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I I Mikhaleva - One of the best experts on this subject based on the ideXlab platform.
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The effects of Delta Sleep-Inducing Peptide on the intensity of lipid peroxidation and xanthine oxidase activity in rat tissues during cold stress.
Neuroscience and Behavioral Physiology, 2020Co-Authors: T. I. Bondarenko, N. P. Milyutina, T. A. Shustanova, I I MikhalevaAbstract:Exogenous Delta Sleep-Inducing Peptide given i.p. to intact rats at a dose of 12 μg/100 g decreased the levels of diene conjugates and Schiff bases in liver and brain tissues and had no effect on xanthine oxidase activity in these tissues. Cold stress was accompanied by increases in xanthine oxidase activity in rat liver and brain, with a consequent accumulation of diene conjugates and Schiff bases, as compared with intact animals. Preliminary administration of Delta Sleep-Inducing Peptide before three days of cold stress led to decreases in xanthine oxidase activity and lipid peroxidation products in the liver and brain, as compared with values in stressed rats. The protective effect of Delta Sleep-Inducing Peptide in stress is discussed.
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Effect of Delta Sleep-Inducing Peptide on the expression of antioxidant enzyme genes in the brain and blood of rats during physiological aging.
Bulletin of Experimental Biology and Medicine, 2014Co-Authors: D. S. Kutilin, T. I. Bondarenko, I. V. Kornienko, I I MikhalevaAbstract:: Subcutaneous injections of exogenous Delta Sleep-Inducing Peptide in a dose of 100 μg/kg (monthly, 5-day courses) to rats of various age groups (2-24 months) were followed by an increase in the expression of genes for SOD 1 (Sod1) and glutathione peroxidase 1 (Gpx1) in the brain and nucleated blood cells. The expression of these genes was shown to decrease during physiological aging of the body.
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Antioxidant and detoxifying activities of analogues of the Delta sleep inducing Peptide
Russian Journal of Bioorganic Chemistry, 2014Co-Authors: I I Mikhaleva, I. A. Prudchenko, V. T. Ivanov, L. V. Onoprienko, L. D. Chikin, R. I. Yakubovskaya, E. R. Nemtsova, O. A. BezborodovaAbstract:Sixteen Peptides differing in structure from the Delta sleep inducing Peptide (DSIP) by one to two substitutions of amino acid residues have been synthesized to study the possibility of their application in oncology. The antioxidant properties of the Peptides in vitro and their detoxifying activity in vivo have been examined on a model of toxicosis caused by cisplatin, a cytostatic drug widely used in the therapy of tumor diseases. It has been shown that almost all DSIP analogues examined exhibit a direct antioxidant activity, with the activity of the ID-6 analogue being higher than that of DSIP and comparable with that of vitamin C and β-carotene. This analogue shows the most pronounced detoxifying activity toward the action of cisplatin, which manifests itself as a decrease in the death of animals from acute toxicity to 17% compared to 50–67% in the control and the restoration of some biochemical parameters of blood, in particular, a decrease in the activity of the enzymes, aspartate and alanine aminotransferases, and the concentration of the end products of nitrogen exchange: creatinine and urea. Thus, the Peptides of the DSIP family may appear promising agents for decreasing the toxic effects of cytostatics used in oncology.
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Effect of Delta-Sleep-Inducing Peptide on the functional activity of certain organs and tissues of rats in the physiological aging of an organism
Advances in Gerontology, 2013Co-Authors: T. I. Bondarenko, I I Mikhaleva, E. A. Mayboroda, I. A. PrudchenkoAbstract:This paper shows that the exogenous Delta-Sleep-Inducing Peptide (DSIP) injected subcutaneously into rats at an age of 2–24 months of postnatal development in a dose of 100 mg/kg of animal body weight in courses for five consecutive days each month has a hepatoprotective effect. DSIP does not affect the functional activity of the pancreas and is not involved in the regulation of calcium homeostasis in the physiological aging of an organism.
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The KND olygoPeptide as a putative endogenous prototype of Delta Sleep Inducing Peptide (DSIP). comparative study of biological properties
Russian Journal of Bioorganic Chemistry, 2013Co-Authors: I I Mikhaleva, V. T. Ivanov, V. B. Voitenkov, E. M. Vechkanov, T. I. BondarenkoAbstract:Biological properties of the known Delta Sleep-Inducing Peptide (DSIP, WAGGDASGE) were studied in vivo in comparison with those of a new DSIP-homologous Peptide (WKGGNASGE — ([ K ^2, N ^5]DSIP, KND). This new Peptide was recently discovered as the 324–332 fragment of the human lysine-specific histone demethylase 3B (EC 1.14.11, Swiss-Prot: Q7LBC6.1, 1761 a.a.) in the course of a computer search in available databases of proteins and nucleic acids. This demethylase belongs to the JmjC-domain-containing family of histone demethylases which are encoded by the JMJD1B gene and present in tissues of various mammals. These studies confirmed our preliminary conclusions on the functional similarity between the biological activities of DSIP and KND. The examined antioxidative, anticonvulsive, and behavioral effects of KND proved to be more pronounced than those of DSIP. The obtained results additionally sup-ported our hypothesis about KND being an endogenous prototype of a “real” DSIP.
Mikhaleva - One of the best experts on this subject based on the ideXlab platform.
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Delta-sleep inducing Peptide and the drug Deltaran: possible approaches to antistress protection
Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova, 2020Co-Authors: E. V. Koplik, I L Konorova, O L Terekhina, Umriukhin Pe, Mikhaleva, Gannushkina, K. V. SudakovAbstract:: An aim of the present study was a comparative investigation of a Delta-sleep inducing Peptide and the drug Deltaran on the neural activity of the brain structures involved in emotional processing. Another goal was to analyze the possibility to prevent negative effects of emotional stress on brain ischemia using, along with Deltaran, glycine and a Delta-sleep inducing Peptide. Deltaran and the Delta-sleep inducing Peptide exert in general similar effect on the burst activity of neurons in the dorsal hippocampus, hypothalamic paraventricular nucleus and ventral anterior thalamic nucleus, inducing amplification of the majority of recorded units. The activation of neuronal activity was seen mostly after the Delta-sleep inducing Peptide microiontophoresis in the dorsal hippocampus and after the Deltaran application in the hypothalamic paraventricular nuclei. The index characterizing blood supply was significantly higher in all rats receiving Deltaran as compared to the controls. Animals receiving Deltaran survived experimental brain ischemia in 100% cases versus 38% in those not exposed to this drug.
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Mechanism of Delta-sleep inducing Peptide geroprotective activity
Advances in gerontology, 2020Co-Authors: T. I. Bondarenko, Mikhaleva, Maĭboroda Ea, Prudchenko IaAbstract:: It is shown that the subcutaneous injection to the rats in the age from 2 to 24 months during 5 consecutive days every month with 10 microg/100 g body weight of Delta-sleep inducing Peptide (DSIP) suppresses lipid peroxidation preventing the increasing of malonic dialdehyde level in rats tissues and plasma, possesses a powerful antioxidant effect, which is realized by means of the activation of different endogenous antioxidant defense system of cell and extracellular fluid, including high- and low-molecular regulators of free radical processes. DSIP exerts stimulating influence upon the superoxid-dismutese, catalase, ceruloplasmin activities as well as the level of nonenzymatic antioxidants--urea and uric acids, because during organism aging the antioxidant defense systems are being suppressed. DSIP increases the volume of tissues and blood endogenous antioxidant defense system mainly by means of enzymatic antioxidant system, especially during later ontogenesis.
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Metabolic effects of Delta-sleep inducing Peptide during physiological aging of the organism
Eksperimental'naia i klinicheskaia farmakologiia, 2020Co-Authors: T. I. Bondarenko, Mikhaleva, Maĭboroda Ea, Prudchenko IaAbstract:: Subcutaneous injection of Delta-sleep inducing Peptide (DSIP) to postnatal rats (aged from 2 to 24 months) during 5 consecutive days every months at a dose of 10 microg/100 g body weight favors normalization of the age-related changes in carbohydrate metabolism and shows hypoglycemic effect, as manifested by a decrease in the level of glycosylated hemoglobin in erythrocytes of test rats. The administration of DSIP in postnatal rats of different age also led to a decrease in serum total lipid level, total cholesterol level, and atherogenicity index and an increase in the level of high-density lipoprotein cholesterol.
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Effect of Delta-sleep inducing Peptide on the functional activity of some organs and tissues of rats during physiological aging
Advances in gerontology, 2020Co-Authors: T. I. Bondarenko, Mikhaleva, Maĭboroda Ea, Prudchenko IaAbstract:: The authors show that exogenous Delta-sleep inducing Peptide (DSIP) injected subcutaneously to the rats in the age of 2-24 months of postnatal development in a dose of 100 mg/kg of animal body weight in courses for 5 consecutive days every month, has a hepatoprotective effect. DSIP does not affect the functional activity of the pancreas, and is not involved in the regulation of calcium homeostasis in the physiological aging of the organism.
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Effect of Delta-Sleep-Inducing Peptide on trypsin and pronase E activities in a model experiment
Eksperimental'naia i klinicheskaia farmakologiia, 2004Co-Authors: T. I. Bondarenko, Matsynova, MikhalevaAbstract:: A Delta-Sleep-Inducing Peptide in various concentrations inhibits the pharmacological activity of trypsin and pronase E under experimental conditions.
T. I. Bondarenko - One of the best experts on this subject based on the ideXlab platform.
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The effects of Delta Sleep-Inducing Peptide on the intensity of lipid peroxidation and xanthine oxidase activity in rat tissues during cold stress.
Neuroscience and Behavioral Physiology, 2020Co-Authors: T. I. Bondarenko, N. P. Milyutina, T. A. Shustanova, I I MikhalevaAbstract:Exogenous Delta Sleep-Inducing Peptide given i.p. to intact rats at a dose of 12 μg/100 g decreased the levels of diene conjugates and Schiff bases in liver and brain tissues and had no effect on xanthine oxidase activity in these tissues. Cold stress was accompanied by increases in xanthine oxidase activity in rat liver and brain, with a consequent accumulation of diene conjugates and Schiff bases, as compared with intact animals. Preliminary administration of Delta Sleep-Inducing Peptide before three days of cold stress led to decreases in xanthine oxidase activity and lipid peroxidation products in the liver and brain, as compared with values in stressed rats. The protective effect of Delta Sleep-Inducing Peptide in stress is discussed.
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Mechanism of Delta-sleep inducing Peptide geroprotective activity
Advances in gerontology, 2020Co-Authors: T. I. Bondarenko, Mikhaleva, Maĭboroda Ea, Prudchenko IaAbstract:: It is shown that the subcutaneous injection to the rats in the age from 2 to 24 months during 5 consecutive days every month with 10 microg/100 g body weight of Delta-sleep inducing Peptide (DSIP) suppresses lipid peroxidation preventing the increasing of malonic dialdehyde level in rats tissues and plasma, possesses a powerful antioxidant effect, which is realized by means of the activation of different endogenous antioxidant defense system of cell and extracellular fluid, including high- and low-molecular regulators of free radical processes. DSIP exerts stimulating influence upon the superoxid-dismutese, catalase, ceruloplasmin activities as well as the level of nonenzymatic antioxidants--urea and uric acids, because during organism aging the antioxidant defense systems are being suppressed. DSIP increases the volume of tissues and blood endogenous antioxidant defense system mainly by means of enzymatic antioxidant system, especially during later ontogenesis.
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Metabolic effects of Delta-sleep inducing Peptide during physiological aging of the organism
Eksperimental'naia i klinicheskaia farmakologiia, 2020Co-Authors: T. I. Bondarenko, Mikhaleva, Maĭboroda Ea, Prudchenko IaAbstract:: Subcutaneous injection of Delta-sleep inducing Peptide (DSIP) to postnatal rats (aged from 2 to 24 months) during 5 consecutive days every months at a dose of 10 microg/100 g body weight favors normalization of the age-related changes in carbohydrate metabolism and shows hypoglycemic effect, as manifested by a decrease in the level of glycosylated hemoglobin in erythrocytes of test rats. The administration of DSIP in postnatal rats of different age also led to a decrease in serum total lipid level, total cholesterol level, and atherogenicity index and an increase in the level of high-density lipoprotein cholesterol.
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Effect of Delta-sleep inducing Peptide on the functional activity of some organs and tissues of rats during physiological aging
Advances in gerontology, 2020Co-Authors: T. I. Bondarenko, Mikhaleva, Maĭboroda Ea, Prudchenko IaAbstract:: The authors show that exogenous Delta-sleep inducing Peptide (DSIP) injected subcutaneously to the rats in the age of 2-24 months of postnatal development in a dose of 100 mg/kg of animal body weight in courses for 5 consecutive days every month, has a hepatoprotective effect. DSIP does not affect the functional activity of the pancreas, and is not involved in the regulation of calcium homeostasis in the physiological aging of the organism.
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Influence of Delta-sleep inducing Peptide on the state of lysosomal membranes and the intensity of lysosomal proteolysis in different rat tissues with physiological aging of the organism
Advances in Gerontology, 2015Co-Authors: D. S. Kutilin, T. I. Bondarenko, I. I. MihalevaAbstract:It is shown that subcutaneous injection of exogenous Delta-sleep inducing Peptide (DSIP) in rats aged 2–24 months at a dose of 100 μg/kg animal body weight in courses of 5 consecutive days per month has a stabilizing effect on the state of lysosomal membranes in rat tissues (brain, heart muscle, and liver) at different ontogenetic stages, and this effect is accompanied by an increased intensity of lysosomal proteolysis in these tissues.
Veselinka Susic - One of the best experts on this subject based on the ideXlab platform.
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interaction of Delta sleep inducing Peptide and valproate on metaphit audiogenic seizure model in rats
Cellular and Molecular Neurobiology, 2007Co-Authors: Olivera Stanojlovic, Dragan Hrncic, A Rasic, H Loncarstevanovic, Dragan Djuric, Veselinka SusicAbstract:Effects of valproate (VPA), a conventional antiepileptic drug and natural Delta Sleep-Inducing Peptide (DSIP) on metaphit (1-[1-(3-isothiocyanatophenyl)-cyclohexyl]-piperidine)-induced audiogenic reflex epilepsy were studied. For the purpose of the study, valproate in the doses of 50 or 75 mg/kg and DSIP (1.0 mg/kg) was i.p. injected either alone or in combination to adult Wistar male rats with fully developed metaphit seizures after eight audiogenic testing. The animals were stimulated using an electric bell (100 ± 3 dB and 5–8 kHz, for 60 s) 60 min after metaphit injection and afterwards at hourly intervals during the experiment. For EEG recording and power spectra analysis, three gold-plated screws were implanted into the scull. In EEGs of metaphit-treated animals polyspikes, spike-wave complexes and sleep-like patterns were recorded, while the power spectra were increased. Combined treatment of metaphit-induced seizures with valproate and DSIP was more effective than drugs alone especially during 4 h after administration. None of the applied dose combinations eliminated the EEG signs of metaphit-provoked epileptiform activity. Taken together, the results of the present study suggest that the combinations of valproate and DSIP should be considered as beneficial polytherapy in metaphit model of epilepsy.
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Delta sleep inducing Peptide potentiates anticonvulsive activity of valproate against metaphit provoked audiogenic seizure in rats
Pharmacology, 2006Co-Authors: Dragan Hrncic, Olivera Stanojlovic, Dragana živanovic, Veselinka SusicAbstract:The effect of Delta-Sleep-Inducing Peptide (DSIP) on the anticonvulsive activity of a nonprotective valproate (VPA) dose in a metaphit model of generalized, reflex audiogenic seizures in adult Wistar
A. A. Shandra - One of the best experts on this subject based on the ideXlab platform.
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Effects of Delta-Sleep-Inducing Peptide on NMDA-induced convulsive activity in rats.
Neuroscience and Behavioral Physiology, 1998Co-Authors: A. A. Shandra, L. S. Godlevskii, A. I. Brusentsov, V. A. KarlyugaAbstract:Acute experiments on rats showed that the ED100 of NMDA for induction of clonic convulsions was 0.53 μg, while the ED100 of NMDA for inducing tonic extension of the forelimbs was 5.02 μg/animal. Determination of these parameters after administration of Delta-Sleep-Inducing Peptide (100 μg/kg, i.p.) revealed 2.3- and 4.46-fold increases. These results provide evidence for a neuroprotective role of Delta-Sleep-Inducing Peptide in relation to excitatory amino acid receptor agonists.
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Effects of Delta-Sleep-Inducing Peptide in cerebral ischemia in rats.
Neuroscience and Behavioral Physiology, 1998Co-Authors: A. A. Shandra, L. S. Godlevskii, A. I. Brusentsov, V. A. Karlyuga, A. F. Dzygal, R. S. Vast’yanov, B. NikelAbstract:Experimental studies were carried out to investigate the neuroprotective effects of Delta-Sleep-Inducing Peptide in animals with cerebral ischemia induced by bilateral compression of both carotid arteries, and to compare the efficacy of this Peptide with that of MK-801. These studies led to the conclusion that the Peptide had pronounced anti-ischemic effects, which were evident within 24 h and consisted of reductions in the severity of postural abnormalities in rats with bilateral cerebral ischemia, along with a reduction in lethality. Comparison of the efficacies of Peptide and MK-801 showed the Peptide to have the greater neuroprotective effect. These results are regarded as providing an experimental basis for using the Peptide as a therapeutic agent in patients with stroke.
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The Delta Sleep-Inducing Peptide, its analogs and the serotoninergic system in the development of anticonvulsant action
Fiziologicheskiĭ zhurnal, 1997Co-Authors: A. A. Shandra, Godlevskiĭ Ls, Brusentsov Ai, Vast'ianov Rs, B Nickel, V. P. Petrashevich, I I MikhalevaAbstract:: A seizure-protecting effect of the Delta-Sleep-Inducing Peptide (DSIP) and its analogues was revealed. An intensive sorption of H3 tryptophan occurred under the effect of the DSIP and its analogues. The data obtained suggests that the serotoninergic system plays no important part in the seizure-protecting effect.
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Effects of Delta-Sleep-Inducing Peptide during ischemic injury of the rat brain
Fiziologicheskiĭ zhurnal, 1997Co-Authors: A. A. Shandra, Godlevskiĭ Ls, Brusentsov Ai, Vast'ianov Rs, Karliuga Va, A. F. Dzygal, B NickelAbstract:: An anti-ischemic effect of the Delta-Sleep-Inducing Peptide (DSIP) was found in rats. The DSIP effect was more obvious than that of the MK-801. The data obtained is discussed considering a possible use of the DSIP for brain stroke prophylaxis.
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The role of the Delta Sleep-Inducing Peptide in the formation of neuropathological syndromes
Fiziologicheskiĭ zhurnal, 1995Co-Authors: A. A. Shandra, Godlevskiĭ Ls, Brusentsov Ai, Vast'ianov Rs, Moalla I, B. NikelAbstract:: The authors considered the pathogenetic role of Delta-sleep inducing Peptide (DSIP) in different neuropathological syndromes development and manifestation. According to own as well as published in the literature data authors showed the parkinsonian and the rotational syndromes development following DSIP central administration. Briefly, DSIP is a neuroPeptide which play significant role in the mechanisms of development of different neuropathological syndromes, namely, epileptic, parkinsonian, withdrawal, rotational and others syndromes.