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Nargess Moghadasi - One of the best experts on this subject based on the ideXlab platform.
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The effects of radiofrequency radiation on mice Fetus Weight, length and tissues.
Data in brief, 2018Co-Authors: Iraj Alimohammadi, Azadeh Ashtarinezhad, Baharak Mohamadzadeh Asl, Batol Masruri, Nargess MoghadasiAbstract:Abstract The public concern of harmful effects of radiofrequency radiation exposure, especially with rapid increase in the use of wireless and telecommunication devices, is increasing. Some studies show fetal and developmental abnormalities as the result of radiofrequency radiation exposure. We aimed to investigate possible teratogenic effects of radiofrequency in 915 MHz on mice Fetus and protective role of vitamin C. 21 pregnant mice were divided into 3 groups. Control group was in normal condition without any stressor agent. Exposure group was exposed to 915 MHz RFR (8 h/day for 10 days) and 0.045 µw/cm2 power density. The exposure plus vitamin C group received 200 mg/kg vitamin C by gavage and was exposed to 915 MHz RFR (8 h/day for 10 days) and 0.045 µw/cm2 power density. The Fetus Weight, C-R length were measured by digital balance and caliper. Tissues were assessed after staining with H & E. Our results showed significant increase in Fetus Weight and C-R length and also enlarged liver, tail deformation in mice Fetus in exposure group. Although usage of vitamin C caused significant decrease in mentioned parameters. The outcome of this study confirms the effects of radiofrequency radiation on growth parameters such as body Weight, length and some tissues in mice Fetuses and protective effect of vitamin C. However more studies on non-ionization radiation in different frequencies and severity, during pregnancy are needed to clarify the exact mechanisms of these changes and better protection.
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The effects of radiofrequency radiation on mice Fetus Weight, length and tissues
Elsevier, 2018Co-Authors: Iraj Alimohammadi, Azadeh Ashtarinezhad, Baharak Mohamadzadeh Asl, Batol Masruri, Nargess MoghadasiAbstract:The public concern of harmful effects of radiofrequency radiation exposure, especially with rapid increase in the use of wireless and telecommunication devices, is increasing. Some studies show fetal and developmental abnormalities as the result of radiofrequency radiation exposure. We aimed to investigate possible teratogenic effects of radiofrequency in 915 MHz on mice Fetus and protective role of vitamin C. 21 pregnant mice were divided into 3 groups. Control group was in normal condition without any stressor agent. Exposure group was exposed to 915 MHz RFR (8 h/day for 10 days) and 0.045 µw/cm2 power density. The exposure plus vitamin C group received 200 mg/kg vitamin C by gavage and was exposed to 915 MHz RFR (8 h/day for 10 days) and 0.045 µw/cm2 power density. The Fetus Weight, C-R length were measured by digital balance and caliper. Tissues were assessed after staining with H & E. Our results showed significant increase in Fetus Weight and C-R length and also enlarged liver, tail deformation in mice Fetus in exposure group. Although usage of vitamin C caused significant decrease in mentioned parameters. The outcome of this study confirms the effects of radiofrequency radiation on growth parameters such as body Weight, length and some tissues in mice Fetuses and protective effect of vitamin C. However more studies on non-ionization radiation in different frequencies and severity, during pregnancy are needed to clarify the exact mechanisms of these changes and better protection. Keywords: Radiofrequency radiation, Mice Fetus tissues, Vitamin C, Fetal and developmental abnormalitie
Michael Bursztyn - One of the best experts on this subject based on the ideXlab platform.
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hyperinsulinemia increases placenta endothelin converting enzyme 1 expression in trophoblasts
American Journal of Hypertension, 2012Co-Authors: Mogher Khamaisi, Galia Skarzinski, Judith Mekler, Farid Zreik, Rawan Damouni, Ilana Ariel, Michael BursztynAbstract:BACKGROUND Exogenous hyperisulinemia causes pregnancy, induced hypertension and intrauterine growth restriction (IUGR) in pregnant rats. Hyperinsulinemia may increase production of endothelin-1 (ET-1), produced by sequential proteolysis of the big endothelin by the endothelin-converting enzyme (ECE)-1, the expression of which is examined here in the placenta, kidney, heart, and liver. METHODS Rats were rendered hyperinsulinemic by subcutaneous insulin pellet, mated and followed to the twenty-first day of pregnancy. They were then killed, and their Fetuses and placentas were examined. RESULTS Hyperinsulinemic dams (HD) had higher blood pressure (BP) (130 ± 17 mm Hg in HD vs. 115 ± 16 mm Hg in normal pregnant dams (NPD), P < 0.05), lower placenta Weight (0.44 ± 0.08 g in HD vs. 0.47 ± 0.08 NPD, P < 0.05) and lower Fetus Weight: males 4.9 ± 0.4 g in HD vs. 5.5 ± 0.4 g in NPD, P < 0.0001; females 4.7 ± 0.4 g in HD vs. 5.2 ± 0.4 g in NPD (P < 0.0001). ECE-1 expression as determined by western blot was significantly increased in the placenta and its implantation site, i.e., the mesometrial triangle (MT) of HD by 46 and 48%, respectively. In the kidney and heart of HD ECE-1, protein expression was increased by 230 and 220%, respectively, but its level in the liver was similar in both groups. Immunohistochemical staining revealed ECE-1 expression in endothelial cells and trophoblastic cells of the placenta and MT. Endothelin receptor A (ET-A), a mediator of vasoconstriction by ET-1, was also expressed in the endothelium and in trophoblasts of the placenta and MT. The expression of both ECE-1 and ET-A, as measured by automated image analysis, was generally stronger in placentas of HD. CONCLUSIONS ECE-1 and ET-A are expressed in the trophoblastic cells of the placenta and MT. This may affect local endothelin levels, BP and IUGR.
Iraj Alimohammadi - One of the best experts on this subject based on the ideXlab platform.
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The effects of radiofrequency radiation on mice Fetus Weight, length and tissues.
Data in brief, 2018Co-Authors: Iraj Alimohammadi, Azadeh Ashtarinezhad, Baharak Mohamadzadeh Asl, Batol Masruri, Nargess MoghadasiAbstract:Abstract The public concern of harmful effects of radiofrequency radiation exposure, especially with rapid increase in the use of wireless and telecommunication devices, is increasing. Some studies show fetal and developmental abnormalities as the result of radiofrequency radiation exposure. We aimed to investigate possible teratogenic effects of radiofrequency in 915 MHz on mice Fetus and protective role of vitamin C. 21 pregnant mice were divided into 3 groups. Control group was in normal condition without any stressor agent. Exposure group was exposed to 915 MHz RFR (8 h/day for 10 days) and 0.045 µw/cm2 power density. The exposure plus vitamin C group received 200 mg/kg vitamin C by gavage and was exposed to 915 MHz RFR (8 h/day for 10 days) and 0.045 µw/cm2 power density. The Fetus Weight, C-R length were measured by digital balance and caliper. Tissues were assessed after staining with H & E. Our results showed significant increase in Fetus Weight and C-R length and also enlarged liver, tail deformation in mice Fetus in exposure group. Although usage of vitamin C caused significant decrease in mentioned parameters. The outcome of this study confirms the effects of radiofrequency radiation on growth parameters such as body Weight, length and some tissues in mice Fetuses and protective effect of vitamin C. However more studies on non-ionization radiation in different frequencies and severity, during pregnancy are needed to clarify the exact mechanisms of these changes and better protection.
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The effects of radiofrequency radiation on mice Fetus Weight, length and tissues
Elsevier, 2018Co-Authors: Iraj Alimohammadi, Azadeh Ashtarinezhad, Baharak Mohamadzadeh Asl, Batol Masruri, Nargess MoghadasiAbstract:The public concern of harmful effects of radiofrequency radiation exposure, especially with rapid increase in the use of wireless and telecommunication devices, is increasing. Some studies show fetal and developmental abnormalities as the result of radiofrequency radiation exposure. We aimed to investigate possible teratogenic effects of radiofrequency in 915 MHz on mice Fetus and protective role of vitamin C. 21 pregnant mice were divided into 3 groups. Control group was in normal condition without any stressor agent. Exposure group was exposed to 915 MHz RFR (8 h/day for 10 days) and 0.045 µw/cm2 power density. The exposure plus vitamin C group received 200 mg/kg vitamin C by gavage and was exposed to 915 MHz RFR (8 h/day for 10 days) and 0.045 µw/cm2 power density. The Fetus Weight, C-R length were measured by digital balance and caliper. Tissues were assessed after staining with H & E. Our results showed significant increase in Fetus Weight and C-R length and also enlarged liver, tail deformation in mice Fetus in exposure group. Although usage of vitamin C caused significant decrease in mentioned parameters. The outcome of this study confirms the effects of radiofrequency radiation on growth parameters such as body Weight, length and some tissues in mice Fetuses and protective effect of vitamin C. However more studies on non-ionization radiation in different frequencies and severity, during pregnancy are needed to clarify the exact mechanisms of these changes and better protection. Keywords: Radiofrequency radiation, Mice Fetus tissues, Vitamin C, Fetal and developmental abnormalitie
Prof Tae-hee - One of the best experts on this subject based on the ideXlab platform.
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Length Measurement of Fetal Long Bone and Fetal Anomaly Detection Length Measurement of Fetal Long Bone and Fetal Anomaly Detection
2020Co-Authors: Prof Tae-hee, S Lee, Kim T, Lee H, Park J, Chung S, Jeon DAbstract:Abstract Fetal long bone estimation is a pivotal estimation for abnormal Fetus development and Fetus Weight. Moreover, estimation of limb length becomes an important indicator for osteochondrodysplasia and chromosomal abnormalities. Especially, femur length is the most commonly estimated limb length that must be measured to monitor fetal malformation. In fetal length measurement, femur length measurement is the only long bone that is commonly estimated in Fetus. Femur length not only helps estimating accurate gestational age, but also becomes an invaluable hint of abnormality in fetal skeletal system. Despite difficulty of accurate diagnosis, detection rate of fatal skeletal abnormality with ultrasonography is as high as 94-96%. Although prenatal ultrasonography plays the most important role in detecting skeletal abnormality, the authors believe that genetics test at molecular level should be employed at needs to confirm chromosomal mutation and help improving accuracy of prenatal diagnosis
Marcia Pinto Alves Mayer - One of the best experts on this subject based on the ideXlab platform.
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porphyromonas gingivalis infection at different gestation periods on Fetus development and cytokines profile
Oral Diseases, 2012Co-Authors: M C A N Michelin, S R L Teixeira, E S Andosuguimoto, S R R Lucas, Marcia Pinto Alves MayerAbstract:Oral Diseases (2012) 18, 648–654 Aim: Infective agents may affect pregnancy outcomes by deregulating homeostasis. Objectives: The effects of Porphyromonas gingivalis infection before and at different gestation periods were evaluated. Materials and Methods: Wistar rats infected via subcutaneous with P. gingivalis W83, one week before mating (BM), days 1 (PR1) and 11 of gestation (PR11), and controls were evaluated, and samples were obtained at the end of gestation. P. gingivalis was detected by PCR. Cytokine was determined by ELISA. Results: Infected rats had lower maternal gain of Weight. Implantation was not observed in 2/12 BM rats. PR11 presented more fetal-placental resorptions and lower placenta/Fetus Weight than controls. P. gingivalis was detected in placenta and Fetus. IL-6 and TNF-α levels were higher in placenta and serum of infected groups, except for TNF-α in placenta of PR1. IL-1β levels were higher in placenta of PR11, but lower in serum and placenta of PR1. There were no differences in IL-10 and PGE2 concentrations among the groups (P < 0.05). Conclusions: The experimental infection by P. gingivalis resulted in alterations in the gestational pattern and in fetal development. The consequences of infection at mid-gestation were more severe than at the beginning, possibly due to the induction of pro-inflammatory cytokines in the fetal compartment.