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Tseng-tong Kuo - One of the best experts on this subject based on the ideXlab platform.

  • Clear Cell Acanthoma cca like lesions of the nipple areola a clinicopathological study of 12 cases supporting a nonneoplastic eczematous disease
    Journal of The American Academy of Dermatology, 2019
    Co-Authors: Kang-ling Kuo, Li-yu Lee, Chih-hsun Yang, Tseng-tong Kuo
    Abstract:

    Background Clear Cell Acanthoma (CCA) of the nipple/areola has been reported. The CCA-like histology more likely represents a feature of eczematous dermatitis of the nipple/areola. Objective We reviewed cases of CCA-like lesions of the nipple/areola and compared them with classic CCA to clarify their relationship. Methods The clinicopathological features of 12 cases of CCA-like lesions of the nipple/areola were compared with classic CCA. The literature on this condition was reviewed, and the results of various treatments were analyzed. Results CCA-like lesions of the nipple/areola were clinically different from those of classic CCA. Although they shared the glycogen-rich Clear epidermal Cells with neutrophilic exocytosis, dermal eosinophils appeared to be a distinctive feature. The anatomic site and association with atopic dermatitis suggested that CCA-like lesions of nipple/areola might represent a manifestation of atopic eczema involving nipple/areola. Topical steroids could be effective. Limitations This was a retrospective study with limited cases. Conclusions Although CCA-like lesions of the nipple/areola shared histopathological features with classic CCA, their clinical changes were consistent with dermatitis. We propose to name this condition CCA-like eczematous dermatitis of the nipple/areola.

  • Clear Cell Acanthoma (CCA)-like lesions of the nipple/areola: A clinicopathological study of 12 cases supporting a nonneoplastic eczematous disease.
    Journal of the American Academy of Dermatology, 2019
    Co-Authors: Kang-ling Kuo, Li-yu Lee, Chih-hsun Yang, Tseng-tong Kuo
    Abstract:

    Background Clear Cell Acanthoma (CCA) of the nipple/areola has been reported. The CCA-like histology more likely represents a feature of eczematous dermatitis of the nipple/areola. Objective We reviewed cases of CCA-like lesions of the nipple/areola and compared them with classic CCA to clarify their relationship. Methods The clinicopathological features of 12 cases of CCA-like lesions of the nipple/areola were compared with classic CCA. The literature on this condition was reviewed, and the results of various treatments were analyzed. Results CCA-like lesions of the nipple/areola were clinically different from those of classic CCA. Although they shared the glycogen-rich Clear epidermal Cells with neutrophilic exocytosis, dermal eosinophils appeared to be a distinctive feature. The anatomic site and association with atopic dermatitis suggested that CCA-like lesions of nipple/areola might represent a manifestation of atopic eczema involving nipple/areola. Topical steroids could be effective. Limitations This was a retrospective study with limited cases. Conclusions Although CCA-like lesions of the nipple/areola shared histopathological features with classic CCA, their clinical changes were consistent with dermatitis. We propose to name this condition CCA-like eczematous dermatitis of the nipple/areola.

  • Malignant Clear Cell Acanthoma: Report of a Rare Case of Clear Cell Acanthoma-Like Tumor With Malignant Features.
    The American Journal of Dermatopathology, 2016
    Co-Authors: Chien-yio Lin, Li-yu Lee, Tseng-tong Kuo
    Abstract:

    An erythematous and moist tumor nodule on the left temple of a 92-year-old woman was biopsied and identified as a Clear Cell Acanthoma (CCA)-like tumor with malignant cytology and high proliferation activity. This case is similar to 2 cases reported previously as atypical CCA. The authors believe that these tumors are malignant counterparts of CCA and propose to call them malignant CCA. The clinicopathologic features of the present case are described along with dermoscopic findings.

  • Urachal duct remnant-like umbilical Clear Cell Acanthoma in an infant: an unusual presentation and pitfall in clinical practice.
    International Journal of Dermatology, 2007
    Co-Authors: Hsiu-cheng Hsu, Tseng-tong Kuo, Chih-hsun Yang, I-hsin Shih, Hong-shang Hong
    Abstract:

    Background  Although an umbilical nodule is common in neonates and young infants, an umbilical nodule of poor therapeutic response will increase the likelihood of other uncommon etiology. Clear Cell Acanthoma (CCA) has never been described as an oozing umbilical nodule on infants. Methods  To present a case of CCA which occurred on an 8-month-old female infant presenting with one weeping nodule on the umbilicus since early neonate. The lesion underwent skin biopsy and subsequent hematoxylin-eosin and periodic acid-Schiff staining. Result  Three courses of liquid nitrogen cryosurgery were performed after the diagnosis of CCA was confirmed. The lesion resolved rapidly. Conclusion  This report presents the first and youngest case of umbilical CCA in the English literature. This case supports the inflammatory dermatosic nature of CCA.

Ioannis G Koutlas - One of the best experts on this subject based on the ideXlab platform.

  • Pale (Clear) Cell Acanthoma of the Palate
    Head and Neck Pathology, 2019
    Co-Authors: Prokopios P Argyris, Dan Ho, Andrew C. Nelson, Ioannis G Koutlas
    Abstract:

    Clear Cell Acanthoma (CCA), also known as pale Cell Acanthoma, represents a rare benign epidermal tumor with strong predilection for the lower extremities of middle-aged individuals and no frank gender preference. The etiology of CCA is poorly understood, although a localized psoriasiform reaction is favored. Herein, we report on the clinicopathologic and immunohistochemical features, and HPV status of an apparent example of oral CCA. A 58-year-old female presented with a well-circumscribed, asymptomatic, exophytic, sessile and erythematous nodule of the right hard palate, measuring 0.7 cm in greatest dimension. Microscopically, the lesion featured parakeratosis and acanthosis with neutrophilic microabscesses and broad elongated rete pegs. In areas, spinous epithelial Cells exhibited pale or Clear cytoplasm without nuClear pleomorphism, mitoses or cytologic atypia. The supporting connective tissue revealed mild chronic inflammation with few scattered neutrophils and numerous capillary vessels. PAS histochemical stain with and without diastase disclosed the presence of cytoplasmic glycogen in the pale Cells. The majority of glycogen-rich epithelial Cells stained strongly for EMA and were negative for D2-40. Ki-67 immunostaining was confined only to the basal Cell layer of the epithelium. A diagnosis of CCA was rendered. The lesion was negative for human papillomavirus (HPV) infection, as assessed by HPV-DNA PCR using the MY09/11 primers for the L1 conserved region, thus HPV infection does not appear to contribute to the pathogenesis of oral CCA. In conclusion, we report an intraoral example of CCA in order to raise awareness about this entity.

Kang-ling Kuo - One of the best experts on this subject based on the ideXlab platform.

  • Clear Cell Acanthoma cca like lesions of the nipple areola a clinicopathological study of 12 cases supporting a nonneoplastic eczematous disease
    Journal of The American Academy of Dermatology, 2019
    Co-Authors: Kang-ling Kuo, Li-yu Lee, Chih-hsun Yang, Tseng-tong Kuo
    Abstract:

    Background Clear Cell Acanthoma (CCA) of the nipple/areola has been reported. The CCA-like histology more likely represents a feature of eczematous dermatitis of the nipple/areola. Objective We reviewed cases of CCA-like lesions of the nipple/areola and compared them with classic CCA to clarify their relationship. Methods The clinicopathological features of 12 cases of CCA-like lesions of the nipple/areola were compared with classic CCA. The literature on this condition was reviewed, and the results of various treatments were analyzed. Results CCA-like lesions of the nipple/areola were clinically different from those of classic CCA. Although they shared the glycogen-rich Clear epidermal Cells with neutrophilic exocytosis, dermal eosinophils appeared to be a distinctive feature. The anatomic site and association with atopic dermatitis suggested that CCA-like lesions of nipple/areola might represent a manifestation of atopic eczema involving nipple/areola. Topical steroids could be effective. Limitations This was a retrospective study with limited cases. Conclusions Although CCA-like lesions of the nipple/areola shared histopathological features with classic CCA, their clinical changes were consistent with dermatitis. We propose to name this condition CCA-like eczematous dermatitis of the nipple/areola.

  • Clear Cell Acanthoma (CCA)-like lesions of the nipple/areola: A clinicopathological study of 12 cases supporting a nonneoplastic eczematous disease.
    Journal of the American Academy of Dermatology, 2019
    Co-Authors: Kang-ling Kuo, Li-yu Lee, Chih-hsun Yang, Tseng-tong Kuo
    Abstract:

    Background Clear Cell Acanthoma (CCA) of the nipple/areola has been reported. The CCA-like histology more likely represents a feature of eczematous dermatitis of the nipple/areola. Objective We reviewed cases of CCA-like lesions of the nipple/areola and compared them with classic CCA to clarify their relationship. Methods The clinicopathological features of 12 cases of CCA-like lesions of the nipple/areola were compared with classic CCA. The literature on this condition was reviewed, and the results of various treatments were analyzed. Results CCA-like lesions of the nipple/areola were clinically different from those of classic CCA. Although they shared the glycogen-rich Clear epidermal Cells with neutrophilic exocytosis, dermal eosinophils appeared to be a distinctive feature. The anatomic site and association with atopic dermatitis suggested that CCA-like lesions of nipple/areola might represent a manifestation of atopic eczema involving nipple/areola. Topical steroids could be effective. Limitations This was a retrospective study with limited cases. Conclusions Although CCA-like lesions of the nipple/areola shared histopathological features with classic CCA, their clinical changes were consistent with dermatitis. We propose to name this condition CCA-like eczematous dermatitis of the nipple/areola.

Eduardo Lopez Bran - One of the best experts on this subject based on the ideXlab platform.

  • Bilateral Clear Cell Acanthoma of the areola and nipple: good response to topical corticosteroids.
    Anais brasileiros de dermatologia, 2017
    Co-Authors: Elena González-guerra, Jorge Ruiz Rodriguez, Alejandro Fueyo Casado, Alberto Conde Taboada, Jose Antonio Cortes Toro, Eduardo Lopez Bran
    Abstract:

    Clear Cell Acanthoma is a rare, epidermal tumor not common in the area of the nipples; indeed, the literature describes only 8 cases, all showing unilateral presentation. We here report the first case of bilateral Clear Cell Acanthoma with good response to topical corticosteroids. A sixteen-year old girl presented with 2 excrescent, fleshy, and exudative tumor masses in both nipples and areola mammae. A biopsy was conducted and confirmed Clear Cell Acanthoma histopathologically. Treatment with strong corticosteroids resulted in rapid improvement and resolution. After one year of follow-up, the patient developed atopic dermatitis. We describe the first case of bilateral Clear Cell Acanthoma localized in the nipple/areola that resolved with powerful corticosteroids, suggesting a reactive etiology of the lesion.

  • Bilateral Clear Cell Acanthoma of the areola and nipple: good response to topical corticosteroids.
    Anais Brasileiros De Dermatologia, 2017
    Co-Authors: Elena González-guerra, Jorge Ruiz Rodriguez, Alejandro Fueyo Casado, Alberto Conde Taboada, Jose Antonio Cortes Toro, Eduardo Lopez Bran
    Abstract:

    Clear Cell Acanthoma is a rare, epidermal tumor not common in the area of the nipples; indeed, the literature describes only 8 cases, all showing unilateral presentation. We here report the first case of bilateral Clear Cell Acanthoma with good response to topical corticosteroids. Case report: A sixteen-year old girl presented with 2 excrescent, fleshy, and exudative tumor masses in both nipples and areola mammae. A biopsy was conducted and confirmed Clear Cell Acanthoma histopathologically. Treatment with strong corticosteroids resulted in rapid improvement and resolution. After one year of follow-up, the patient developed atopic dermatitis. Discussion: We describe the first case of bilateral Clear Cell Acanthoma localized in the nipple/areola that resolved with powerful corticosteroids, suggesting a reactive etiology of the lesion

C. Crosti - One of the best experts on this subject based on the ideXlab platform.

  • Successful cryotherapic treatment and overview of multiple Clear Cell Acanthomas
    'Elsevier BV', 1995
    Co-Authors: R. Betti, C. Bruscagin, E. Inselvini, M. Palvarini, C. Crosti
    Abstract:

    Clear Cell Acanthoma (CCA) is a usually solitary benign epidermal-tumor. Multiple lesions are infrequently reported

  • Successful cryotherapic treatment and overview of multiple Clear Cell Acanthomas
    Dermatologic Surgery, 1995
    Co-Authors: R. Betti, C. Bruscagin, E. Inselvini, M. Palvarini, C. Crosti
    Abstract:

    BACKGROUND Clear Cell Acanthoma (CCA) is a usually solitary benign epidermal tumor. Multiple lesions are infrequently reported. OBJECTIVE A case of multiple eruptive CCA is reported in which a successful cryotherapic treatment was performed. METHODS A 59-year-old man with varicose veins and dry skin presented with 17 eruptive asymptomatic papulonodular lesions on both legs. RESULTS Two lesions were excised with a histologically confirmed diagnosis of CCA. Other lesions were treated with liquid nitrogen. All the lesions resolved with minimal residual scarring after three to four treatments. CONCLUSIONS Multiple CCA is a rare condition; fewer than 20 cases having been described. The presence of associated conditions like dry skin and varicose veins are discussed. Because of the tendency of persistence of the lesions, cryotherapic treatment may be a useful method of therapy.