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Natasa Bukovec - One of the best experts on this subject based on the ideXlab platform.
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crystal structures and cytotoxicity of isopropylamine pt ii complexes a trinuclear squarato bridged pt3 μ2 c4o4 3 h2npri 6 3h2o and a mononuclear cis pt no3 2 h2npri 2
Journal of Inorganic Biochemistry, 2005Co-Authors: Sabina Grabner, Barbara Modec, Maja Cemažar, Natasa BukovecAbstract:Abstract Crystals of a novel platinum(II) complex with squarato ligand, [Pt3(μ2-C4O4)3(H2NPri)6] · 3H2O (1) (H2NPri = ipa), have been isolated from the aqueous solution of cis-[Pt(H2O)2(H2NPri)2]SO4 and barium squarate. Slow evaporation of methanol solution of cis-[Pt(NO3)2(H2NPri)2] (2) resulted in crystallization of nitrato complex. The single crystal X-ray diffraction method was used to determine structures of 1 and 2. Complex 1 crystallizes in a triclinic space group P 1 ¯ with a = 11.17380(10) A, b = 14.4535(2) A, c = 14.8010(2) A, α = 86.0901(10)°, β = 78.4343(11)°, γ = 69.1915(5)°, and complex 2 in a monoclinic space group P21/n, with a = 10.1161(2) A, b = 9.9188(2) A, c = 13.3766(2) A, β = 102.7360(7)°. The X-ray structure analysis revealed that three platinum atoms in 1 are connected with three squarates which adopt bis(unidentate) binding modes. The squarato ligands span relatively long intramolecular Pt⋯Pt distances (4.8842(3)–5.2699(3) A). A pair of cis positioned isopropylamine ligands completes a square planar coordination sphere of each Pt(II) ion. The square–planar coordination of complex 2 consists of two cis positioned isopropylamine ligands and two nitrato ligands. The results of cytotoxicity assay of trimer 1, monomer 2 and cis-diamminedichloroplatinum(II) (cisplatin) performed on human bladder tumor cell line T24 provide evidence that complex 2 is less cytotoxic compared to cisplatin and that the survival of tumor cells after exposure to 1 was minimally reduced.
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Crystal structures and cytotoxicity of isopropylamine Pt(II) complexes: A trinuclear squarato-bridged [Pt3(μ2-C4O4)3(H2NPri)6] · 3H2O and a mononuclear cis-[Pt(NO3)2(H2NPri)2]
Journal of inorganic biochemistry, 2005Co-Authors: Sabina Grabner, Barbara Modec, Maja Čemažar, Natasa BukovecAbstract:Crystals of a novel platinum(II) complex with squarato ligand, [Pt(3)(mu(2)-C(4)O(4))(3)(H(2)NPr(i))(6)].3H(2)O (1) (H(2)NPr(i)=ipa), have been isolated from the aqueous solution of cis-[Pt(H(2)O)(2)(H(2)NPr(i))(2)]SO(4) and barium squarate. Slow evaporation of methanol solution of cis-[Pt(NO(3))(2)(H(2)NPr(i))(2)] (2) resulted in crystallization of nitrato complex. The single crystal X-ray diffraction method was used to determine structures of 1 and 2. Complex 1 crystallizes in a triclinic space group P1 with a=11.17380(10)A, b=14.4535(2)A, c=14.8010(2)A, alpha=86.0901(10) degrees , beta=78.4343(11) degrees , gamma=69.1915(5) degrees , and complex 2 in a monoclinic space group P2(1)/n, with a=10.1161(2)A, b=9.9188(2)A, c=13.3766(2)A, beta=102.7360(7) degrees . The X-ray structure analysis revealed that three platinum atoms in 1 are connected with three squarates which adopt bis(unidentate) binding modes. The squarato ligands span relatively long intramolecular Ptcdots, three dots, centeredPt distances (4.8842(3)-5.2699(3)A). A pair of cis positioned isopropylamine ligands completes a square planar coordination sphere of each Pt(II) ion. The square-planar coordination of complex 2 consists of two cis positioned isopropylamine ligands and two nitrato ligands. The results of cytotoxicity assay of trimer 1, monomer 2 and cis-diamminedichloroplatinum(II) (cisplatin) performed on human bladder tumor cell line T24 provide evidence that complex 2 is less cytotoxic compared to cisplatin and that the survival of tumor cells after exposure to 1 was minimally reduced.
Corine Mathonière - One of the best experts on this subject based on the ideXlab platform.
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Solvent-Triggered Cis/Trans Isomerism in Cobalt Dioxolene Chemistry: Distinguishing Effects of Packing on Valence Tautomerism.
Inorganic Chemistry, 2016Co-Authors: Anangamohan Panja, Narayan Ch Jana, Antonio Bauzá, Antonio Frontera, Corine MathonièreAbstract:In this article, the synthesis and X-ray crystal structures of two cis/trans isomers of valence tautomeric (VT) cobalt dioxolene compounds are reported. The cis isomer (1) was isolated from the polar protic methanol solvent as a kinetic product, whereas the less polar nonprotic solvent acetone yielded the trans isomer (2). It should be noted that, although some coordination polymers involving cobalt bis(dioxolene) with the cis disposition are known for bridging ancillary ligands, such an arrangement is unprecedented for mononuclear compounds. A careful study of intermocular interactions revealed that the methanol solvent does not have much influence on the crystal growth in 1, whereas acetone forms strong halogen-bonding interactions that are crucial in the solid-state architecture of 2. This behavior can likely be used in crystal engineering to design new organic-inorganic hybrid materials. The energy difference between the two isomers was examined using DFT calculations, confirming that the trans form is in the thermodynamic state whereas the cis isomer is a kinetic product that can be converted into the trans isomer with time. Finally, both isomers exhibit solvent loss at elevated temperatures that is accompanied by a change in magnetic properties, associated with an irreversible valence tautomerism. Our results highlight the crucial role of the solvents for the isolation of cis/trans isomers in cobalt dioxolene chemistry, as well as the distinguishing effects of intermolecular forces and the solid-state packing on VT behavior.
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solvent triggered cis trans isomerism in cobalt dioxolene chemistry distinguishing effects of packing on valence tautomerism
Inorganic Chemistry, 2016Co-Authors: Anangamohan Panja, Narayan Ch Jana, Antonio Bauzá, Antonio Frontera, Corine MathonièreAbstract:In this article, the synthesis and X-ray crystal structures of two cis/trans isomers of valence tautomeric (VT) cobalt dioxolene compounds are reported. The cis isomer (1) was isolated from the polar protic methanol solvent as a kinetic product, whereas the less polar nonprotic solvent acetone yielded the trans isomer (2). It should be noted that, although some coordination polymers involving cobalt bis(dioxolene) with the cis disposition are known for bridging ancillary ligands, such an arrangement is unprecedented for mononuclear compounds. A careful study of intermocular interactions revealed that the methanol solvent does not have much influence on the crystal growth in 1, whereas acetone forms strong halogen-bonding interactions that are crucial in the solid-state architecture of 2. This behavior can likely be used in crystal engineering to design new organic–inorganic hybrid materials. The energy difference between the two isomers was examined using DFT calculations, confirming that the trans form i...
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Solvent-Triggered Cis/Trans Isomerism in Cobalt Dioxolene Chemistry: Distinguishing Effects of Packing on Valence Tautomerism.
Inorganic Chemistry, 2016Co-Authors: Anangamohan Panja, Narayan Ch Jana, Antonio Bauzá, Antonio Frontera, Corine MathonièreAbstract:In this article, the synthesis and X-ray crystal structures of two cis/trans isomers of valence tautomeric (VT) cobalt dioxolene compounds are reported. The cis isomer (1) was isolated from the polar protic methanol solvent as a kinetic product, whereas the less polar nonprotic solvent acetone yielded the trans isomer (2). It should be noted that, although some coordination polymers involving cobalt bis(dioxolene) with the cis disposition are known for bridging ancillary ligands, such an arrangement is unprecedented for mononuclear compounds. A careful study of intermocular interactions revealed that the methanol solvent does not have much influence on the crystal growth in 1, whereas acetone forms strong halogen-bonding interactions that are crucial in the solid-state architecture of 2. This behavior can likely be used in crystal engineering to design new organic–inorganic hybrid materials. The energy difference between the two isomers was examined using DFT calculations, confirming that the trans form i...
Sabina Grabner - One of the best experts on this subject based on the ideXlab platform.
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crystal structures and cytotoxicity of isopropylamine pt ii complexes a trinuclear squarato bridged pt3 μ2 c4o4 3 h2npri 6 3h2o and a mononuclear cis pt no3 2 h2npri 2
Journal of Inorganic Biochemistry, 2005Co-Authors: Sabina Grabner, Barbara Modec, Maja Cemažar, Natasa BukovecAbstract:Abstract Crystals of a novel platinum(II) complex with squarato ligand, [Pt3(μ2-C4O4)3(H2NPri)6] · 3H2O (1) (H2NPri = ipa), have been isolated from the aqueous solution of cis-[Pt(H2O)2(H2NPri)2]SO4 and barium squarate. Slow evaporation of methanol solution of cis-[Pt(NO3)2(H2NPri)2] (2) resulted in crystallization of nitrato complex. The single crystal X-ray diffraction method was used to determine structures of 1 and 2. Complex 1 crystallizes in a triclinic space group P 1 ¯ with a = 11.17380(10) A, b = 14.4535(2) A, c = 14.8010(2) A, α = 86.0901(10)°, β = 78.4343(11)°, γ = 69.1915(5)°, and complex 2 in a monoclinic space group P21/n, with a = 10.1161(2) A, b = 9.9188(2) A, c = 13.3766(2) A, β = 102.7360(7)°. The X-ray structure analysis revealed that three platinum atoms in 1 are connected with three squarates which adopt bis(unidentate) binding modes. The squarato ligands span relatively long intramolecular Pt⋯Pt distances (4.8842(3)–5.2699(3) A). A pair of cis positioned isopropylamine ligands completes a square planar coordination sphere of each Pt(II) ion. The square–planar coordination of complex 2 consists of two cis positioned isopropylamine ligands and two nitrato ligands. The results of cytotoxicity assay of trimer 1, monomer 2 and cis-diamminedichloroplatinum(II) (cisplatin) performed on human bladder tumor cell line T24 provide evidence that complex 2 is less cytotoxic compared to cisplatin and that the survival of tumor cells after exposure to 1 was minimally reduced.
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Crystal structures and cytotoxicity of isopropylamine Pt(II) complexes: A trinuclear squarato-bridged [Pt3(μ2-C4O4)3(H2NPri)6] · 3H2O and a mononuclear cis-[Pt(NO3)2(H2NPri)2]
Journal of inorganic biochemistry, 2005Co-Authors: Sabina Grabner, Barbara Modec, Maja Čemažar, Natasa BukovecAbstract:Crystals of a novel platinum(II) complex with squarato ligand, [Pt(3)(mu(2)-C(4)O(4))(3)(H(2)NPr(i))(6)].3H(2)O (1) (H(2)NPr(i)=ipa), have been isolated from the aqueous solution of cis-[Pt(H(2)O)(2)(H(2)NPr(i))(2)]SO(4) and barium squarate. Slow evaporation of methanol solution of cis-[Pt(NO(3))(2)(H(2)NPr(i))(2)] (2) resulted in crystallization of nitrato complex. The single crystal X-ray diffraction method was used to determine structures of 1 and 2. Complex 1 crystallizes in a triclinic space group P1 with a=11.17380(10)A, b=14.4535(2)A, c=14.8010(2)A, alpha=86.0901(10) degrees , beta=78.4343(11) degrees , gamma=69.1915(5) degrees , and complex 2 in a monoclinic space group P2(1)/n, with a=10.1161(2)A, b=9.9188(2)A, c=13.3766(2)A, beta=102.7360(7) degrees . The X-ray structure analysis revealed that three platinum atoms in 1 are connected with three squarates which adopt bis(unidentate) binding modes. The squarato ligands span relatively long intramolecular Ptcdots, three dots, centeredPt distances (4.8842(3)-5.2699(3)A). A pair of cis positioned isopropylamine ligands completes a square planar coordination sphere of each Pt(II) ion. The square-planar coordination of complex 2 consists of two cis positioned isopropylamine ligands and two nitrato ligands. The results of cytotoxicity assay of trimer 1, monomer 2 and cis-diamminedichloroplatinum(II) (cisplatin) performed on human bladder tumor cell line T24 provide evidence that complex 2 is less cytotoxic compared to cisplatin and that the survival of tumor cells after exposure to 1 was minimally reduced.
Minkyu Song - One of the best experts on this subject based on the ideXlab platform.
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ISCAS - A one-shot digital correlated double sampling with a differential difference amplifier for a high speed CMOS image sensor
2015 IEEE International Symposium on Circuits and Systems (ISCAS), 2015Co-Authors: Shiwon Jeon, Seol Namgung, Minkyu SongAbstract:In order to raise the operating speed of a CMOS image sensor (CIS), a new technique of digital correlated double sampling (CDS) is described. In general, a fixed pattern noise (FPN) of a CIS has been reduced with the subtraction algorithm between the reset signal and pixel signal. This is because a single-slope analog-to-digital converter (ADC) has been normally adopted in the conventional digital CDS with the reset ramp and signal ramp. Thus, the operating speed of a digital CDS is much slower than that of an analog CDS. In order to improve the operating speed, we propose a one-shot digital CDS based on a differential difference amplifier (DDA) that compares the reset signal and the pixel signal using only one ramp. The prototype CIS has been fabricated with 0.13μm CIS technology and it has the VGA resolution of 640×480. The measured conversion time is 16 μs, and a high frame rate of 131fps is achieved at the VGA resolution.
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A High Speed CMOS Image Sensor with a Novel Digital Correlated Double Sampling and a Differential Difference Amplifier
Sensors, 2015Co-Authors: Minkyu SongAbstract:In order to increase the operating speed of a CMOS image sensor (CIS), a new technique of digital correlated double sampling (CDS) is described. In general, the fixed pattern noise (FPN) of a CIS has been reduced with the subtraction algorithm between the reset signal and pixel signal. This is because a single-slope analog-to-digital converter (ADC) has been normally adopted in the conventional digital CDS with the reset ramp and signal ramp. Thus, the operating speed of a digital CDS is much slower than that of an analog CDS. In order to improve the operating speed, we propose a novel digital CDS based on a differential difference amplifier (DDA) that compares the reset signal and the pixel signal using only one ramp. The prototype CIS has been fabricated with 0.13 µm CIS technology and it has the VGA resolution of 640 × 480. The measured conversion time is 16 µs, and a high frame rate of 131 fps is achieved at the VGA resolution.
Kazuhiro Yoshioka - One of the best experts on this subject based on the ideXlab platform.
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o 012 utilization of blood sampling global oxygen extraction fraction to anticipate cerebral hyperfusion syndrome following elective carotid artery stenting
Journal of NeuroInterventional Surgery, 2015Co-Authors: Takahisa Mori, Tomonori Iwata, Shigen Kasakura, Y Tannoo, Kazuhiro YoshiokaAbstract:Background It is required to anticipate cerebral hyperperfusion syndrome (CHS) following elective carotid artery stenting (eCAS). Purpose The purpose of our retrospective study was to investigate whether or not blood sampling oxygen extraction fraction (OEF) had relation to CHS following eCAS. Methods Included in our analysis were patients (1) who underwent eCAS in our institution between October 2010 and May 2014, and (2) who underwent blood sampling for OEF calculation just before and immediately after eCAS, and (3) who underwent SPECT before and just after eCAS. OEF was calculated from cerebral arteriovenous oxygen difference. Arterial blood was sampled from the common carotid artery and venous blood from the dominant-sided superior jugular bulb. CHS was defined as restlessness or altered level of conscious in addition to classical triad of headache, seizure or neurological symptoms not due to cerebral ischemia within seven days following CAS. CBF was measured before and just after eCAS. CBF increase in the eCAS side was defined as follows; (post-CAS CBF ratio - pre-CAS CBF ratio) of more than 10%, where CBF ratio was defined as CBF in the CAS-sided MCA territory divided by ipsilateral cerebellar CBF (%). Evaluated were baseline features in patients, pre-CAS OEF, post-CAS OEF, CBF ratio, CBF increase and the incidence of CHS. Results Median pre-CAS OEF and post-CAS OEF were 0.41 and 0.42, respectively. Nine patients presented CHS. Scattergrams of the two groups with CHS and without CHS showed that the cut-off values of the pre-CAS OEF, the post-CAS OEF, the pre-CAS CBF ratio and the increase of CBF ratio to anticipate CHS were more than 0.46 (p Conclusion Elevation of blood sampling pre-CAS or post-CAS OEF can anticipate CHS following eCAS. Disclosures T. Mori: 2; C; Kaneka Medix. 6; C; Medikit. T. Iwata: None. Y. Tannoo: None. S. Kasakura: None. K. Yoshioka: None.
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abstract w p115 utilization of blood sampling global oxygen extraction fraction and spect to anticipate cerebral hyperperfusion syndrome following elective carotid artery stenting
Stroke, 2015Co-Authors: Takahisa Mori, Tomonori Iwata, Yuhei Tanno, Shigen Kasakura, Yoshinori Aoyagi, Kazuhiro YoshiokaAbstract:Background: It is required to anticipate cerebral hyperperfusion syndrome (CHS) following carotid artery stenting (CAS). Purpose: The purpose of our retrospective study was to investigate whether or not blood sampling oxygen extraction fraction (OEF) and post-CAS CBF increase in SPECT had relation to CHS following CAS. Methods: Included in our analysis were patients (1) who underwent elective CAS in our institution between October 2010 and May 2014, and (2) who underwent blood sampling for OEF calculation before and immediately after CAS, and (3) who underwent SPECT before and just after CAS. OEF was calculated from cerebral arteriovenous oxygen difference. Arterial blood was sampled from the common carotid artery and venous blood from the dominant-sided superior jugular bulb. CHS was defined as pulsatile headaches, restlessness, convulsion, and/or new neurological symptoms not due to cerebral ischemia within seven days following CAS. CBF was measured before and just after CAS. CBF increase in the CAS side was defined as follows; (post-CAS CBF ratio - pre-CAS CBF ratio) of more than 10%, where CBF ratio was defined as CAS-sided fronto-parietal CBF divided by ipsilateral cerebellar CBF (%). Evaluated were baseline features in patients, pre-CAS OEF, post-CAS OEF, CBF ratio, CBF increase and CHS. Results: During the study period, 134 patients matched our criteria for analysis. Pre-CAS OEF was 0.41+-0.06, post-CAS OEF was 0.42+-0.08, pre-CAS CBF ratio: 88.7+-15.4%, CBF increase: 1.86+-12.3%. Nine patients presented CHS. Among them, pre-CAS OEF, CBF ratio and CBF increase were significant. ROC curves showed that pre-CAS OEF of 0.46 (p Conclusion: Elevation of pre-CAS OEF and increase of post-CAS CBF were strongly related to CHS.