The Experts below are selected from a list of 3945 Experts worldwide ranked by ideXlab platform
Reza Haji Hosseini Baghdad Abadi - One of the best experts on this subject based on the ideXlab platform.
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suitable conditions for liquid phase microextraction using solidification of a floating drop for extraction of Fat Soluble Vitamins established using an orthogonal array experimental design
Journal of Chromatography A, 2008Co-Authors: Hamid Reza Sobhi, Yadollah Yamini, Ali Esrafili, Reza Haji Hosseini Baghdad AbadiAbstract:A simple, rapid and efficient microextraction method for the extraction and determination of some Fat-Soluble Vitamins (A, D 2 , D 3 ) in aqueous samples was developed. For the first time orthogonal array designs (OADs) were employed to screen the liquid-phase microextraction (LPME) method in which few microliters of 1-undecanol were delivered to the surface of the aqueous sample and it was agitated for a selected time. Then sample vial was cooled by inserting it into an ice bath for 5 min. The solidified solvent was transferred into a suitable vial and immediately melted. Then, the extract was directly injected into a high-performance liquid chromatography (HPLC) for analysis. Several factors affecting the microextraction efficiency such as sample solution temperature, stirring speed, volume of the organic solvent, ionic strength and extraction time were investigated and screened using an OA 16 (4 5 ) matrix. Under the best conditions (temperature, 55°C; stirring speed, 1000 rpm; the volume of extracting solvent, 15.0 μL; no salt addition and extraction time, 60 min), detection limits of the method were in the range of 1.0-3.5 μg L -1 . The relative standard deviations (RSDs) to determine the Vitamins at μg L -1 levels by applying the proposed method varied in the range of 5.1-10.7%. Dynamic linear ranges of 5-500 μg L -1 with good correlation coefficients (0.9984 < r 2 < 0.9991) were observed. Finally, the study was applied to determine the Vitamins in several real aqueous samples including mixed juice fruit, urine and tap water samples and relatively good results were obtained.
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suitable conditions for liquid phase microextraction using solidification of a floating drop for extraction of Fat Soluble Vitamins established using an orthogonal array experimental design
Journal of Chromatography A, 2008Co-Authors: Hamid Reza Sobhi, Yadollah Yamini, Ali Esrafili, Reza Haji Hosseini Baghdad AbadiAbstract:A simple, rapid and efficient microextraction method for the extraction and determination of some Fat-Soluble Vitamins (A, D2, D3) in aqueous samples was developed. For the first time orthogonal array designs (OADs) were employed to screen the liquid-phase microextraction (LPME) method in which few microliters of 1-undecanol were delivered to the surface of the aqueous sample and it was agitated for a selected time. Then sample vial was cooled by inserting it into an ice bath for 5 min. The solidified solvent was transferred into a suitable vial and immediately melted. Then, the extract was directly injected into a high-performance liquid chromatography (HPLC) for analysis. Several factors affecting the microextraction efficiency such as sample solution temperature, stirring speed, volume of the organic solvent, ionic strength and extraction time were investigated and screened using an OA16 (4(5)) matrix. Under the best conditions (temperature, 55 degrees C; stirring speed, 1000 rpm; the volume of extracting solvent, 15.0 microL; no salt addition and extraction time, 60 min), detection limits of the method were in the range of 1.0-3.5 microgL(-1). The relative standard deviations (RSDs) to determine the Vitamins at microg L(-1) levels by applying the proposed method varied in the range of 5.1-10.7%. Dynamic linear ranges of 5-500 mugL(-1) with good correlation coefficients (0.9984
Per Magne Ueland - One of the best experts on this subject based on the ideXlab platform.
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pre diagnostic circulating concentrations of Fat Soluble Vitamins and risk of glioma in three cohort studies
Scientific Reports, 2021Co-Authors: Yiyang Yue, Jordan H Creed, David J Cote, Meir J Stampfer, Molin Wang, Oivind Midttun, Adrian Mccann, Per Magne UelandAbstract:Few prospective studies have evaluated the relation between Fat-Soluble Vitamins and glioma risk. Using three cohorts-UK Biobank (UKB), Nurses' Health Study (NHS), and Health Professionals Follow-Up Study (HPFS), we investigated associations of pre-diagnostic concentrations of Fat-Soluble Vitamins D, A, and E with incident glioma. In 346,785 participants (444 cases) in UKB, associations with vitamin D (25-hydroxyvitamin D [25(OH)D]) were evaluated by Cox proportional hazards regression. In NHS (52 cases, 104 controls) and HPFS (32 cases, 64 controls), associations with 25(OH)D, vitamin A (retinol), and vitamin E (α- and γ-tocopherol) were assessed using conditional logistic regression. Our results suggested plasma concentrations of 25(OH)D and retinol were not associated with glioma risk. Comparing the highest to lowest tertile, the multivariable hazard ratio (MVHR) for 25(OH)D was 0.87 (95% confidence interval [CI] 0.68-1.11) in UKB and the multivariable risk ratio (MVRR) was 0.97 (95% CI 0.51-1.85) in NHS and HPFS. In NHS and HPFS, the MVRR for the same comparison for retinol was 1.16 (95% CI 0.56-2.38). Nonsignificant associations were observed for α-tocopherol (MVRRtertile3vs1 = 0.61, 95% CI 0.29-1.32) and γ-tocopherol (MVRR tertile3vs1 = 1.30, 95% CI 0.63-2.69) that became stronger in 4-year lagged analyses. Further investigation is warranted on a potential association between α- and γ-tocopherol and glioma risk.
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combined measurement of 6 Fat Soluble Vitamins and 26 water Soluble functional vitamin markers and amino acids in 50 μl of serum or plasma by high throughput mass spectrometry
Analytical Chemistry, 2016Co-Authors: Oivind Midttun, Adrian Mccann, Per Magne Ueland, Ove Aarseth, Marit Krokeide, Gry Kvalheim, Klaus MeyerAbstract:Targeted metabolic profiling characterized by complementary platforms, multiplexing and low volume consumption are increasingly used for studies using biobank material. Using liquid–liquid extraction, we developed a sample workup suitable for quantification of 6 Fat- and 26 water-Soluble biomarkers. 50 μL of serum/plasma was mixed with dithioerythritol, ethanol, and isooctane/chloroform. The organic layer was used for analysis of the Fat-Soluble Vitamins all-trans retinol (A), 25-hydroxyvitamin D2, 25-hydroxyvitamin D3, α-tocopherol (E), γ-tocopherol (E), and phylloquinone (K1) by LC-MS/MS. The remaining aqueous fraction was mixed with ethanol, water, pyridine, and methylchloroformate (in toluene) to derivatize the water-Soluble biomarkers. The resulting toluene layer was used for GC-MS/MS analysis of alanine, α-ketoglutarate, asparagine, aspartic acid, cystathionine, total cysteine, glutamic acid, glutamine, glycine, histidine, total homocysteine, isoleucine, kynurenine, leucine, lysine, methionine, meth...
Andreas Schieber - One of the best experts on this subject based on the ideXlab platform.
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quantification of selected Fat Soluble Vitamins and carotenoids in infant formula and dietary supplements using fast liquid chromatography coupled with tandem mass spectrometry
Food Research International, 2014Co-Authors: Chamila Nimalaratne, Chenxing Sun, Jonathan M Curtis, Andreas SchieberAbstract:Abstract A sensitive and fast analytical method has been developed and validated for the simultaneous identification and quantification of nine Fat Soluble Vitamins and their derivatives (retinol, retinyl acetate, retinyl palmitate, cholecalciferol (D3), α-, β-, γ-, and δ-tocopherol, α-tocopheryl acetate) along with three carotenoids (β-carotene, lutein and zeaxanthin) in dietary supplements and infant formulas using a fast liquid chromatography (UFLC) system coupled with tandem mass spectrometry. Separation was performed within 15 min on a YMC C 30 column (100 mm × 2 mm I.D., 3 μm) using methanol:water (90:10 v/v) and tert -butyl methyl ether (TBME):methanol (80:20 v/v) as the mobile phase with gradient elution. Quantification was carried out by multiple reaction monitoring in combination with information dependent acquisition (IDA) using atmospheric pressure chemical ionization (APCI) in the positive mode. Enhanced product ion scan was used and the mass spectrum of each target compound confirmed their presence in the analyzed extracts. Extraction recovery for all analytes spiked at two levels ranged from 90% to 105%. The overall intra-day precision values for the method based on the relative standard deviation for three QC levels were below 6% for all analytes. The accuracy ranged from 87.6% to 113.5%. A selection of multivitamin supplements and infant formulas available on the Canadian market was analyzed and the results showed good agreement with the values declared on the labels.
Hamid Reza Sobhi - One of the best experts on this subject based on the ideXlab platform.
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suitable conditions for liquid phase microextraction using solidification of a floating drop for extraction of Fat Soluble Vitamins established using an orthogonal array experimental design
Journal of Chromatography A, 2008Co-Authors: Hamid Reza Sobhi, Yadollah Yamini, Ali Esrafili, Reza Haji Hosseini Baghdad AbadiAbstract:A simple, rapid and efficient microextraction method for the extraction and determination of some Fat-Soluble Vitamins (A, D 2 , D 3 ) in aqueous samples was developed. For the first time orthogonal array designs (OADs) were employed to screen the liquid-phase microextraction (LPME) method in which few microliters of 1-undecanol were delivered to the surface of the aqueous sample and it was agitated for a selected time. Then sample vial was cooled by inserting it into an ice bath for 5 min. The solidified solvent was transferred into a suitable vial and immediately melted. Then, the extract was directly injected into a high-performance liquid chromatography (HPLC) for analysis. Several factors affecting the microextraction efficiency such as sample solution temperature, stirring speed, volume of the organic solvent, ionic strength and extraction time were investigated and screened using an OA 16 (4 5 ) matrix. Under the best conditions (temperature, 55°C; stirring speed, 1000 rpm; the volume of extracting solvent, 15.0 μL; no salt addition and extraction time, 60 min), detection limits of the method were in the range of 1.0-3.5 μg L -1 . The relative standard deviations (RSDs) to determine the Vitamins at μg L -1 levels by applying the proposed method varied in the range of 5.1-10.7%. Dynamic linear ranges of 5-500 μg L -1 with good correlation coefficients (0.9984 < r 2 < 0.9991) were observed. Finally, the study was applied to determine the Vitamins in several real aqueous samples including mixed juice fruit, urine and tap water samples and relatively good results were obtained.
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suitable conditions for liquid phase microextraction using solidification of a floating drop for extraction of Fat Soluble Vitamins established using an orthogonal array experimental design
Journal of Chromatography A, 2008Co-Authors: Hamid Reza Sobhi, Yadollah Yamini, Ali Esrafili, Reza Haji Hosseini Baghdad AbadiAbstract:A simple, rapid and efficient microextraction method for the extraction and determination of some Fat-Soluble Vitamins (A, D2, D3) in aqueous samples was developed. For the first time orthogonal array designs (OADs) were employed to screen the liquid-phase microextraction (LPME) method in which few microliters of 1-undecanol were delivered to the surface of the aqueous sample and it was agitated for a selected time. Then sample vial was cooled by inserting it into an ice bath for 5 min. The solidified solvent was transferred into a suitable vial and immediately melted. Then, the extract was directly injected into a high-performance liquid chromatography (HPLC) for analysis. Several factors affecting the microextraction efficiency such as sample solution temperature, stirring speed, volume of the organic solvent, ionic strength and extraction time were investigated and screened using an OA16 (4(5)) matrix. Under the best conditions (temperature, 55 degrees C; stirring speed, 1000 rpm; the volume of extracting solvent, 15.0 microL; no salt addition and extraction time, 60 min), detection limits of the method were in the range of 1.0-3.5 microgL(-1). The relative standard deviations (RSDs) to determine the Vitamins at microg L(-1) levels by applying the proposed method varied in the range of 5.1-10.7%. Dynamic linear ranges of 5-500 mugL(-1) with good correlation coefficients (0.9984
Adrienne R. Minerick - One of the best experts on this subject based on the ideXlab platform.
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data representing two separate lc ms methods for detection and quantification of water Soluble and Fat Soluble Vitamins in tears and blood serum
Data in Brief, 2017Co-Authors: Maryam Khaksari, Robert T Kennedy, Chunhai Ruan, Lynn Mazzoleni, Adrienne R. MinerickAbstract:Two separate liquid chromatography (LC)-mass spectrometry (MS) methods were developed for determination and quantification of water-Soluble and Fat-Soluble Vitamins in human tear and blood serum samples. The water-Soluble vitamin method was originally developed to detect Vitamins B1, B2, B3 (nicotinamide), B5, B6 (pyridoxine), B7, B9 and B12 while the Fat-Soluble vitamin method detected Vitamins A, D3, 25(OH)D3, E and K1. These methods were then validated with tear and blood serum samples. In this data in brief article, we provide details on the two LC-MS methods development, methods sensitivity, as well as precision and accuracy for determination of Vitamins in human tears and blood serum. These methods were then used to determine the vitamin concentrations in infant and parent samples under a clinical study which were reported in "Determination of Water-Soluble and Fat-Soluble Vitamins in Tears and Blood Serum of Infants and Parents by Liquid Chromatography/Mass Spectrometry DOI:10.1016/j.exer.2016.12.007 [1]". This article provides more details on comparison of vitamin concentrations in the samples with the ranges reported in the literature along with the medically accepted normal ranges. The details on concentrations below the limits of detection (LOD) and limits of quantification (LOQ) are also discussed. Vitamin concentrations were also compared and cross-correlated with clinical data and nutritional information. Significant differences and strongly correlated data were reported in [1]. This article provides comprehensive details on the data with slight differences or slight correlations.
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Determination of water-Soluble and Fat-Soluble Vitamins in tears and blood serum of infants and parents by liquid chromatography/mass spectrometry
Experimental Eye Research, 2017Co-Authors: Maryam Khaksari, Lynn R. Mazzoleni, Robert T Kennedy, Chunhai Ruan, Adrienne R. MinerickAbstract:Tears serve as a viable diagnostic fluid with advantages including less invasive sample to collect and less complex to prepare for analysis. Several water-Soluble and Fat-Soluble Vitamins were detected and quantified in human tears and compared with blood serum levels. Samples from 15 family pairs, each pair consisting of a four-month-old infant and one parent were analyzed; vitamin concentrations were compared between tears and blood serum for individual subjects, between infants and parents, and against self-reported dietary intakes. Water-Soluble Vitamins B1, B2, B3(nicotinamide), B5, B9and Fat-Soluble vitamin E (α-tocopherol) were routinely detected in tears and blood serum while Fat-Soluble vitamin A (retinol) was detected only in blood serum. Water-Soluble vitamin concentrations measured in tears and blood serum of single subjects were comparable, while higher concentrations were measured in infants compared to their parents. Fat-Soluble vitamin E concentrations were lower in tears than blood serum with no significant difference between infants and parents. Serum vitamin A concentrations were higher in parents than infants. Population trends were compiled and quantified using a cross correlation factor. Strong positive correlations were found between tear and blood serum concentrations of vitamin E from infants and parents and vitamin B3concentrations from parents, while slight positive correlations were detected for infants B3and parents B1and B2concentrations. Correlations between infants and parents were found for the concentrations of B1, B2, B3, and E in tears, and the concentrations of B2,A, and E in blood serum. Stronger vitamin concentration correlations were found between infants and parents for the breast-fed infants, while no significant difference was observed between breast-fed and bottle-fed infants. This work is the first to demonstrate simultaneous vitamin A, B, and E detection and to quantify correlations between vitamin concentrations in tears and blood serum. Our results suggest that tears are a viable biofluid to monitor nutritional health because they sufficiently mirror blood serum data and may enhance the speed of deficiency diagnoses.