The Experts below are selected from a list of 11745 Experts worldwide ranked by ideXlab platform
Didier Raoult - One of the best experts on this subject based on the ideXlab platform.
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new insights in Coxiella burnetii infection diagnosis and therapeutic update
Expert Review of Anti-infective Therapy, 2020Co-Authors: Clea Melenotte, Matthieu Million, Didier RaoultAbstract:Introduction: Coxiella burnetii infection is still challenging physicians, mainly because no international coordination has been stated to standardize the therapeutic strategy and improve the clini...
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Case report: Coxiella burnetii vascular infection and lymphoma in the Netherlands
Infection, 2017Co-Authors: Sonja E. Van Roeden, Clea Melenotte, Didier Raoult, Mirjam H. A. Hermans, Harm A. M. Sinnige, Peet T. G. A. Nooijen, Gilles Audoly, Andy I. M. Hoepelman, Jan Jelrik Oosterheert, Peter C. WeverAbstract:Objectives and design Non-Hodgkin lymphoma has been linked to infection with Coxiella burnetii, potentially through overproduction of IL-10 during infection with C. burnetii.
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Bartonella quintana endocarditis with positive serology for Coxiella burnetii
The Journal of infection, 2005Co-Authors: Joseph Rahimian, Didier Raoult, Yi-wei Tang, Bruce A. HannaAbstract:Both Bartonella quintana and Coxiella burnetii are known to cause of blood culture negative endocarditis. In such case, the diagnosis is usually established by serology. A case of Bartonella quintana endocarditis is described where the serology was falsely positive for Coxiella burnetii. This case demonstrates the difficulty in distinguishing these two etiologic agents by routine serologic testing.
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Coxiella burnetii vascular graft infection
BMC infectious diseases, 2005Co-Authors: Laurence Senn, Didier Raoult, Mario Franciolli, Alexandre Moulin, Ludwig K. Von Segesser, Thierry Calandra, Gilbert GreubAbstract:Background Coxiella burnetii, the causative agent of Q fever, may cause culture-negative vascular graft infections. Very few cases of C. burnetii infection of a vascular graft have been reported. All were diagnosed by serology.
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Bacteriostatic and Bactericidal Activities of Moxifloxacin against Coxiella burnetii
Antimicrobial agents and chemotherapy, 2001Co-Authors: Jean-marc Rolain, Max Maurin, Didier RaoultAbstract:The in vitro activity of moxifloxacin against Coxiella burnetii was compared to those of pefloxacin, ofloxacin, and doxycycline. MICs of moxifloxacin ranged from 0.5 to 1 μg/ml for the Nine Mile, Priscilla, and Q212 strains. Moxifloxacin was not bactericidal against C. burnetii at 4 μg/ml.
Clea Melenotte - One of the best experts on this subject based on the ideXlab platform.
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new insights in Coxiella burnetii infection diagnosis and therapeutic update
Expert Review of Anti-infective Therapy, 2020Co-Authors: Clea MelenotteAbstract:AbstractIntroduction: Coxiella burnetii infection is still challenging physicians, mainly because no international coordination has been stated to standardize the therapeutic strategy and improve t...
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new insights in Coxiella burnetii infection diagnosis and therapeutic update
Expert Review of Anti-infective Therapy, 2020Co-Authors: Clea Melenotte, Matthieu Million, Didier RaoultAbstract:Introduction: Coxiella burnetii infection is still challenging physicians, mainly because no international coordination has been stated to standardize the therapeutic strategy and improve the clini...
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Coxiella burnetii a hidden pathogen in interstitial lung disease
Clinical Infectious Diseases, 2018Co-Authors: Clea Melenotte, Jalaljean Izaaryene, Carine Gomez, Marion Delord, Elsa Prudent, Hubert Lepidi, Oleg Mediannikov, Marion Lacoste, Felix Djossou, Alexandre ManiaAbstract:We report 7 patients with interstitial lung disease seen at computed tomographic scan review. Coxiella burnetii infection was diagnosed in situ in 1 lung biopsy specimen. Q fever may be a cofactor of interstitial lung disease, especially in endemic areas.
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Case report: Coxiella burnetii vascular infection and lymphoma in the Netherlands
Infection, 2017Co-Authors: Sonja E. Van Roeden, Clea Melenotte, Didier Raoult, Mirjam H. A. Hermans, Harm A. M. Sinnige, Peet T. G. A. Nooijen, Gilles Audoly, Andy I. M. Hoepelman, Jan Jelrik Oosterheert, Peter C. WeverAbstract:Objectives and design Non-Hodgkin lymphoma has been linked to infection with Coxiella burnetii, potentially through overproduction of IL-10 during infection with C. burnetii.
Gilbert Greub - One of the best experts on this subject based on the ideXlab platform.
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Seroprevalence of Coxiella burnetii and Brucella abortus among pregnant women.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2009Co-Authors: David Baud, O. Peter, C. Langel, Lesley Regan, Gilbert GreubAbstract:Abstract Coxiella burnetii and Brucella abortus are two intracellular bacteria implicated in zoonotic miscarriage. In the present study, C. burnetii and B. abortus seroprevalence was compared among women from London with and without miscarriage. Coxiella burnetii seroprevalence was high (4.6%, 95% CI 2.8–7.1) despite the rare apparent exposure of this urban population. Only two patients exhibited anti- B. abortus antibodies. As a result of the risk of chronic Q fever with endocarditis and/or hepatitis, the mode of Coxiella burnetii infection in this population merits further investigation.
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Coxiella burnetii vascular graft infection
BMC infectious diseases, 2005Co-Authors: Laurence Senn, Didier Raoult, Mario Franciolli, Alexandre Moulin, Ludwig K. Von Segesser, Thierry Calandra, Gilbert GreubAbstract:Background Coxiella burnetii, the causative agent of Q fever, may cause culture-negative vascular graft infections. Very few cases of C. burnetii infection of a vascular graft have been reported. All were diagnosed by serology.
Henri Seegers - One of the best experts on this subject based on the ideXlab platform.
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Coxiella burnetii shedding by dairy cows.
Veterinary research, 2007Co-Authors: Raphaël Guatteo, François Beaudeau, A. Joly, Henri SeegersAbstract:While shedding routes of Coxiella burnetii are identified, the characteristics of Coxiella shedding are still widely unknown, especially in dairy cattle. However, this information is crucial to assess the natural course of Coxiella burnetii infection within a herd and then to elaborate strategies to limit the risks of transmission between animals and to humans. The present study aimed at (i) describing the characteristics of Coxiella burnetii shedding by dairy cows (in milk, vaginal mucus, faeces) in five infected dairy herds, and at (ii) investigating the possible relationships between shedding patterns and serological responses. A total of 145 cows were included in a follow-up consisting of seven concomitant samplings of milk, vaginal mucus, faeces and blood (Day 0, D7, D14, D21, D28, D63, D90). Detection and quantification of Coxiella burnetii titres were performed in milk, vaginal mucus and faeces samples using real-time PCR assay, while antibodies against Coxiella were detected using an ELISA technique. For a given shedding route, and a given periodicity (weekly or monthly), cows were gathered into different shedding kinetic patterns according to the sequence of PCR responses. Distribution of estimated titres in Coxiella burnetii was described according to shedding kinetic patterns. Coxiella burnetii shedding was found scarcely and sporadically in faeces. Vaginal mucus shedding concerned almost 50% of the cows studied and was found intermittently or sporadically, depending on the periodicity considered. Almost 40% of cows were detected as milk shedders, with two predominant shedding patterns: persistent and sporadic, regardless of the sampling periodicity. Significantly higher estimated titres in Coxiella burnetii were observed in cows with persistent shedding patterns suggesting the existence of heavy shedder cows. These latter cows were mostly, persistently highly-seropositive, suggesting that repeated serological testings could be a reliable tool to screen heavy shedders, before using PCR assays.
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Shedding routes of Coxiella burnetii in dairy cows : implications for detection and control
Veterinary research, 2006Co-Authors: Raphaël Guatteo, François Beaudeau, A. Joly, Mustapha Berri, Annie Rodolakis, Henri SeegersAbstract:Reliable detection of Coxiella burnetii shedders is a critical point for the control of the spread of this bacterium among animals and from animals to humans. Coxiella burnetii is shed by ruminants mainly by birth products (placenta, birth fluids), but may also be shed by vaginal mucus, milk, and faeces, urine and semen. However, the informative value of these types of samples to identify shedders under field conditions is unknown. Our aim was then to describe the responses obtained using a real-time PCR technique applied to milk, vaginal mucus and faeces samples taken from 242 dairy cows in commercial dairy herds known to be naturally infected with Coxiella burnetii, and to assess their putative associations. Positive results were found in all types of tested samples even in faeces. No predominant shedding route was identified. Among the shedder cows, 65.4% were detected as shedders by only one route. By contrast, cows with positive results for all three samples were scarce (less than 7%). Testing a cow based on only one type of biological sample may lead to misclassify it with regards to its shedding of Coxiella burnetii and thereby underestimate the risk of bacterial spread within a herd.
Emilio Bouza - One of the best experts on this subject based on the ideXlab platform.
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Coxiella burnetii infection in hemodialysis and other vascular grafts.
Medicine, 2014Co-Authors: Marcela González-del Vecchio, Antonio Vena, Maricela Valerio, Mercedes Marín, Eduardo Verde, Patricia Muñoz, Emilio BouzaAbstract:Prosthetic arteriovenous (AV) graft infection is the principal cause of morbidity related to chronic hemodialysis AV graft fistula. Coxiella burnetii is a known pathogen that causes fever, pneumonia, and intravascular infections with the limitation of negative cultures. Herein, we report the first case of a patient who presented to the emergency department of our hospital with a prosthetic hemodialysis AV graft infection due to Coxiella burnetii. We also performed a literature search with PubMed to identify studies reporting cases of Coxiella burnetii vascular graft infection. Overall, we reviewed 15 cases of vascular graft infection, including ours. We found a high prevalence of male patients (87%); mean age ± standard deviation (SD) of the entire population was 60.4 ± 9.6 years. The dacron infrarenal aortic and the aortobifemoral bypass were the most common involved grafts. The early diagnosis of infection due to Coxiella burnetii was done by serology or with polymerase chain reaction (PCR), in 12 and 3 cases, respectively. All patients underwent partial or complete resection of the infected grafts; the most common antibiotic treatment for this entity was doxycycline and hydroxycloroquine. Although this is a relatively rare disease, Coxiella burnetii should be included in the differential diagnosis of all patients who present with infection of an endovascular graft of any nature with an inconclusive etiologic diagnosis.
