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David G. Hewett - One of the best experts on this subject based on the ideXlab platform.
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Assessment of Colorectal Polyp recognition skill: development and validation of an objective test
Surgical Endoscopy, 2017Co-Authors: Andrew Hill, Mark S. Horswill, Annaliese M. Plooy, Marcus O. Watson, Lachlan N. Rowlands, Guy M. Wallis, Stephan Riek, Robin Burgess-limerick, David G. HewettAbstract:Background The quality of colonoscopy is known to vary. The extent to which colonoscopists can recognize the presence of subtle Colorectal lesions by visually distinguishing them from the surrounding mucosa (i.e., Polyp recognition skill ) may be one of several attributes that influence Polyp detection rates. The aim of the present study was to develop and validate the first objective test of Polyp recognition skill. Methods Validation study. Twenty-eight experienced colonoscopists and eighty novices took a preliminary 280-item computer-based Polyp recognition test. Items were genuine endoscopic images which participants assessed for the presence of “likely Polyps.” Half included clinically identified Polyps. Participants clicked on a suspected lesion or a button marked “no likely Polyp”, and the main outcome measures were accuracy and response latency. The best items were selected for the final 50-item test. Results In the preliminary test, experienced colonoscopists correctly identified more Polyps than novices ( P
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assessment of Colorectal Polyp recognition skill development and validation of an objective test
Surgical Endoscopy and Other Interventional Techniques, 2017Co-Authors: Andrew Hill, Mark S. Horswill, Annaliese M. Plooy, Lachlan N. Rowlands, Stephan Riek, Marcus Watson, Guy Wallis, Robin Burgesslimerick, David G. HewettAbstract:Background The quality of colonoscopy is known to vary. The extent to which colonoscopists can recognize the presence of subtle Colorectal lesions by visually distinguishing them from the surrounding mucosa (i.e., Polyp recognition skill) may be one of several attributes that influence Polyp detection rates. The aim of the present study was to develop and validate the first objective test of Polyp recognition skill.
Wei Zheng - One of the best experts on this subject based on the ideXlab platform.
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associations between dietary fiber and Colorectal Polyp risk differ by Polyp type and smoking status
Journal of Nutrition, 2014Co-Authors: Martha J Shrubsole, Walter E Smalley, Reid M Ness, Zhenming Fu, Wei ZhengAbstract:The association of dietary fiber intake with Colorectal cancer risk is established. However, the association may differ between cigarette smokers and nonsmokers. We evaluated this hypothesis in a large colonoscopy-based case-control study. Dietary fiber intakes were estimated by self-administered food frequency questionnaire. Unconditional logistic regression analysis was used to estimate ORs and 95% CIs with adjustment for potential confounders. Analysis also was stratified by cigarette smoking and sex. High dietary fiber intake was associated with reduced risk of Colorectal Polyps (P-trend = 0.003). This association was found to be stronger among cigarette smokers (P-trend = 0.006) than nonsmokers (P-trend = 0.21), although the test for multiplicative interaction was not statistically significant (P = 0.11). This pattern of association was more evident for high-risk adenomatous Polyps (ADs), defined as advanced or multiple ADs (P-interaction smoking and dietary fiber intake = 0.09). Among cigarette smokers who smoked ≥23 y, a 38% reduced risk of high-risk ADs was found to be associated with high intake of dietary fiber compared with those in the lowest quartile fiber intake group (P-trend = 0.004). No inverse association with dietary fiber intake was observed for low-risk ADs, defined as single nonadvanced ADs. Cigarette smoking may modify the association of dietary fiber intake with the risk of Colorectal Polyps, especially high-risk ADs, a well-established precursor of Colorectal cancer.
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abstract 1674 two phase study of kcnj1 polymorphisms calcium magnesium and Colorectal adenoma risk results from the tennessee Colorectal Polyp study
Cancer Research, 2012Co-Authors: Martha J Shrubsole, Jirong Long, Walter E Smalley, Reid M Ness, Todd L Edwards, Zhi Chen, Xinqing Deng, Wei ZhengAbstract:Background: Previous studies generated inconsistent results on the associations between intakes of calcium and magnesium with risk of Colorectal adenoma and cancer. It is possible that some of the inconsistency is due to a modifying effect by genetic polymorphisms involved in calcium and magnesium homeostasis. The KCNJ1 gene encodes the Inward-rectifier potassium channel (ROMK). ROMK plays an essential role in the homeostasis of potassium, which is critical for the reabsorption of calcium and magnesium. Objectives: We hypothesize that common variants in KCNJ1 may modify the associations between intakes of calcium and/or magnesium and risk of Colorectal adenoma risk. Methods: Included were participants of the Tennessee Colorectal Polyp Study (TCPS), a colonoscopy-based case control study conducted in Nashville, TN. In the phase I study, genotyping was performed using the Affymetrix Human Mapping 500K array set in 958 Colorectal adenoma cases and 909 controls and 13 tagging single-nucleotide polymorphisms (SNPs) in the KCNJ1 gene were evaluated. SNPs identified as significant in phase I were genotyped in phase II in an independent set (860 cases and 3083 controls). Results: In phase I, 1 tagging SNP was significantly associated with adenoma risk and 8 SNPs were interacted significantly with calcium or magnesium intake in risk of Colorectal adenoma. In phase II, only 1 of the 9 SNPs significantly interacted with calcium and magnesium intakes in relation to Colorectal adenoma although the genotype per se was not directly associated with the risk. In combined analysis, the p value for the interaction between the SNP and calcium intake was 0.00015 and it remained statistically significant after Bonferroni correction for multiple comparisons. In stratified analyses by levels of calcium and magnesium (above or below RDA levels), we found adenoma risk significantly increased for those who with at least 1 variant allele and whose intake levels of calcium and magnesium were below the RDA levels, with ORs (95% CI) of 1.35 (1.10, 1.67) and 1.43 (1.08, 1.89) respectively, compared to those who did not possess the variant allele. The corresponding ORs (95% CI) increased to 1.84 (1.33, 2.53) and 2.30 (1.53, 3.46), respectively, multiple adenomas versus controls. Conclusions: In this two-stage analysis, we found no overall association of adenoma with KCNJ1 genotype. However, common KCNJ1 variants significantly interacted with intakes of calcium and magnesium in risk of Colorectal adenoma, particular for multiple adenomas. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1674. doi:1538-7445.AM2012-1674
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dietary intake of pufas and Colorectal Polyp risk
The American Journal of Clinical Nutrition, 2012Co-Authors: Harvey J Murff, Martha J Shrubsole, Walter E Smalley, Reid M Ness, Ginger L Milne, Wei ZhengAbstract:Background: Marine-derived n−3 (omega-3) PUFAs may reduce risk of developing Colorectal cancer; however, few studies have investigated the association of n−3 PUFA intakes on Colorectal Polyp risk. Objective: The objective of this study was to examine the associations of dietary PUFA intake on risk of Colorectal adenomatous and hyperplastic Polyps. Design: This was a colonoscopy-based case-control study that included 3166 Polyp-free control subjects, 1597 adenomatous Polyp cases, and 544 hyperplastic Polyp cases. Dietary PUFA intake was calculated from food-frequency questionnaires and tested for association by using unconditional logistic regression. The urinary prostaglandin E2 metabolite, which is a biomarker of prostaglandin E2 production, was measured in 896 participants by using liquid chromatography and tandem mass spectrometry. Results: n−6 PUFAs were not associated with adenomatous or hyperplastic Polyps in either men or women. Marine-derived n−3 PUFAs were associated with reduced risk of Colorectal adenomas in women only, with an adjusted OR of 0.67 (95% CI: 0.47, 0.97) for the highest quintile of intake compared with the lowest quintile of intake (P-trend = 0.01). Dietary intake of α-linolenic acid was associated with an increased risk of hyperplastic Polyps in men (P-trend = 0.03), which was not seen in women. In women, but not in men, dietary intake of marine-derived n−3 PUFAs was negatively correlated with urinary prostaglandin E2 production (r = −0.18; P = 0.002). Conclusion: Higher intakes of marine-derived n−3 PUFAs are associated with lower risk of adenomatous Polyps in women, and the association may be mediated in part through a reduction in the production of prostaglandin E2. This trial was registered at clinicaltrials.gov as NCT00625066.
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abstract 3763 calcium intake cabp1 polymorphisms and the risk of Colorectal adenoma results from tennessee Colorectal Polyp study
Cancer Research, 2011Co-Authors: Martha J Shrubsole, Jirong Long, Walter E Smalley, Reid M Ness, Todd L Edwards, Zhi Chen, Xinqing Deng, Wei ZhengAbstract:Background: High calcium consumption may confer a reduced risk of Colorectal adenoma and cancer. This effect could differ by polymorphisms in the genes involved in calcium regulation. The calcium binding protein 1(CABP1) gene encodes a calbindin-D9k protein, an important component of calcium mediated cellular signal transduction. CABP1 express primarily in intestine, and increased levels of Calbindin-D9k in intestine were found to be correlated with calcium hyperabsorption. A recent study found that deletion of CABP1 and another gene had a significant effect on calcium processing under calcium-deficient conditions. These findings suggest the variations in CABP1 expression in intestine may explain some of the variability in calcium absorption. However, so far no study has evaluated genetic variations in CABP1 with the risk of Colorectal adenoma. Objectives: In the current study, we first screened whether CABP1 variants or their interactions with calcium intake were associated with urinary calcium among 256 normal controls. Further, single-nucleotide polymorphisms (SNPs) were evaluated for their independent association and interactions with calcium intake in relation to Colorectal adenoma risk. Methods: Included in the study were 958 adenoma cases and 909 controls from the Tennessee Colorectal Polyp Study (TCPS), an ongoing colonoscopy-based case-control study conducted in Nashville, TN. Genotyping was performed using the Affymetrix Human Mapping 500K array set. Seven tagging SNPs in CABP1 were analyzed. Linear regression models were used to estimate the association between genotypes and urinary calcium level. Multivariate unconditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI). Multiplicative interactions for gene-diet interactions were evaluated in logistic regression models by using likelihood ratio tests. Results: Although no SNPs were observed to be associated with urinary calcium levels, one SNP (rs7956304) was found to be significantly associated with risk of adenoma. In comparison to participants with the GG genotype, participants with GA had higher risk of Colorectal adenoma (OR=1.29, 95% CI 1.03-1.61, P=0.027), while participants with the AA genotype had no appreciable difference in risk (OR=0.82, 95% CI 0.50-1.35, P=0.428). This SNP was not observed to interact with calcium intake. Conclusions: These findings suggest that genetic variations in CABP1 may affect the risk of Colorectal adenoma. To the best of our knowledge, this study is the first to evaluate CABP1 polymorphisms in relation to the risk of adenoma. Our finding of a significant association is promising; however, the finding should be confirmed in future studies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3763. doi:10.1158/1538-7445.AM2011-3763
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abstract 3758 the relationship of calcium and magnesium intakes vdr polymorphisms and the risk of Colorectal adenoma results from the tennessee Colorectal Polyp study
Cancer Research, 2011Co-Authors: Zhu Xiangzhu, Martha J Shrubsole, Jirong Long, Reid M Ness, Todd L Edwards, Zhi Chen, Xinqing Deng, Waltersmalley E Smalley, Wei ZhengAbstract:Background: Epidemiological studies suggest that high calcium intake and adequate vitamin D levels may reduce risk of Colorectal cancer or adenoma although findings have not been entirely consistent. Some previous studies found that the association between calcium intake and Colorectal cancer or adenoma was modified by polymorphisms in vitamin D receptor (VDR) gene. In addition to regulating calcium level, vitamin D is also involved in magnesium homeostasis. However, no study has investigated possible interaction between magnesium intake and VDR polymorphisms. Objectives: To investigate whether intakes of calcium, particularly magnesium, interact with VDR genetic variants in relation to Colorectal adenoma risk. Methods: Included in the study are 958 adenoma cases and 909 healthy controls from the Tennessee Colorectal Polyp Study (TCPS), an ongoing colonoscopy-based case control study conducted in Nashville, TN. Genotyping was performed using the Affymetrix Human Mapping 500K array set. Dietary nutrients intakes were obtained from food frequency questionnaire (FFQ) and dietary supplements and adjusted for total energy intake using the residual method. Multivariate unconditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI). Multiplicative interactions for gene-nutrients interactions were evaluated in logistic regression models by using likelihood ratio tests. Results: Eighteen tagging SNPs in the VDR gene were analyzed. Two SNPs (rs12717991, rs2189480) were significantly associated with a reduced risk of Colorectal adenoma. Furthermore, intakes of calcium (p for interaction, 0.01) and magnesium (p for interaction, 0.03) significantly interacted with rs2189480 in relation to adenoma risk. The inverse association with rs2189480 was of borderline significance among participants with a low calcium intake (P for trend=0.06) with ORs (95% CI) of 0.80 (0.58, 1.10) and 0.67 (0.41, 1.10), respectively, for GT and TT. Among participants with high intake of magnesium, the inverse association was significant (P for trend=0.007) with ORs (95%CI) of 0.52 (0.38, 0.72) and 0.72 (0.44, 1.18), respectively for GT and TT. Conclusions: These findings suggest that some genetic variations in the VDR gene may interact with dietary intakes of calcium and magnesium intake in the risk of Colorectal adenoma. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3758. doi:10.1158/1538-7445.AM2011-3758
Andrew Hill - One of the best experts on this subject based on the ideXlab platform.
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Assessment of Colorectal Polyp recognition skill: development and validation of an objective test
Surgical Endoscopy, 2017Co-Authors: Andrew Hill, Mark S. Horswill, Annaliese M. Plooy, Marcus O. Watson, Lachlan N. Rowlands, Guy M. Wallis, Stephan Riek, Robin Burgess-limerick, David G. HewettAbstract:Background The quality of colonoscopy is known to vary. The extent to which colonoscopists can recognize the presence of subtle Colorectal lesions by visually distinguishing them from the surrounding mucosa (i.e., Polyp recognition skill ) may be one of several attributes that influence Polyp detection rates. The aim of the present study was to develop and validate the first objective test of Polyp recognition skill. Methods Validation study. Twenty-eight experienced colonoscopists and eighty novices took a preliminary 280-item computer-based Polyp recognition test. Items were genuine endoscopic images which participants assessed for the presence of “likely Polyps.” Half included clinically identified Polyps. Participants clicked on a suspected lesion or a button marked “no likely Polyp”, and the main outcome measures were accuracy and response latency. The best items were selected for the final 50-item test. Results In the preliminary test, experienced colonoscopists correctly identified more Polyps than novices ( P
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assessment of Colorectal Polyp recognition skill development and validation of an objective test
Surgical Endoscopy and Other Interventional Techniques, 2017Co-Authors: Andrew Hill, Mark S. Horswill, Annaliese M. Plooy, Lachlan N. Rowlands, Stephan Riek, Marcus Watson, Guy Wallis, Robin Burgesslimerick, David G. HewettAbstract:Background The quality of colonoscopy is known to vary. The extent to which colonoscopists can recognize the presence of subtle Colorectal lesions by visually distinguishing them from the surrounding mucosa (i.e., Polyp recognition skill) may be one of several attributes that influence Polyp detection rates. The aim of the present study was to develop and validate the first objective test of Polyp recognition skill.
Martha J Shrubsole - One of the best experts on this subject based on the ideXlab platform.
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associations between dietary fiber and Colorectal Polyp risk differ by Polyp type and smoking status
Journal of Nutrition, 2014Co-Authors: Martha J Shrubsole, Walter E Smalley, Reid M Ness, Zhenming Fu, Wei ZhengAbstract:The association of dietary fiber intake with Colorectal cancer risk is established. However, the association may differ between cigarette smokers and nonsmokers. We evaluated this hypothesis in a large colonoscopy-based case-control study. Dietary fiber intakes were estimated by self-administered food frequency questionnaire. Unconditional logistic regression analysis was used to estimate ORs and 95% CIs with adjustment for potential confounders. Analysis also was stratified by cigarette smoking and sex. High dietary fiber intake was associated with reduced risk of Colorectal Polyps (P-trend = 0.003). This association was found to be stronger among cigarette smokers (P-trend = 0.006) than nonsmokers (P-trend = 0.21), although the test for multiplicative interaction was not statistically significant (P = 0.11). This pattern of association was more evident for high-risk adenomatous Polyps (ADs), defined as advanced or multiple ADs (P-interaction smoking and dietary fiber intake = 0.09). Among cigarette smokers who smoked ≥23 y, a 38% reduced risk of high-risk ADs was found to be associated with high intake of dietary fiber compared with those in the lowest quartile fiber intake group (P-trend = 0.004). No inverse association with dietary fiber intake was observed for low-risk ADs, defined as single nonadvanced ADs. Cigarette smoking may modify the association of dietary fiber intake with the risk of Colorectal Polyps, especially high-risk ADs, a well-established precursor of Colorectal cancer.
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abstract 1674 two phase study of kcnj1 polymorphisms calcium magnesium and Colorectal adenoma risk results from the tennessee Colorectal Polyp study
Cancer Research, 2012Co-Authors: Martha J Shrubsole, Jirong Long, Walter E Smalley, Reid M Ness, Todd L Edwards, Zhi Chen, Xinqing Deng, Wei ZhengAbstract:Background: Previous studies generated inconsistent results on the associations between intakes of calcium and magnesium with risk of Colorectal adenoma and cancer. It is possible that some of the inconsistency is due to a modifying effect by genetic polymorphisms involved in calcium and magnesium homeostasis. The KCNJ1 gene encodes the Inward-rectifier potassium channel (ROMK). ROMK plays an essential role in the homeostasis of potassium, which is critical for the reabsorption of calcium and magnesium. Objectives: We hypothesize that common variants in KCNJ1 may modify the associations between intakes of calcium and/or magnesium and risk of Colorectal adenoma risk. Methods: Included were participants of the Tennessee Colorectal Polyp Study (TCPS), a colonoscopy-based case control study conducted in Nashville, TN. In the phase I study, genotyping was performed using the Affymetrix Human Mapping 500K array set in 958 Colorectal adenoma cases and 909 controls and 13 tagging single-nucleotide polymorphisms (SNPs) in the KCNJ1 gene were evaluated. SNPs identified as significant in phase I were genotyped in phase II in an independent set (860 cases and 3083 controls). Results: In phase I, 1 tagging SNP was significantly associated with adenoma risk and 8 SNPs were interacted significantly with calcium or magnesium intake in risk of Colorectal adenoma. In phase II, only 1 of the 9 SNPs significantly interacted with calcium and magnesium intakes in relation to Colorectal adenoma although the genotype per se was not directly associated with the risk. In combined analysis, the p value for the interaction between the SNP and calcium intake was 0.00015 and it remained statistically significant after Bonferroni correction for multiple comparisons. In stratified analyses by levels of calcium and magnesium (above or below RDA levels), we found adenoma risk significantly increased for those who with at least 1 variant allele and whose intake levels of calcium and magnesium were below the RDA levels, with ORs (95% CI) of 1.35 (1.10, 1.67) and 1.43 (1.08, 1.89) respectively, compared to those who did not possess the variant allele. The corresponding ORs (95% CI) increased to 1.84 (1.33, 2.53) and 2.30 (1.53, 3.46), respectively, multiple adenomas versus controls. Conclusions: In this two-stage analysis, we found no overall association of adenoma with KCNJ1 genotype. However, common KCNJ1 variants significantly interacted with intakes of calcium and magnesium in risk of Colorectal adenoma, particular for multiple adenomas. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1674. doi:1538-7445.AM2012-1674
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dietary intake of pufas and Colorectal Polyp risk
The American Journal of Clinical Nutrition, 2012Co-Authors: Harvey J Murff, Martha J Shrubsole, Walter E Smalley, Reid M Ness, Ginger L Milne, Wei ZhengAbstract:Background: Marine-derived n−3 (omega-3) PUFAs may reduce risk of developing Colorectal cancer; however, few studies have investigated the association of n−3 PUFA intakes on Colorectal Polyp risk. Objective: The objective of this study was to examine the associations of dietary PUFA intake on risk of Colorectal adenomatous and hyperplastic Polyps. Design: This was a colonoscopy-based case-control study that included 3166 Polyp-free control subjects, 1597 adenomatous Polyp cases, and 544 hyperplastic Polyp cases. Dietary PUFA intake was calculated from food-frequency questionnaires and tested for association by using unconditional logistic regression. The urinary prostaglandin E2 metabolite, which is a biomarker of prostaglandin E2 production, was measured in 896 participants by using liquid chromatography and tandem mass spectrometry. Results: n−6 PUFAs were not associated with adenomatous or hyperplastic Polyps in either men or women. Marine-derived n−3 PUFAs were associated with reduced risk of Colorectal adenomas in women only, with an adjusted OR of 0.67 (95% CI: 0.47, 0.97) for the highest quintile of intake compared with the lowest quintile of intake (P-trend = 0.01). Dietary intake of α-linolenic acid was associated with an increased risk of hyperplastic Polyps in men (P-trend = 0.03), which was not seen in women. In women, but not in men, dietary intake of marine-derived n−3 PUFAs was negatively correlated with urinary prostaglandin E2 production (r = −0.18; P = 0.002). Conclusion: Higher intakes of marine-derived n−3 PUFAs are associated with lower risk of adenomatous Polyps in women, and the association may be mediated in part through a reduction in the production of prostaglandin E2. This trial was registered at clinicaltrials.gov as NCT00625066.
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abstract 3763 calcium intake cabp1 polymorphisms and the risk of Colorectal adenoma results from tennessee Colorectal Polyp study
Cancer Research, 2011Co-Authors: Martha J Shrubsole, Jirong Long, Walter E Smalley, Reid M Ness, Todd L Edwards, Zhi Chen, Xinqing Deng, Wei ZhengAbstract:Background: High calcium consumption may confer a reduced risk of Colorectal adenoma and cancer. This effect could differ by polymorphisms in the genes involved in calcium regulation. The calcium binding protein 1(CABP1) gene encodes a calbindin-D9k protein, an important component of calcium mediated cellular signal transduction. CABP1 express primarily in intestine, and increased levels of Calbindin-D9k in intestine were found to be correlated with calcium hyperabsorption. A recent study found that deletion of CABP1 and another gene had a significant effect on calcium processing under calcium-deficient conditions. These findings suggest the variations in CABP1 expression in intestine may explain some of the variability in calcium absorption. However, so far no study has evaluated genetic variations in CABP1 with the risk of Colorectal adenoma. Objectives: In the current study, we first screened whether CABP1 variants or their interactions with calcium intake were associated with urinary calcium among 256 normal controls. Further, single-nucleotide polymorphisms (SNPs) were evaluated for their independent association and interactions with calcium intake in relation to Colorectal adenoma risk. Methods: Included in the study were 958 adenoma cases and 909 controls from the Tennessee Colorectal Polyp Study (TCPS), an ongoing colonoscopy-based case-control study conducted in Nashville, TN. Genotyping was performed using the Affymetrix Human Mapping 500K array set. Seven tagging SNPs in CABP1 were analyzed. Linear regression models were used to estimate the association between genotypes and urinary calcium level. Multivariate unconditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI). Multiplicative interactions for gene-diet interactions were evaluated in logistic regression models by using likelihood ratio tests. Results: Although no SNPs were observed to be associated with urinary calcium levels, one SNP (rs7956304) was found to be significantly associated with risk of adenoma. In comparison to participants with the GG genotype, participants with GA had higher risk of Colorectal adenoma (OR=1.29, 95% CI 1.03-1.61, P=0.027), while participants with the AA genotype had no appreciable difference in risk (OR=0.82, 95% CI 0.50-1.35, P=0.428). This SNP was not observed to interact with calcium intake. Conclusions: These findings suggest that genetic variations in CABP1 may affect the risk of Colorectal adenoma. To the best of our knowledge, this study is the first to evaluate CABP1 polymorphisms in relation to the risk of adenoma. Our finding of a significant association is promising; however, the finding should be confirmed in future studies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3763. doi:10.1158/1538-7445.AM2011-3763
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abstract 3758 the relationship of calcium and magnesium intakes vdr polymorphisms and the risk of Colorectal adenoma results from the tennessee Colorectal Polyp study
Cancer Research, 2011Co-Authors: Zhu Xiangzhu, Martha J Shrubsole, Jirong Long, Reid M Ness, Todd L Edwards, Zhi Chen, Xinqing Deng, Waltersmalley E Smalley, Wei ZhengAbstract:Background: Epidemiological studies suggest that high calcium intake and adequate vitamin D levels may reduce risk of Colorectal cancer or adenoma although findings have not been entirely consistent. Some previous studies found that the association between calcium intake and Colorectal cancer or adenoma was modified by polymorphisms in vitamin D receptor (VDR) gene. In addition to regulating calcium level, vitamin D is also involved in magnesium homeostasis. However, no study has investigated possible interaction between magnesium intake and VDR polymorphisms. Objectives: To investigate whether intakes of calcium, particularly magnesium, interact with VDR genetic variants in relation to Colorectal adenoma risk. Methods: Included in the study are 958 adenoma cases and 909 healthy controls from the Tennessee Colorectal Polyp Study (TCPS), an ongoing colonoscopy-based case control study conducted in Nashville, TN. Genotyping was performed using the Affymetrix Human Mapping 500K array set. Dietary nutrients intakes were obtained from food frequency questionnaire (FFQ) and dietary supplements and adjusted for total energy intake using the residual method. Multivariate unconditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI). Multiplicative interactions for gene-nutrients interactions were evaluated in logistic regression models by using likelihood ratio tests. Results: Eighteen tagging SNPs in the VDR gene were analyzed. Two SNPs (rs12717991, rs2189480) were significantly associated with a reduced risk of Colorectal adenoma. Furthermore, intakes of calcium (p for interaction, 0.01) and magnesium (p for interaction, 0.03) significantly interacted with rs2189480 in relation to adenoma risk. The inverse association with rs2189480 was of borderline significance among participants with a low calcium intake (P for trend=0.06) with ORs (95% CI) of 0.80 (0.58, 1.10) and 0.67 (0.41, 1.10), respectively, for GT and TT. Among participants with high intake of magnesium, the inverse association was significant (P for trend=0.007) with ORs (95%CI) of 0.52 (0.38, 0.72) and 0.72 (0.44, 1.18), respectively for GT and TT. Conclusions: These findings suggest that some genetic variations in the VDR gene may interact with dietary intakes of calcium and magnesium intake in the risk of Colorectal adenoma. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3758. doi:10.1158/1538-7445.AM2011-3758
Stephan Riek - One of the best experts on this subject based on the ideXlab platform.
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Assessment of Colorectal Polyp recognition skill: development and validation of an objective test
Surgical Endoscopy, 2017Co-Authors: Andrew Hill, Mark S. Horswill, Annaliese M. Plooy, Marcus O. Watson, Lachlan N. Rowlands, Guy M. Wallis, Stephan Riek, Robin Burgess-limerick, David G. HewettAbstract:Background The quality of colonoscopy is known to vary. The extent to which colonoscopists can recognize the presence of subtle Colorectal lesions by visually distinguishing them from the surrounding mucosa (i.e., Polyp recognition skill ) may be one of several attributes that influence Polyp detection rates. The aim of the present study was to develop and validate the first objective test of Polyp recognition skill. Methods Validation study. Twenty-eight experienced colonoscopists and eighty novices took a preliminary 280-item computer-based Polyp recognition test. Items were genuine endoscopic images which participants assessed for the presence of “likely Polyps.” Half included clinically identified Polyps. Participants clicked on a suspected lesion or a button marked “no likely Polyp”, and the main outcome measures were accuracy and response latency. The best items were selected for the final 50-item test. Results In the preliminary test, experienced colonoscopists correctly identified more Polyps than novices ( P
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assessment of Colorectal Polyp recognition skill development and validation of an objective test
Surgical Endoscopy and Other Interventional Techniques, 2017Co-Authors: Andrew Hill, Mark S. Horswill, Annaliese M. Plooy, Lachlan N. Rowlands, Stephan Riek, Marcus Watson, Guy Wallis, Robin Burgesslimerick, David G. HewettAbstract:Background The quality of colonoscopy is known to vary. The extent to which colonoscopists can recognize the presence of subtle Colorectal lesions by visually distinguishing them from the surrounding mucosa (i.e., Polyp recognition skill) may be one of several attributes that influence Polyp detection rates. The aim of the present study was to develop and validate the first objective test of Polyp recognition skill.