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Christophe N. Peyrefitte - One of the best experts on this subject based on the ideXlab platform.

  • epidemic resurgence of chikungunya virus in Democratic Republic of the congo identification of a new central african strain
    Journal of Medical Virology, 2004
    Co-Authors: Boris Pastorino, Fabienne Tock, J J Muyembetamfum, Hugues Tolou, Mael Bessaud, J P Durand, Christophe N. Peyrefitte
    Abstract:

    The resurgence of Chikungunya virus is described during an urban epidemic in Kinshasa Democratic Republic of the Congo, after 39 years without any isolation of the virus. Chikungunya virus was isolated in sera from nine patients with clinical symptoms. A 1,200 bp long partial sequence of the E1/3'UTR genomic region was determined for each isolate. All sequences clustered in the central African lineage. They constitute Chikungunya virus reference sequences for the Democratic Republic of the Congo. J. Med. Virol. 74:277–282, 2004. © 2004 Wiley-Liss, Inc.

  • epidemic resurgence of chikungunya virus in Democratic Republic of the congo identification of a new central african strain
    Journal of Medical Virology, 2004
    Co-Authors: Boris Pastorino, Fabienne Tock, J J Muyembetamfum, Hugues Tolou, Mael Bessaud, J P Durand, Christophe N. Peyrefitte
    Abstract:

    The resurgence of Chikungunya virus is described during an urban epidemic in Kinshasa Democratic Republic of the Congo, after 39 years without any isolation of the virus. Chikungunya virus was isolated in sera from nine patients with clinical symptoms. A 1,200 bp long partial sequence of the E1/3'UTR genomic region was determined for each isolate. All sequences clustered in the central African lineage. They constitute Chikungunya virus reference sequences for the Democratic Republic of the Congo.

Michael J. Vanrooyen - One of the best experts on this subject based on the ideXlab platform.

Benoit Kebela Ilunga - One of the best experts on this subject based on the ideXlab platform.

  • ebola virus disease in the Democratic Republic of the congo 1976 2014
    eLife, 2015
    Co-Authors: Placide Mbala, Alicia Rosello, Mathias Mossoko, Stefan Flasche, Albert Jan Van Hoek, Anton Camacho, Sebastian Funk, Adam J Kucharski, Benoit Kebela Ilunga
    Abstract:

    The Democratic Republic of the Congo has experienced the most outbreaks of Ebola virus disease since the virus' discovery in 1976. This article provides for the first time a description and a line list for all outbreaks in this country, comprising 996 cases. Compared to patients over 15 years old, the odds of dying were significantly lower in patients aged 5 to 15 and higher in children under five (with 100% mortality in those under 2 years old). The odds of dying increased by 11% per day that a patient was not hospitalised. Outbreaks with an initially high reproduction number, R (>3), were rapidly brought under control, whilst outbreaks with a lower initial R caused longer and generally larger outbreaks. These findings can inform the choice of target age groups for interventions and highlight the importance of both reducing the delay between symptom onset and hospitalisation and rapid national and international response.

  • ebola virus disease in the Democratic Republic of congo
    The New England Journal of Medicine, 2014
    Co-Authors: Gael Darren Maganga, Jimmy Kapetshi, Benoit Kebela Ilunga, Felix Kabange, Placide Mbala Kingebeni, Vital Mondonge, Eric Bertherat, Jean Jacques Muyembe, Nicolas Berthet, Sylvie Briand
    Abstract:

    Background The seventh reported outbreak of Ebola virus disease (EVD) in the equatorial African country of the Democratic Republic of Congo (DRC) began on July 26, 2014, as another large EVD epidemic continued to spread in West Africa. Simultaneous reports of EVD in equatorial and West Africa raised the question of whether the two outbreaks were linked. Methods We obtained data from patients in the DRC, using the standard World Health Organization clinical-investigation form for viral hemorrhagic fevers. Patients were classified as having suspected, probable, or confirmed EVD or a non-EVD illness. Blood samples were obtained for polymerase-chain-reaction–based diagnosis, viral isolation, sequencing, and phylogenetic analysis. Results

  • description of a large measles epidemic in Democratic Republic of congo 2010 2013
    Conflict and Health, 2014
    Co-Authors: Silvia Mancini, Benoit Kebela Ilunga, Axelle Ronsse, Klaudia Porten, Matthew E Coldiron, Rebecca Freeman Grais
    Abstract:

    Background: Although measles mortality has declined dramatically in Sub-Saharan Africa, measles remains a major public health problem in countries like the Democratic Republic of Congo (DRC). Here, we describe the large measles epidemic that occurred in the Democratic Republic of Congo between 2010 and 2013 using data from the national surveillance system as well as vaccine coverage surveys to provide a snapshot of the epidemiology of measles in DRC. Methods: Standardized national surveillance data were used to describe measles cases from 2010 to 2013. Attack rates and case fatality ratios were calculated and the temporal and spatial evolution of the epidemic described. Data on laboratory confirmation and vaccination coverage surveys as a part of routine program monitoring are also presented. Findings: Between week 1 of 2010 and week 45 of 2013, a total of 294,455 cases and 5,045 deaths were reported. The cumulative attack rate (AR) was 0.4%. The Case Fatality Ratio (CFR) was 1.7% among cases reported in health structures through national surveillance. A total of 186,178 cases (63%) were under 5 years old, representing an estimated AR of 1.4% in this age group. Following the first mass vaccination campaigns, weekly reported cases decreased by 21.5%. Results of post-vaccination campaign coverage surveys indicated sub-optimal (under 95%) vaccination coverage among children surveyed. Conclusions: The data reported here highlight the need to seek additional means to reinforce routine immunization as well as ensure the timely implementation of Supplementary Immunization Activities to prevent large and repeated measles epidemics in DRC. Although reactive campaigns were conducted in response to the epidemic, strategies to ensure that children are vaccinated in the routine system remains the foundation of measles control.

  • prevalence study of yaws in the Democratic Republic of congo using the lot quality assurance sampling method
    PLOS ONE, 2009
    Co-Authors: Sibylle Gerstl, Benoit Kebela Ilunga, Gedeon Kiwila, Mehul Dhorda, Sylvaine Lonlas, Mark Myatt, Denis Lemasson, Elisabeth Szumilin, Philippe J Guerin, Laurent Ferradini
    Abstract:

    Background Until the 1970s the prevalence of non-venereal trepanomatosis, including yaws, was greatly reduced after worldwide mass treatment. In 2005, cases were again reported in the Democratic Republic of the Congo. We carried out a survey to estimate the village-level prevalence of yaws in the region of Equator in the north of the country in order to define appropriate strategies to effectively treat the affected population.

Boris Pastorino - One of the best experts on this subject based on the ideXlab platform.

  • epidemic resurgence of chikungunya virus in Democratic Republic of the congo identification of a new central african strain
    Journal of Medical Virology, 2004
    Co-Authors: Boris Pastorino, Fabienne Tock, J J Muyembetamfum, Hugues Tolou, Mael Bessaud, J P Durand, Christophe N. Peyrefitte
    Abstract:

    The resurgence of Chikungunya virus is described during an urban epidemic in Kinshasa Democratic Republic of the Congo, after 39 years without any isolation of the virus. Chikungunya virus was isolated in sera from nine patients with clinical symptoms. A 1,200 bp long partial sequence of the E1/3'UTR genomic region was determined for each isolate. All sequences clustered in the central African lineage. They constitute Chikungunya virus reference sequences for the Democratic Republic of the Congo. J. Med. Virol. 74:277–282, 2004. © 2004 Wiley-Liss, Inc.

  • epidemic resurgence of chikungunya virus in Democratic Republic of the congo identification of a new central african strain
    Journal of Medical Virology, 2004
    Co-Authors: Boris Pastorino, Fabienne Tock, J J Muyembetamfum, Hugues Tolou, Mael Bessaud, J P Durand, Christophe N. Peyrefitte
    Abstract:

    The resurgence of Chikungunya virus is described during an urban epidemic in Kinshasa Democratic Republic of the Congo, after 39 years without any isolation of the virus. Chikungunya virus was isolated in sera from nine patients with clinical symptoms. A 1,200 bp long partial sequence of the E1/3'UTR genomic region was determined for each isolate. All sequences clustered in the central African lineage. They constitute Chikungunya virus reference sequences for the Democratic Republic of the Congo.

Kapay Kibadi - One of the best experts on this subject based on the ideXlab platform.

  • new foci of buruli ulcer angola and Democratic Republic of congo
    Emerging Infectious Diseases, 2008
    Co-Authors: Kapay Kibadi, Mbutu Panda, Adhemar Longatto Filho, Gladys Anyo, Patrick Suykerbuyk, Alexandra G Fraga, Yoshinori Nakazawa, Jorge Pedrosa, Jean Jacques Muyembe Tamfum, Wayne M Meyers
    Abstract:

    We report 3 patients with laboratory-confirmed Buruli ulcer in Kafufu/Luremo, Angola, and Kasongo-Lunda, Democratic Republic of Congo. These villages are near the Kwango/Cuango River, which flows through both countries. Further investigation of artisanal alluvial mining as a risk factor for Buruli ulcer is recommended.

  • late ophthalmologic manifestations in survivors of the 1995 ebola virus epidemic in kikwit Democratic Republic of the congo
    The Journal of Infectious Diseases, 1999
    Co-Authors: Kapay Kibadi, Kibadi Mupapa, Kivudi Kuvula, Djuma Ndaberey, Mpia Ado Bwaka, M Massamba, Jeanjacques Muyembetamfum, Ann De Roo, Robert Colebunders
    Abstract:

    Three (15%) of 20 survivors of the 1995 Ebola outbreak in the Democratic Republic of the Congo enrolled in a follow-up study and 1 other survivor developed ocular manifestations after being asymptomatic for 1 month. Patients complained of ocular pain, photophobia, hyperlacrimation, and loss of visual acuity. Ocular examination revealed uveitis in all 4 patients. All patients improved with a topical treatment of 1% atropine and steroids.

  • organization of patient care during the ebola hemorrhagic fever epidemic in kikwit Democratic Republic of the congo 1995
    The Journal of Infectious Diseases, 1999
    Co-Authors: Yves Guimard, Kibadi Mupapa, Kivudi Kuvula, Mpia Ado Bwaka, Philippe Calain, M Massamba, Robert Colebunders, Kapay Kibadi, Ann De Roo, Djuma Ndaberey
    Abstract:

    Yves Guimard, Mpia Ado Bwaka, Robert Colebunders, Philippe Calain, Matondo Massamba, Ann De Roo, Kibadi Donat Mupapa, Kapay Kibadi, Kivudi Jos6 Kuvula, Djuma Eduard Ndaberey, Kasongo Rene Katwiki, Bwas Bienvenu Mapanda, Okumi Berthe Nkuku, Yon Fleerackers, Erwin Van den Enden, and Mungala Anicet Kipasa Institute of Tropical Medicine, Antwerp, Belgium; Kikwit General Hospital and Ministry of Health, Sanitary Region Kikwit North, Kikwit, Democratic Republic of the Congo; Centers for Disease Control and Prevention, Atlanta, Georgia