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Timothy Clive Marrs - One of the best experts on this subject based on the ideXlab platform.
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The efficacy and adverse effects of diCobalt edetate in cyanide poisoning.
Clinical toxicology (Philadelphia Pa.), 2016Co-Authors: Timothy Clive Marrs, John Paul ThompsonAbstract:AbstractIntroduction: DiCobalt edetate is one of a number of Cobalt Compounds that have been studied in the treatment of cyanide poisoning, their efficacy being based upon the fact that cyanide combines with Cobalt to form relatively non-toxic complexes. Inorganic Cobalt salts are quite toxic (cyanide and Cobalt antagonise one another's toxicity) and complexes such as diCobalt edetate were studied with the aim of identifying Compounds that were less acutely toxic, but which retained the antidotal properties of Cobalt salts. The proprietary preparation, Kelocyanor™, contains free Cobalt and glucose as well as diCobalt edetate.Objective: The aim of this study was to evaluate the published evidence for the efficacy and adverse effects of diCobalt edetate.Methods: A Pubmed search was undertaken for the period 1961–September 2015. The search terms were “diCobalt edetate”, “Cobalt edetate” and “Kelocyanor”, which produced 24 relevant citations. A review of the references in four relevant books (L'intoxication c...
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Hydroxocobalamin in cyanide poisoning.
Clinical Toxicology, 2012Co-Authors: John P. Thompson, Timothy Clive MarrsAbstract:Introduction. On theoretical grounds, hydroxocobalamin is an attractive antidote for cyanide poisoning as Cobalt Compounds have the ability to bind and detoxify cyanide. This paper reviews the pharmacokinetic and pharmacodynamic aspects of hydroxocobalamin, its efficacy in human cyanide poisoning and its adverse effects. Methods. PubMed was searched for the period 1952 to April 2012. A total of 71 papers were identified in this way; and none was excluded. Pharmacokinetics and pharmacodynamics. Pharmacokinetic studies in dogs and humans suggest a two-compartment model, with first order elimination kinetics. Pharmacodynamic studies in animals suggest that hydroxocobalamin would be a satisfactory antidote for human cyanide poisoning. Efficacy in human poisoning. There is limited evidence that hydroxocobalamin alone is effective in severe poisoning by cyanide salts. The evidence for the efficacy of hydroxocobalamin in smoke inhalation is complicated by lack of evidence for the importance of cyanide exposure i...
Cedric Desroches - One of the best experts on this subject based on the ideXlab platform.
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polynuclear complex family of Cobalt ii sulfonylcalixarene one pot synthesis of cluster salt co 14 ii co 4 ii and field induced slow magnetic relaxation in a six coordinate dinuclear Cobalt ii sulfonylcalixarene complex
Inorganic Chemistry, 2014Co-Authors: Meriem Lamouchi, Erwann Jeanneau, Ghenadie Novitchi, Dominique Luneau, Arnaud Brioude, Cedric DesrochesAbstract:In this paper, we report the synthesis and description of a new family of polynuclear Cobalt(II) complexes. Starting from the same initial Compounds but varying the reaction time results in the formation of several new clusters, an original structure based on [Co14][Co4] clusters was obtained, representing the first one-pot synthesis of a Cobalt aggregate salt reported in the literature. The synthesis and magnetic properties of these Cobalt Compounds are discussed. Three of them display a binuclear molecular structure (1–3) with two encapsulated CoII ions and show slow relaxation of magnetization at small applied magnetic field (Ueff = 10.7 K for 2 and Ueff = 20.3 K for 3), a characteristic of single-molecule-magnet materials.
Yaping Gong - One of the best experts on this subject based on the ideXlab platform.
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three new d10 transition metal selenites containing po4 tetrahedron cd7 hpo4 2 po4 2 seo3 2 cd6 po4 1 34 seo3 4 66 and zn3 hpo4 seo3 2 h2o
Journal of Solid State Chemistry, 2018Co-Authors: Jiang-gao Mao, Yaping Gong, Fang KongAbstract:Abstract Three new d10 transition metal selenites containing PO4 tetrahedron, namely, Cd7(HPO4)2(PO4)2(SeO3)2 (1), Cd6(PO4)1.34(SeO3)4.66 (2) and Zn3(HPO4)(SeO3)2(H2O) (3), have been synthesized by hydrothermal reaction. They feature three different structural types. Compound 1 exhibits a novel 3D network composed of 3D cadmium selenite open framework with phosphate groups filled in the 1D helical tunnels. The structure of compound 2 displays a new 3D framework consisted of 2D cadmium oxide layers bridged by SeO3 and PO4 groups. Compound 3 is isostructural with the reported solids of Co3(SeO3)3-x(PO3OH)x(H2O) when x is equal to 1.0. Its structure could be viewed as a 3D zinc oxide open skeleton with SeO3 and HPO4 polyhedra attached on the wall of the tunnels. They represent the only examples in metal selenite phosphates in addition to the above Cobalt Compounds. Optical diffuse reflectance spectra revealed that these solids are insulators, which are consistent with the results of band structure computations based on DFT algorithm.
Jinghua Guo - One of the best experts on this subject based on the ideXlab platform.
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influence of crystal structure ligand environment and morphology on co l edge xas spectral characteristics in Cobalt Compounds
Journal of Synchrotron Radiation, 2015Co-Authors: Debajeet K Bora, X Cheng, Mukes Kapilashrami, Peranders Glans, Yi Luo, Jinghua GuoAbstract:The electronic structure of a material plays an important role in its functionality for different applications which can be probed using synchrotron-based spectroscopy techniques. Here, various Cobalt-based Compounds, differing in crystal structure, ligands surrounding the central metal ion and morphology, have been studied by soft X-ray absorption spectroscopy (XAS) at the Co L-edge in order to measure the effect of these parameters on the electronic structure. A careful qualitative analysis of the spectral branching ratio and relative intensities of the L3 and L2 peaks provide useful insight into the electronic properties of Compounds such as CoO/Co(OH)2, CoCl2.6H2O/CoF2.4H2O, CoCl2/CoF2, Co3O4 (bulk/nano/micro). For further detailed analysis of the XAS spectra, quantitative analysis has been performed by fitting the spectral profile with simulated spectra for a number of Cobalt Compounds using crystal field atomic multiplet calculations.
Vassil Skumryev - One of the best experts on this subject based on the ideXlab platform.
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Why the iron magnetization in Gd2Fe14B and the spontaneous magnetization of Y2Fe14B depend on temperature differently
Journal of Applied Analysis, 2009Co-Authors: Michael Kuz'min, Dominique Givord, Vassil SkumryevAbstract:It is demonstrated that the temperature dependence of the iron sublattice magnetization in Gd2Fe14B is affected significantly by the Gd-Fe exchange interaction. This is at variance with the common perception that MFe T in iron-rich rare-earth intermetallics is determined predominantly by the Fe-Fe exchange. This phenomenon is discussed by considering the modification of the low-energy spin-wave spectrum of Gd2Fe14B, as compared to that of Y2Fe14B, under the influence of the Gd-Fe interaction. The result is of particular significance for evaluating the temperature dependence of the magnetocrystalline anisotropy of iron or Cobalt Compounds with anisotropic rare earths e.g., Nd2Fe14B and in turn, of the hard magnetic properties of such Compounds.