The Experts below are selected from a list of 7500 Experts worldwide ranked by ideXlab platform

Ronald M. Lindsay - One of the best experts on this subject based on the ideXlab platform.

  • Ciliary Neurotrophic Factor protects striatal output neurons in an animal model of Huntington disease.
    Proceedings of the National Academy of Sciences of the United States of America, 1996
    Co-Authors: Keith D. Anderson, Ronald M. Lindsay, Nikos Panayotatos, T. L. Corcoran, Stanley J. Wiegand
    Abstract:

    Abstract Huntington disease is a dominantly inherited, untreatable neurological disorder featuring a progressive loss of striatal output neurons that results in dyskinesia, cognitive decline, and, ultimately, death. Neurotrophic Factors have recently been shown to be protective in several animal models of neurodegenerative disease, raising the possibility that such substances might also sustain the survival of compromised striatal output neurons. We determined whether intracerebral administration of brain-derived Neurotrophic Factor, nerve growth Factor, neurotrophin-3, or Ciliary Neurotrophic Factor could protect striatal output neurons in a rodent model of Huntington disease. Whereas treatment with brain-derived Neurotrophic Factor, nerve growth Factor, or neurotrophin-3 provided no protection of striatal output neurons from death induced by intrastriatal injection of quinolinic acid, an N-methyl-D-aspartate glutamate receptor agonist, treatment with Ciliary Neurotrophic Factor afforded marked protection against this neurodegenerative insult.

  • histometric effects of Ciliary Neurotrophic Factor in wobbler mouse motor neuron disease
    Annals of Neurology, 1995
    Co-Authors: Ken Ikeda, Ronald M. Lindsay, Vivien Wong, Thomas H Holmlund, Tom Greene, Jesse M Cedarbaum, Hiroshi Mitsumoto
    Abstract:

    We investigated the histological effects of Ciliary Neurotrophic Factor on degenerating motor neurons, their axons, and skeletal muscles in 68 wobbler mice with motor neuron disease. Treatment consisted of recombinant rat or human Ciliary Neurotrophic Factor (or a vehicle solution), 1-mg/kg subcutaneous injection, three times per week for 4 weeks after the clinical diagnosis. The number of motor neurons immunoreactive for calcitonin gene--related peptide was higher in mice receiving rat Ciliary Neurotrophic Factor (p < 0.03), although the number of choline acetyltransferase-reactive neurons was the same in both treated and untreated control groups. Treatment did not prevent vacuolar degeneration of motor neurons. In mice treated with human Ciliary Neurotrophic Factor, the percentage of axons undergoing acute axonal degeneration (myelin ovoids) was smaller in the entire C5 ventral root (p < 0.02) and in the musculocutaneous nerve (p < 0.04), and the number of myelinated nerve fibers was 30% higher in both nerves (p < 0.01 and p < 0.04, respectively) than in controls. In Ciliary Neurotrophic Factor-treated mice, the biceps muscle weight was 20% greater, the mean muscle fiber diameter was 30% larger, and the number of atrophied muscle fibers was 75% lower than that in the vehicle-treated wobbler mice (p < 0.001 for all three results). The number of terminal axonal branching points and the mean length of motor end-plates were also higher in the Ciliary Neurotrophic Factor-treated mice (p < 0.001 and p < 0.02, respectively). Our study thus suggests that Ciliary Neurotrophic Factor slowed neuronal degeneration, enhanced axonal regeneration at both the proximal and distal motor axons, and reduced muscle atrophy in this motor neuron disease.

  • the effects of Ciliary Neurotrophic Factor on motor dysfunction in wobbler mouse motor neuron disease
    Annals of Neurology, 1994
    Co-Authors: Hiroshi Mitsumoto, Ken Ikeda, Vivien Wong, Tom Greene, Jesse M Cedarbaum, Tomas Holmlund, Ronald M. Lindsay
    Abstract:

    Ciliary Neurotrophic Factor is the first Neurotrophic Factor to show survival-promoting effects in developing motor neurons in vitro, in ovo, and in vivo. In the present study we tested the effects of recombinant rat or human Ciliary Neurotrophic Factor in the wobbler mouse model of motor neuron disease. Mice received 1 mg/kg of the Factor or a vehicle solution subcutaneously three times a week for 4 weeks, after the disease was diagnosed between the ages of 3 and 4 weeks. Although treatment with rat Ciliary Neurotrophic Factor (n=6) resulted in delayed weight gain (p<0.001), grip strength normalized to body weight in the Factor-treated mice was significantly greater (p<0.02) and declined at a slower rate (p<0.05) compared to that in vehicle-treated animals

  • trophic effect of Ciliary Neurotrophic Factor on denervated skeletal muscle
    Cell, 1994
    Co-Authors: Maureen E. Helgren, Ronald M. Lindsay, David J. Parry, George D. Yancopoulos, Stephen P Squinto, Heather L Davis, Teri G Boulton, Carol S Heck, Peter S Distefano
    Abstract:

    Abstract The actions and receptor for Ciliary Neurotrophic Factor (CNTF) are largely restricted to cells of the nervous system, although one of the CNTF receptor components, CNTFRα, is expressed by skeletal muscle. Here we show that the other CNTF receptor components, LIFRβ and gp130, are also expressed by skeletal muscle and that expression of all three CNTF receptor components is greatly increased in denervated muscle. In vivo, administration of CNTF activates these receptors on skeletal muscle by inducing receptor phosphorylation and immediate-early gene responses. Furthermore, CNTF reduces the denervation-induced atrophy of muscle and attenuates the reduced twitch and tetanic tensions that result from muscle denervation. Our findings reveal that, in addition to its known Neurotrophic actions, CNTF exerts myotrophic effects by attenuating the morphological and functional changes associated with denervation of rat skeletal muscle.

  • The effects of Ciliary Neurotrophic Factor on motor dysfunction in wobbler mouse motor neuron disease.
    Annals of neurology, 1994
    Co-Authors: Hiroshi Mitsumoto, Ken Ikeda, Vivien Wong, Tom Greene, Jesse M Cedarbaum, Tomas Holmlund, Ronald M. Lindsay
    Abstract:

    Ciliary Neurotrophic Factor is the first Neurotrophic Factor to show survival-promoting effects in developing motor neurons in vitro, in ovo, and in vivo. In the present study we tested the effects of recombinant rat or human Ciliary Neurotrophic Factor in the wobbler mouse model of motor neuron disease. Mice received 1 mg/kg of the Factor or a vehicle solution subcutaneously three times a week for 4 weeks, after the disease was diagnosed between the ages of 3 and 4 weeks. Although treatment with rat Ciliary Neurotrophic Factor (n=6) resulted in delayed weight gain (p

Hiroshi Mitsumoto - One of the best experts on this subject based on the ideXlab platform.

  • histometric effects of Ciliary Neurotrophic Factor in wobbler mouse motor neuron disease
    Annals of Neurology, 1995
    Co-Authors: Ken Ikeda, Ronald M. Lindsay, Vivien Wong, Thomas H Holmlund, Tom Greene, Jesse M Cedarbaum, Hiroshi Mitsumoto
    Abstract:

    We investigated the histological effects of Ciliary Neurotrophic Factor on degenerating motor neurons, their axons, and skeletal muscles in 68 wobbler mice with motor neuron disease. Treatment consisted of recombinant rat or human Ciliary Neurotrophic Factor (or a vehicle solution), 1-mg/kg subcutaneous injection, three times per week for 4 weeks after the clinical diagnosis. The number of motor neurons immunoreactive for calcitonin gene--related peptide was higher in mice receiving rat Ciliary Neurotrophic Factor (p < 0.03), although the number of choline acetyltransferase-reactive neurons was the same in both treated and untreated control groups. Treatment did not prevent vacuolar degeneration of motor neurons. In mice treated with human Ciliary Neurotrophic Factor, the percentage of axons undergoing acute axonal degeneration (myelin ovoids) was smaller in the entire C5 ventral root (p < 0.02) and in the musculocutaneous nerve (p < 0.04), and the number of myelinated nerve fibers was 30% higher in both nerves (p < 0.01 and p < 0.04, respectively) than in controls. In Ciliary Neurotrophic Factor-treated mice, the biceps muscle weight was 20% greater, the mean muscle fiber diameter was 30% larger, and the number of atrophied muscle fibers was 75% lower than that in the vehicle-treated wobbler mice (p < 0.001 for all three results). The number of terminal axonal branching points and the mean length of motor end-plates were also higher in the Ciliary Neurotrophic Factor-treated mice (p < 0.001 and p < 0.02, respectively). Our study thus suggests that Ciliary Neurotrophic Factor slowed neuronal degeneration, enhanced axonal regeneration at both the proximal and distal motor axons, and reduced muscle atrophy in this motor neuron disease.

  • the effects of Ciliary Neurotrophic Factor on motor dysfunction in wobbler mouse motor neuron disease
    Annals of Neurology, 1994
    Co-Authors: Hiroshi Mitsumoto, Ken Ikeda, Vivien Wong, Tom Greene, Jesse M Cedarbaum, Tomas Holmlund, Ronald M. Lindsay
    Abstract:

    Ciliary Neurotrophic Factor is the first Neurotrophic Factor to show survival-promoting effects in developing motor neurons in vitro, in ovo, and in vivo. In the present study we tested the effects of recombinant rat or human Ciliary Neurotrophic Factor in the wobbler mouse model of motor neuron disease. Mice received 1 mg/kg of the Factor or a vehicle solution subcutaneously three times a week for 4 weeks, after the disease was diagnosed between the ages of 3 and 4 weeks. Although treatment with rat Ciliary Neurotrophic Factor (n=6) resulted in delayed weight gain (p<0.001), grip strength normalized to body weight in the Factor-treated mice was significantly greater (p<0.02) and declined at a slower rate (p<0.05) compared to that in vehicle-treated animals

  • The effects of Ciliary Neurotrophic Factor on motor dysfunction in wobbler mouse motor neuron disease.
    Annals of neurology, 1994
    Co-Authors: Hiroshi Mitsumoto, Ken Ikeda, Vivien Wong, Tom Greene, Jesse M Cedarbaum, Tomas Holmlund, Ronald M. Lindsay
    Abstract:

    Ciliary Neurotrophic Factor is the first Neurotrophic Factor to show survival-promoting effects in developing motor neurons in vitro, in ovo, and in vivo. In the present study we tested the effects of recombinant rat or human Ciliary Neurotrophic Factor in the wobbler mouse model of motor neuron disease. Mice received 1 mg/kg of the Factor or a vehicle solution subcutaneously three times a week for 4 weeks, after the disease was diagnosed between the ages of 3 and 4 weeks. Although treatment with rat Ciliary Neurotrophic Factor (n=6) resulted in delayed weight gain (p

Christian C. Naus - One of the best experts on this subject based on the ideXlab platform.

Ken Ikeda - One of the best experts on this subject based on the ideXlab platform.

  • histometric effects of Ciliary Neurotrophic Factor in wobbler mouse motor neuron disease
    Annals of Neurology, 1995
    Co-Authors: Ken Ikeda, Ronald M. Lindsay, Vivien Wong, Thomas H Holmlund, Tom Greene, Jesse M Cedarbaum, Hiroshi Mitsumoto
    Abstract:

    We investigated the histological effects of Ciliary Neurotrophic Factor on degenerating motor neurons, their axons, and skeletal muscles in 68 wobbler mice with motor neuron disease. Treatment consisted of recombinant rat or human Ciliary Neurotrophic Factor (or a vehicle solution), 1-mg/kg subcutaneous injection, three times per week for 4 weeks after the clinical diagnosis. The number of motor neurons immunoreactive for calcitonin gene--related peptide was higher in mice receiving rat Ciliary Neurotrophic Factor (p < 0.03), although the number of choline acetyltransferase-reactive neurons was the same in both treated and untreated control groups. Treatment did not prevent vacuolar degeneration of motor neurons. In mice treated with human Ciliary Neurotrophic Factor, the percentage of axons undergoing acute axonal degeneration (myelin ovoids) was smaller in the entire C5 ventral root (p < 0.02) and in the musculocutaneous nerve (p < 0.04), and the number of myelinated nerve fibers was 30% higher in both nerves (p < 0.01 and p < 0.04, respectively) than in controls. In Ciliary Neurotrophic Factor-treated mice, the biceps muscle weight was 20% greater, the mean muscle fiber diameter was 30% larger, and the number of atrophied muscle fibers was 75% lower than that in the vehicle-treated wobbler mice (p < 0.001 for all three results). The number of terminal axonal branching points and the mean length of motor end-plates were also higher in the Ciliary Neurotrophic Factor-treated mice (p < 0.001 and p < 0.02, respectively). Our study thus suggests that Ciliary Neurotrophic Factor slowed neuronal degeneration, enhanced axonal regeneration at both the proximal and distal motor axons, and reduced muscle atrophy in this motor neuron disease.

  • the effects of Ciliary Neurotrophic Factor on motor dysfunction in wobbler mouse motor neuron disease
    Annals of Neurology, 1994
    Co-Authors: Hiroshi Mitsumoto, Ken Ikeda, Vivien Wong, Tom Greene, Jesse M Cedarbaum, Tomas Holmlund, Ronald M. Lindsay
    Abstract:

    Ciliary Neurotrophic Factor is the first Neurotrophic Factor to show survival-promoting effects in developing motor neurons in vitro, in ovo, and in vivo. In the present study we tested the effects of recombinant rat or human Ciliary Neurotrophic Factor in the wobbler mouse model of motor neuron disease. Mice received 1 mg/kg of the Factor or a vehicle solution subcutaneously three times a week for 4 weeks, after the disease was diagnosed between the ages of 3 and 4 weeks. Although treatment with rat Ciliary Neurotrophic Factor (n=6) resulted in delayed weight gain (p<0.001), grip strength normalized to body weight in the Factor-treated mice was significantly greater (p<0.02) and declined at a slower rate (p<0.05) compared to that in vehicle-treated animals

  • The effects of Ciliary Neurotrophic Factor on motor dysfunction in wobbler mouse motor neuron disease.
    Annals of neurology, 1994
    Co-Authors: Hiroshi Mitsumoto, Ken Ikeda, Vivien Wong, Tom Greene, Jesse M Cedarbaum, Tomas Holmlund, Ronald M. Lindsay
    Abstract:

    Ciliary Neurotrophic Factor is the first Neurotrophic Factor to show survival-promoting effects in developing motor neurons in vitro, in ovo, and in vivo. In the present study we tested the effects of recombinant rat or human Ciliary Neurotrophic Factor in the wobbler mouse model of motor neuron disease. Mice received 1 mg/kg of the Factor or a vehicle solution subcutaneously three times a week for 4 weeks, after the disease was diagnosed between the ages of 3 and 4 weeks. Although treatment with rat Ciliary Neurotrophic Factor (n=6) resulted in delayed weight gain (p

Vivien Wong - One of the best experts on this subject based on the ideXlab platform.

  • histometric effects of Ciliary Neurotrophic Factor in wobbler mouse motor neuron disease
    Annals of Neurology, 1995
    Co-Authors: Ken Ikeda, Ronald M. Lindsay, Vivien Wong, Thomas H Holmlund, Tom Greene, Jesse M Cedarbaum, Hiroshi Mitsumoto
    Abstract:

    We investigated the histological effects of Ciliary Neurotrophic Factor on degenerating motor neurons, their axons, and skeletal muscles in 68 wobbler mice with motor neuron disease. Treatment consisted of recombinant rat or human Ciliary Neurotrophic Factor (or a vehicle solution), 1-mg/kg subcutaneous injection, three times per week for 4 weeks after the clinical diagnosis. The number of motor neurons immunoreactive for calcitonin gene--related peptide was higher in mice receiving rat Ciliary Neurotrophic Factor (p < 0.03), although the number of choline acetyltransferase-reactive neurons was the same in both treated and untreated control groups. Treatment did not prevent vacuolar degeneration of motor neurons. In mice treated with human Ciliary Neurotrophic Factor, the percentage of axons undergoing acute axonal degeneration (myelin ovoids) was smaller in the entire C5 ventral root (p < 0.02) and in the musculocutaneous nerve (p < 0.04), and the number of myelinated nerve fibers was 30% higher in both nerves (p < 0.01 and p < 0.04, respectively) than in controls. In Ciliary Neurotrophic Factor-treated mice, the biceps muscle weight was 20% greater, the mean muscle fiber diameter was 30% larger, and the number of atrophied muscle fibers was 75% lower than that in the vehicle-treated wobbler mice (p < 0.001 for all three results). The number of terminal axonal branching points and the mean length of motor end-plates were also higher in the Ciliary Neurotrophic Factor-treated mice (p < 0.001 and p < 0.02, respectively). Our study thus suggests that Ciliary Neurotrophic Factor slowed neuronal degeneration, enhanced axonal regeneration at both the proximal and distal motor axons, and reduced muscle atrophy in this motor neuron disease.

  • the effects of Ciliary Neurotrophic Factor on motor dysfunction in wobbler mouse motor neuron disease
    Annals of Neurology, 1994
    Co-Authors: Hiroshi Mitsumoto, Ken Ikeda, Vivien Wong, Tom Greene, Jesse M Cedarbaum, Tomas Holmlund, Ronald M. Lindsay
    Abstract:

    Ciliary Neurotrophic Factor is the first Neurotrophic Factor to show survival-promoting effects in developing motor neurons in vitro, in ovo, and in vivo. In the present study we tested the effects of recombinant rat or human Ciliary Neurotrophic Factor in the wobbler mouse model of motor neuron disease. Mice received 1 mg/kg of the Factor or a vehicle solution subcutaneously three times a week for 4 weeks, after the disease was diagnosed between the ages of 3 and 4 weeks. Although treatment with rat Ciliary Neurotrophic Factor (n=6) resulted in delayed weight gain (p<0.001), grip strength normalized to body weight in the Factor-treated mice was significantly greater (p<0.02) and declined at a slower rate (p<0.05) compared to that in vehicle-treated animals

  • The effects of Ciliary Neurotrophic Factor on motor dysfunction in wobbler mouse motor neuron disease.
    Annals of neurology, 1994
    Co-Authors: Hiroshi Mitsumoto, Ken Ikeda, Vivien Wong, Tom Greene, Jesse M Cedarbaum, Tomas Holmlund, Ronald M. Lindsay
    Abstract:

    Ciliary Neurotrophic Factor is the first Neurotrophic Factor to show survival-promoting effects in developing motor neurons in vitro, in ovo, and in vivo. In the present study we tested the effects of recombinant rat or human Ciliary Neurotrophic Factor in the wobbler mouse model of motor neuron disease. Mice received 1 mg/kg of the Factor or a vehicle solution subcutaneously three times a week for 4 weeks, after the disease was diagnosed between the ages of 3 and 4 weeks. Although treatment with rat Ciliary Neurotrophic Factor (n=6) resulted in delayed weight gain (p

  • the receptor for Ciliary Neurotrophic Factor
    Science, 1991
    Co-Authors: Samuel Davis, Mark E. Furth, Vivien Wong, Thomas H Aldrich, David M Valenzuela, Stephen P Squinto, George D. Yancopoulos
    Abstract:

    Although Neurotrophic Factors were originally isolated on the basis of their ability to support the survival of neurons, these molecules are now thought to influence many aspects of the development and maintenance of the nervous system. Identifying the receptors for these Neurotrophic Factors should aid in identifying the cells on which these Factors act and in understanding their precise mechanisms of action. A "tagged-ligand panning" procedure was used to clone a receptor for Ciliary Neurotrophic Factor (CNTF). This receptor is expressed exclusively within the nervous system and skeletal muscle. The CNTF receptor has a structure unrelated to the receptors utilized by the nerve growth Factor family of Neurotrophic molecules, but instead is most homologous to the receptor for a cytokine, interleukin-6. This similarity suggestes that the CNTF receptor, like the interleukin-6 receptor, requires a second, signal-transducing component. In contrast to all known receptors, the CNTF receptor is anchored to cell membranes by a glycosyl-phosphatidylinositol linkage.