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Hervé Rogez - One of the best experts on this subject based on the ideXlab platform.
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Anticonvulsant properties of Euterpe Oleracea in mice.
Neurochemistry international, 2015Co-Authors: José Rogério Souza-monteiro, Moisés Hamoy, Danielle Santana-coelho, Gabriela P. F. Arrifano, Ricardo Sousa De Oliveira Paraense, Allan Costa-malaquias, Jackson R. Mendonça, Rafael F. Da Silva, Wallena S.c. Monteiro, Hervé RogezAbstract:Abstract Acai ( Euterpe Oleracea Mart.), a highly consumed fruit in Amazon, is from a common palm with remarkable antioxidant properties. Because oxidative stress and seizures are intimately linked, this study investigated the potential neuroprotective and anticonvulsant effects of commercial clarified acai juice (EO). EO did not alter spontaneous locomotor activity. Four doses of EO were sufficient to increase latencies to both first myoclonic jerk and first generalized tonic–clonic seizure and significantly decrease the total duration of tonic-clonic seizures caused by pentylenetetrazol administration. Also, electrocortical alterations provoked by pentylenetetrazol were prevented, significantly decreasing amplitude of discharges and frequencies above 50 Hz. EO was also able to completely prevent lipid peroxidation in the cerebral cortex, showing a potent direct scavenging property. These results demonstrate for the first time that E. Oleracea significantly protects against seizures and seizure-related oxidative stress, indicating an additional protection for humans who consume this fruit.
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Spontaneous postharvest fermentation of açai (Euterpe Oleracea) fruit
Postharvest Biology and Technology, 2013Co-Authors: Fagner Sousa De Aguiar, Verena Menezes, Hervé RogezAbstract:Abstract Acai ( Euterpe Oleracea ) fruit (EOF) are widely commercialized in the Brazilian Amazon. These fruit contain a high bacterial load and are transported on boards stowed inside or outside the holds of small boats. In this context, postharvest parameters were assessed under conditions that simulated these two methods of EOF transport: stowage in closed polystyrene boxes, simulating the inside of cargo holds, i.e., transport in a closed system; and open baskets, simulating transport in an open environment, i.e., transport in the prow or bow of the boat. EOF suffered spontaneous fermentation of alcoholic, acetic, and lactic types in the closed system, which is the most common type of transportation of this fruit. In the closed system, there was a predominance of lactic acid bacteria over acetic acid bacteria, with 82% and 95% of the initial content of d -glucose and d -fructose being consumed, respectively, after 27 h of experiment. The weight loss reached 1.7% and there was a logarithmic decrease of the major phenolic compounds of the fruit in the closed system, with losses of 78% of cyanidin-3-rutinoside, 88% of cyanidin-3-glucoside, 78% of homorientin, and 72% of orientin after 27 h, which was higher than in the open system (58%, 66%, 73% and 62%, respectively). Analyses on EOF stowed in a closed system indicated that the respiratory rate was characteristic of a non-climacteric fruit, i.e., it showed a logarithmic decay in the production of CO 2 ( R 2 = 0.995; P
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a rapid validated uhplc pda method for anthocyanins quantification from Euterpe Oleracea fruits
Journal of Chromatography B, 2012Co-Authors: A. Dias, Hervé Rogez, Eric Rozet, Gabrielle Chataigné, Ana Cristina M. Oliveira, C A S Rabelo, Philippe Hubert, Joelle QuetinleclercqAbstract:The aim of this work is to develop the first validated UHPLC-PDA method for major anthocyanins quantification in Euterpe Oleracea fruits after fast extraction procedures and samples preparation. The separation was performed on HSS C18 column (1.8 μm) using a gradient elution with acetonitrile and 5% formic acid in a total run time of only 17 min. Total error and accuracy profiles were used as criteria for the validation process. Calibration in the matrix was found to be more accurate than calibration without matrix. Trueness (<6.76% relative bias), repeatability (<4.6% RSD), intermediate precision (<5.3% RSD), selectivity, response function and linearity for major anthocyanins, cyanidin-3-glucoside and cyanidin-3-rutinoside, were evaluated. The concentration range validated was 1-48 μg/mL for both compounds. In addition two cyanidin-di-O-glycosides were detected for the fist time in this fruit. We also showed that a first extraction of the fruits with ethyl acetate removes the lipophilic compounds and allows an easier extraction by methanol and quantification of anthocyanins in this extract.
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A rapid validated UHPLC-PDA method for anthocyanins quantification from Euterpe Oleracea fruits
Journal of chromatography. B Analytical technologies in the biomedical and life sciences, 2012Co-Authors: A. Dias, Hervé Rogez, Eric Rozet, Gabrielle Chataigné, Ana Cristina M. Oliveira, C A S Rabelo, Philippe Hubert, Joëlle Quetin-leclercqAbstract:The aim of this work is to develop the first validated UHPLC-PDA method for major anthocyanins quantification in Euterpe Oleracea fruits after fast extraction procedures and samples preparation. The separation was performed on HSS C18 column (1.8 μm) using a gradient elution with acetonitrile and 5% formic acid in a total run time of only 17 min. Total error and accuracy profiles were used as criteria for the validation process. Calibration in the matrix was found to be more accurate than calibration without matrix. Trueness (
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A rapid UHPLC-DAD-ESI-MSn method for anthocyanins quantification from Euterpe Oleracea fruits harvested at different times
2011Co-Authors: A. Dias, Hervé Rogez, Eric Rozet, Gabrielle Chataigné, Ana Cristina M. Oliveira, A. Silva, Joëlle Quetin-leclercqAbstract:Euterpe Oleracea is a palm tree widely distributed in the floodplains of the Amazonian delta (Brazil). The fruits called acai (Fig 1) are an interesting source of different anthocyanins [1]. Lately they have gained popularity in North America and in the European countries in the food industry and in the health sector due to their extremely high antioxidant capacity and potential antiinflammatory activities [2]. Acai fruits are normally sold from different maturation stages. The evaluation of the anthocyanin profile during different maturation stages is thus important for the post-harvest industry. Thus, the aim of this study was to characterize the anthocyanin profiles of acai fruits at different stages of maturity from specific region of harvest.
Joëlle Quetin-leclercq - One of the best experts on this subject based on the ideXlab platform.
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A rapid validated UHPLC-PDA method for anthocyanins quantification from Euterpe Oleracea fruits
Journal of chromatography. B Analytical technologies in the biomedical and life sciences, 2012Co-Authors: A. Dias, Hervé Rogez, Eric Rozet, Gabrielle Chataigné, Ana Cristina M. Oliveira, C A S Rabelo, Philippe Hubert, Joëlle Quetin-leclercqAbstract:The aim of this work is to develop the first validated UHPLC-PDA method for major anthocyanins quantification in Euterpe Oleracea fruits after fast extraction procedures and samples preparation. The separation was performed on HSS C18 column (1.8 μm) using a gradient elution with acetonitrile and 5% formic acid in a total run time of only 17 min. Total error and accuracy profiles were used as criteria for the validation process. Calibration in the matrix was found to be more accurate than calibration without matrix. Trueness (
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A rapid UHPLC-DAD-ESI-MSn method for anthocyanins quantification from Euterpe Oleracea fruits harvested at different times
2011Co-Authors: A. Dias, Hervé Rogez, Eric Rozet, Gabrielle Chataigné, Ana Cristina M. Oliveira, A. Silva, Joëlle Quetin-leclercqAbstract:Euterpe Oleracea is a palm tree widely distributed in the floodplains of the Amazonian delta (Brazil). The fruits called acai (Fig 1) are an interesting source of different anthocyanins [1]. Lately they have gained popularity in North America and in the European countries in the food industry and in the health sector due to their extremely high antioxidant capacity and potential antiinflammatory activities [2]. Acai fruits are normally sold from different maturation stages. The evaluation of the anthocyanin profile during different maturation stages is thus important for the post-harvest industry. Thus, the aim of this study was to characterize the anthocyanin profiles of acai fruits at different stages of maturity from specific region of harvest.
A. Dias - One of the best experts on this subject based on the ideXlab platform.
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a rapid validated uhplc pda method for anthocyanins quantification from Euterpe Oleracea fruits
Journal of Chromatography B, 2012Co-Authors: A. Dias, Hervé Rogez, Eric Rozet, Gabrielle Chataigné, Ana Cristina M. Oliveira, C A S Rabelo, Philippe Hubert, Joelle QuetinleclercqAbstract:The aim of this work is to develop the first validated UHPLC-PDA method for major anthocyanins quantification in Euterpe Oleracea fruits after fast extraction procedures and samples preparation. The separation was performed on HSS C18 column (1.8 μm) using a gradient elution with acetonitrile and 5% formic acid in a total run time of only 17 min. Total error and accuracy profiles were used as criteria for the validation process. Calibration in the matrix was found to be more accurate than calibration without matrix. Trueness (<6.76% relative bias), repeatability (<4.6% RSD), intermediate precision (<5.3% RSD), selectivity, response function and linearity for major anthocyanins, cyanidin-3-glucoside and cyanidin-3-rutinoside, were evaluated. The concentration range validated was 1-48 μg/mL for both compounds. In addition two cyanidin-di-O-glycosides were detected for the fist time in this fruit. We also showed that a first extraction of the fruits with ethyl acetate removes the lipophilic compounds and allows an easier extraction by methanol and quantification of anthocyanins in this extract.
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A rapid validated UHPLC-PDA method for anthocyanins quantification from Euterpe Oleracea fruits
Journal of chromatography. B Analytical technologies in the biomedical and life sciences, 2012Co-Authors: A. Dias, Hervé Rogez, Eric Rozet, Gabrielle Chataigné, Ana Cristina M. Oliveira, C A S Rabelo, Philippe Hubert, Joëlle Quetin-leclercqAbstract:The aim of this work is to develop the first validated UHPLC-PDA method for major anthocyanins quantification in Euterpe Oleracea fruits after fast extraction procedures and samples preparation. The separation was performed on HSS C18 column (1.8 μm) using a gradient elution with acetonitrile and 5% formic acid in a total run time of only 17 min. Total error and accuracy profiles were used as criteria for the validation process. Calibration in the matrix was found to be more accurate than calibration without matrix. Trueness (
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A rapid UHPLC-DAD-ESI-MSn method for anthocyanins quantification from Euterpe Oleracea fruits harvested at different times
2011Co-Authors: A. Dias, Hervé Rogez, Eric Rozet, Gabrielle Chataigné, Ana Cristina M. Oliveira, A. Silva, Joëlle Quetin-leclercqAbstract:Euterpe Oleracea is a palm tree widely distributed in the floodplains of the Amazonian delta (Brazil). The fruits called acai (Fig 1) are an interesting source of different anthocyanins [1]. Lately they have gained popularity in North America and in the European countries in the food industry and in the health sector due to their extremely high antioxidant capacity and potential antiinflammatory activities [2]. Acai fruits are normally sold from different maturation stages. The evaluation of the anthocyanin profile during different maturation stages is thus important for the post-harvest industry. Thus, the aim of this study was to characterize the anthocyanin profiles of acai fruits at different stages of maturity from specific region of harvest.
Roberto Soares De Moura - One of the best experts on this subject based on the ideXlab platform.
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Açaí (Euterpe Oleracea Mart) seed extract protects against maternal vascular dysfunction, hypertension, and fetal growth restriction in experimental preeclampsia
Hypertension in pregnancy, 2020Co-Authors: Alexandre De Souza Da Silva, Lenize Costa Reis Marins De Carvalho, Cristiane Aguiar Da Costa, Roberto Soares De Moura, Angela Castro Resende, Izabelle Barcellos Santos, Douglas Val Quintans Nunes, Matheus Pontes De Menezes, Dayane Teixeira OgnibeneAbstract:Objective: To investigate whether Euterpe Oleracea Mart. (acai) seed extract (ASE) prevents maternal cardiovascular changes and intrauterine growth restriction (IUGR) in experimental preeclampsia (PE).Methods: ASE administration (200 mg/kg/day) during mid to late pregnancy in a rat model of L-NAME-induced PE.Results: ASE impaired the maternal hypertension and microalbuminuria as well as the lower fetal and placental weight in experimental PE. ASE also prevented the maternal vascular dysfunction and lipoperoxidation in this model.Conclusion: ASE protected against maternal cardiovascular changes and IUGR in the L-NAME-induced PE. The protective effect of ASE may be partly explained by its antioxidant property.
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Euterpe Oleracea Mart. seed extract protects against renal injury in diabetic and spontaneously hypertensive rats: role of inflammation and oxidative stress.
European journal of nutrition, 2017Co-Authors: Viviane Da Silva Cristino Cordeiro, Lenize Costa Reis Marins De Carvalho, Cristiane Aguiar Da Costa, Jorge José De Carvalho, Roberto Soares De Moura, Izabelle Barcellos Santos, Dayane Teixeira Ognibene, Ana Paula Machado Da Rocha, Angela Castro ResendeAbstract:Purpose Euterpe Oleracea Mart. (acai) seed extract (ASE), through its anti-hypertensive, antioxidant and anti-inflammatory properties, may be useful to treat or prevent human diseases. Several evidences suggest that oxidative stress and inflammation contribute to the pathogenesis of diabetic nephropathy; therefore, we tested the hypothesis that ASE (200 mg/kg−1day−1) prevents diabetes and hypertension-related oxidative stress and inflammation, attenuating renal injury.
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Euterpe Oleracea Mart. extract prevents vascular remodeling and endothelial dysfunction in spontaneously hypertensive rats
International Journal of Applied Research in Natural Products, 2015Co-Authors: Viviane Da Silva Cristino Cordeiro, Lenize Costa Reis Marins De Carvalho, Cristiane Aguiar Da Costa, Marcelo Augusto Vieira De Souza, Pergentino José Da Cunha Sousa, Vinícius Novaes Rocha, Jorge José De Carvalho, Roberto Soares De Moura, Angela Castro ResendeAbstract:Summary. We assessed the effects of Euterpe Oleracea Mart. (acai) seed extract (ASE) rich in proanthocyanidins and catechin on vascular dysfunction and oxidative stress associated with hypertension in spontaneously hypertensive rats (SHR). SHR and control rats were treated with ASE (200 mg/kg/day) or vehicle for 10 weeks. In the rat mesenteric arterial bed (MAB), acetylcholine response, endothelial nitric oxide synthase (eNOS) and superoxide dismutase 1 (SOD 1) expressions were studied. The antioxidant enzyme activity, oxidative damage and nitrite quantification were assessed in MAB and heart homogenates. eNOS immunohistochemistry and histological analysis was carried out on aortic sections. ASE was able to attenuate the hypertension and prevent the endothelial dysfunction in MAB of SHR. The increased levels of protein carbonylation and associated low levels of nitrite in MAB and heart of SHR were attenuated by ASE. The up-regulation of eNOS and SOD1 expression and the increased activity of SOD in MAB from SHR were normalized by ASE. In aorta from SHR, ASE prevented the increase in media thickness, media:lumen ratio and the decrease in the percentage of elastic fibers. Our results suggest that ASE produces antihypertensive effect and prevents the vascular dysfunction in SHR, through mechanisms involving antioxidant effects and NO production. Industrial relevance. Euterpe Oleracea Mart. (Acai) has been considered one of the most important medicinal plants of the Amazon by its beneficial effects in the treatment of fever, pain, inflammation and anemia. More recently, Euterpe Oleracea Mart. has been reported to reduce blood pressure with an important antioxidant property. The present research reports the protective effect of the extract of the seeds from Euterpe oleraca Mart. against high blood pressure and the associated vascular structural and functional changes. The test for antihypertensive and vascular anti-hypertrophic effect of the hydro-alcoholic extract of the seed of Euterpe Oleracea Mart. provides scientific data to confirm the potentials of Euterpe Oleracea Mart as an antihypertensive medicinal plant. Considering the large supply of Acai fruit in Brazil to obtain the extract, it provides a new therapeutic possibility of low cost for hypertensive patients. Keywords. Euterpe Oleracea Mart; hypertension; oxidative stress; endothelial dysfunction; vascular hypertrophy.
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Oral treatment with Euterpe Oleracea Mart. (açaí) extract improves cardiac dysfunction and exercise intolerance in rats subjected to myocardial infarction
BMC complementary and alternative medicine, 2014Co-Authors: Gisele Zapata-sudo, Roberto Soares De Moura, Jaqueline Da Silva, Sharlene L Pereira, Pergentino J C Souza, Roberto T. SudoAbstract:Background This study was designed to evaluate the cardioprotective effects of Euterpe Oleracea Mart., popularly known as “acai”, on rats subjected to myocardial infarction (MI).
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Cytotoxic effects of Euterpe Oleracea Mart. in malignant cell lines.
BMC complementary and alternative medicine, 2014Co-Authors: Dulcelena Ferreira Silva, Flávia Castello Branco Vidal, Débora Silva Santos, Maria Célia Pires Costa, José Andrés Morgado-díaz, Maria Do Desterro Soares Brandão Nascimento, Roberto Soares De MouraAbstract:Euterpe Oleracea Mart., a plant from the Amazon region, is commonly known as acai or jucara; it has high nutritional value and elevated levels of lipids, proteins, and minerals. Acai is an abundant and much consumed fruit by the Amazon local population, and studies have demonstrated that it is rich in phytochemicals with antioxidant, anti-inflammatory, and anticancer activities. Therefore, the aim of this study was to test this plant for anticancer activity in different human malignant cell lines. Cell lines derived from breast and colorectal adenocarcinomas were treated with 10, 20, and 40 μg/mL of bark, seed, and total acai fruit hydroalcoholic extracts for 24 and 48 h. After treatment, cell viability was measured using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays, and cell morphological features were observed by light and transmission electron microscopy. The type of cell death was also evaluated. The data were analyzed statistically by one-way analysis of variance (ANOVA), followed by Dunnett’s or Tukey’s post hoc tests, as appropriate. We observed that of all the cell lines tested, MCF-7 was the only line that responded to acai treatment. The extracts caused significant reduction (p
Angela Castro Resende - One of the best experts on this subject based on the ideXlab platform.
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Açaí (Euterpe Oleracea Mart) seed extract protects against maternal vascular dysfunction, hypertension, and fetal growth restriction in experimental preeclampsia
Hypertension in pregnancy, 2020Co-Authors: Alexandre De Souza Da Silva, Lenize Costa Reis Marins De Carvalho, Cristiane Aguiar Da Costa, Roberto Soares De Moura, Angela Castro Resende, Izabelle Barcellos Santos, Douglas Val Quintans Nunes, Matheus Pontes De Menezes, Dayane Teixeira OgnibeneAbstract:Objective: To investigate whether Euterpe Oleracea Mart. (acai) seed extract (ASE) prevents maternal cardiovascular changes and intrauterine growth restriction (IUGR) in experimental preeclampsia (PE).Methods: ASE administration (200 mg/kg/day) during mid to late pregnancy in a rat model of L-NAME-induced PE.Results: ASE impaired the maternal hypertension and microalbuminuria as well as the lower fetal and placental weight in experimental PE. ASE also prevented the maternal vascular dysfunction and lipoperoxidation in this model.Conclusion: ASE protected against maternal cardiovascular changes and IUGR in the L-NAME-induced PE. The protective effect of ASE may be partly explained by its antioxidant property.
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Euterpe Oleracea Mart. seed extract protects against renal injury in diabetic and spontaneously hypertensive rats: role of inflammation and oxidative stress.
European journal of nutrition, 2017Co-Authors: Viviane Da Silva Cristino Cordeiro, Lenize Costa Reis Marins De Carvalho, Cristiane Aguiar Da Costa, Jorge José De Carvalho, Roberto Soares De Moura, Izabelle Barcellos Santos, Dayane Teixeira Ognibene, Ana Paula Machado Da Rocha, Angela Castro ResendeAbstract:Purpose Euterpe Oleracea Mart. (acai) seed extract (ASE), through its anti-hypertensive, antioxidant and anti-inflammatory properties, may be useful to treat or prevent human diseases. Several evidences suggest that oxidative stress and inflammation contribute to the pathogenesis of diabetic nephropathy; therefore, we tested the hypothesis that ASE (200 mg/kg−1day−1) prevents diabetes and hypertension-related oxidative stress and inflammation, attenuating renal injury.
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Euterpe Oleracea Mart. extract prevents vascular remodeling and endothelial dysfunction in spontaneously hypertensive rats
International Journal of Applied Research in Natural Products, 2015Co-Authors: Viviane Da Silva Cristino Cordeiro, Lenize Costa Reis Marins De Carvalho, Cristiane Aguiar Da Costa, Marcelo Augusto Vieira De Souza, Pergentino José Da Cunha Sousa, Vinícius Novaes Rocha, Jorge José De Carvalho, Roberto Soares De Moura, Angela Castro ResendeAbstract:Summary. We assessed the effects of Euterpe Oleracea Mart. (acai) seed extract (ASE) rich in proanthocyanidins and catechin on vascular dysfunction and oxidative stress associated with hypertension in spontaneously hypertensive rats (SHR). SHR and control rats were treated with ASE (200 mg/kg/day) or vehicle for 10 weeks. In the rat mesenteric arterial bed (MAB), acetylcholine response, endothelial nitric oxide synthase (eNOS) and superoxide dismutase 1 (SOD 1) expressions were studied. The antioxidant enzyme activity, oxidative damage and nitrite quantification were assessed in MAB and heart homogenates. eNOS immunohistochemistry and histological analysis was carried out on aortic sections. ASE was able to attenuate the hypertension and prevent the endothelial dysfunction in MAB of SHR. The increased levels of protein carbonylation and associated low levels of nitrite in MAB and heart of SHR were attenuated by ASE. The up-regulation of eNOS and SOD1 expression and the increased activity of SOD in MAB from SHR were normalized by ASE. In aorta from SHR, ASE prevented the increase in media thickness, media:lumen ratio and the decrease in the percentage of elastic fibers. Our results suggest that ASE produces antihypertensive effect and prevents the vascular dysfunction in SHR, through mechanisms involving antioxidant effects and NO production. Industrial relevance. Euterpe Oleracea Mart. (Acai) has been considered one of the most important medicinal plants of the Amazon by its beneficial effects in the treatment of fever, pain, inflammation and anemia. More recently, Euterpe Oleracea Mart. has been reported to reduce blood pressure with an important antioxidant property. The present research reports the protective effect of the extract of the seeds from Euterpe oleraca Mart. against high blood pressure and the associated vascular structural and functional changes. The test for antihypertensive and vascular anti-hypertrophic effect of the hydro-alcoholic extract of the seed of Euterpe Oleracea Mart. provides scientific data to confirm the potentials of Euterpe Oleracea Mart as an antihypertensive medicinal plant. Considering the large supply of Acai fruit in Brazil to obtain the extract, it provides a new therapeutic possibility of low cost for hypertensive patients. Keywords. Euterpe Oleracea Mart; hypertension; oxidative stress; endothelial dysfunction; vascular hypertrophy.
