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Jin-ho Chung - One of the best experts on this subject based on the ideXlab platform.
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the effect of Erythrodiol 3 acetate on the expressions of matrix metalloproteinase 1 and type 1 procollagen caused by ultraviolet irradiated cultured primary old aged human skin fibroblasts
Phytomedicine, 2006Co-Authors: H I Moon, Joongku Lee, Jin-ho ChungAbstract:Methanol and aqueous extracts of Styrax japonica used traditionally for the treatments of skin elastic materials were screened in vitro for the matrix metalloproteinase (MMP)-1 inhibitor actions. The methylene chloride soluble fraction of methanol extract from the stems of S. japonica showed significant MMP-1 inhibition in primary old aged human skin fibroblasts caused by ultraviolet (UV) irradiation. Main triterpenoids were isolated by repeated column chromatography. Among them, the triterpenoid Erythrodiol-3-acetate reduced the expression of MMP-1 and induced the expression of type-1 procollagen at the protein levels in a dose-dependent manner caused by UV irradiated cultured old aged human skin fibroblasts. Taken together, our results suggest that Erythrodiol-3-acetate plays an important role in the skin aging process caused by UV irradiation.
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triterpenoid from styrax japonica s ieb et z ucc and its effects on the expression of matrix metalloproteinases 1 and type 1 procollagen caused by ultraviolet irradiated cultured primary human skin fibroblasts
Biological & Pharmaceutical Bulletin, 2005Co-Authors: Hyungin Moon, Jin-ho ChungAbstract:Long term and repeated exposure of ultraviolet light on the skin often induces chronic skin diseases such as skin cancer as well as photoaging, and the mechanisms of these skin damages are closely associated with up-regulation of matrix metalloproteinase's (MMPs) activities. The methylene chloride soluble fraction of methanol extract from the stems of Styrax japonica. (Styracaceae) showed significant MMP-1 inhibition in primary human skin fibroblasts cause by ultraviolet irradiation. Four triterpenoids were isolated by column chromatography. Among them, Erythrodiol-3-acetate reduced of MMP-1 and induced of type 1 procollagen at the protein levels in a dose-dependent manner.
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Erythrodiol 3 acetate pentacyclic triterpenoid from styrax japonica expressions of matrix metalloproteinase 1 2 in cultured human skin fibroblasts
Journal of Ethnopharmacology, 2005Co-Authors: Hyungin Moon, Dongwan Seo, Kyu Han Kim, Kwang Hyun Cho, Heechul Eun, Jin-ho ChungAbstract:Although many studies have been performed to elucidate the molecular consequences of ultraviolet irradiation, little is known about the effect of natural products. Ultraviolet irradiation is widely considered to be an environmental stress. Here we investigated the effect of Erythrodiol-3-acetate on the expressions of MMP-1,2 in cultured human skin fibroblasts. Erythrodiol-3-acetate was isolated from the stems of Styrax japonica (Styracaceae). Erythrodiol-3-acetate reduced the expression of MMP-1 but not MMP-2, at the mRNA and protein levels in a dose-dependent manner by ultraviolet irradiation. Taken together, our results suggest that Erythrodiol-3-acetate an important role in the reduction of MMP-1 induction by ultraviolet irradiation.
Valentina Ruizgutierrez - One of the best experts on this subject based on the ideXlab platform.
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vasorelaxant effects of oleanolic acid and Erythrodiol in pomace olive oil
Olives and olive oil in health and disease prevention, 2010Co-Authors: Rosalia Rodriguezrodriguez, Valentina RuizgutierrezAbstract:Publisher Summary Among olive and pomace olive oil triterpenoids, oleanolic acid has been the most widely studied and distributed in the vegetable kingdom. In fact, a wide range of biological activities has been attributed to this triterpenoid. Nevertheless, there are not many studies focused on the cardiovascular properties ascribed to oleanolic acid and structure-related triterpenoids such as Erythrodiol. Accordingly, parenteral administration of this triterpenic acid lowers blood pressure in salt-sensitive rats, an effect mainly associated with antioxidative actions. In addition, it has been recently reported that ingestion of pomace olive oil with a high proportion of oleanolic acid and Erythrodiol offers a delay in the progression of lipid peroxidation in rat liver microsomes. Despite these recent findings, the effects of oleanolic acid and pomace olive oil on vascular and endothelial function have remained unknown until now. This chapter summarizes the recent and novel advances in the vasoprotective profile provided by olive and pomace olive oil and their triterpenoids in terms of vasodilatation.
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modulation of cytokine secretion by pentacyclic triterpenes from olive pomace oil in human mononuclear cells
Cytokine, 2006Co-Authors: Ana Marquezmartin, Rocio De La Puerta, Angeles Fernandezarche, Valentina Ruizgutierrez, Parveen YaqoobAbstract:Olive pomace oil, also known as "orujo" olive oil, is a blend of refined-pomace oil and virgin olive oil, fit for human consumption. Maslinic acid, oleanolic acid, Erythrodiol, and uvaol are pentacyclic triterpenes, found in the non-glyceride fraction of orujo oil, which have previously been reported to have anti-inflammatory properties. In the present work, we investigated the effect of these minor components on pro-inflammatory cytokine production by human peripheral blood mononuclear cells in six different samples. Uvaol, Erythrodiol, and oleanolic acid significantly decreased IL-1beta and IL-6 production in a dose-dependent manner. All three compounds significantly reduced TNF-alpha production at 100microM; however, at 10microM, uvaol and oleanolic acid enhanced the generation of TNF-alpha. In contrast, maslinic acid did not significantly alter the concentration of those cytokines, with the exception of a slight inhibitory effect at 100microM. All four triterpenes inhibited production of I-309, at 50microM and 100microM. However, uvaol enhanced I-309 production at 10microM. The triterpenic dialcohols had a similar effect on MIG production. In conclusion, this study demonstrates that pentacyclic triterpenes in orujo oil exhibit pro- and anti-inflammatory properties depending on chemical structure and dose, and may be useful in modulating the immune response.
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potential vasorelaxant effects of oleanolic acid and Erythrodiol two triterpenoids contained in orujo olive oil on rat aorta
British Journal of Nutrition, 2004Co-Authors: Rosalia Rodriguezrodriguez, Maria Dolores Herrera, Javier S Perona, Valentina RuizgutierrezAbstract:‘Orujo’ olive oil is obtained by chemical processes from the waste resulting from the mechanical extraction of virgin olive oil. The aim of the present study was to evaluate a new pharmacological property of two natural triterpenoids contained in olive oil, as vasodilatory agents, and to determine their mechanism of action. The two compounds studied were oleanolic acid and Erythrodiol. The vasorelaxant effect induced by these pentacyclic triterpenoids was studied in isolated thoracic rat aorta. Oleanolic acid and Erythrodiol, accumulatively added, showed vasorelaxant activities in aortic rings with endothelium pre-contracted by 10 26 M-phenylephrine (maximum percentage of relaxation 86·38 (SEM 2·89) and 73·53 (SEM 6·01), respectively). They had almost no relaxant effect on depolarised or endotheliumdenuded aortic segments. The relaxation was significantly attenuated by pre-treatment with the NO synthase inhibitor N v -nitro-L-arginine-methylester (L-NAME; 3 £ 10 24 M). To characterise the involvement of endothelial factors, in addition to NO, arteries with endothelium were exposed to 10 25 M-indomethacin (INDO), a cyclo-oxygenase inhibitor, or INDO plus L-NAME. INDO did not have any significant effect on the relaxant response of both compounds. The combination of L-NAME plus INDO only abolished the oleanolic acid-induced relaxation. The present results suggest that the mechanism of relaxation seems to be mainly mediated by the endothelial production of NO; however, other mechanisms cannot be excluded. It can be concluded that oleanolic acid and Erythrodiol may have interesting therapeutic potential as new vasodilator drugs, thus protecting the cardiovascular system. Therefore, the intake of ‘orujo’ olive oil, as a source of these compounds, might be beneficial in this regard. ‘Orujo’ olive oil: Oleanolic acid: Erythrodiol: Vasorelaxation: Endothelium: Rat aorta
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potential vasorelaxant effects of oleanolic acid and Erythrodiol two triterpenoids contained in orujo olive oil on rat aorta
British Journal of Nutrition, 2004Co-Authors: Rosalia Rodriguezrodriguez, Maria Dolores Herrera, Javier S Perona, Valentina RuizgutierrezAbstract:'Orujo' olive oil is obtained by chemical processes from the waste resulting from the mechanical extraction of virgin olive oil. The aim of the present study was to evaluate a new pharmacological property of two natural triterpenoids contained in olive oil, as vasodilatory agents, and to determine their mechanism of action. The two compounds studied were oleanolic acid and Erythrodiol. The vasorelaxant effect induced by these pentacyclic triterpenoids was studied in isolated thoracic rat aorta. Oleanolic acid and Erythrodiol, accumulatively added, showed vasorelaxant activities in aortic rings with endothelium pre-contracted by 10(-6) m-phenylephrine (maximum percentage of relaxation 86.38 (sem 2.89) and 73.53 (sem 6.01), respectively). They had almost no relaxant effect on depolarised or endothelium-denuded aortic segments. The relaxation was significantly attenuated by pre-treatment with the NO synthase inhibitor N(omega)-nitro-L-arginine-methylester (L-NAME; 3x10(-4) m). To characterise the involvement of endothelial factors, in addition to NO, arteries with endothelium were exposed to 10(-5) m-indomethacin (INDO), a cyclo-oxygenase inhibitor, or INDO plus L-NAME. INDO did not have any significant effect on the relaxant response of both compounds. The combination of L-NAME plus INDO only abolished the oleanolic acid-induced relaxation. The present results suggest that the mechanism of relaxation seems to be mainly mediated by the endothelial production of NO; however, other mechanisms cannot be excluded. It can be concluded that oleanolic acid and Erythrodiol may have interesting therapeutic potential as new vasodilator drugs, thus protecting the cardiovascular system. Therefore, the intake of 'orujo' olive oil, as a source of these compounds, might be beneficial in this regard.
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m 634 beneficial vascular effects of oleanolic acid and Erythrodiol
Atherosclerosis Supplements, 2004Co-Authors: Rosalia Rodriguezrodriguez, Herrera M Gonzalez, Valentina RuizgutierrezAbstract:Trabajo presentado en el 74th European Atherosclerosis Society (EAS) Congress, celebrado en Sevilla (Espana) del 17 al 20 de abril de 2004.
Young Maria Claudia Marx - One of the best experts on this subject based on the ideXlab platform.
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Chemical constituents of Arrabidaea samydoides (Bignoniaceae)
Sociedade Brasileira de Química, 2003Co-Authors: Pauletti Patrícia Mendonça, Bolzani Vanderlan Da Silva, Young Maria Claudia MarxAbstract:Chemical investigation of Arrabidaea samydoides resulted in the isolation of the flavone chrysin; five triterpenes: lupeol, ursolic acid, 3b,16a-dihydroxy-urs-12-ene, uvaol, and Erythrodiol; and two sterols: sitosterol and stigmasterol. The structures of these compounds were established by spectroscopic analysis. This paper deal with the first phytochemical study of Arrabidaea samydoides
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Constituintes químicos de Arrabidaea samydoides (Bignoniaceae)
Sociedade Brasileira de Química, 2003Co-Authors: Pauletti Patrícia Mendonça, Bolzani Vanderlan Da Silva, Young Maria Claudia MarxAbstract:Chemical investigation of Arrabidaea samydoides resulted in the isolation of the flavone chrysin; five triterpenes: lupeol, ursolic acid, 3b,16a-dihydroxy-urs-12-ene, uvaol, and Erythrodiol; and two sterols: sitosterol and stigmasterol. The structures of these compounds were established by spectroscopic analysis. This paper deal with the first phytochemical study of Arrabidaea samydoides.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq
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Constituintes químicos de Arrabidaea samydoides (Bignoniaceae)
Sociedade Brasileira de Química, 2003Co-Authors: Pauletti Patrícia Mendonça, Bolzani Vanderlan Da Silva, Young Maria Claudia MarxAbstract:Chemical investigation of Arrabidaea samydoides resulted in the isolation of the flavone chrysin; five triterpenes: lupeol, ursolic acid, 3b,16a-dihydroxy-urs-12-ene, uvaol, and Erythrodiol; and two sterols: sitosterol and stigmasterol. The structures of these compounds were established by spectroscopic analysis. This paper deal with the first phytochemical study of Arrabidaea samydoides
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Triterpenes from Styrax camporum (styracaceae)
Sociedade Brasileira de Química, 2002Co-Authors: Pauletti Patrícia Mendonça, Bolzani Vanderlan Da Silva, Araújo, Angela Regina, Young Maria Claudia MarxAbstract:Chemical investigation of the leaves of Styrax camporum (Styracaceae) resulted in the isolation of the lignan lariciresinol and six triterpenes: ursolic acid, 2alpha,3alpha-dihydroxy-urs-12-en-28-oic acid and mixtures of uvaol and Erythrodiol, as well as 3beta-O-trans-p-coumaroyl-2alpha-hydroxy-urs-12-en-28-oic acid and 3b-O-trans-p-coumaroylmaslinic acid. The structures of these compounds were established by spectroscopic analysis. This paper deals with the first report of these compounds in S. camporum
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Triterpenos de Styrax camporum (styracaceae)
Sociedade Brasileira de Química, 2002Co-Authors: Pauletti Patrícia Mendonça, Bolzani Vanderlan Da Silva, Araújo, Angela Regina, Young Maria Claudia MarxAbstract:Chemical investigation of the leaves of Styrax camporum (Styracaceae) resulted in the isolation of the lignan lariciresinol and six triterpenes: ursolic acid, 2alpha,3alpha-dihydroxy-urs-12-en-28-oic acid and mixtures of uvaol and Erythrodiol, as well as 3beta-O-trans-p-coumaroyl-2alpha-hydroxy-urs-12-en-28-oic acid and 3b-O-trans-p-coumaroylmaslinic acid. The structures of these compounds were established by spectroscopic analysis. This paper deals with the first report of these compounds in S. camporum
Atanas G Atanasov - One of the best experts on this subject based on the ideXlab platform.
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Erythrodiol an olive oil constituent increases the half life of abca1 and enhances cholesterol efflux from thp 1 derived macrophages
Frontiers in Pharmacology, 2017Co-Authors: Limei Wang, Sarah Wesemann, Liselotte Krenn, Angela Ladurner, Elke H Heiss, Verena M Dirsch, Atanas G AtanasovAbstract:Cholesterol efflux (ChE) from macrophages is an initial step of reverse cholesterol transport (RCT). The ATP-binding cassette transporter A1 (ABCA1) is a key transporter for ChE and its increased expression is regarded to attenuate atherosclerosis. Thus, the identification and characterization of molecules raising ABCA1 and thereby stimulating ChE is of pharmacological relevance. In this study, we tested dietary compounds from olive oil for their capacity of enhancing cellular ABCA1 protein level. We identified Erythrodiol (Olean-12-ene-3β,28-diol) as an ABCA1 stabilizer and revealed its positive influence on ChE in THP-1-derived human macrophages. Among the 9 tested compounds from olive oil, Erythrodiol was the sole compound raising ABCA1 protein level (at 10 μM). None of the tested compounds impaired viability of THP-1 macrophages from 5 to 20 μM as determined by resazurin conversion. Western blot analyses of key membrane transporters contributing to ChE showed that the protein level of ABCG1 and scavenger receptor class B member 1 (SR-B1) remain unaffected by Erythrodiol. Besides, Erythrodiol (10 µM) did not influence the mRNA level of ABCA1, ABCG1 and SR-B1, as determined by quantitative reverse transcription PCR, but significantly inhibited the degradation of ABCA1 as evident by an increased half-life of the protein in the presence of cycloheximide, an inhibitor of de novo protein synthesis. Therefore, Erythrodiol promotes ChE from THP-1-derived human macrophages by stabilizing the ABCA1 protein. This bioactivity makes Erythrodiol a good candidate to be further explored for therapeutic or preventive application in the context of atherosclerosis.
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Erythrodiol, an Olive Oil Constituent, Increases the Half-Life of ABCA1 and Enhances Cholesterol Efflux from THP-1-Derived Macrophages
Frontiers Media S.A., 2017Co-Authors: Limei Wang, Sarah Wesemann, Liselotte Krenn, Angela Ladurner, Elke H Heiss, Verena M Dirsch, Atanas G AtanasovAbstract:Cholesterol efflux (ChE) from macrophages is an initial step of reverse cholesterol transport (RCT). The ATP-binding cassette transporter A1 (ABCA1) is a key transporter for ChE and its increased expression is regarded to attenuate atherosclerosis. Thus, the identification and characterization of molecules raising ABCA1 and thereby stimulating ChE is of pharmacological relevance. In this study, we tested dietary compounds from olive oil for their capacity of enhancing cellular ABCA1 protein level. We identified Erythrodiol (Olean-12-ene-3β,28-diol) as an ABCA1 stabilizer and revealed its positive influence on ChE in THP-1-derived human macrophages. Among the nine tested compounds from olive oil, Erythrodiol was the sole compound raising ABCA1 protein level (at 10 μM). None of the tested compounds impaired viability of THP-1 macrophages from 5 to 20 μM as determined by resazurin conversion. Western blot analyses of key membrane transporters contributing to ChE showed that the protein level of ABCG1 and scavenger receptor class B member 1 (SR-B1) remain unaffected by Erythrodiol. Besides, Erythrodiol (10 μM) did not influence the mRNA level of ABCA1, ABCG1, and SR-B1, as determined by quantitative reverse transcription PCR, but significantly inhibited the degradation of ABCA1 as evident by an increased half-life of the protein in the presence of cycloheximide, an inhibitor of de novo protein synthesis. Therefore, Erythrodiol promotes ChE from THP-1-derived human macrophages by stabilizing the ABCA1 protein. This bioactivity makes Erythrodiol a good candidate to be further explored for therapeutic or preventive application in the context of atherosclerosis
Pauletti Patrícia Mendonça - One of the best experts on this subject based on the ideXlab platform.
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Chemical constituents of Arrabidaea samydoides (Bignoniaceae)
Sociedade Brasileira de Química, 2003Co-Authors: Pauletti Patrícia Mendonça, Bolzani Vanderlan Da Silva, Young Maria Claudia MarxAbstract:Chemical investigation of Arrabidaea samydoides resulted in the isolation of the flavone chrysin; five triterpenes: lupeol, ursolic acid, 3b,16a-dihydroxy-urs-12-ene, uvaol, and Erythrodiol; and two sterols: sitosterol and stigmasterol. The structures of these compounds were established by spectroscopic analysis. This paper deal with the first phytochemical study of Arrabidaea samydoides
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Constituintes químicos de Arrabidaea samydoides (Bignoniaceae)
Sociedade Brasileira de Química, 2003Co-Authors: Pauletti Patrícia Mendonça, Bolzani Vanderlan Da Silva, Young Maria Claudia MarxAbstract:Chemical investigation of Arrabidaea samydoides resulted in the isolation of the flavone chrysin; five triterpenes: lupeol, ursolic acid, 3b,16a-dihydroxy-urs-12-ene, uvaol, and Erythrodiol; and two sterols: sitosterol and stigmasterol. The structures of these compounds were established by spectroscopic analysis. This paper deal with the first phytochemical study of Arrabidaea samydoides.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq
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Constituintes químicos de Arrabidaea samydoides (Bignoniaceae)
Sociedade Brasileira de Química, 2003Co-Authors: Pauletti Patrícia Mendonça, Bolzani Vanderlan Da Silva, Young Maria Claudia MarxAbstract:Chemical investigation of Arrabidaea samydoides resulted in the isolation of the flavone chrysin; five triterpenes: lupeol, ursolic acid, 3b,16a-dihydroxy-urs-12-ene, uvaol, and Erythrodiol; and two sterols: sitosterol and stigmasterol. The structures of these compounds were established by spectroscopic analysis. This paper deal with the first phytochemical study of Arrabidaea samydoides
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Triterpenes from Styrax camporum (styracaceae)
Sociedade Brasileira de Química, 2002Co-Authors: Pauletti Patrícia Mendonça, Bolzani Vanderlan Da Silva, Araújo, Angela Regina, Young Maria Claudia MarxAbstract:Chemical investigation of the leaves of Styrax camporum (Styracaceae) resulted in the isolation of the lignan lariciresinol and six triterpenes: ursolic acid, 2alpha,3alpha-dihydroxy-urs-12-en-28-oic acid and mixtures of uvaol and Erythrodiol, as well as 3beta-O-trans-p-coumaroyl-2alpha-hydroxy-urs-12-en-28-oic acid and 3b-O-trans-p-coumaroylmaslinic acid. The structures of these compounds were established by spectroscopic analysis. This paper deals with the first report of these compounds in S. camporum
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Triterpenos de Styrax camporum (styracaceae)
Sociedade Brasileira de Química, 2002Co-Authors: Pauletti Patrícia Mendonça, Bolzani Vanderlan Da Silva, Araújo, Angela Regina, Young Maria Claudia MarxAbstract:Chemical investigation of the leaves of Styrax camporum (Styracaceae) resulted in the isolation of the lignan lariciresinol and six triterpenes: ursolic acid, 2alpha,3alpha-dihydroxy-urs-12-en-28-oic acid and mixtures of uvaol and Erythrodiol, as well as 3beta-O-trans-p-coumaroyl-2alpha-hydroxy-urs-12-en-28-oic acid and 3b-O-trans-p-coumaroylmaslinic acid. The structures of these compounds were established by spectroscopic analysis. This paper deals with the first report of these compounds in S. camporum
