The Experts below are selected from a list of 246738 Experts worldwide ranked by ideXlab platform
Michael A. Dyer - One of the best experts on this subject based on the ideXlab platform.
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neuroblastoma Developmental Biology cancer genomics and immunotherapy
Nature Reviews Cancer, 2013Co-Authors: Naikong V Cheung, Michael A. DyerAbstract:Neuroblastoma is a solid tumour that arises from the developing sympathetic nervous system. Over the past decade, our understanding of this disease has advanced tremendously. The future challenge is to apply the knowledge gained to developing risk-based therapies and, ultimately, improving outcome. In this Review we discuss the key discoveries in the Developmental Biology, molecular genetics and immunology of neuroblastoma, as well as new translational tools for bringing these promising scientific advances into the clinic.
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Current Topics in Developmental Biology - Childhood Cancer and Developmental Biology
Current Topics in Developmental Biology, 2011Co-Authors: Sara M. Federico, Rachel C. Brennan, Michael A. DyerAbstract:For many years, there were relatively few research efforts that bridged the fields of Developmental Biology and cancer genetics. However, in the past decade, we have witnessed a dramatic shift and now these two fields are intertwined. Part of the impetus for this transition came from the discovery that regulatory pathways that were previously thought to be uniquely important for Developmental processes were also perturbed in cancer. In addition, the conceptual framework for understanding how cells self-renew or undergo unidirectional changes in competence during development has proven to be very useful in cancer Biology as researchers explore tumor initiation and progression. Finally, a deeper understanding of the process of terminal differentiation and how that relates to cellular plasticity may have important implications for both cancer Biology and Developmental Biology. Here we highlight some of the important connections between Developmental neuroBiology and cancer Biology in retinoblastoma. By bridging these fields, important advances have been made in modeling retinoblastoma in mice, elucidating the cell-of-origin for retinoblastoma and identifying novel therapeutic approaches.
Brian K Hall - One of the best experts on this subject based on the ideXlab platform.
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Summarizing craniofacial genetics and Developmental Biology (SCGDB).
American journal of medical genetics. Part A, 2014Co-Authors: Brian K HallAbstract:This overview article highlights active areas of research in craniofacial genetics and Developmental Biology as reflected in presentations given at the 34th annual meeting of the Society of Craniofacial Genetics and Developmental Biology (SCGDB) in Montreal, Quebec on October 11, 2011. This 1-day meeting provided a stimulating occasion that demonstrated the present status of research in craniofacial genetics and Developmental Biology and where the field is heading. To accompany the abstracts published in this issue I have selected several themes that emerged from the meeting. After discussing the basis on which craniofacial defects/syndromes are classified and investigated, I address the multi-gene basis of craniofacial syndromes with an examination of the roles of Sox9 and FGF receptors in normal and abnormal craniofacial development. I then turn to the knowledge being gained from population-wide and longitudinal cohort studies and from the discovery of new signaling centers that regulate craniofacial development.
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Summarizing craniofacial genetics and Developmental Biology (SCGDB)
American Journal of Medical Genetics Part A, 2014Co-Authors: Brian K HallAbstract:This overview article highlights active areas of research in craniofacial genetics and Developmental Biology as reflected in presentations given at the 34th annual meeting of the Society of Craniofacial Genetics and Developmental Biology (SCGDB) in Montreal, Quebec on October 11, 2011. This 1-day meeting provided a stimulating occasion that demonstrated the present status of research in craniofacial genetics and Developmental Biology and where the field is heading. To accompany the abstracts published in this issue I have selected several themes that emerged from the meeting. After discussing the basis on which craniofacial defects/syndromes are classified and investigated, I address the multi-gene basis of craniofacial syndromes with an examination of the roles of Sox9 and FGF receptors in normal and abnormal craniofacial development. I then turn to the knowledge being gained from population-wide and longitudinal cohort studies and from the discovery of new signaling centers that regulate craniofacial development. © 2014 Wiley Periodicals, Inc.
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Keywords and Concepts in Evolutionary Developmental Biology
2004Co-Authors: Brian K Hall, Wendy M. OlsonAbstract:Evolutionary Developmental Biology is one of the most exciting areas of contemporary Biology. The fundamental principle of evolutional Developmental Biology ("evo-devo") is that evolution acts through inherited changes in the development of the organism. Evo-devo is not merely a fusion of the fields of Developmental and evolutionary Biology, the grafting of a Developmental perspective onto evolutionary Biology, or the incorporation of an evolutionary perspective into Developmental Biology. Evo-devo strives for a unification of genomic, Developmental, organismal, population and natural selection approaches to evolutionary change. It draws from Developmental, evolution, palaeontology, ecology and molecular and systematic Biology, but has its own set of questions, approaches and methods. This volume is a comprehensive reference work for this expanding field. Covering more than 50 central terms and concepts in entries written by leading experts, the book offers an overview of all that is embraced by this sub-discipline of Biology, providing the core insights and ideas that show how embryonic development relates to life-history evolution, adaptation and responses and integration with environmental factors.
Jan Huisken - One of the best experts on this subject based on the ideXlab platform.
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light sheet microscopy for real time Developmental Biology
Current Opinion in Genetics & Development, 2011Co-Authors: Michael Weber, Jan HuiskenAbstract:Within only a few short years, light sheet microscopy has contributed substantially to the emerging field of real-time Developmental Biology. Low photo-toxicity and high-speed multiview acquisition have made selective plane illumination microscopy (SPIM) a popular choice for studies of organ morphogenesis and function in zebrafish, Drosophila, and other model organisms. A multitude of different light sheet microscopes have emerged for the noninvasive imaging of specimens ranging from single molecules to cells, tissues, and entire embryos. In particular, Developmental Biology can benefit from the ability to watch Developmental events occur in real time in an entire embryo, thereby advancing our understanding on how cells form tissues and organs. However, it presents a new challenge to our existing data and image processing tools. This review gives an overview of where we stand as light sheet microscopy branches out, explores new areas, and becomes more specialized.
Scott F. Gilbert - One of the best experts on this subject based on the ideXlab platform.
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Developmental Biology, the stem cell of biological disciplines.
PLOS Biology, 2017Co-Authors: Scott F. GilbertAbstract:Developmental Biology (including embryology) is proposed as "the stem cell of biological disciplines." Genetics, cell Biology, oncology, immunology, evolutionary mechanisms, neuroBiology, and systems Biology each has its ancestry in Developmental Biology. Moreover, Developmental Biology continues to roll on, budding off more disciplines, while retaining its own identity. While its descendant disciplines differentiate into sciences with a restricted set of paradigms, examples, and techniques, Developmental Biology remains vigorous, pluripotent, and relatively undifferentiated. In many disciplines, especially in evolutionary Biology and oncology, the Developmental perspective is being reasserted as an important research program.
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Ecological Developmental Biology: Integrating Epigenetics, Medicine, And Evolution
2009Co-Authors: Scott F. Gilbert, David EpelAbstract:PART I: ENVIRONMENTAL SIGNALS AND NORMAL DEVELOPMENT The Environment as a Normal Agent in Producing Phenotypes How Agents in the Environment Effect Molecular Changes in Development Developmental Symbiosis: Co-Development as a Strategy for Life Embryonic Defenses: Survival in a Hostile World PART II: ECOLOGICAL Developmental Biology AND DISEASE STATES Teratogenesis: Environmental Assaults on Development Endocrine Disruptors The Epigenetic Origin of Adult Diseases PART III: TOWARD A Developmental EVOLUTIONARY SYNTHESIS The Modern Synthesis: Natural Selection of Allelic Variation Evolution through Developmental Regulatory Genes Environment, Development, and Evolution: Toward a New Synthesis CODA: Philosophical Concerns Raised by Ecological Developmental Biology APPENDX A: Lysenko, Kammerer, and the Truncated Tradition of Ecological Developmental Biology APPENDIX B: The Molecular Mechanisms of Epigenetic Change APPENDIX C: Writing Development Out of the Modern Synthesis APPENDIX D: Epigenetic Inheritance Systems: The Inheritance of Environmentally Induced Traits
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Ecological Developmental Biology
2008Co-Authors: Scott F. GilbertAbstract:Ecological Developmental Biology is the science that studies the interactions between developing organisms and their environmental contexts. It studies development in the ‘real world’ of predators, competitors, symbionts, toxic compounds, temperature changes and nutritional differences. The environment plays a substantial role in development, and in many instances, normal development cannot occur without environmental signalling. Symbionts, for instance are needed in many organisms for the development of particular organs. Environmental agents can elicit epigenetic changes in gene expression that can change an organism's phenotype. In many instances, however, substances in the environment of developing organisms can act detrimentally, causing birth defects and predisposing the organism to diseases in adulthood. Epigenetics has recently provided startling insights into how environmental agents experienced during embryonic development can predispose one to cancer, obesity, hypertension and diabetes later in life. Key Concepts The environment plays critical roles during normal development. The genome encodes a repertoire of possible phenotypes. Environment often selects which of those genes will become active and which phenotypes will become expressed. Reaction norms are phenotypes that quantitatively respond to environmental conditions, such that the phenotype reflects small differences in the environmental conditions. Polyphenisms represent ‘either/or’ phenotypes wherein one set of conditions elicits one phenotype, while another set of conditions elicits another phenotype. Organisms usually develop in symbiotic relationships with other organisms; and signals from the symbionts are often critical for normal development. Teratogens (such as ethanol) are compounds that can cause birth defects by disrupting normal development. Endocrine disruptors are compounds in the environment that can disrupt normal development by changing gene expression in ways that are not seen phenotypically for years after birth. Ecological Developmental Biology proposes new mechanisms through which evolution can occur. These include epialleles (inherited patterns of chromatin alterations giving inherited variants of gene expression patterns), plasticity-driven adaptation and symbiont-mediated variation. Keywords: ecological Developmental Biology; symbiosis; epigenetics; teratogens; plasticity; evolution
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The Morphogenesis Of Evolutionary Developmental Biology
The International Journal of Developmental Biology, 2003Co-Authors: Scott F. GilbertAbstract:The early studies of evolutionary Developmental Biology (Evo-Devo) come from several sources. Tributaries flowing into Evo-Devo came from such disciplines as embryology, Developmental genetics, evolutionary Biology, ecology, paleontology, systematics, medical embryology and mathematical modeling. This essay will trace one of the major pathways, that from evolutionary embryology to Evo-Devo and it will show the interactions of this pathway with two other sources of Evo-Devo: ecological Developmental Biology and medical Developmental Biology. Together, these three fields are forming a more inclusive evolutionary Developmental Biology that is revitalizing and providing answers to old and important questions involving the formation of biodiversity on Earth. The phenotype of Evo-Devo is limited by internal constraints on what could be known given the methods and equipment of the time and it has been framed by external factors that include both academic and global politics.
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Ecological Developmental Biology: preface to the symposium.
Evolution and Development, 2003Co-Authors: Scott F. Gilbert, Jessica A. BolkerAbstract:The symposium “Ecological Developmental Biology: Developmental Biology Meets the Real World” was presented at the annual meeting of the Society for Integrative and Comparative Biology, January 6–10, 2002, in Anaheim, California, USA
Michael Weber - One of the best experts on this subject based on the ideXlab platform.
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light sheet microscopy for real time Developmental Biology
Current Opinion in Genetics & Development, 2011Co-Authors: Michael Weber, Jan HuiskenAbstract:Within only a few short years, light sheet microscopy has contributed substantially to the emerging field of real-time Developmental Biology. Low photo-toxicity and high-speed multiview acquisition have made selective plane illumination microscopy (SPIM) a popular choice for studies of organ morphogenesis and function in zebrafish, Drosophila, and other model organisms. A multitude of different light sheet microscopes have emerged for the noninvasive imaging of specimens ranging from single molecules to cells, tissues, and entire embryos. In particular, Developmental Biology can benefit from the ability to watch Developmental events occur in real time in an entire embryo, thereby advancing our understanding on how cells form tissues and organs. However, it presents a new challenge to our existing data and image processing tools. This review gives an overview of where we stand as light sheet microscopy branches out, explores new areas, and becomes more specialized.
