The Experts below are selected from a list of 3960 Experts worldwide ranked by ideXlab platform

Anton Yu Dolganov - One of the best experts on this subject based on the ideXlab platform.

  • development of a decision support system for neuro Electrostimulation diagnosing disorders of the cardiovascular system and evaluation of the treatment efficiency
    Applied Soft Computing, 2019
    Co-Authors: Vladimir S Kublanov, Anton Yu Dolganov
    Abstract:

    Abstract The study describes a preliminary stage of the decision support system development for physician performing neuro-Electrostimulation of neck neural formations for patients suffering from cardiovascular system disorders. The arterial hypertension was used as the clinical model of the disorders. The study consisted of two steps: diagnosing of the arterial hypertension and an evaluation of the treatment efficiency during the neuro-Electrostimulation application. For the diagnosing part, a clinical study was conducted involving heart rate variability signals recorded while performing tilt-test functional load. Heart rate variability signal is an indirect mean of accessing autonomic nervous system functioning. Disturbances of the autonomic nervous system are essential in pathology of arterial hypertension. Performance of different machine learning techniques and feature selection strategies in task of binary classification (healthy volunteers and patients suffering from arterial hypertension) were compared. The genetic programming feature selection and quadratic discriminant analysis classifier reached the highest classification accuracy. Best feature combinations were used to evaluate treatment efficiency. Predictions based on the selected heart rate variability features have a high level of agreement with the arterial pressure dynamics. The results indicate the potential of the proposed decision support system.

  • on some possibilities of organizing a mobile hardware information system for polyfactorial neuro Electrostimulation
    Biomedical Engineering Systems and Technologies, 2019
    Co-Authors: V S Kublanov, Mikhail V Babich, Anton Yu Dolganov
    Abstract:

    In paper the organizational principles of the mobile hardware-information system for polyfactorial neuro-Electrostimulation were considered. It was shown that the system can be implemented by three functionally separate blocks, one of which ensures the formation of a spatially distributed field of current pulses, the second is the specialized interface for the patient, and the third is the specialized interface for the doctor. The exchange of information between the blocks is provided by a telemetric communication channel or via the global network using mobile wearable computers (which can include a personal computer, tablet or smartphone). A personalized patient information system can be implemented on the basis of the neuro-Electrostimulation system. In this case patient data can be placed on the server of the medical institution. The prospects for using artificial intelligence and machine learning to control the treatment process were discussed.

  • mobile hardware information system for neuro Electrostimulation
    Mobile Information Systems, 2018
    Co-Authors: V S Kublanov, Mikhail V Babich, Anton Yu Dolganov
    Abstract:

    The article describes organizational principles of the mobile hardware-informational system based on the multifactorial neuro-Electrostimulation device. The system is implemented with two blocks: the first block forms the spatially distributed field of low-frequency monopolar current pulses between two multielement electrodes in the neck region. Functions of the second block, specialized control interface, are performed by a smartphone. Information is exchanged between two blocks through a telemetric channel. The mobile hardware-informational system allows to remotely change the structure of the current pulses field, to control its biotropic characteristics and to change the targets of the stimulation. Moreover, it provides patient data collection and processing, as well as access to the specialized databases. The basic circuit solutions for the neuro-Electrostimulation device, implemented by means of microcontroller and elements of high-level hardware integration, are described. The prospects of artificial intelligence and machine learning application for treatment process management are discussed.

Hugues Duffau - One of the best experts on this subject based on the ideXlab platform.

  • mapping the connectivity underlying multimodal verbal and non verbal semantic processing a brain Electrostimulation study
    Neuropsychologia, 2013
    Co-Authors: Sylvie Moritzgasser, Hugues Duffau, Guillaume Herbet
    Abstract:

    Abstract Accessing the meaning of words, objects, people and facts is a human ability, made possible thanks to semantic processing. Although studies concerning its cortical organization are proficient, the subcortical connectivity underlying this semantic network received less attention. We used intraoperative direct Electrostimulation, which mimics a transient virtual lesion during brain surgery for glioma in eight awaken patients, to map the anatomical white matter substrate subserving the semantic system. Patients performed a picture naming task and a non-verbal semantic association test during the electrical mapping. Direct Electrostimulation of the inferior fronto-occipital fascicle, a poorly known ventral association pathway which runs throughout the brain, induced in all cases semantic disturbances. These transient disorders were highly reproducible, and concerned verbal as well as non-verbal output. Our results highlight for the first time the essential role of the left inferior fronto-occipital fascicle in multimodal (and not only in verbal) semantic processing. On the basis of these original findings, and in the lights of phylogenetic considerations regarding this fascicle, we suggest its possible implication in the monitoring of the human level of consciousness related to semantic memory, namely noetic consciousness.

  • is the human left middle longitudinal fascicle essential for language a brain Electrostimulation study
    Human Brain Mapping, 2011
    Co-Authors: Philip C De Witt Hamer, Sylvie Moritzgasser, Hugues Duffau, Peggy Gatignol
    Abstract:

    Human brain pathways required for language processing are poorly known. A new white matter tract in humans, the middle longitudinal fascicle, has recently been anatomically determined by diffusion tensor imaging and suggested to be essential for language. Our aim is to determine the importance of the middle longitudinal fascicle for language processing. This study is based on 8 patients with glioma resection at least involving the superior temporal gyrus of the left dominant hemisphere. Language is systematically examined pre- and postoperatively at 3 months. Intraoperative Electrostimulation is used to map cortical and subcortical structures as functional boundaries of the glioma resection, including those essential for language processing. The resections are extensive (on average 62 ml, ranging from 21 to 111 ml) and include a large part of the middle longitudinal fascicle in all patients. Intraoperatively, no interference with picture naming is observed by Electrostimulation of the middle longitudinal fascicle, while in all patients the inferior fronto-occipital fascicle is identified by eliciting semantic paraphasia as functional boundary. Postoperatively, no new permanent language deficits are detected by systematic language examination. Therefore, we suggest that the middle longitudinal fascicle may participate but is not essential for language processing.

  • discrepancies between preoperative stereoencephalography language stimulation mapping and intraoperative awake mapping during resection of focal cortical dysplasia in eloquent areas
    Stereotactic and Functional Neurosurgery, 2008
    Co-Authors: Santiago Gil Robles, Philippe Gelisse, Francesco Vergani, Sylvie Moritzgasser, Valerie Rigau, Philippe Coubes, Arielle Crespel, Hugues Duffau
    Abstract:

    Background/Aims: To compare the reliability of preoperative stereoencephalography (SEEG) and intraoperative Electrostimulation regarding functional mapping, and to select the indica

Gregg J Suaning - One of the best experts on this subject based on the ideXlab platform.

  • mimicking natural neural encoding through retinal Electrostimulation
    International IEEE EMBS Conference on Neural Engineering, 2017
    Co-Authors: Tianruo Guo, Gregg J Suaning, Socrates Dokos, John W. Morley, Alejandro Barrigarivera, David Tsai, Nigel H Lovell
    Abstract:

    Retinal neuroprostheses or ‘bionic eyes’, aim to restore patterned vision to those with vision loss by electrically stimulating the remaining neurons in the degenerate retina. Despite considerable progress over the last two decades, such devices generally stimulate indiscriminately both the ‘ON’ and ‘OFF’ visual pathways in the retina, conveying highly non-physiological signals to the brain.

  • high amplitude electrical stimulation can reduce elicited neuronal activity in visual prosthesis
    Scientific Reports, 2017
    Co-Authors: Alejandro Barrigarivera, Nigel H Lovell, Gregg J Suaning, Chih Yu Yang, Tianruo Guo, Socrates Dokos, John W. Morley, Amr Al Abed
    Abstract:

    Retinal Electrostimulation is promising a successful therapy to restore functional vision. However, a narrow stimulating current range exists between retinal neuron excitation and inhibition which may lead to misperformance of visual prostheses. As the conveyance of representation of complex visual scenes may require neighbouring electrodes to be activated simultaneously, electric field summation may contribute to reach this inhibitory threshold. This study used three approaches to assess the implications of relatively high stimulating conditions in visual prostheses: (1) in vivo, using a suprachoroidal prosthesis implanted in a feline model, (2) in vitro through Electrostimulation of murine retinal preparations, and (3) in silico by computing the response of a population of retinal ganglion cells. Inhibitory stimulating conditions led to diminished cortical activity in the cat. Stimulus-response relationships showed non-monotonic profiles to increasing stimulating current. This was observed in vitro and in silico as the combined response of groups of neurons (close to the stimulating electrode) being inhibited at certain stimulating amplitudes, whilst other groups (far from the stimulating electrode) being recruited. These findings may explain the halo-like phosphene shapes reported in clinical trials and suggest that simultaneous stimulation in retinal prostheses is limited by the inhibitory threshold of the retinal ganglion cells.

Amit Patel - One of the best experts on this subject based on the ideXlab platform.

  • cardiac pre differentiation of human mesenchymal stem cells by Electrostimulation
    Frontiers in Bioscience, 2009
    Co-Authors: Jorge A Genovese, Cristiano Spadaccio, Emmanuel Chachques, Olivier Schussler, A Carpentier, Juan C Chachques, Amit Patel
    Abstract:

    Myocardial repair using stem-cell therapy has become a promising therapeutic tool. However, many questions concerning a precise functional integration of injected cells remain unanswered. The use of cardiac pre-committed cells may improve integration, as these cells may complete their differentiation in the myocardium reducing fibrosis and restoring muscle function. We have previously demonstrated that Electrostimulation (ES) induces cardiomyocyte pre-commitment of fibroblasts in vitro and is an effective alternative to cytokine-induced differentiation. In this study, we evaluated the effects of long term Electrostimulation on human mesenchymal stem cells (hMSCs). ES induced both morphological and biochemical changes in hMSCs resulting in a shift toward a striated muscle cell phenotype expressing cardiac specific markers. This partially differentiated phenotype might allow a gradual, ongoing differentiation within the cardiac environment, providing time for both myocardial regeneration and electro-mechanical integration, and convey potential advantages in clinical applications.

  • Electrostimulation induces cardiomyocyte predifferentiation of fibroblasts
    Biochemical and Biophysical Research Communications, 2008
    Co-Authors: Jorge A Genovese, Cristiano Spadaccio, Jason Langer, Jaclyn Habe, Johnna Jackson, Amit Patel
    Abstract:

    Stem-cell therapy has become a promising therapeutic tool for myocardial repair. Cardiac pre-committed cells, which complete their differentiation in the myocardium, may reduce fibrosis and restore muscle function. However, many questions concerning a precise, functional integration of injected cells remain unanswered. Fibroblasts regulate the cardiac extracellular matrix and are the most abundant cell population in an infarcted area. Electrostimulation is a well-known trophic factor and can induce phenotypic changes in myoblasts. The objective of this study was to evaluate the effectiveness of electrical stimulation to induce pre-commitment of fibroblasts into cardiomyocytes in vitro. Using short-time Electrostimulation in a cytokine-free culture system, we induced pre-commitment of two fibroblast cell lines to a cardiomyocyte phenotype. This partial differentiation in vitro may facilitate further differentiation within the cardiac environment and result in better electro-mechanical integration of the therapeutically introduced cells.

Anil S Cakmak - One of the best experts on this subject based on the ideXlab platform.

  • synergistic effect of exogeneous and endogeneous Electrostimulation on osteogenic differentiation of human mesenchymal stem cells seeded on silk scaffolds
    Journal of Orthopaedic Research, 2016
    Co-Authors: Anil S Cakmak, Soner Cakmak, James D White, Waseem K Raja, Kyung Sook Kim, Sezin Yigit, David L Kaplan, Menemse Gumusderelioglu
    Abstract:

    Bioelectrical regulation of bone fracture healing is important for many cellular events such as proliferation, migration, and differentiation. The aim of this study was to investigate the osteogenic differentiation potential of human mesenchymal stem cells (hMSCs) cultivated on silk scaffolds in response to different modes of Electrostimulation (e.g., exogeneous and/or endogeneous). Endogeneous electrophysiology was altered through the use of monensin (10 nM) and glibenclamide (10 μM), along with external Electrostimulation (60 kHz; 100-500 mV). Monensin enhanced the expression of early osteogenic markers such as alkaline phosphatase (ALP) and runt-related transcription factor 2 (RUNX-2). When exogeneous Electrostimulation was combined with glibenclamide, more mature osteogenic marker upregulation based on bone sialoprotein expression (BSP) and mineralization was found. These results suggest the potential to exploit both exogeneous and endogeneous biophysical control of cell functions towards tissue-specific goals.