines for an elderly dependent population.
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the effect of xylitol and Chlorhexidine Acetate xylitol chewing gums on plaque accumulation and gingival inflammation
Journal of Clinical Periodontology, 1999Co-Authors: D Simons, E A M Kidd, David Beighton, F. I. CollierAbstract:Abstract. Chewing gums may be suitable vehicles for the delivery of xylitol (X) and Chlorhexidine Acetate (CHX), both of which can aid oral health. The aim of this study was to determine the clinical effectiveness of chewing gums containing X or a combination of X and CHX in a double-blind, randomised, cross over, 5-day clinical trial, with a 9-day washout period in a group of participants over 40 years old. After professional tooth cleaning, 8 subjects (mean age 51.3±10.4 years) used in a random order 2 pieces of ACHX (a liquorice flavoured CHX/X) gum, 2 pieces of BCHX (a chocolate mint flavoured CHX/X), 2 pieces of X (a liquorice flavoured X gum) and 1 piece of ACHX. Gums were chewed 2× daily for 15 min and volunteers refrained from all other oral hygiene procedures. Data were analysed using Friedman nonparametric analysis of variance. Plaque indices for chewing 2 pieces of ACHX gum (0.78±0.15) and BCHX gum (0.52±0.15) were significantly lower (p<0.0006) than for X gum (1.57±0.08). The gingival index was significantly greater (p<0.05) for X containing gum than for the other chewing regimes. The subjects' attitudes to the gums were also assessed by structured questionnaires which showed that all gums were easy to chew, did not adhere to dentures, teeth or restorations and that the subjects preferred to chew 2 pellets rather than 1.
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The effect of xylitol and Chlorhexidine Acetate/xylitol chewing gums on plaque accumulation and gingival inflammation.
Journal of clinical periodontology, 1999Co-Authors: D Simons, David Beighton, Edwina Kidd, F. I. CollierAbstract:Abstract. Chewing gums may be suitable vehicles for the delivery of xylitol (X) and Chlorhexidine Acetate (CHX), both of which can aid oral health. The aim of this study was to determine the clinical effectiveness of chewing gums containing X or a combination of X and CHX in a double-blind, randomised, cross over, 5-day clinical trial, with a 9-day washout period in a group of participants over 40 years old. After professional tooth cleaning, 8 subjects (mean age 51.3±10.4 years) used in a random order 2 pieces of ACHX (a liquorice flavoured CHX/X) gum, 2 pieces of BCHX (a chocolate mint flavoured CHX/X), 2 pieces of X (a liquorice flavoured X gum) and 1 piece of ACHX. Gums were chewed 2× daily for 15 min and volunteers refrained from all other oral hygiene procedures. Data were analysed using Friedman nonparametric analysis of variance. Plaque indices for chewing 2 pieces of ACHX gum (0.78±0.15) and BCHX gum (0.52±0.15) were significantly lower (p
D Simons - One of the best experts on this subject based on the ideXlab platform.
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The effect of Chlorhexidine Acetate/xylitol chewing gum on the plaque and gingival indices of elderly occupants in residential homes.
Journal of clinical periodontology, 2008Co-Authors: D Simons, Susan Brailsford, Edwina Kidd, David BeightonAbstract:Aim: A randomised, controlled, double-blind, clinical trial was conducted to investigate the effect of a Chlorhexidine Acetate/xylitol gum (ACHX) on the plaque and gingival indices of 111 elderly occupants in residential homes. A gum containing xylitol alone (X) and a no gum (N) group was included. Participants’ opinions about chewing gum were also investigated. Methods: Subjects chewed 2 pellets, for 15 min, 2× daily for 12 months. Results: In the ACHX group, the plaque and gingival indices significantly decreased (p
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the effect of Chlorhexidine Acetate xylitol chewing gum on the plaque and gingival indices of elderly occupants in residential homes
Journal of Clinical Periodontology, 2001Co-Authors: D Simons, Susan Brailsford, E A M Kidd, David BeightonAbstract:Aim: A randomised, controlled, double-blind, clinical trial was conducted to investigate the effect of a Chlorhexidine Acetate/xylitol gum (ACHX) on the plaque and gingival indices of 111 elderly occupants in residential homes. A gum containing xylitol alone (X) and a no gum (N) group was included. Participants’ opinions about chewing gum were also investigated. Methods: Subjects chewed 2 pellets, for 15 min, 2× daily for 12 months. Results: In the ACHX group, the plaque and gingival indices significantly decreased (p<0.001) over the 12 months. In the X group, only the plaque score significantly decreased (p<0.05) and in the N control group, both indices remained high and did not change significantly. The acceptance of both chewing gums was high but more participants in the ACHX group felt that the gum kept their mouth healthy (p<0.05). The effect of the ACHX gum on plaque and gingival indices was significantly greater than for the X gum. Conclusion: The long-term use of a Chlorhexidine Acetate/xylitol chewing gum may therefore support oral hygiene routines for an elderly dependent population.
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the effect of xylitol and Chlorhexidine Acetate xylitol chewing gums on plaque accumulation and gingival inflammation
Journal of Clinical Periodontology, 1999Co-Authors: D Simons, E A M Kidd, David Beighton, F. I. CollierAbstract:Abstract. Chewing gums may be suitable vehicles for the delivery of xylitol (X) and Chlorhexidine Acetate (CHX), both of which can aid oral health. The aim of this study was to determine the clinical effectiveness of chewing gums containing X or a combination of X and CHX in a double-blind, randomised, cross over, 5-day clinical trial, with a 9-day washout period in a group of participants over 40 years old. After professional tooth cleaning, 8 subjects (mean age 51.3±10.4 years) used in a random order 2 pieces of ACHX (a liquorice flavoured CHX/X) gum, 2 pieces of BCHX (a chocolate mint flavoured CHX/X), 2 pieces of X (a liquorice flavoured X gum) and 1 piece of ACHX. Gums were chewed 2× daily for 15 min and volunteers refrained from all other oral hygiene procedures. Data were analysed using Friedman nonparametric analysis of variance. Plaque indices for chewing 2 pieces of ACHX gum (0.78±0.15) and BCHX gum (0.52±0.15) were significantly lower (p<0.0006) than for X gum (1.57±0.08). The gingival index was significantly greater (p<0.05) for X containing gum than for the other chewing regimes. The subjects' attitudes to the gums were also assessed by structured questionnaires which showed that all gums were easy to chew, did not adhere to dentures, teeth or restorations and that the subjects preferred to chew 2 pellets rather than 1.
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The effect of xylitol and Chlorhexidine Acetate/xylitol chewing gums on plaque accumulation and gingival inflammation.
Journal of clinical periodontology, 1999Co-Authors: D Simons, David Beighton, Edwina Kidd, F. I. CollierAbstract:Abstract. Chewing gums may be suitable vehicles for the delivery of xylitol (X) and Chlorhexidine Acetate (CHX), both of which can aid oral health. The aim of this study was to determine the clinical effectiveness of chewing gums containing X or a combination of X and CHX in a double-blind, randomised, cross over, 5-day clinical trial, with a 9-day washout period in a group of participants over 40 years old. After professional tooth cleaning, 8 subjects (mean age 51.3±10.4 years) used in a random order 2 pieces of ACHX (a liquorice flavoured CHX/X) gum, 2 pieces of BCHX (a chocolate mint flavoured CHX/X), 2 pieces of X (a liquorice flavoured X gum) and 1 piece of ACHX. Gums were chewed 2× daily for 15 min and volunteers refrained from all other oral hygiene procedures. Data were analysed using Friedman nonparametric analysis of variance. Plaque indices for chewing 2 pieces of ACHX gum (0.78±0.15) and BCHX gum (0.52±0.15) were significantly lower (p
Ersin Ulkur - One of the best experts on this subject based on the ideXlab platform.
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comparison of silver coated dressing acticoat Chlorhexidine Acetate 0 5 bactigrass and nystatin for topical antifungal effect in candida albicans contaminated full skin thickness rat burn wounds
Burns, 2011Co-Authors: Ali Acar, Ersin Ulkur, Oral Oncul, Fatih Uygur, Husrev Diktas, Rahmi Evinc, Levent GorenekAbstract:Abstract Background In this experimental animal study, the effects of three different topical antimicrobial dressings on Candida albicans contaminated full-thickness burn in rats were analyzed. Methods In total 32 adult Wistar rats (body weight 200–220g) were used. Silver-coated dressing (Acticoat™ ® ), Chlorhexidine Acetate 0.5% (Bactigrass ® ) and Mycostatine (Nystatin ® ) were compared to assess the antifungal effect of a once-daily application on experimental rat 15% full-skin thickness burn wound seeded 24h earlier with a 10 8 CFU/mL standard strain of C. albicans ATCC 90028. All the animals were sacrificed at post burn day 7. The quantitative counts of seeded organism in burn eschar and subjacent muscle were determined, in addition to the cultures of left ventricle blood and lung biopsies. Results While there were significant differences between Acticoat™ ® group (4±10×10 4 ) and control group (5±6×10 6 ), and between Nystatin group (4±4×10 4 ) and control group ( P =0.01, P =0.01), there were no significant differences between Chlorhexidine Acetate 0.5% group (2±3×10 4 ) and control group ( P =0.7 ) respectively. Acticoat™ ® and Nystatin were sufficient to prevent to C. albicans from invading to the muscle and from causing systemic infection. Conclusions The animal data suggest that nystatin is the most effective agents in the treatment of C. albicans -contaminated burn wounds, and Acticoat™ ® is a choice of treatment on fungal burn wound infection with antibacterial effect and the particular advantage of limiting the frequency of replacement of the dressing.
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comparison of silver coated dressing acticoat Chlorhexidine Acetate 0 5 bactigrass and fusidic acid 2 fucidin for topical antibacterial effect in methicillin resistant staphylococci contaminated full skin thickness rat burn wounds
Burns, 2005Co-Authors: Ersin Ulkur, Oral Oncul, Huseyin Karagoz, Esma Yeniz, Bahattin CelikozAbstract:Acticoat, Chlorhexidine Acetate 0.5%, and fusidic acid 2% were compared to assess the antibacterial effect of an application on experimental 15% BSA, full-thickness burn wounds in rats swabbed 24 h earlier with a 10(8) standard strain of methicillin-resistant Staphylococci. The swabbed organism was recovered from the eschar of all groups except the fusidic acid group. While there were significant differences between treatment groups and control group, the mean eschar concentrations did not differ significantly between the Acticoat and Chlorhexidine Acetate groups, but there were significant differences between the fusidic acid group and the other treatment groups. There were no statistically significant differences between treatment groups, and between control group and the Chlorhexidine Acetate group regarding recovery of the seeded organism from muscle, but there were significant differences between the control group and Acticoat group, and between control the group and the fusidic acid group. While no systemic spread was seen in the treatment groups, it was seen in six animals in the control group. The animal data suggest that fusidic acid is the most effective agent in the treatment of methicillin-resistant Staphylococcus aureus-contaminated burn wounds, and Acticoat is a choice of treatment with the particular advantage of limiting the frequency of replacement of the dressing.
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comparison of silver coated dressing acticoat Chlorhexidine Acetate 0 5 bactigrass and silver sulfadiazine 1 silverdin for topical antibacterial effect in pseudomonas aeruginosa contaminated full skin thickness burn wounds in rats
Journal of Burn Care & Rehabilitation, 2005Co-Authors: Ersin Ulkur, Oral Oncul, Huseyin Karagoz, Bahattin Celikoz, Saban CavusluAbstract:Acticoat (Smith and Nephew, Istanbul, Turkey), Chlorhexidine Acetate 0.5%, and silver sulfadiazine 1% were compared to assess the antibacterial effect of their application on experimental burn wounds in contaminated with Pseudomonas aeruginosa in rats. All treatment modalities were effective against P. aeruginosa because there were significant differences between treatment groups and control groups. The mean eschar concentrations did not differ significantly between Acticoat and Chlorhexidine Acetate groups, but there were significant differences between the silver sulfadiazine group and the other treatment groups, indicating that silver sulfadiazine significantly eliminated P. aeruginosa more effectively in the tissues than did the other two agents. All treatment modalities were sufficient to prevent the P. aeruginosa from invading to the muscle and from causing systemic infection. In conclusion, silver sulfadiazine is the most effective agent in the treatment of the P. aeruginosa-contaminated burn wounds; Acticoat can be considered as a treatment choice because of its peculiar ability of limiting the frequency of replacing wound dressings.
Oral Oncul - One of the best experts on this subject based on the ideXlab platform.
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comparison of silver coated dressing acticoat Chlorhexidine Acetate 0 5 bactigrass and nystatin for topical antifungal effect in candida albicans contaminated full skin thickness rat burn wounds
Burns, 2011Co-Authors: Ali Acar, Ersin Ulkur, Oral Oncul, Fatih Uygur, Husrev Diktas, Rahmi Evinc, Levent GorenekAbstract:Abstract Background In this experimental animal study, the effects of three different topical antimicrobial dressings on Candida albicans contaminated full-thickness burn in rats were analyzed. Methods In total 32 adult Wistar rats (body weight 200–220g) were used. Silver-coated dressing (Acticoat™ ® ), Chlorhexidine Acetate 0.5% (Bactigrass ® ) and Mycostatine (Nystatin ® ) were compared to assess the antifungal effect of a once-daily application on experimental rat 15% full-skin thickness burn wound seeded 24h earlier with a 10 8 CFU/mL standard strain of C. albicans ATCC 90028. All the animals were sacrificed at post burn day 7. The quantitative counts of seeded organism in burn eschar and subjacent muscle were determined, in addition to the cultures of left ventricle blood and lung biopsies. Results While there were significant differences between Acticoat™ ® group (4±10×10 4 ) and control group (5±6×10 6 ), and between Nystatin group (4±4×10 4 ) and control group ( P =0.01, P =0.01), there were no significant differences between Chlorhexidine Acetate 0.5% group (2±3×10 4 ) and control group ( P =0.7 ) respectively. Acticoat™ ® and Nystatin were sufficient to prevent to C. albicans from invading to the muscle and from causing systemic infection. Conclusions The animal data suggest that nystatin is the most effective agents in the treatment of C. albicans -contaminated burn wounds, and Acticoat™ ® is a choice of treatment on fungal burn wound infection with antibacterial effect and the particular advantage of limiting the frequency of replacement of the dressing.
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comparison of silver coated dressing acticoat Chlorhexidine Acetate 0 5 bactigrass and fusidic acid 2 fucidin for topical antibacterial effect in methicillin resistant staphylococci contaminated full skin thickness rat burn wounds
Burns, 2005Co-Authors: Ersin Ulkur, Oral Oncul, Huseyin Karagoz, Esma Yeniz, Bahattin CelikozAbstract:Acticoat, Chlorhexidine Acetate 0.5%, and fusidic acid 2% were compared to assess the antibacterial effect of an application on experimental 15% BSA, full-thickness burn wounds in rats swabbed 24 h earlier with a 10(8) standard strain of methicillin-resistant Staphylococci. The swabbed organism was recovered from the eschar of all groups except the fusidic acid group. While there were significant differences between treatment groups and control group, the mean eschar concentrations did not differ significantly between the Acticoat and Chlorhexidine Acetate groups, but there were significant differences between the fusidic acid group and the other treatment groups. There were no statistically significant differences between treatment groups, and between control group and the Chlorhexidine Acetate group regarding recovery of the seeded organism from muscle, but there were significant differences between the control group and Acticoat group, and between control the group and the fusidic acid group. While no systemic spread was seen in the treatment groups, it was seen in six animals in the control group. The animal data suggest that fusidic acid is the most effective agent in the treatment of methicillin-resistant Staphylococcus aureus-contaminated burn wounds, and Acticoat is a choice of treatment with the particular advantage of limiting the frequency of replacement of the dressing.
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comparison of silver coated dressing acticoat Chlorhexidine Acetate 0 5 bactigrass and silver sulfadiazine 1 silverdin for topical antibacterial effect in pseudomonas aeruginosa contaminated full skin thickness burn wounds in rats
Journal of Burn Care & Rehabilitation, 2005Co-Authors: Ersin Ulkur, Oral Oncul, Huseyin Karagoz, Bahattin Celikoz, Saban CavusluAbstract:Acticoat (Smith and Nephew, Istanbul, Turkey), Chlorhexidine Acetate 0.5%, and silver sulfadiazine 1% were compared to assess the antibacterial effect of their application on experimental burn wounds in contaminated with Pseudomonas aeruginosa in rats. All treatment modalities were effective against P. aeruginosa because there were significant differences between treatment groups and control groups. The mean eschar concentrations did not differ significantly between Acticoat and Chlorhexidine Acetate groups, but there were significant differences between the silver sulfadiazine group and the other treatment groups, indicating that silver sulfadiazine significantly eliminated P. aeruginosa more effectively in the tissues than did the other two agents. All treatment modalities were sufficient to prevent the P. aeruginosa from invading to the muscle and from causing systemic infection. In conclusion, silver sulfadiazine is the most effective agent in the treatment of the P. aeruginosa-contaminated burn wounds; Acticoat can be considered as a treatment choice because of its peculiar ability of limiting the frequency of replacing wound dressings.
Jian Shen - One of the best experts on this subject based on the ideXlab platform.
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study on montmorillonite Chlorhexidine Acetate terbinafine hydrochloride intercalation composites as drug release systems
RSC Advances, 2018Co-Authors: Baohong Sun, Ninglin Zhou, Ming Zhang, Xiaohong Chu, Cheng Chi, Ping Yuan, Jian ShenAbstract:This paper focuses on the intercalation of Chlorhexidine Acetate (CA) and terbinafine hydrochloride (TBH) into montmorillonite as sustained release drug carriers. The intercalation compounds were characterized by X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, and thermogravimetric analysis (TGA). The basal spacing of montmorillonite increased from 1.23 to 2.97 nm. It was confirmed that CA and TBH molecules were well-stabilized in the interlayer space of clay via mono-, double or triplicate layer stacking. The adsorption amounts and molecular structures of CA and TBH appeared to depend on the cation exchange capacity of MMT, which in turn, tailored the drug release patterns. In vitro release tests of MMT–CA–TBH in 0.9 wt% NaCl solution at 37 °C show a biphasic and sustained profile of CA and TBH ion release. After release, dissolution–diffusion kinetic models were fitted. The mechanism of MMT–CA–TBH release is probably due to surface diffusion and bulk diffusion via ionic exchange of MMT ions on or in the MMT with ions in the NaCl solution. The in vitro release experiments revealed that CA and TBH were released from MMT steadily, depending on the cooperation between the drugs themselves and the electrostatic interactions between the drugs and MMT. It was found that the cross-linking ratio increased due to a decrease in the free volume available for diffusion.
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Study on montmorillonite–Chlorhexidine Acetate–terbinafine hydrochloride intercalation composites as drug release systems
RSC Advances, 2018Co-Authors: Baohong Sun, Ninglin Zhou, Ming Zhang, Xiaohong Chu, Yuan Ping, Cheng Chi, Jian ShenAbstract:This paper focuses on the intercalation of Chlorhexidine Acetate (CA) and terbinafine hydrochloride (TBH) into montmorillonite as sustained release drug carriers. The intercalation compounds were characterized by X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, and thermogravimetric analysis (TGA). The basal spacing of montmorillonite increased from 1.23 to 2.97 nm. It was confirmed that CA and TBH molecules were well-stabilized in the interlayer space of clay via mono-, double or triplicate layer stacking. The adsorption amounts and molecular structures of CA and TBH appeared to depend on the cation exchange capacity of MMT, which in turn, tailored the drug release patterns. In vitro release tests of MMT–CA–TBH in 0.9 wt% NaCl solution at 37 °C show a biphasic and sustained profile of CA and TBH ion release. After release, dissolution–diffusion kinetic models were fitted. The mechanism of MMT–CA–TBH release is probably due to surface diffusion and bulk diffusion via ionic exchange of MMT ions on or in the MMT with ions in the NaCl solution. The in vitro release experiments revealed that CA and TBH were released from MMT steadily, depending on the cooperation between the drugs themselves and the electrostatic interactions between the drugs and MMT. It was found that the cross-linking ratio increased due to a decrease in the free volume available for diffusion.
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Controlled release and antibacterial activity Chlorhexidine Acetate (CA) intercalated in montmorillonite.
International journal of pharmaceutics, 2009Co-Authors: Na Meng, Ninglin Zhou, Shuangquan Zhang, Jian ShenAbstract:The aim of this study was to prepare Chlorhexidine Acetate (CA)/montmorillonite intercalation composites and its antibacterial potential was evaluated with pathogenic bacteria, Staphylococcus aureus and Pseudomonas aeruginosa. The CA/MMT was characterized by X-ray diffraction (XRD), Fourier transformed infrared (FT-IR), and thermogravimetric analysis (TGA). CA was successfully intercalated into the interlayer of MMT and in vitro release properties of the intercalated CA have been investigated in phosphate buffered saline media (pH 7.4) at 37+/-0.5 degrees C. At drug release study, CA showed initial burst effect for 24 h and then continuously released for 72 h. Their antibacterial activity was assayed by the inhibitory zone method. The CA/MMT was tested for antimicrobial activity against S. aureus and P. aeruginosa. The CA/MMT strongly inhibited the growth of a wide variety of microorganisms, including gram-positive bacteria, gram-negative bacteria.
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Controlled release and antibacterial activity Chlorhexidine Acetate (CA) intercalated in montmorillonite.
International Journal of Pharmaceutics, 2009Co-Authors: Na Meng, Ninglin Zhou, Shuangquan Zhang, Jian ShenAbstract:Abstract The aim of this study was to prepare Chlorhexidine Acetate (CA)/montmorillonite intercalation composites and its antibacterial potential was evaluated with pathogenic bacteria, Staphylococcus aureus and Pseudomonas aeruginosa . The CA/MMT was characterized by X-ray diffraction (XRD), Fourier transformed infrared (FT-IR), and thermogravimetric analysis (TGA). CA was successfully intercalated into the interlayer of MMT and in vitro release properties of the intercalated CA have been investigated in phosphate buffered saline media (pH 7.4) at 37 ± 0.5 °C. At drug release study, CA showed initial burst effect for 24 h and then continuously released for 72 h. Their antibacterial activity was assayed by the inhibitory zone method. The CA/MMT was tested for antimicrobial activity against S. aureus and P. aeruginosa . The CA/MMT strongly inhibited the growth of a wide variety of microorganisms, including Gram-positive bacteria, Gram-negative bacteria.
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synthesis and antimicrobial activities of polymer montmorillonite Chlorhexidine Acetate nanocomposite films
Applied Clay Science, 2009Co-Authors: Na Meng, Ninglin Zhou, Shuangquan Zhang, Jian ShenAbstract:ARTICLE I NFO + -montmorillonite Nanocomposite films The PDMS/montmorillonite-Chlorhexidine Acetate (PDMS/OMMT) nanocomposite films were successfully obtained by intercalation from solution. Organo-montmorillonite (OMMT) with antibacterial activity was prepared from Na + -montmorillonite (Na + -MMT) and Chlorhexidine Acetate (CA) by ion exchange. The microstructure of these nanocomposite films were characterized by TEM and XRD. The effect of OMMT on mechanical propertiesandthermal stabilityof thenanocompositeswasinvestigated.WhentheOMMTcontent was lower than 0.5 mass %, the nanocomposites showed excellent mechanical properties. The polymers were tested for antimicrobial activity against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). The PDMS/OMMT nanocomposite films strongly inhibited the growth of a wide variety of microorganisms, including Gram-positive bacteria, Gram-negative bacteria.