The Experts below are selected from a list of 240 Experts worldwide ranked by ideXlab platform
Ni Xiao - One of the best experts on this subject based on the ideXlab platform.
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determination of Dimetridazole using carbon paste electrode modified with aluminum doped surface molecularly imprinted siloxane
Electrochimica Acta, 2015Co-Authors: Jian Deng, Kaihui Huang, Xilin Xiao, Xiaozhu Zhan, Ni XiaoAbstract:Abstract For the first time, a simple and highly sensitive electrochemical Dimetridazole (DMZ) sensor based on a carbon paste electrode modified with core-shell aluminum doped surface molecularly imprinted siloxane has been developed and tested. Because of aluminum doping, the surface imprinting sensor exhibits higher rebinding capacity, recognition ability and affinity for DMZ in comparison with the aluminum free and the non-imprinted ones. In addition, the as-prepared sensor shows good stability and satisfactory reproducibility for the determination of DMZ. Under optimal experimental conditions, the peak currents by differential pulse stripping voltammetry were found to vary linearly with DMZ concentrations in the range from 1.0 × 10 −8 to 1.0 × 10 −6 mol L −1 and 1.0 × 10 −6 to 1.0 × 10 −4 mol L −1 , with a detection limit of 3.6 × 10 −9 mol L −1 . This sensor was successfully employed to detect DMZ in egg, milk powder, and pig feed samples with acceptable recoveries of 91.4% to 107.6%, which was verified by high performance liquid chromatography.
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a novel core shell magnetic nano sorbent with surface molecularly imprinted polymer coating for the selective solid phase extraction of Dimetridazole
Food Chemistry, 2014Co-Authors: Jian Deng, Yubao Zhao, Liangshu Xia, Kaihui Huang, Ni XiaoAbstract:A novel core–shell magnetic nano-sorbent with surface molecularly-imprinted polymer coating was prepared via a sol–gel process. Methyltrimethoxysilane and 3-aminopropyltriethoxysilane were used as functional monomers, tetraethyl orthosilicate as cross-linker, and Al3+ as dopant to generate Lewis acid sites in the silica matrix for the metal coordinate interactions with the template Dimetridazole (DMZ). The ratios of the monomers, the dopant, and the cross-linker, were optimised by a OA9 (34) orthogonal array design. The resultant sorbent was characterised by scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, powder X-ray diffraction, and magnetometry. The binding performances of the sorbent were evaluated by static, kinetic and selective adsorption experiments. The nano-sorbent was successfully applied to solid phase extraction followed by spectrophotometric determination of DMZ in real samples. Spiked recoveries ranged from 90.33% to 106.20% for egg, milk powder, and pig feed samples, with relative standard deviations of less than 4.54%.
J. Žmudzki - One of the best experts on this subject based on the ideXlab platform.
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selective determination of fourteen nitroimidazoles in honey by high performance liquid chromatography tandem mass spectrometry
Analytical Letters, 2014Co-Authors: Kamila Mitrowska, A. Posyniak, J. ŽmudzkiAbstract:A selective method for the determination of fourteen nitroimidazoles and their hydroxy-metabolites in honey was developed based on improved molecularly imprinted solid-phase extraction followed by liquid chromatography–tandem mass spectrometry. The separation of analytes was performed on a C18 column using a mobile phase of 0.1% formic acid in acetonitrile and 0.1% formic acid in water with gradient elution. The method was suitable for metronidazole, hydroxymetronidazole, Dimetridazole, ronidazole, hydroxyDimetridazole, ipronidazole, hydroxyipronidazole, carnidazole, menidazole, nimorazole, ornidazole, secnidazole, ternidazole, and tinidazole. The procedure was evaluated according to EU Commission Decision 2002/657/EC requirements by determining linearity, specificity, recovery, repeatability, within-laboratory reproducibility, decision limit, detection capability, matrix effects, and stability. The method determined nitroimidazoles and their hydroxy-metabolites below the recommended concentration level o...
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multiresidue method for the determination of nitroimidazoles and their hydroxy metabolites in poultry muscle plasma and egg by isotope dilution liquid chromatography mass spectrometry
Talanta, 2010Co-Authors: Kamila Mitrowska, A. Posyniak, J. ŽmudzkiAbstract:Abstract A multiresidue analytical procedure for the determination of four nitroimidazoles (metronidazole, Dimetridazole, ronidazole, ipronidazole) and their hydroxy-metabolites in poultry muscle, plasma and egg is presented. The procedure is based on ion-exchange solid phase extraction with acetonitrile as an extractant followed by liquid chromatography–mass spectrometry. The separation of analytes was performed on a C18 column using a mobile phase of 0.1% formic acid in acetonitrile and 0.1% formic acid in water with gradient elution. The electrospray ionization was used to obtain the protonated molecules [M+H] + and two product ions were monitored for each compound. For the quantification stable isotope-labelled analogues of the analytes were used as internal standards. The whole procedure was evaluated according to EU Commission Decision 2002/657/EC requirements. Specificity, decision limit (CCα), detection capacity (CCβ), recovery and precision were determined during validation process. The overall recoveries ranged between 93 and 103% with a good coefficient of variation, less than 14.0% under within-laboratory reproducibility conditions. CCα and CCβ were 0.05–0.44 and 0.08–0.90 μg kg −1 depending on analyte and matrix.
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tissue concentration of Dimetridazole in laying hens
Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment, 1996Co-Authors: A. Posyniak, S. Semeniuk, J. Žmudzki, J. Niedzielska, B. BiernackiAbstract:After laying hens had been dosed orally with Dimetridazole (DMZ) for 3 days (50 and 250 mg/kg body weight (b.w.)) or intramuscularly, also for 3 days (50 mg/kg b.w.), the residues were determined in serum, liver, breast and thigh muscle by liquid chromatography. The limit of determination was 0.01 μg/g. The maximum concentration of DMZ was found at 1 h following application. After oral doses (50 and 250 mg/kg b.w.) no residues were found in muscle (breast and thigh) at 48 and 72 h, respectively. After intramuscular injection, residues in thigh muscle were below 0.01 μg/g at 72 h but breast muscle (injection site) still had concentrations above this level. Bioavailability (F > 80%) and some pharmacokinetic parameters were determined. The elimination half‐lives from serum were 2.56 h and 2.69 h, after both oral doses, respectively, and 2.88 h after intramuscular application.
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Residues of Dimetridazole in eggs after treatment of laying hens
Veterinary Research Communications, 1996Co-Authors: A. Posyniak, S. Semeniuk, J. Žmudzki, J. Niedzielska, B. BiernackiAbstract:Laying hens were dosed orally with Dimetridazole (DMZ) (50 and 250 mg/kg) for 3 days or intramuscularly (50 mg/kg), also for 3 days, and the residues were determined by liquid chromatography in albumen and yolk. The sensitivity of the whole procedure was 2 ng/g. The drug was excreted preferentially into the yolk (about 57% of the total) and the elimination period lasted for 4–6 days after treatment.
Jian Deng - One of the best experts on this subject based on the ideXlab platform.
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determination of Dimetridazole using carbon paste electrode modified with aluminum doped surface molecularly imprinted siloxane
Electrochimica Acta, 2015Co-Authors: Jian Deng, Kaihui Huang, Xilin Xiao, Xiaozhu Zhan, Ni XiaoAbstract:Abstract For the first time, a simple and highly sensitive electrochemical Dimetridazole (DMZ) sensor based on a carbon paste electrode modified with core-shell aluminum doped surface molecularly imprinted siloxane has been developed and tested. Because of aluminum doping, the surface imprinting sensor exhibits higher rebinding capacity, recognition ability and affinity for DMZ in comparison with the aluminum free and the non-imprinted ones. In addition, the as-prepared sensor shows good stability and satisfactory reproducibility for the determination of DMZ. Under optimal experimental conditions, the peak currents by differential pulse stripping voltammetry were found to vary linearly with DMZ concentrations in the range from 1.0 × 10 −8 to 1.0 × 10 −6 mol L −1 and 1.0 × 10 −6 to 1.0 × 10 −4 mol L −1 , with a detection limit of 3.6 × 10 −9 mol L −1 . This sensor was successfully employed to detect DMZ in egg, milk powder, and pig feed samples with acceptable recoveries of 91.4% to 107.6%, which was verified by high performance liquid chromatography.
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a novel core shell magnetic nano sorbent with surface molecularly imprinted polymer coating for the selective solid phase extraction of Dimetridazole
Food Chemistry, 2014Co-Authors: Jian Deng, Yubao Zhao, Liangshu Xia, Kaihui Huang, Ni XiaoAbstract:A novel core–shell magnetic nano-sorbent with surface molecularly-imprinted polymer coating was prepared via a sol–gel process. Methyltrimethoxysilane and 3-aminopropyltriethoxysilane were used as functional monomers, tetraethyl orthosilicate as cross-linker, and Al3+ as dopant to generate Lewis acid sites in the silica matrix for the metal coordinate interactions with the template Dimetridazole (DMZ). The ratios of the monomers, the dopant, and the cross-linker, were optimised by a OA9 (34) orthogonal array design. The resultant sorbent was characterised by scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, powder X-ray diffraction, and magnetometry. The binding performances of the sorbent were evaluated by static, kinetic and selective adsorption experiments. The nano-sorbent was successfully applied to solid phase extraction followed by spectrophotometric determination of DMZ in real samples. Spiked recoveries ranged from 90.33% to 106.20% for egg, milk powder, and pig feed samples, with relative standard deviations of less than 4.54%.
J. Z. Shen - One of the best experts on this subject based on the ideXlab platform.
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Confirmation of four nitroimidazoles in porcine liver by liquid chromatography-tandem mass spectrometry.
Analytica Chimica Acta, 2006Co-Authors: Xiangmei Li, Suxia Zhang, Shuangyang Ding, Hai-yang Jiang, J. Z. ShenAbstract:Abstract A sensitive and reliable multiresidue method is described for analysis of ronidazole, metronidazole, Dimetridazole and the common metabolite of ronidazole and Dimetridazole, 2-hydroxymethyl-1-methyl-5-nitroimidazole in swine liver. The sample preparation procedure was based on liquid–liquid extraction and mixed mode cation exchange/reverse phase solid-phase extraction. The compounds of interest were determined by reverse phase gradient liquid chromatography separation and tandem mass spectrometry (MS/MS) in the multiple reaction monitoring (MRM) mode. The limits of confirmation were 0.1–0.5 μg kg −1 for the analytes.
Philippe A Guy - One of the best experts on this subject based on the ideXlab platform.
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analysis of four 5 nitroimidazoles and their corresponding hydroxylated metabolites in egg processed egg and chicken meat by isotope dilution liquid chromatography tandem mass spectrometry
Journal of Agricultural and Food Chemistry, 2006Co-Authors: Pascal Mottier, Isabelle Hure, Eric Gremaud, Philippe A GuyAbstract:An isotope dilution liquid chromatography−electrospray ionization−tandem mass spectrometry method is presented for the simultaneous analysis of several 5-nitroimidazole-based veterinary drugs, which are Dimetridazole (DMZ), ronidazole (RNZ), metronidazole (MNZ), ipronidazole (IPZ), and their hydroxylated metabolites (DMZOH, MNZOH, and IPZOH), in egg (fresh egg, whole egg powder, and egg yolk powder) and chicken meat. Data acquisition was achieved by applying multiple reaction monitoring, and quantitation was performed by means of five deuterated internal standards (ISs), namely, DMZ-d3, RNZ-d3, IPZ-d3, DMZOH-d3, and IPZOH-d3, whereas MNZ and MNZOH were quantitated using DMZOH-d3. At the lowest fortification levels (i.e., 0.5 μg/kg for fresh egg and chicken meat and 1.0 μg/kg for other egg-based matrices) and for compounds having their own corresponding deuterated analogue used as an IS, acceptable performance data were obtained (corrected recoveries, 88−111%; decision limits, 0.07−0.36 μg/kg; detection ca...