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S. Subramanian - One of the best experts on this subject based on the ideXlab platform.
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effect of Eugenia jambolana seed kernel on antioxidant defense system in streptozotocin induced diabetes in rats
Life Sciences, 2004Co-Authors: Kasiappan Ravi, Balasubramanian Ramachandran, S. SubramanianAbstract:Increased oxidative stress has been suggested to be involved in the pathogenesis and progression of diabetic tissue damage. The aim of this study was to investigate the effect of ethanolic extract of Eugenia jambolana seed kernel on antioxidant defense systems of plasma and pancreas in streptozotocin-induced diabetes in rats. The levels of glucose, vitamin-C, vitamin-E, ceruloplasmin, reduced glutathione and lipidperoxides were estimated in plasma of control and experimental groups of rats. The levels of lipidperoxides, reduced glutathione and activities of superoxide dismutase, catalase and glutathione peroxidase were assayed in pancreatic tissue of control and experimental groups of rats. A significant increase in the levels of plasma glucose, vitamin-E, ceruloplasmin, lipid peroxides and a concomitant decrease in the levels of vitamin-C, reduced glutathione were observed in diabetic rats. The activities of pancreatic antioxidant enzymes were altered in diabetic rats. These alterations were reverted back to near normal level after the treatment with Eugenia jambolana seed kernel and glibenclamide. Histopathological studies also revealed that the protective effect of Eugenia jambolana seed kernel on pancreatic β-cells. The present study shows that Eugenia jambolana seed kernel decreased oxidative stress in diabetic rats, which inturn may be due to its hypoglycemic property.
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protective effect of Eugenia jambolana seed kernel on tissue antioxidants in streptozotocin induced diabetic rats
Biological & Pharmaceutical Bulletin, 2004Co-Authors: Kasi Ravi, Balasubramanian Ramachandran, S. SubramanianAbstract:Oxidative stress plays an important role in chronic complications of diabetes. In the present study the antioxidant effect of oral administration of ethanolic extract of Eugenia jambolana seed kernel on tissue antioxidant enzymes and lipid peroxidation in liver and kidney of streptozotocin-induced diabetic rats was evaluated. Administration of seed kernel to diabetic rats significantly decreased the levels of blood glucose, glycosylated hemoglobin and increased body weight gain, plasma insulin and hemoglobin. The diabetic rats showed the low activities of superoxide dismutase, catalase, glutathione peroxidase and reduced glutathione content in liver and kidney, which were restored to near normal levels by treatment with the seed kernel extract. The increased levels of lipid peroxidation and hydroperoxides in diabetic rats were reverted back to near normal levels after the treatment with seed kernel extract. Diabetic rats treated with seed kernel extract restored almost normal architecture of liver and kidney and were confirmed by histopathological examination. The present study reveals the efficacy of Eugenia jambolana seed kernel in the amelioration of diabetes, which may be attributed to its hypoglycemic property along with its antioxidant potential. The antioxidant effect of Eugenia jambolana seed kernel was also compared with glibenclamide, a standard hypoglycemic drug.
Henrique D.m. Coutinho - One of the best experts on this subject based on the ideXlab platform.
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Eugenia uniflora leaves essential oil induces toxicity in drosophila melanogaster involvement of oxidative stress mechanisms
Toxicology Research, 2015Co-Authors: Francisco Assis Bezerra Da Cunha, Gabriel Da Luz Wallau, Nadghia F Leite, Galberto Martins Da Costa, Mauro Eugenio Medina Nunes, Margareth Linde Athayde, Antonio I. Pinho, Aline Augusti Boligon, Saulo R. Tintino, Henrique D.m. CoutinhoAbstract:Eugenia uniflora L. (Myrtaceae family), also known as “pitanga”, is a tree species widely used in popular medicine. Despite the well documented beneficial effects of the extracts and essential oils from this plant, little is known about its toxicity. We performed a phytochemical fingerprinting and evaluated the toxicity induced by the Eugenia uniflora leaves essential oil in a Drosophila melanogaster model. In order to understand the biochemical mechanisms involved in E. uniflora essential oil toxicity, changes in the Nrf2 signaling as well as the hallmarks of oxidative stress were measured. The exposure of adult flies to the essential oil via a fumigant method resulted in increased mortality and locomotor deficits. In parallel, an oxidative stress response signaling, evidenced by changes in ROS production, lipid peroxidation, alterations in the activity of antioxidant enzymes and expression of Nrf2 protein targets occurred. In the light of our findings, attention is drawn to the indiscriminate use of this plant for medicinal purposes. In addition, a potential bio-insecticidal activity of Eugenia uniflora volatile compounds is suggested, a fact that needs to be further explored.
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evaluation of the cytoprotective and antioxidant activity of the extracts of Eugenia uniflora lineau e psidium sobraleanum proenca landrum against heavy metals
Revista Ciencias de la Salud, 2014Co-Authors: Celestina E Sobralsouza, Nadghia F Leite, Antonio I. Pinho, Francisco Assis Bezerra Da Cunha, José Galberto Martins Da Costa, Henrique D.m. CoutinhoAbstract:Objetivo: Estudios recientes reportan la utilizacion de plantas en forma de zumos o te como fuente de agentes antioxidantes naturales que presentan bajo riesgo, pudiendo ser utilizados como complemento del tratamiento de diversas enfermedades. Materiales y metodos: En este contexto, se evaluaran in vitro, los potenciales antioxidantes, de los extractos de Eugenia uniflora y Psidium sobraleanum, ademas de cuantificar fenoles y flavonoides presentes en los extractos. Resultados: De acuerdo con los resultados obtenidos, se observo una mejor actividad antioxidante con el extracto de Eugenia uniflora, en el test de TBARS con fofolipidos de huevo, los extractos redujeron los niveles basales en el proceso de peroxidacion lipidica; y cuando fue inducida con Fe+2, el extracto de Psidium sobraleanum se mostro mas eficiente. Conclusiones: Por lo tanto, a traves de estos ensayos se pudo comprobar que los extractos de las hojas de las especies Eugenia uniflora y Psidium sobraleanum presentan actividad antioxidante, directamente relacionada con sustancias fenolicas producidas a partir de sus metabolitos secundarios.
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atividade leishmanicida in vitro de Eugenia uniflora e momordica charantia
Revista de Ciências Farmacêuticas Básica e Aplicada, 2013Co-Authors: Karla K.a. Santos, Celeste Vega, Miriam Rolón, Antonieta Rojas De Arias, José Galberto Martins Da Costa, Henrique D.m. CoutinhoAbstract:A Leishmaniose Tegumentar Americana no Brasil e causada por uma variedade de especies de Leishmania e uma grande diversidade destes parasitas pode ser encontrada na Regiao Amazonica. Revisoes recentes na quimioterapia de leishmaniose enfatizam as deficiencias dos agentes terapeuticos atualmente disponiveis e mostram a necessidade urgente de novos candidatos. Uma alternativa para substituir esses medicamentos sao extratos naturais deEugenia uniflora e Momordica charantia. Foram preparados extratos etanolicos das folhas de E. uniflora e M. charantia.Para os testes in vitrode Leishmania brasiliensisforam utilizadas formas promastigotas. O ensaio de citotoxicidade foi realizado com linhagens de fibroblastos. Nossos resultados indicam que E. uniflora foi eficaz contra a cepa de parasita testada, representando uma fonte alternativa de produtos naturais com atividade contra L. brasiliensis. Palavras-chave: Eugenia uiniflora. Momordica charantia. Leishmania brasiliensis. Atividade citotoxica. Promastigotas. ABSTRACT Antileishmanial in vitro activity of Eugenia uniflora and Momordica charantia Cutaneous leishmaniasis is caused in Brazil by several species of the genus Leishmaniaand a wide variety of these protozoan parasites can be found in Brazil, mainly in the Amazon region. Recent reviews on the chemotherapy of leishmaniasis show the low effectiveness of the usual therapeutic agents, demonstrating the need for new drugs. An interesting possible alternative to the conventional drugs is offered by natural products extracted from Eugenia uniflora and Momordica charantia. Ethanol extracts were prepared from the leaves of Eugenia uniflora and Momordica charantiaand assayed in vitro against Leishmania brasiliensispromastigotes and fibroblasts to assess their antileishmanial and cytotoxic activities, respectively. Our results indicate that E. uniflora was active against the parasitic forms of L. brasiliensis. Keywords: Eugenia uniflora. Momordica charantia. Leishmania brasiliensis. Cytotoxic activity. Promastigotes.
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potentiation of antibiotic activity by Eugenia uniflora and Eugenia jambolanum
Journal of Medicinal Food, 2010Co-Authors: Henrique D.m. Coutinho, Vivyanne S Falcaosilva, Jose P Siqueirajunior, José Galberto Martins Da Costa, Edeltrudes De Oliveira LimaAbstract:Abstract This is the first report about the modifying antibiotic activity of Eugenia uniflora L. and Eugenia jambolanum L. In this study the ethanol extract of E. uniflora and E. jambolanum was tested for their antimicrobial activity against strains of Escherichia coli. The growth of the two strains of E. coli bacteria tested was not inhibited in a clinically relevant form by the extract. The minimal inhibitory concentration was ≥1,024 μg/mL for both strains of E. coli assayed. Synergism between this extract and gentamicin was demonstrated. In the same extract synergism was observed between chlorpromazine and kanamycin and between amikacin and tobramycin, indicating the involvement of an efflux system in the resistance to these aminoglycosides. It is therefore suggested that extracts from E. uniflora L. and E. jambolanum L. could be used as a source of plant-derived natural products with modifying antibiotic activity to gentamicin.
Zamudio Sergio - One of the best experts on this subject based on the ideXlab platform.
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Tres especies nuevas de Myrtaceae de la Sierra Madre Oriental, México
2016Co-Authors: Sánchez-chávez Erandi, Zamudio SergioAbstract:Abstract Three new species of Myrtaceae from Querétaro and Hidalgo, México are described and illustrated: Calyptranthes moctezumae, Eugenia queretaroana and E. huasteca. Calyptranthes moctezumae is related with C. schlechtendaliana and C. schiedeana, from which it is distinguished by the lesser number of nerves per leaf, petioles 1 to 5 mm long, and because it occurs in tropical deciduous and subdeciduous forest, as well as submontane scrub. Eugenia queretaroana is similar to E. crenularis and E. pueblana; nevertheless, it is distinguished by the coppery indumentum, terete petiole, infundibuliform hypanthium, and ellipsoid fruit with a false stipe at base. Eugenia huasteca is related with E. capuli; however, the new species is distinguishable from all the other species in the genus by the brownishred to whitish indumentum of simple hairs and the sessile flowers.Resumen Se describen e ilustran tres especies nuevas de Myrtaceae de los estados de Querétaro e Hidalgo: Calyptranthes moctezumae, Eugenia queretaroana y E. huasteca. Calyptranthes moctezumae está relacionada con C. schlechtendaliana y C. schiedeana, de las que se distingue por el menor número de nervaduras por hoja, peciolos de 1 a 5 mm de largo, y por habitar en bosque tropical caducifolio, subcaducifolio y matorral submontano. Eugenia queretaroana es similar a E. crenularis y E. pueblana, de las que se diferencia por el indumento cobrizo, peciolo terete, hipantio infundibuliforme y frutos elipsoidales con un falso estípite en la base. Por su parte Eugenia huasteca se puede relacionar morfológicamente con E. capuli; sin embargo, la primera presenta indumento simple, pardo rojizo a blanquecino y flores sésiles, características que la separan claramente de cualquier otra especie de este género
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Tres especies nuevas de Myrtaceae de la Sierra Madre Oriental, México
'Instituto de Ecologia A.C.', 2016Co-Authors: Sánchez-chávez Erandi, Zamudio SergioAbstract:Three new species of Myrtaceae from Querétaro and Hidalgo, México are described and illustrated: Calyptranthes moctezumae, Eugenia queretaroana and E. huasteca. Calyptranthes moctezumae is related with C. schlechtendaliana and C. schiedeana, from which it is distinguished by the lesser number of nerves per leaf, petioles 1 to 5 mm long, and because it occurs in tropical deciduous and subdeciduous forest, as well as submontane scrub. Eugenia queretaroana is similar to E. crenularis and E. pueblana; nevertheless, it is distinguished by the coppery indumentum, terete petiole, infundibuliform hypanthium, and ellipsoid fruit with a false stipe at base. Eugenia huasteca is related with E. capuli; however, the new species is distinguishable from all the other species in the genus by the brownish-red to whitish indumentum of simple hairs and the sessile flowers.Se describen e ilustran tres especies nuevas de Myrtaceae de los estados de Querétaro e Hidalgo: Calyptranthes moctezumae, Eugenia queretaroana y E. huasteca. Calyptranthes moctezumae está relacionada con C. schlechtendaliana y C. schiedeana, de las que se distingue por el menor número de nervaduras por hoja, peciolos de 1 a 5 mm de largo, y por habitar en bosque tropical caducifolio, subcaducifolio y matorral submontano. Eugenia queretaroana es similar a E. crenularis y E. pueblana, de las que se diferencia por el indumento cobrizo, peciolo terete, hipantio infundibuliforme y frutos elipsoidales con un falso estípite en la base. Por su parte Eugenia huasteca se puede relacionar morfológicamente con E. capuli; sin embargo, la primera presenta indumento simple, pardo rojizo a blanquecino y flores sésiles, características que la separan claramente de cualquier otra especie de este género
Iguatemy Lourenco Brunetti - One of the best experts on this subject based on the ideXlab platform.
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fruit of the jambolan tree Eugenia jambolana lam and experimental diabetes
Journal of Ethnopharmacology, 2005Co-Authors: Maria Teresa Pepato, D M Mori, Amanda Martins Baviera, J B Harami, Regina Celia Vendramini, Iguatemy Lourenco BrunettiAbstract:Abstract The fruit of Indian Eugenia jambolana have been shown to have therapeutic properties, but because the therapeutic potential of a plant is related to the geographic region in which the plant was grown and to the part of the plant used, we investigated Brazilian Eugenia jambolana fruit using the same preparation and experimental methods as have been used in India. The well-established metabolic cage model was used to evaluate the physiological and metabolic parameters associated with streptozotocin-induced diabetes in rats ( n = 10) which had been administered, by gavage, 50 mg per day of lyophilised Eugenia jambolana fruit-pulp extract for 41 days. We found that, compared to untreated controls, rats treated with the lyophilised fruit-pulp showed no observable difference in body weight, food or water intake, urine volume, glycaemia, urinary urea and glucose, hepatic glycogen, or on serum levels of total cholesterol, HDL cholesterol or triglycerides. No change was observed in the masses of epididymal or retroperitoneal adipose tissue or of soleus or extensor digitorum longus muscles. This lack of any apparent effect on the diabetes may be attributable to the regional ecosystem where the fruit was collected and/or to the severity of the induced diabetes.
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lack of antidiabetic effect of a Eugenia jambolana leaf decoction on rat streptozotocin diabetes
Brazilian Journal of Medical and Biological Research, 2001Co-Authors: Maria Tereza Pepato, V B B Folgado, Isis Do Carmo Kettelhut, Iguatemy Lourenco BrunettiAbstract:Streptozotocin-diabetic rats were treated for 17 days with a decoction of Eugenia jambolana (Myrtaceae) leaves (15%, w/v) as a substitute for water. Body weight, food and fluid intake, urine volume, glycemia, urinary glucose and urea were evaluated every 5 days. The animals were sacrificed by decapitation and blood samples collected for the determination of glycemia, serum cholesterol, HDL-cholesterol, triglycerides and angiotensin-converting enzyme. The weight of adipose and muscle tissues was also determined. There were no statistically significant differences between treated and untreated rats for any of the biochemical or physiological parameters. We conclude that, at least in this experimental model, Eugenia jambolana leaf decoction has no antidiabetic activity.
Glaucia Maria Pastore - One of the best experts on this subject based on the ideXlab platform.
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wild brazilian species of Eugenia genera myrtaceae as an innovation hotspot for food and pharmacological purposes
Food Research International, 2019Co-Authors: Fabio Fernandes De Araujo, Iramaia Angelica Nerinuma, David De Paulo Farias, Gabryelle Rahyara Miranda Castro Da Cunha, Glaucia Maria PastoreAbstract:The Myrtaceae is one of the most common plant families in Brazil, including >1000 species of native fruit spread from North to South, where around 50% of all species are endemic to the Atlantic Rain Forest Biome. Most Brazilian species belong to Eugenia, Campomanesia, Psidium and Myrciaria genera. In general, they are characterized by the presence of leaves opposite, simple, entire, with pellucid glands containing ethereal oils and produces berry-like, fleshy fruits with a wide diversity of beneficial characteristics. Several parts of these plants are widely used in regional folk medicine as an astringent, anti-inflammatory, antihypertensive, to treat gastrointestinal disorders, and so on. Some species have already been studied and most of their metabolic effects are attributed to the presence of polyphenols, carotenoids as well as sesquiterpenes and monoterpenes. In addition, the Myrtaceae family has great economic potential, because of the sensory characteristics which encourages their commercial exploitation plus the presence of phytochemicals which play an important role in managing several degenerative chronic diseases besides representing a hotspot of technological innovation for food, cosmetic and pharmaceutical purposes. In this context, this review discusses about the importance of some Eugenia genera representatives such as Eugenia uniflora, Eugenia stipitata, Eugenia brasiliensis, Eugenia pyriformis and Eugenia dysenterica, emphasizing its profile of bioactive compounds as well as the knowledge of the nutritional and functional fruit potential, providing information for further studies aiming to stimulate the cultivation of Brazilian wild berries, for consumption and new food ingredients.
