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Mohd Zobir Hussein - One of the best experts on this subject based on the ideXlab platform.

  • carboxymethyl cellulose hydrogel based Formulations of zinc hydroxide nitrate sodium dodecylsulphate bispyribac nanocomposite advancements in Controlled Release Formulation of herbicide
    Journal of Nanoscience and Nanotechnology, 2021
    Co-Authors: Sharifah Norain Mohd Sharif, Mohd Zobir Hussein, Norhayati Hashim, Illyas Md Isa, Suriani Abu Bakar, Mazidah Mamat, Mohamad Idris Saidin, Mohamad Syahrizal Ahmad, Rahadian Zainul
    Abstract:

    The usefulness of carboxymethyl cellulose (CMC) as a matrix material in enhancing the Controlled Release Formulations of bispyribac (BP) herbicide from the interlayer gallery of zinc hydroxide nitratesodium dodecylsulphate-bispyribac (ZHN-SDS-BP) nanocomposite was investigated. The CMC coated nanocomposite, ZHN-SDS-BP-CMC was characterised using several instruments for the determination of its physicochemical properties. The Release rates of the BP were measured using a UV spectrophotometer, and the aqueous solutions containing PO3-₄ , SO2-₄ and Cl- were selected as Release media in the Release studies so as to mimic the real conditions of environmental soil. Significant Release time delays, triggered by the gelation forming ability and hygroscopic nature of CMC, were observed in all Release media, and the Release processes were found to behave in a concentration-dependent manner in all Release media. Fitting the Release data into several kinetic models demonstrated that Release in aqueous solutions of Na₃PO₄ and Na₂SO₄ was governed by pseudo second order processes, whereas the Release in an aqueous NaCl solution was governed by the parabolic diffusion kinetic model. The potential of CMC in prolonging the Release of BP from ZHN-SDS-BP-CMC can potentially help in reducing the pollution resulting from the overuse of pesticides.

  • the effect of swellable carboxymethyl cellulose coating on the physicochemical stability and Release profile of a zinc hydroxide nitrate sodium dodecylsulphate imidacloprid
    Chemical Physics Impact, 2021
    Co-Authors: Sharifah Norain Mohd Sharif, Mohd Zobir Hussein, Norhayati Hashim, Illyas Md Isa, Suriani Abu Bakar, Mazidah Mamat, Mohamad Idris Saidin, Mohamad Syahrizal Ahmad, Rahadian Zainul, Azlan Kamari
    Abstract:

    Abstract The environmental pollution that results from the excessive usage of pesticides has been threatening the communities for decades. In this study, carboxymethyl cellulose (CMC) is proposed as a coating agent to encapsulate zinc hydroxide nitrate–sodium dodecylsulphate–imidacloprid (ZHN–SDS–IC) for the implementation of Controlled Release Formulation (CRF) in pesticide. The physicochemical properties of the ZHN–SDS–IC–CMC were characterised so that their crystallinity, thermal behaviour and surface morphology could be examined. The findings from the Release study revealed the potential for CMC to prolong the Release of imidacloprid (IC). A strong hygroscopic and adequate swelling characteristic enabled the CMC to develop an external gel layer on the surface of the ZHN–SDS–IC–CMC that acted as an additional barrier and slowed the Release of the intercalated IC. The ZHN–SDS–IC–CMC that was synthesised can contribute to overcoming the environmental issues due to excessive usage of pesticides and can create a better future for the community.

  • adsolubilisation of thiacloprid pesticide into the layered zinc hydroxide salt intercalated with dodecyl sulphate for Controlled Release Formulation
    Materials Research Innovations, 2020
    Co-Authors: Zuhailimuna Muda, Norhayati Hashim, Illyas Md Isa, Suzaliza Mustafar, Suriani Abu Bakar, Mazidah Mamat, Mohd Zobir Hussein
    Abstract:

    ABSTRACTSodium dodecyl sulphate surfactant was intercalated into the layered zinc hydroxide salt for the successful adsolubilisation of poor water-soluble pesticide, thiacloprid. The intercalation ...

  • Synthesis and Characteristics of Valeric Acid-Zinc Layered Hydroxide Intercalation Material for Insect Pheromone Controlled Release Formulation
    Journal of Materials, 2016
    Co-Authors: Rozita Ahmad, Siti Halimah Sarijo, Mohd Zobir Hussein, Wan Rasidah Kadir, Taufiq-yap Yun Hin
    Abstract:

    A new intercalation compound of insect pheromone, valeric acid (VA), based on zinc layered hydroxide (ZLH) as host Release material, was successfully prepared through coprecipitation method. The as-produced organic-inorganic nanolayered material, valerate nanohybrid, VAN, shows the formation of a new peak at lower 2θ angle with basal spacing of 19.8 A with no ZnO reflections, which indicate that the intercalation of anion between the inorganic ZLH interlamellae was accomplished. The elemental, FTIR, and ATR analyses of the nanohybrid supported the fact that the intercalation with the percentage anion loading was calculated to be 23.0% (w/w). The thermal stability property of the resulting nanohybrid was enhanced compared to the unbound anion. Field emission scanning electron micrograph of the ZnO has a nonuniform granular structure but transforms into flake-like structure with various sizes after the intercalation process. Release kinetics of anion from the interlayer of intercalated compound exhibited a slow Release behavior governed by the pseudo-second-order kinetic model at different pHs of aqueous media. The valerate anion was Released from VAN with the highest Release rate at pH 4. These findings provide the basis to further development of Controlled Release Formulation for insect pheromone based on ZLH intercalation.

  • Controlled Release Formulation of antihistamine based on cetirizine zinc layered hydroxide nanocomposites and its effect on histamine Release from basophilic leukemia rbl 2h3 cells
    International Journal of Nanomedicine, 2012
    Co-Authors: Samer Hasan, Mothanna Alqubaisi, Zulkarnain Zainal, Mohd Zobir Hussein, Maznah Ismail, Hussein Al Ali, Muhammad Nazrul Hakim
    Abstract:

    A Controlled-Release Formulation of an antihistamine, cetirizine, was synthesized using zinc-layered hydroxide as the host and cetirizine as the guest. The resulting well-ordered nanolayered structure, a cetirizine nanocomposite “CETN,” had a basal spacing of 33.9 A, averaged from six harmonics observed from X-ray diffraction. The guest, cetirizine, was arranged in a horizontal bilayer between the zinc-layered hydroxide (ZLH) inorganic interlayers. Fourier transform infrared spectroscopy studies indicated that the intercalation takes place without major change in the structure of the guest and that the thermal stability of the guest in the nanocomposites is markedly enhanced. The loading of the guest in the nanocomposites was estimated to be about 49.4% (w/w). The Release study showed that about 96% of the guest could be Released in 80 hours by phosphate buffer solution at pH 7.4 compared with about 97% in 73 hours at pH 4.8. It was found that Release was governed by pseudo-second order kinetics. Release of histamine from rat basophilic leukemia cells was found to be more sensitive to the intercalated cetirizine in the CETN compared with its free counterpart, with inhibition of 56% and 29%, respectively, at 62.5 ng/mL. The cytotoxicity assay toward Chang liver cells line show the IC50 for CETN and ZLH are 617 and 670 μg/mL, respectively.

Zulkarnain Zainal - One of the best experts on this subject based on the ideXlab platform.

  • Controlled Release Formulation of antihistamine based on cetirizine zinc layered hydroxide nanocomposites and its effect on histamine Release from basophilic leukemia rbl 2h3 cells
    International Journal of Nanomedicine, 2012
    Co-Authors: Samer Hasan, Mothanna Alqubaisi, Zulkarnain Zainal, Mohd Zobir Hussein, Maznah Ismail, Hussein Al Ali, Muhammad Nazrul Hakim
    Abstract:

    A Controlled-Release Formulation of an antihistamine, cetirizine, was synthesized using zinc-layered hydroxide as the host and cetirizine as the guest. The resulting well-ordered nanolayered structure, a cetirizine nanocomposite “CETN,” had a basal spacing of 33.9 A, averaged from six harmonics observed from X-ray diffraction. The guest, cetirizine, was arranged in a horizontal bilayer between the zinc-layered hydroxide (ZLH) inorganic interlayers. Fourier transform infrared spectroscopy studies indicated that the intercalation takes place without major change in the structure of the guest and that the thermal stability of the guest in the nanocomposites is markedly enhanced. The loading of the guest in the nanocomposites was estimated to be about 49.4% (w/w). The Release study showed that about 96% of the guest could be Released in 80 hours by phosphate buffer solution at pH 7.4 compared with about 97% in 73 hours at pH 4.8. It was found that Release was governed by pseudo-second order kinetics. Release of histamine from rat basophilic leukemia cells was found to be more sensitive to the intercalated cetirizine in the CETN compared with its free counterpart, with inhibition of 56% and 29%, respectively, at 62.5 ng/mL. The cytotoxicity assay toward Chang liver cells line show the IC50 for CETN and ZLH are 617 and 670 μg/mL, respectively.

  • herbicide intercalated zinc layered hydroxide nanohybrid for a dual guest Controlled Release Formulation
    International Journal of Molecular Sciences, 2012
    Co-Authors: Mohd Zobir Hussein, Nor Shazlirah Shazlyn Abdul Rahman, Siti Halimah Sarijo, Zulkarnain Zainal
    Abstract:

    Herbicides, namely 4-(2,4-dichlorophenoxy) butyrate (DPBA) and 2-(3-chlorophenoxy) propionate (CPPA), were intercalated simultaneously into the interlayers of zinc layered hydroxide (ZLH) by direct reaction of zinc oxide with both anions under aqueous environment to form a new nanohybrid containing both herbicides labeled as ZCDX. Successful intercalation of both anions simultaneously into the interlayer gallery space of ZLH was studied by PXRD, with basal spacing of 28.7 A and supported by FTIR, TGA/DTG and UV-visible studies. Simultaneous Release of both CPPA and DPBA anions into the Release media was found to be governed by a pseudo second-order equation. The loading and percentage Release of the DPBA is higher than the CPPA anion, which indicates that the DPBA anion was preferentially intercalated into and Released from the ZLH interlayer galleries. This work shows that layered single metal hydroxide, particularly ZLH, is a suitable host for the Controlled Release Formulation of two herbicides simultaneously.

  • Controlled Release and angiotensin converting enzyme inhibition properties of an antihypertensive drug based on a perindopril erbumine layered double hydroxide nanocomposite
    International Journal of Nanomedicine, 2012
    Co-Authors: Samer Hasan Hussein Al Ali, Mothanna Alqubaisi, Zulkarnain Zainal, Mohd Zobir Hussein, Maznah Ismail, Muhammad Nazrul Hakim
    Abstract:

    Background: The intercalation of perindopril erbumine into Zn/Al-NO 3 -layered double hydroxide resulted in the formation of a host-guest type of material. By virtue of the ionexchange properties of layered double hydroxide, perindopril erbumine was Released in a sustained manner. Therefore, this intercalated material can be used as a Controlled-Release Formulation. Results: Perindopril was intercalated into the interlayers and formed a well ordered, layered organic-inorganic nanocomposite. The basal spacing of the products was expanded to 21.7 A and 19.9 A by the ion-exchange and coprecipitation methods, respectively, in a bilayer and a monolayer arrangement, respectively. The Release of perindopril from the nanocomposite synthesized by the coprecipitation method was slower than that of its counterpart synthesized by the ion-exchange method. The rate of Release was governed by pseudo-second order kinetics. An in vitro antihypertensive assay showed that the intercalation process results in effectiveness similar to that of the antihypertensive properties of perindopril. Conclusion: Intercalated perindopril showed better thermal stability than its free counterpart. The resulting material showed sustained-Release properties and can therefore be used as a Controlled-Release Formulation.

  • preparation of hippurate zinc layered hydroxide nanohybrid and its synergistic effect with tamoxifen on hepg2 cell lines
    International Journal of Nanomedicine, 2011
    Co-Authors: Mothanna Alqubaisi, Zulkarnain Zainal, Mohd Zobir Hussein, Muhammad Nazrul Hakim
    Abstract:

    BACKGROUND: A new simple preparation method for a hippurate-intercalated zinc-layered hydroxide (ZLH) nanohybrid has been established, which does not need an anion-exchange procedure to intercalate the hippurate anion into ZLH interlayers. METHODS: The hippuric acid nanohybrid (HAN) was prepared by direct reaction of an aqueous suspension of zinc oxide with a solution of hippuric acid via a one-step method. RESULTS: The basal spacing of the nanohybrid was 21.3 A, indicating that the hippurate anion was successfully intercalated into the interlayer space of ZLH, and arranged in a monolayer fashion with the carboxylate group pointing toward the ZLH inorganic interlayers. A Fourier transform infrared study confirmed the formation of the nanohybrid, while thermogravimetry and differential thermogravimetry analyses showed that the thermal stability of the nanohybrid was markedly enhanced. The loading of hippurate in the nanohybrid was estimated to be about 38.7% (w/w), and the Release of hippurate from the nanohybrid was of a Controlled manner, and therefore the resulting material was suitable for use as a Controlled-Release Formulation. HAN has synergistic properties with tamoxifen toward a HepG2 cell line, with an IC50 value of 0.35 compared with hippurate. In the antiproliferative assay, the ratio of viable cells account for cells treated by the combination tamoxifen with HAN to untreated cells was sharply reduced from 66% to 13% after 24 and 72 hours, respectively. CONCLUSION: The Release of hippuric acid anions from HAN occurred in a Controlled manner, and the resulting material is suitable for a Controlled-Release Formulation.

  • synthesis of dichlorprop zn al hydrotalcite nanohybrid and its Controlled Release property
    2011
    Co-Authors: Mohd Zobir Hussein, Asmah Hj Yahaya, Norhayati Hashim, Zulkarnain Zainal
    Abstract:

    New phase-pure nanohybrids of dichlorprop[2(2,4-dichlorophenoxy)propionate]-intercalated Zn/Al-LDH were successfully prepared using either co-precipitation or ion exchange methods. The basal spacing expansion from 8.9 A in the layered double hydroxide (LDH) to 18.7 and 21.7 A of the nanohybrids was observed. This together with FTIR, DTG/TGA and compositional studies show that dichlorprop was successfully intercalated into the Zn/Al-layered double hydroxides interlayer. Release study of dichlorprop showed that it is dependent on the concentration of the incoming ionic species and governed by the pseudo-second order kinetic. This study suggests that the layered double hydroxide might be used as a matrix for Controlled Release Formulation for a herbicide, dichlorprop and the Release of the herbicide can be tuned using parameters such as method of synthesis and the concentration of the incoming ionic species to be ion exchange with. This is towards new generation of agrochemicals which are safer as well as user- and environmentally-friendly.

Muhammad Nazrul Hakim - One of the best experts on this subject based on the ideXlab platform.

  • Controlled Release Formulation of antihistamine based on cetirizine zinc layered hydroxide nanocomposites and its effect on histamine Release from basophilic leukemia rbl 2h3 cells
    International Journal of Nanomedicine, 2012
    Co-Authors: Samer Hasan, Mothanna Alqubaisi, Zulkarnain Zainal, Mohd Zobir Hussein, Maznah Ismail, Hussein Al Ali, Muhammad Nazrul Hakim
    Abstract:

    A Controlled-Release Formulation of an antihistamine, cetirizine, was synthesized using zinc-layered hydroxide as the host and cetirizine as the guest. The resulting well-ordered nanolayered structure, a cetirizine nanocomposite “CETN,” had a basal spacing of 33.9 A, averaged from six harmonics observed from X-ray diffraction. The guest, cetirizine, was arranged in a horizontal bilayer between the zinc-layered hydroxide (ZLH) inorganic interlayers. Fourier transform infrared spectroscopy studies indicated that the intercalation takes place without major change in the structure of the guest and that the thermal stability of the guest in the nanocomposites is markedly enhanced. The loading of the guest in the nanocomposites was estimated to be about 49.4% (w/w). The Release study showed that about 96% of the guest could be Released in 80 hours by phosphate buffer solution at pH 7.4 compared with about 97% in 73 hours at pH 4.8. It was found that Release was governed by pseudo-second order kinetics. Release of histamine from rat basophilic leukemia cells was found to be more sensitive to the intercalated cetirizine in the CETN compared with its free counterpart, with inhibition of 56% and 29%, respectively, at 62.5 ng/mL. The cytotoxicity assay toward Chang liver cells line show the IC50 for CETN and ZLH are 617 and 670 μg/mL, respectively.

  • Controlled Release and angiotensin converting enzyme inhibition properties of an antihypertensive drug based on a perindopril erbumine layered double hydroxide nanocomposite
    International Journal of Nanomedicine, 2012
    Co-Authors: Samer Hasan Hussein Al Ali, Mothanna Alqubaisi, Zulkarnain Zainal, Mohd Zobir Hussein, Maznah Ismail, Muhammad Nazrul Hakim
    Abstract:

    Background: The intercalation of perindopril erbumine into Zn/Al-NO 3 -layered double hydroxide resulted in the formation of a host-guest type of material. By virtue of the ionexchange properties of layered double hydroxide, perindopril erbumine was Released in a sustained manner. Therefore, this intercalated material can be used as a Controlled-Release Formulation. Results: Perindopril was intercalated into the interlayers and formed a well ordered, layered organic-inorganic nanocomposite. The basal spacing of the products was expanded to 21.7 A and 19.9 A by the ion-exchange and coprecipitation methods, respectively, in a bilayer and a monolayer arrangement, respectively. The Release of perindopril from the nanocomposite synthesized by the coprecipitation method was slower than that of its counterpart synthesized by the ion-exchange method. The rate of Release was governed by pseudo-second order kinetics. An in vitro antihypertensive assay showed that the intercalation process results in effectiveness similar to that of the antihypertensive properties of perindopril. Conclusion: Intercalated perindopril showed better thermal stability than its free counterpart. The resulting material showed sustained-Release properties and can therefore be used as a Controlled-Release Formulation.

  • preparation of hippurate zinc layered hydroxide nanohybrid and its synergistic effect with tamoxifen on hepg2 cell lines
    International Journal of Nanomedicine, 2011
    Co-Authors: Mothanna Alqubaisi, Zulkarnain Zainal, Mohd Zobir Hussein, Muhammad Nazrul Hakim
    Abstract:

    BACKGROUND: A new simple preparation method for a hippurate-intercalated zinc-layered hydroxide (ZLH) nanohybrid has been established, which does not need an anion-exchange procedure to intercalate the hippurate anion into ZLH interlayers. METHODS: The hippuric acid nanohybrid (HAN) was prepared by direct reaction of an aqueous suspension of zinc oxide with a solution of hippuric acid via a one-step method. RESULTS: The basal spacing of the nanohybrid was 21.3 A, indicating that the hippurate anion was successfully intercalated into the interlayer space of ZLH, and arranged in a monolayer fashion with the carboxylate group pointing toward the ZLH inorganic interlayers. A Fourier transform infrared study confirmed the formation of the nanohybrid, while thermogravimetry and differential thermogravimetry analyses showed that the thermal stability of the nanohybrid was markedly enhanced. The loading of hippurate in the nanohybrid was estimated to be about 38.7% (w/w), and the Release of hippurate from the nanohybrid was of a Controlled manner, and therefore the resulting material was suitable for use as a Controlled-Release Formulation. HAN has synergistic properties with tamoxifen toward a HepG2 cell line, with an IC50 value of 0.35 compared with hippurate. In the antiproliferative assay, the ratio of viable cells account for cells treated by the combination tamoxifen with HAN to untreated cells was sharply reduced from 66% to 13% after 24 and 72 hours, respectively. CONCLUSION: The Release of hippuric acid anions from HAN occurred in a Controlled manner, and the resulting material is suitable for a Controlled-Release Formulation.

  • development of antiproliferative nanohybrid compound with Controlled Release property using ellagic acid as the active agent
    International Journal of Nanomedicine, 2011
    Co-Authors: Mohd Zobir Hussein, Zulkarnain Zainal, Samer Hasan Hussein Al Ali, Muhammad Nazrul Hakim
    Abstract:

    An ellagic acid (EA)-zinc layered hydroxide (ZLH) nanohybrid (EAN) was synthesized under a nonaqueous environment using EA and zinc oxide (ZnO) as the precursors. Powder X-ray diffraction showed that the basal spacing of the nanohybrid was 10.4 A, resulting in the spatial orientation of EA molecules between the interlayers of 22.5° from z-axis with two negative charges at 8,8' position of the molecules pointed toward the ZLH interlayers. FTIR study showed that the intercalated EA spectral feature is generally similar to that of EA, but with bands slightly shifted. This indicates that some chemical bonding of EA presence between the nanohybrid interlayers was slightly changed, due to the formation of host-guest interaction. The nanohybrid is of mesopores type with 58.8% drug loading and enhanced thermal stability. The Release of the drug active, EA from the nanohybrid was found to be sustained and therefore has good potential to be used as a drug Controlled-Release Formulation. In vitro bioassay study showed that the EAN has a mild effect on the hepatocytes cells, similar to its counterpart, free EA.

  • development of antiproliferative nanohybrid compound with Controlled Release property using ellagic acid as the active agent
    International Journal of Nanomedicine, 2011
    Co-Authors: Mohd Zobir Hussein, Zulkarnain Zainal, Al Ali Sh, Muhammad Nazrul Hakim
    Abstract:

    An ellagic acid (EA)–zinc layered hydroxide (ZLH) nanohybrid (EAN) was synthesized under a nonaqueous environment using EA and zinc oxide (ZnO) as the precursors. Powder X-ray diffraction showed that the basal spacing of the nanohybrid was 10.4 A, resulting in the spatial orientation of EA molecules between the interlayers of 22.5° from z-axis with two negative charges at 8,8′ position of the molecules pointed toward the ZLH interlayers. FTIR study showed that the intercalated EA spectral feature is generally similar to that of EA, but with bands slightly shifted. This indicates that some chemical bonding of EA presence between the nanohybrid interlayers was slightly changed, due to the formation of host–guest interaction. The nanohybrid is of mesopores type with 58.8% drug loading and enhanced thermal stability. The Release of the drug active, EA from the nanohybrid was found to be sustained and therefore has good potential to be used as a drug Controlled-Release Formulation. In vitro bioassay study showed that the EAN has a mild effect on the hepatocytes cells, similar to its counterpart, free EA.

Mothanna Alqubaisi - One of the best experts on this subject based on the ideXlab platform.

  • Controlled Release Formulation of antihistamine based on cetirizine zinc layered hydroxide nanocomposites and its effect on histamine Release from basophilic leukemia rbl 2h3 cells
    International Journal of Nanomedicine, 2012
    Co-Authors: Samer Hasan, Mothanna Alqubaisi, Zulkarnain Zainal, Mohd Zobir Hussein, Maznah Ismail, Hussein Al Ali, Muhammad Nazrul Hakim
    Abstract:

    A Controlled-Release Formulation of an antihistamine, cetirizine, was synthesized using zinc-layered hydroxide as the host and cetirizine as the guest. The resulting well-ordered nanolayered structure, a cetirizine nanocomposite “CETN,” had a basal spacing of 33.9 A, averaged from six harmonics observed from X-ray diffraction. The guest, cetirizine, was arranged in a horizontal bilayer between the zinc-layered hydroxide (ZLH) inorganic interlayers. Fourier transform infrared spectroscopy studies indicated that the intercalation takes place without major change in the structure of the guest and that the thermal stability of the guest in the nanocomposites is markedly enhanced. The loading of the guest in the nanocomposites was estimated to be about 49.4% (w/w). The Release study showed that about 96% of the guest could be Released in 80 hours by phosphate buffer solution at pH 7.4 compared with about 97% in 73 hours at pH 4.8. It was found that Release was governed by pseudo-second order kinetics. Release of histamine from rat basophilic leukemia cells was found to be more sensitive to the intercalated cetirizine in the CETN compared with its free counterpart, with inhibition of 56% and 29%, respectively, at 62.5 ng/mL. The cytotoxicity assay toward Chang liver cells line show the IC50 for CETN and ZLH are 617 and 670 μg/mL, respectively.

  • Controlled Release and angiotensin converting enzyme inhibition properties of an antihypertensive drug based on a perindopril erbumine layered double hydroxide nanocomposite
    International Journal of Nanomedicine, 2012
    Co-Authors: Samer Hasan Hussein Al Ali, Mothanna Alqubaisi, Zulkarnain Zainal, Mohd Zobir Hussein, Maznah Ismail, Muhammad Nazrul Hakim
    Abstract:

    Background: The intercalation of perindopril erbumine into Zn/Al-NO 3 -layered double hydroxide resulted in the formation of a host-guest type of material. By virtue of the ionexchange properties of layered double hydroxide, perindopril erbumine was Released in a sustained manner. Therefore, this intercalated material can be used as a Controlled-Release Formulation. Results: Perindopril was intercalated into the interlayers and formed a well ordered, layered organic-inorganic nanocomposite. The basal spacing of the products was expanded to 21.7 A and 19.9 A by the ion-exchange and coprecipitation methods, respectively, in a bilayer and a monolayer arrangement, respectively. The Release of perindopril from the nanocomposite synthesized by the coprecipitation method was slower than that of its counterpart synthesized by the ion-exchange method. The rate of Release was governed by pseudo-second order kinetics. An in vitro antihypertensive assay showed that the intercalation process results in effectiveness similar to that of the antihypertensive properties of perindopril. Conclusion: Intercalated perindopril showed better thermal stability than its free counterpart. The resulting material showed sustained-Release properties and can therefore be used as a Controlled-Release Formulation.

  • preparation of hippurate zinc layered hydroxide nanohybrid and its synergistic effect with tamoxifen on hepg2 cell lines
    International Journal of Nanomedicine, 2011
    Co-Authors: Mothanna Alqubaisi, Zulkarnain Zainal, Mohd Zobir Hussein, Muhammad Nazrul Hakim
    Abstract:

    BACKGROUND: A new simple preparation method for a hippurate-intercalated zinc-layered hydroxide (ZLH) nanohybrid has been established, which does not need an anion-exchange procedure to intercalate the hippurate anion into ZLH interlayers. METHODS: The hippuric acid nanohybrid (HAN) was prepared by direct reaction of an aqueous suspension of zinc oxide with a solution of hippuric acid via a one-step method. RESULTS: The basal spacing of the nanohybrid was 21.3 A, indicating that the hippurate anion was successfully intercalated into the interlayer space of ZLH, and arranged in a monolayer fashion with the carboxylate group pointing toward the ZLH inorganic interlayers. A Fourier transform infrared study confirmed the formation of the nanohybrid, while thermogravimetry and differential thermogravimetry analyses showed that the thermal stability of the nanohybrid was markedly enhanced. The loading of hippurate in the nanohybrid was estimated to be about 38.7% (w/w), and the Release of hippurate from the nanohybrid was of a Controlled manner, and therefore the resulting material was suitable for use as a Controlled-Release Formulation. HAN has synergistic properties with tamoxifen toward a HepG2 cell line, with an IC50 value of 0.35 compared with hippurate. In the antiproliferative assay, the ratio of viable cells account for cells treated by the combination tamoxifen with HAN to untreated cells was sharply reduced from 66% to 13% after 24 and 72 hours, respectively. CONCLUSION: The Release of hippuric acid anions from HAN occurred in a Controlled manner, and the resulting material is suitable for a Controlled-Release Formulation.

  • hippurate zinc layered hydroxide nanohybrid and its synergistic effect with tamoxifen on the hepg2 cell lines
    2011
    Co-Authors: Mohd Zobir Hussein, Muhammad Nazrul Hakim Abdullah, Zulkarnain Zainal, Mothanna Alqubaisi
    Abstract:

    A new simple preparation method for a hippurate intercalated zinc-layered hydroxide (ZLH) nanohybrid has been established, which does not need an anion-exchange procedure to intercalate the hippurate anion into ZLH interlayers. Methods: The hippuric acid nanohybrid (HAN) was prepared by direct reaction of an aqueous suspension of zinc oxide with a solution of hippuric acid via a one-step method. Results: The basal spacing of the nanohybrid was 21.3 A, indicating that the hippurate anion was successfully intercalated into the interlayer space of ZLH, and arranged in a monolayer fashion with the carboxylate group pointing toward the ZLH inorganic interlayers. A Fourier transform infrared study confirmed the formation of the nanohybrid, while thermogravimetry and differential thermogravimetry analyses showed that the thermal stability of the nanohybrid was markedly enhanced. The loading of hippurate in the nanohybrid was estimated to be about 38.7% (w/w), and the Release of hippurate from the nanohybrid was of a Controlled manner, and therefore the resulting material was suitable for use as a Controlled-Release Formulation. HAN has synergistic properties with tamoxifen toward a HepG2 cell line, with an IC 50 value of 0.35 compared with hippurate. In the antiproliferative assay, the ratio of viable cells account for cells treated by the combination tamoxifen with HAN to untreated cells was sharply reduced from 66% to 13% after 24 and 72 hours, respectively. The Release of hippuric acid anions from HAN occurred in a Controlled manner, and the resulting material is suitable for a Controlled-Release Formulation.

Asmah Hj Yahaya - One of the best experts on this subject based on the ideXlab platform.

  • synthesis of dichlorprop zn al hydrotalcite nanohybrid and its Controlled Release property
    2011
    Co-Authors: Mohd Zobir Hussein, Asmah Hj Yahaya, Norhayati Hashim, Zulkarnain Zainal
    Abstract:

    New phase-pure nanohybrids of dichlorprop[2(2,4-dichlorophenoxy)propionate]-intercalated Zn/Al-LDH were successfully prepared using either co-precipitation or ion exchange methods. The basal spacing expansion from 8.9 A in the layered double hydroxide (LDH) to 18.7 and 21.7 A of the nanohybrids was observed. This together with FTIR, DTG/TGA and compositional studies show that dichlorprop was successfully intercalated into the Zn/Al-layered double hydroxides interlayer. Release study of dichlorprop showed that it is dependent on the concentration of the incoming ionic species and governed by the pseudo-second order kinetic. This study suggests that the layered double hydroxide might be used as a matrix for Controlled Release Formulation for a herbicide, dichlorprop and the Release of the herbicide can be tuned using parameters such as method of synthesis and the concentration of the incoming ionic species to be ion exchange with. This is towards new generation of agrochemicals which are safer as well as user- and environmentally-friendly.

  • Controlled Release Formulation of agrochemical pesticide based on 4 2 4 dichlorophenoxy butyrate nanohybrid
    Journal of Nanoscience and Nanotechnology, 2009
    Co-Authors: Mohd Zobir Hussein, Asmah Hj Yahaya, Norhayati Hashim, Zulkarnain Zainal
    Abstract:

    Hybridization of beneficial organic guest with inorganic host affords scientists an opportunity to synthesize various combinations of new organic-inorganic nanohybrids with various potential applications, especially for Controlled delivery of beneficial agent and storage. A new layered organic-inorganic nanohybrid material containing an agrochemical, 4-(2,4-dichlorophenoxy)butyrate (DPBA) in Zn-Al-layered double hydroxide inorganic interlayer was synthesised by direct and indirect methods. Both methods yielded mesoporous-type, phase pure, well-ordered layered nanohybrids with similar basal spacing of 28.5-28.7 angstroms and organic loading of around 54.3%. Compared to the material prepared by direct method, the ion exchanged product inherited more of the host's properties especially the pore structure and the organic moiety is also more easily Released. This shows that the method of preparation plays an important role in determining the resulting physicochemical properties, in particular the Release property and therefore can be used as a means to tune up the Release property of the beneficial agent.

  • nanocomposite based Controlled Release Formulation of an herbicide 2 4 dichlorophenoxyacetate incapsulated in zinc aluminium layered double hydroxide
    Science and Technology of Advanced Materials, 2005
    Co-Authors: Mohd Zobir Hussein, Zulkarnain Zainal, Asmah Hj Yahaya, Loo Hee Kian
    Abstract:

    Controlled Release Formulation of an herbicide, 2,4-dichlorophenoxyacetate (24D) was developed by the virtue of the formation of organic–inorganic nanohybrid material and its ion exchange property. The inorganic Zn–Al layered double hydroxide (ZAL) was used as a matrix, hosting an active agent or a guest, 24D by self-assembly technique. The resulting material (ZAD) was subsequently used to study the Release property of 24D into aqueous solutions containing chloride, carbonate as well as distilled water. The Release of the guest 24D was found to be rapid initially followed by a more sustained Release thereafter and this behavior was dependent on the type of anions and their concentrations in the Release medium, the aqueous solution. The mechanism of Release has been interpreted on the basis of the ion exchange process between the 24D anion intercalated into the interlamellae host and carbonate or chloride and/or hydroxyl anions in the aqueous solution.

  • Controlled Release of a plant growth regulator α naphthaleneacetate from the lamella of zn al layered double hydroxide nanocomposite
    Journal of Controlled Release, 2002
    Co-Authors: Mohd Zobir Hussein, Zulkarnain Zainal, Asmah Hj Yahaya, Dickens Wong Vui Foo
    Abstract:

    Formation of the so-called organic–inorganic nanohybrid material was exploited for the preparation of a Controlled Release Formulation. The inorganic Zn–Al-layered double hydroxide (LDH) was used as a matrix, hosting an active agent or a guest, α-naphthaleneacetate (NAA), a plant growth regulator by self-assembly technique. The reverse process, i.e., the deintercalation or Release of the guest, NAA was found to be rapid initially, followed by a more sustained Release thereafter and this behavior was dependent on the pH of the Release medium, the aqueous solution. The mechanism of Release has been interpreted on the basis of the ion-exchange process between the NAA anion intercalated in the lamella host and nitrate or hydroxyl anions in the aqueous solution.