The Experts below are selected from a list of 60195 Experts worldwide ranked by ideXlab platform
Carolyn M Primus - One of the best experts on this subject based on the ideXlab platform.
-
bioactive tri dicalcium silicate cements for treatment of pulpal and periapical tissues
Acta Biomaterialia, 2019Co-Authors: Carolyn M PrimusAbstract:Abstract Over 2500 articles and 200 reviews have been published on the bioactive tri/dicalcium silicate Dental Materials. The indications have expanded since their introduction in the 1990s from endodontic restorative and pulpal treatments to endodontic sealing and obturation. Bioactive ceramics, based on tri/dicalcium silicate cements, are now an indispensable part of the contemporary Dental armamentarium for specialists including endodontists, pediatric dentists, oral surgeons andfor general dentists. This review emphasizes research on how these Materials have conformed to international standards for Dental Materials ranging from biocompatibility (ISO 7405) to conformance as root canal sealers (ISO 6876). Potential future developments of alternative hydraulic Materials were included. This review provides accurate Materials science information on these important Materials. Statement of Significance The broadening indications and the proliferation of tri/dicalcium silicate-based products make this relatively new Dental Material important for all dentists and bioMaterials scientists. Presenting the variations in compositions, properties, indications and clinical performance enable clinicians to choose the Material most suitable for their cases. Researchers may expand their bioactive investigations to further validate and improve Materials and outcomes.
-
Bioactive tri/dicalcium silicate cements for treatment of pulpal and periapical tissues.
Acta Biomaterialia, 2019Co-Authors: Carolyn M PrimusAbstract:Abstract Over 2500 articles and 200 reviews have been published on the bioactive tri/dicalcium silicate Dental Materials. The indications have expanded since their introduction in the 1990s from endodontic restorative and pulpal treatments to endodontic sealing and obturation. Bioactive ceramics, based on tri/dicalcium silicate cements, are now an indispensable part of the contemporary Dental armamentarium for specialists including endodontists, pediatric dentists, oral surgeons andfor general dentists. This review emphasizes research on how these Materials have conformed to international standards for Dental Materials ranging from biocompatibility (ISO 7405) to conformance as root canal sealers (ISO 6876). Potential future developments of alternative hydraulic Materials were included. This review provides accurate Materials science information on these important Materials. Statement of Significance The broadening indications and the proliferation of tri/dicalcium silicate-based products make this relatively new Dental Material important for all dentists and bioMaterials scientists. Presenting the variations in compositions, properties, indications and clinical performance enable clinicians to choose the Material most suitable for their cases. Researchers may expand their bioactive investigations to further validate and improve Materials and outcomes.
Reinhard Hickel - One of the best experts on this subject based on the ideXlab platform.
-
Cell death effects of resin-based Dental Material compounds and mercurials in human gingival fibroblasts
Archives of Toxicology, 2006Co-Authors: Franz-xaver Reichl, Magali Esters, Sabine Simon, Mario Seiss, Kai Kehe, Norbert Kleinsasser, Matthias Folwaczny, Jürgen Glas, Reinhard HickelAbstract:In order to test the hypothesis that released Dental restorative Materials can reach toxic levels in human oral tissues, the cytotoxicities of the resin-based Dental (co)monomers hydroxyethylmethacrylate (HEMA), triethyleneglycoldimethacrylate (TEGDMA), urethanedimethacrylate (UDMA), and bisglycidylmethacrylate (BisGMA) compared with methyl mercury chloride (MeHgCl) and the amalgam component mercuric chloride (HgCl_2) were investigated on human gingival fibroblasts (HGF) using two different test systems: (1) the modified XTT-test and (2) the modified H 33342 staining assay. The HGF were exposed to various concentrations of the test-substances in all test systems for 24 h. All tested (co)monomers and mercury compounds significantly ( P
-
cell death effects of resin based Dental Material compounds and mercurials in human gingival fibroblasts
Archives of Toxicology, 2006Co-Authors: Franz-xaver Reichl, Magali Esters, Sabine Simon, Mario Seiss, Kai Kehe, Norbert Kleinsasser, Matthias Folwaczny, Jürgen Glas, Reinhard HickelAbstract:In order to test the hypothesis that released Dental restorative Materials can reach toxic levels in human oral tissues, the cytotoxicities of the resin-based Dental (co)monomers hydroxyethylmethacrylate (HEMA), triethyleneglycoldimethacrylate (TEGDMA), urethanedimethacrylate (UDMA), and bisglycidylmethacrylate (BisGMA) compared with methyl mercury chloride (MeHgCl) and the amalgam component mercuric chloride (HgCl2) were investigated on human gingival fibroblasts (HGF) using two different test systems: (1) the modified XTT-test and (2) the modified H 33342 staining assay. The HGF were exposed to various concentrations of the test-substances in all test systems for 24 h. All tested (co)monomers and mercury compounds significantly (P<0.05) decreased the formazan formation in the XTT-test. EC50 values in the XTT assay were obtained as half-maximum-effect concentrations from fitted curves. Following EC50 values were found (mean [mmol/l]; s.e.m. in parentheses; n=12; * significantly different to HEMA): HEMA 11.530 (0.600); TEGDMA* 3.460 (0.200); UDMA* 0.106 (0.005); BisGMA* 0.087 (0.001); HgCl2* 0.013 (0.001); MeHgCl* 0.005 (0.001). Following relative toxicities were found: HEMA 1; TEGDMA 3; UDMA 109; BisGMA 133; HgCl2 887; MeHgCl 2306. A significant (P<0.05) increase of the toxicity of (co)monomers and mercurials was found in the XTT-test in the following order: HEMA < TEGDMA < UDMA < BisGMA < HgCl2 < MeHgCl. TEGDMA and MeHgCl induced mainly apoptotic cell death. HEMA, UDMA, BisGMA, and HgCl2 induced mainly necrotic cell death. The results of this study indicate that resin composite components have a lower toxicity than mercury from amalgam in HGF. HEMA, BisGMA, UDMA, and HgCl2 induced mainly necrosis, but it is rather unlikely that eluted substances (solely) can reach concentrations, which might induce necrotic cell death in the human physiological situation, indicating that other (additional) factors may be involved in the induction of tissue (pulp) inflammation effects after Dental restauration.
Alessandra Nara De Souza Rastelli - One of the best experts on this subject based on the ideXlab platform.
-
titanium dioxide and modified titanium dioxide by silver nanoparticles as an anti biofilm filler content for composite resins
Dental Materials, 2019Co-Authors: Hercules Bezerra Dias, Maria Ines Basso Bernardi, Tais Maria Bauab, A C Hernandes, Alessandra Nara De Souza RastelliAbstract:Abstract Objective The aim of this study was to evaluate the antibacterial activity of a composite resin modified by TiO 2 and TiO 2 /Ag nanoparticles and their influence over different properties. Methods TiO 2 and TiO 2 /Ag NPs were synthesized by polymeric precursor and microwave-assisted hydrothermal methods and then, characterized by different techniques. Direct contact test was performed using Filtek™ Z350XT blended with 0.5; 1 and 2% (wt.) of NPs against Streptococcus mutans to determine the best concentration to the other tests. After that, the modified composite resin was tested against S. mutans 7-day biofilm (CFU/mL). Also, compressive and diametral tensile strength (n = 40), degree of conversion (n = 25) and surface roughness (n = 50) was performed. The data were analyzed by ANOVA and Tukey’s test for multiple comparison at 5% significance level. Results The direct contact test demonstrates that by increasing the nanoparticle content, the bacterial growth is significantly reduceed (p 2 /Ag NPs significantly decreased (p S. mutans on the composite resin surface compared to the control Group. The TiO 2 NPs treated with an organosilane increased compressive strength of composite resin (p 0.05) and the surface roughness increased with the NPs (p 2 by polymeric precursor Group (p > 0.05). Significance The development of an antibacterial Dental restorative Material that hinder S. mutans biofilm without sacrificing the mechanical and physical properties is desirable in Dental Material science.
Josimeri Hebling - One of the best experts on this subject based on the ideXlab platform.
-
short term evaluation of the pulpo dentin complex response to a resin modified glass ionomer cement and a bonding agent applied in deep cavities
Dental Materials, 2003Co-Authors: Carlos Alberto De Souza Costa, Elisa Maria Aparecida Giro, Alexandre Batista Lopes Do Nascimento, Hilcia Mezzalira Teixeira, Josimeri HeblingAbstract:Abstract Objectives. To evaluate the response of the pulpo-dentin complex following application of a resin-modified glass-ionomer cement or an adhesive system in deep cavities performed in human teeth. Methods. Deep class V cavities were prepared on the buccal surface of 26 premolars. In Group 1 the cavity walls (dentin) and enamel were conditioned with 32% phosphoric acid and the dentin adhesive system One Step (Bisco, Inc., Itasca, IL, USA) was applied. In Groups 2 and 3, before total etching and application of bonding agent, the cavity floor was lined with the resin-modified glass-ionomer cement—Vitrebond (3M ESPE Dental Products Division, St. Paul, MN, USA) or the calcium hydroxide cement—Dycal (control group, Dentsply, Mildford, DE, USA), respectively. The cavities were restored using light-cured Z-100 composite resin (3M ESPE). The teeth were extracted between 5 and 30 days and prepared for microscopic assessment. Serial sections were stained with H/E, Masson's trichrome and Brown and Brenn techniques. Results. In Group 1, the inflammatory response was more evident than in Groups 2 and 3. Diffusion of Dental Material components across dentinal tubules was observed only in Group 1, in which the intensity of the pulp response increased as the remaining dentin thickness decreased. Bacteria were evidenced in the lateral walls of two samples (Group 2) which exhibited no inflammatory response or tissue disorganization. Conclusions. Based on the experimental conditions, it was concluded total acid etching followed by application of One Step bonding agent cannot be recommended as adequate procedures. In this clinical condition the cavity walls should be lined with a biocompatible Dental Material, such as Vitrebond or Dycal.
Franz-xaver Reichl - One of the best experts on this subject based on the ideXlab platform.
-
Cell death effects of resin-based Dental Material compounds and mercurials in human gingival fibroblasts
Archives of Toxicology, 2006Co-Authors: Franz-xaver Reichl, Magali Esters, Sabine Simon, Mario Seiss, Kai Kehe, Norbert Kleinsasser, Matthias Folwaczny, Jürgen Glas, Reinhard HickelAbstract:In order to test the hypothesis that released Dental restorative Materials can reach toxic levels in human oral tissues, the cytotoxicities of the resin-based Dental (co)monomers hydroxyethylmethacrylate (HEMA), triethyleneglycoldimethacrylate (TEGDMA), urethanedimethacrylate (UDMA), and bisglycidylmethacrylate (BisGMA) compared with methyl mercury chloride (MeHgCl) and the amalgam component mercuric chloride (HgCl_2) were investigated on human gingival fibroblasts (HGF) using two different test systems: (1) the modified XTT-test and (2) the modified H 33342 staining assay. The HGF were exposed to various concentrations of the test-substances in all test systems for 24 h. All tested (co)monomers and mercury compounds significantly ( P
-
cell death effects of resin based Dental Material compounds and mercurials in human gingival fibroblasts
Archives of Toxicology, 2006Co-Authors: Franz-xaver Reichl, Magali Esters, Sabine Simon, Mario Seiss, Kai Kehe, Norbert Kleinsasser, Matthias Folwaczny, Jürgen Glas, Reinhard HickelAbstract:In order to test the hypothesis that released Dental restorative Materials can reach toxic levels in human oral tissues, the cytotoxicities of the resin-based Dental (co)monomers hydroxyethylmethacrylate (HEMA), triethyleneglycoldimethacrylate (TEGDMA), urethanedimethacrylate (UDMA), and bisglycidylmethacrylate (BisGMA) compared with methyl mercury chloride (MeHgCl) and the amalgam component mercuric chloride (HgCl2) were investigated on human gingival fibroblasts (HGF) using two different test systems: (1) the modified XTT-test and (2) the modified H 33342 staining assay. The HGF were exposed to various concentrations of the test-substances in all test systems for 24 h. All tested (co)monomers and mercury compounds significantly (P<0.05) decreased the formazan formation in the XTT-test. EC50 values in the XTT assay were obtained as half-maximum-effect concentrations from fitted curves. Following EC50 values were found (mean [mmol/l]; s.e.m. in parentheses; n=12; * significantly different to HEMA): HEMA 11.530 (0.600); TEGDMA* 3.460 (0.200); UDMA* 0.106 (0.005); BisGMA* 0.087 (0.001); HgCl2* 0.013 (0.001); MeHgCl* 0.005 (0.001). Following relative toxicities were found: HEMA 1; TEGDMA 3; UDMA 109; BisGMA 133; HgCl2 887; MeHgCl 2306. A significant (P<0.05) increase of the toxicity of (co)monomers and mercurials was found in the XTT-test in the following order: HEMA < TEGDMA < UDMA < BisGMA < HgCl2 < MeHgCl. TEGDMA and MeHgCl induced mainly apoptotic cell death. HEMA, UDMA, BisGMA, and HgCl2 induced mainly necrotic cell death. The results of this study indicate that resin composite components have a lower toxicity than mercury from amalgam in HGF. HEMA, BisGMA, UDMA, and HgCl2 induced mainly necrosis, but it is rather unlikely that eluted substances (solely) can reach concentrations, which might induce necrotic cell death in the human physiological situation, indicating that other (additional) factors may be involved in the induction of tissue (pulp) inflammation effects after Dental restauration.