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Joseph Wang - One of the best experts on this subject based on the ideXlab platform.

  • wearable Electrochemical Biosensors in north america
    Biosensors and Bioelectronics, 2021
    Co-Authors: Jihong Min, Joseph Wang, Juliane R Sempionatto, Hazhir Teymourian, Wei Gao
    Abstract:

    Tremendous research and commercialization efforts around the world are focused on developing novel wearable Electrochemical Biosensors that can noninvasively and continuously screen for biochemical markers in body fluids for the prognosis, diagnosis and management of diseases, as well as the monitoring of fitness. Researchers in North America are leading the development of innovative wearable platforms that can comfortably comply to the human body and efficiently sample fluids such as sweat, interstitial fluids, tear and saliva for the Electrochemical detection of biomarkers through various sensing approaches such as potentiometric ion selective electrodes and amperometric enzymatic sensors. We start this review with a historical timeline overviewing the major milestones in the development of wearable Electrochemical sensors by North American institutions. We then describe how such research efforts have led to pioneering developments and are driving the advancement and commercialization of wearable Electrochemical sensors: from minimally invasive continuous glucose monitors for chronic disease management to non-invasive sweat electrolyte sensors for dehydration monitoring in fitness applications. While many countries across the globe have contributed significantly to this rapidly emerging field, their contributions are beyond the scope of this review. Furthermore, we share our perspective on the promising future of wearable Electrochemical sensors in applications spanning from remote and personalized healthcare to wellness.

  • Electrochemical Biosensors towards point of care cancer diagnostics
    Biosensors and Bioelectronics, 2006
    Co-Authors: Joseph Wang
    Abstract:

    Wide-scale point-of-care diagnostic systems hold great promise for early detection of cancer at a curable stage of the disease. This review discusses the prospects and challenges of Electrochemical Biosensors for next-generation cancer diagnostics. Electrochemical Biosensors have played an important significant role in the transition towards point-of-care diagnostic devices. Such electrical devices are extremely useful for delivering the diagnostic information in a fast, simple, and low cost fashion in connection to compact (hand-held) analyzers. Modern Electrochemical bioaffinity sensors, such as DNA- or immunosensors, offer remarkable sensitivity essential for early cancer detection. The coupling of Electrochemical devices with nanoscale materials offers a unique multiplexing capability for simultaneous measurements of multiple cancer markers. The attractive properties of Electrochemical devices are extremely promising for improving the efficiency of cancer diagnostics and therapy monitoring. With further development and resources, such portable devices are expected to speed up the diagnosis of cancer, making analytical results available at patient bedside or physician office within few minutes.

  • carbon nanotube based Electrochemical Biosensors a review
    Electroanalysis, 2005
    Co-Authors: Joseph Wang
    Abstract:

    Carbon nanofibers (CNFs), a novel carbon nanomaterial, have the similar conductivity and stability to carbon nanotubes (CNTs). The main distinguishing characteristic of CNFs from CNTs is the stacking of graphene sheets of varying shapes, producing more edge sites on the outer wall of CNFs than CNTs, which can facilitate the electron transfer of electroactive analytes. The unique chemical and physical properties make CNFs exceptional candidates for electrode materials and promising candidates as immobilization substrates. This review is an attempt to give an overview on Electrochemical Biosensors based on CNFs and their various applications. We discussed the application of CNFs as electrode material in electroanalysis, as well as their functionalization and surface immobilization. Vertically aligned carbon nanofibers (VACNFs) as substrates for the immobilization of biological molecules have also been discussed.

  • sol gel materials for Electrochemical Biosensors
    Analytica Chimica Acta, 1999
    Co-Authors: Joseph Wang
    Abstract:

    Abstract An overview is presented of the state-of-the art of Electrochemical Biosensors employing sol–gel materials. Low-temperature, porous sol–gel ceramics represent a relatively new class of materials for the immobilization of biomolecules. The rational design of sol–gel sensing materials, based on the judicious choice of the starting alkoxide, encapsulated reagents, and preparation conditions, allows tailoring of material properties in a wide range, and offers great promise for the development of Electrochemical Biosensors. The various advantages of biogels for amperometric biosensing are discussed, along with common designs of sol–gel-derived bioelectrodes, recent advances and trends, and future prospects.

  • Sol–gel materials for Electrochemical Biosensors
    Analytica Chimica Acta, 1999
    Co-Authors: Joseph Wang
    Abstract:

    Abstract An overview is presented of the state-of-the art of Electrochemical Biosensors employing sol–gel materials. Low-temperature, porous sol–gel ceramics represent a relatively new class of materials for the immobilization of biomolecules. The rational design of sol–gel sensing materials, based on the judicious choice of the starting alkoxide, encapsulated reagents, and preparation conditions, allows tailoring of material properties in a wide range, and offers great promise for the development of Electrochemical Biosensors. The various advantages of biogels for amperometric biosensing are discussed, along with common designs of sol–gel-derived bioelectrodes, recent advances and trends, and future prospects.

Yuehe Lin - One of the best experts on this subject based on the ideXlab platform.

  • Nanomaterial-based Electrochemical Biosensors for food safety
    Journal of Electroanalytical Chemistry, 2016
    Co-Authors: Yan Zeng, Zhihong Zhu, Dan Du, Yuehe Lin
    Abstract:

    Currently, nano-biotechnology in the field of Electrochemical Biosensors has been a crucially novel strategy to construct simple and reliable monitoring systems for food safety. Due to the diversity of molecular species related to food safety, the characteristics of sensors must be designed according to concentration distribution level of target analyte, the specific reaction, the food source, and ease of operation. Therefore, the classification and characteristics of analytes for food safety (e.g., pesticides, veterinary drug residues, additives, inorganic and organic contaminants, pathogens and toxins) are clarified in this article. It focuses on an overview of Electrochemical Biosensors based on carbon nanotubes (CNTs), graphene (GR) and its derivatives, various metal nanoparticles, and polymers in food analyses. With the help of nanomaterials, the traditional advantages of Electrochemical Biosensors, such as rapidity, ease of fabrication and field applicability can be further improved. In addition, nanomaterials endow Electrochemical Biosensors with device miniaturization and high sensitivity and specificity, giving them great potential to assess the food safety on-site.

  • Recent advances in Electrochemical Biosensors based on graphene two-dimensional nanomaterials.
    Biosensors & bioelectronics, 2015
    Co-Authors: Yang Song, Yanan Luo, Chengzhou Zhu, Yuehe Lin
    Abstract:

    Graphene as a star among two-dimensional nanomaterials has attracted tremendous research interest in the field of electrochemistry due to their intrinsic properties, including the electronic, optical, and mechanical properties associated with their planar structure. The marriage of graphene and Electrochemical Biosensors has created many ingenious biosensing strategies for applications in the areas of clinical diagnosis and food safety. This review provides a comprehensive overview of the recent advances in the development of graphene based Electrochemical Biosensors. Special attention is paid to graphene-based enzyme Biosensors, immunosensors, and DNA Biosensors. Future perspectives on high-performance graphene-based Electrochemical Biosensors are also discussed.

Zhenxin Wang - One of the best experts on this subject based on the ideXlab platform.

  • Two-Dimensional Layered Nanomaterial-Based Electrochemical Biosensors for Detecting Microbial Toxins.
    Toxins, 2019
    Co-Authors: Minghong Jian, Girma Selale Geleta, Zhenxin Wang
    Abstract:

    Toxin detection is an important issue in numerous fields, such as agriculture/food safety, environmental monitoring, and homeland security. During the past two decades, nanotechnology has been extensively used to develop various Biosensors for achieving fast, sensitive, selective and on-site analysis of toxins. In particular, the two dimensional layered (2D) nanomaterials (such as graphene and transition metal dichalcogenides (TMDs)) and their nanocomposites have been employed as label and/or biosensing transducers to construct Electrochemical Biosensors for cost-effective detection of toxins with high sensitivity and specificity. This is because the 2D nanomaterials have good electrical conductivity and a large surface area with plenty of active groups for conjugating 2D nanomaterials with the antibodies and/or aptamers of the targeted toxins. Herein, we summarize recent developments in the application of 2D nanomaterial-based Electrochemical Biosensors for detecting toxins with a particular focus on microbial toxins including bacterial toxins, fungal toxins and algal toxins. The integration of 2D nanomaterials with some existing antibody/aptamer technologies into Electrochemical Biosensors has led to an unprecedented impact on improving the assaying performance of microbial toxins, and has shown great promise in public health and environmental protection.

  • Electrochemical Biosensors for Detecting Microbial Toxins by Graphene-Based Nanocomposites
    Journal of Analysis and Testing, 2018
    Co-Authors: Girma Selale Geleta, Zhen Zhao, Zhenxin Wang
    Abstract:

    It is important to develop methods to determine microbial toxins at trace levels since these toxins are ubiquitous commonly found in water and foods, and pose potential threats to both human health and ecosystem safety. Taking the advantages of ultrahigh electron-transfer capability, extra-large surface area and easily functionalized ability, the graphene-based nanocomposites have been employed to fabricate Electrochemical Biosensors including immunosensors and aptasensors for detecting microbial toxins with high sensitivity. The specificity and selectivity of the Electrochemical Biosensors for targeting toxins can be achieved by combining graphene nanocomposites with antibodies and/or aptamers. The graphene nanocomposite-based Electrochemical Biosensors could become a promising technique in the detection of microbial toxins for public and environmental health protection.

Mònica Campàs - One of the best experts on this subject based on the ideXlab platform.

  • new advances in Electrochemical Biosensors for the detection of toxins nanomaterials magnetic beads and microfluidics systems a review
    Analytica Chimica Acta, 2016
    Co-Authors: Laia Reverte, Beatriz Prietosimon, Mònica Campàs
    Abstract:

    The use of nanotechnology in bioanalytical devices has special advantages in the detection of toxins of interest in food safety and environmental applications. The low levels to be detected and the small size of toxins justify the increasing number of publications dealing with Electrochemical Biosensors, due to their high sensitivity and design versatility. The incorporation of nanomaterials in their development has been exploited to further increase their sensitivity, providing simple and fast devices, with multiplexed capabilities. This paper gives an overview of the Electrochemical Biosensors that have incorporated carbon and metal nanomaterials in their configurations for the detection of toxins. Biosensing systems based on magnetic beads or integrated into microfluidics systems have also been considered because of their contribution to the development of compact analytical devices. The roles of these materials, the methods used for their incorporation in the biosensor configurations as well as the advantages they provide to the analyses are summarised.

  • Novel nanobiotechnological concepts in Electrochemical Biosensors for the analysis of toxins
    The Analyst, 2012
    Co-Authors: Mònica Campàs, Diana Garibo, Beatriz Prieto-simón
    Abstract:

    This article gives an overview of the Biosensors for the analysis of mycotoxins, marine toxins and cyanobacterial toxins, describing in depth the Electrochemical Biosensors that incorporate nanobiotechnological concepts. Firstly, it presents tailor-designed biomolecules, such as recombinant enzymes, recombinant antibody fragments and aptamers as novel biorecognition elements in Biosensors. It also reviews the use of metallic nanoparticles (NPs) and carbon nanotubes (CNTs) aiming at improving the Electrochemical transduction strategies. Finally, the exploitation of magnetic particles (MPs) as immobilisation carriers in flow-systems and the development of arrays are also described. The incorporation of these nanobiotechnological concepts provides with Electrochemical Biosensors with superior analytical performance in terms of specificity, sensitivity, stability and analysis time.

  • A review of the use of genetically engineered enzymes in Electrochemical Biosensors
    Seminars in cell & developmental biology, 2009
    Co-Authors: Mònica Campàs, Beatriz Prieto-simón, Jean Louis Marty
    Abstract:

    This article gives an overview of the Electrochemical Biosensors that incorporate genetically modified enzymes. Firstly, the improvements on the sensitivity and selectivity of Biosensors that integrate mutated enzymes are summarised. Next, new trends focused on the oriented immobilisation of mutated enzymes through specific functional groups located at their surface are reviewed. Finally, the effect of enzyme mutations on the electron transfer distance and kinetics of Electrochemical Biosensors is described.

Erkang Wang - One of the best experts on this subject based on the ideXlab platform.

  • engineering the bioElectrochemical interface using functional nanomaterials and microchip technique toward sensitive and portable Electrochemical Biosensors
    Biosensors and Bioelectronics, 2016
    Co-Authors: Xiaofang Jia, Shaojun Dong, Erkang Wang
    Abstract:

    Electrochemical Biosensors have played active roles at the forefront of bioanalysis because they have the potential to achieve sensitive, specific and low-cost detection of biomolecules and many others. Engineering the Electrochemical sensing interface with functional nanomaterials leads to novel Electrochemical Biosensors with improved performances in terms of sensitivity, selectivity, stability and simplicity. Functional nanomaterials possess good conductivity, catalytic activity, biocompatibility and high surface area. Coupled with bio-recognition elements, these features can amplify signal transduction and biorecognition events, resulting in highly sensitive biosensing. Additionally, microfluidic Electrochemical Biosensors have attracted considerable attention on account of their miniature, portable and low-cost systems as well as high fabrication throughput and ease of scaleup. For example, Electrochemical enzymetic Biosensors and aptamer Biosensors (aptasensors) based on the integrated microchip can be used for portable point-of-care diagnostics and environmental monitoring. This review is a summary of our recent progress in the field of Electrochemical Biosensors, including aptasensors, cytosensors, enzymatic Biosensors and self-powered Biosensors based on biofuel cells. We presented the advantages that functional nanomaterials and microfluidic chip technology bring to the Electrochemical Biosensors, together with future prospects and possible challenges.

  • Electrochemical Biosensors on platforms of graphene
    Chemical Communications, 2013
    Co-Authors: Youxing Fang, Erkang Wang
    Abstract:

    In recent years, graphene, the two-dimensional closely packed honeycomb carbon lattice, has been attracting much attention in the field of electrochemistry due to its intrinsic properties and merits. Efforts to create novel graphene based Electrochemical Biosensors have led to the establishment of effective strategies for diverse bioassays, from simple molecules to complex biotargets. In this Feature Article, we provide an overview of Electrochemical biosensing with graphene related materials, and discuss the role of graphene in different sensing protocols.