The Experts below are selected from a list of 321 Experts worldwide ranked by ideXlab platform
William D. Spotnitz - One of the best experts on this subject based on the ideXlab platform.
-
Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive—a Laboratory and Clinical Perspective
ISRN Surgery, 2014Co-Authors: William D. SpotnitzAbstract:Background. Fibrin Sealant became the first modern era material approved as a hemostat in the United States in 1998. It is the only agent presently approved as a hemostat, Sealant, and adhesive by the Food and Drug Administration (FDA). The product is now supplied as patches in addition to the original liquid formulations. Both laboratory and clinical uses of Fibrin Sealant continue to grow. The new literature on this material also continues to proliferate rapidly (approximately 200 papers/year). Methods. An overview of current Fibrin Sealant products and their approved uses and a comprehensive PubMed based review of the recent literature (February 2012, through March 2013) on the laboratory and clinical use of Fibrin Sealant are provided. Product information is organized into sections based on a classification system for commercially available materials. Publications are presented in sections based on both laboratory research and clinical topics are listed in order of decreasing frequency. Results. Fibrin Sealant remains useful hemostat, Sealant, and adhesive. New formulations and applications continue to be developed. Conclusions. This agent remains clinically important with the recent introduction of new commercially available products. Fibrin Sealant has multiple new uses that should result in further improvements in patient care.
-
Fibrin Sealant the only approved hemostat Sealant and adhesive a laboratory and clinical perspective
International Scholarly Research Notices, 2014Co-Authors: William D. SpotnitzAbstract:Background. Fibrin Sealant became the first modern era material approved as a hemostat in the United States in 1998. It is the only agent presently approved as a hemostat, Sealant, and adhesive by the Food and Drug Administration (FDA). The product is now supplied as patches in addition to the original liquid formulations. Both laboratory and clinical uses of Fibrin Sealant continue to grow. The new literature on this material also continues to proliferate rapidly (approximately 200 papers/year). Methods. An overview of current Fibrin Sealant products and their approved uses and a comprehensive PubMed based review of the recent literature (February 2012, through March 2013) on the laboratory and clinical use of Fibrin Sealant are provided. Product information is organized into sections based on a classification system for commercially available materials. Publications are presented in sections based on both laboratory research and clinical topics are listed in order of decreasing frequency. Results. Fibrin Sealant remains useful hemostat, Sealant, and adhesive. New formulations and applications continue to be developed. Conclusions. This agent remains clinically important with the recent introduction of new commercially available products. Fibrin Sealant has multiple new uses that should result in further improvements in patient care.
-
Fibrin Sealant patches: powerful and easy-to-use hemostats
Open Access Surgery, 2014Co-Authors: William D. SpotnitzAbstract:William D SpotnitzSurgical Therapeutic Advancement Center (STAC), Department of Surgery, University of Virginia Health System, Charlottesville, VA, USA Abstract: Fibrin Sealant liquid was approved for use in the US in 1998 by the Food and Drug Administration as the first of a new generation of hemostats, Sealants, and adhesives. The initial Fibrin Sealant liquid use in the country was limited by obstacles in the formulation's ease of use (usability). Specifically, it was associated with cumbersome preparation, including thawing, mixing, and applicator loading. Although these challenges have been addressed to some extent, a new generation of Fibrin Sealants in the form of patches has been introduced, boasting significant efficacy as well as elimination of the liquid preparation complexities. Additionally, the patches may provide enhancements in efficacy because they are easily combined with manual pressure to arrest bleeding. In addition, usability has been increased because they may be stored at room temperature and they are provided in packages ready for immediate use. This review will highlight the capabilities of the two Food and Drug Administration-approved Fibrin Sealant patches and review the recent literature on Fibrin Sealant patch use. Keywords: Fibrin Sealant, liquid, patches, hemostats, safety, efficacy, usability, cos
-
Efficacy and safety of Fibrin Sealant for tissue adherence in facial rhytidectomy.
Clinical cosmetic and investigational dermatology, 2012Co-Authors: William D. SpotnitzAbstract:The purpose of this review is to clarify the present use of Fibrin Sealant in rhyditectomy procedures and help maximize the appropriate and safe application of this material. A set of terms and definitions for hemostats, Sealants, and adhesives based on group, category, and class will be employed to highlight the specific capabilities of Fibrin Sealant. Fibrin Sealant has now emerged as an example of maximizing the usefulness of a surgical agent and is the only product with Food and Drug Administration approval in all three groupings: hemostats; Sealants; and adhesives. A variety of manufacturers’ Fibrin Sealant products are available including multiple liquids and one patch. A single liquid product is now specifically indicated for skin flap adherence during rhytidectomy. The unique characteristic of this particular two component Fibrin Sealant adhesive agent is its slower polymerization rate as a result of a low thrombin concentration which when combined with Fibrinogen permits adequate time for manipulation of flaps and tissues prior to final fixation. In addition to its flap adherence and potential space elimination capability, Fibrin Sealant is also an excellent blood clotting agent and can seal tissues to prevent lymphatic leak or serous fluid accumulation. Thus, it is almost ideally suited to reduce the occurrence of fluid accumulation, hematomas, ecchymoses, and swelling, as well as to possibly eliminate the need for drains following rhytidectomy. A literature review of Fibrin Sealant in rhytidectomy is included to help define the current state of its clinical use. The author’s recommendations for the best use of this material during facial procedures are also provided.
-
Fibrin Sealant tissue adhesive--review and update.
Journal of long-term effects of medical implants, 2005Co-Authors: William D. Spotnitz, Roshan S. PrabhuAbstract:Abstract The field of surgical tissue adhesives is rapidly developing, with multiple products now available. Fibrin Sealant, the first widely available tissue adhesive, continues to be used in traditional as well as in new and creative ways. The product is now fully mature as a hemostatic agent in cardiac, liver, and spleen surgery. It is also useful as a Sealant in a variety of clinical applications, including procedures such as colonic anastomosis, as well as in seroma prevention following soft tissue dissection. Newer uses such as reduced suture vascular and intestinal anastomosis, fistula closure, surgery in patients with hemophilia, and laparoscopic/endoscopic procedures are being studied in both laboratory and clinical settings. The most recent additions to the capabilities of Fibrin Sealant include the use of this tissue adhesive as a slow-release drug delivery system and as a substrate for cellular growth and tissue engineering. This article will review the basis of Fibrin Sealant effectiveness and will also cover the recent developments in the rapidly evolving employment of this material.
Engin Deniz - One of the best experts on this subject based on the ideXlab platform.
-
A new aneurysm wrapping material : polyglactin 910 + Fibrin Sealant
Neurosurgical review, 1996Co-Authors: Mustafa Uzan, Mura Hanci, Cengiz Kuday, Ali A Shamsi, Ziya Akar, Fatma Ozlen, Engin DenizAbstract:Aneurysms experimentally induced by using the silver nitrate coagulation method in 10 Wistar Albino rats are wrapped with Polyglactin 910 and Fibrin Sealant. 6 weeks later the rats are sacrificed and compared with the control group. In the group in which Polyglactin 910 and Fibrin Sealant were used as the wrapping material, non-specific inflammatory granulation tissue development around the ancurysms is observed. We suggest that a Polyglactin 910 and Fibrin Sealant combination can be used as a wrapping material in the treatment of aneurysms where clipping is not possible.
Engi Deniz - One of the best experts on this subject based on the ideXlab platform.
-
a new aneurysm wrapping material polyglactin 910 Fibrin Sealant
Neurosurgical Review, 1996Co-Authors: Mustafa Uza, Mura Hanci, Cengiz Kuday, Ziya Aka, Ali A Shamsi, Fatma Ozle, Engi DenizAbstract:Aneurysms experimentally induced by using the silver nitrate coagulation method in 10 Wistar Albino rats are wrapped with Polyglactin 910 and Fibrin Sealant. 6 weeks later the rats are sacrificed and compared with the control group. In the group in which Polyglactin 910 and Fibrin Sealant were used as the wrapping material, non-specific inflammatory granulation tissue development around the ancurysms is observed. We suggest that a Polyglactin 910 and Fibrin Sealant combination can be used as a wrapping material in the treatment of aneurysms where clipping is not possible.
Cengiz Kuday - One of the best experts on this subject based on the ideXlab platform.
-
a new aneurysm wrapping material polyglactin 910 Fibrin Sealant
Neurosurgical Review, 1996Co-Authors: Mustafa Uza, Mura Hanci, Cengiz Kuday, Ziya Aka, Ali A Shamsi, Fatma Ozle, Engi DenizAbstract:Aneurysms experimentally induced by using the silver nitrate coagulation method in 10 Wistar Albino rats are wrapped with Polyglactin 910 and Fibrin Sealant. 6 weeks later the rats are sacrificed and compared with the control group. In the group in which Polyglactin 910 and Fibrin Sealant were used as the wrapping material, non-specific inflammatory granulation tissue development around the ancurysms is observed. We suggest that a Polyglactin 910 and Fibrin Sealant combination can be used as a wrapping material in the treatment of aneurysms where clipping is not possible.
-
A new aneurysm wrapping material : polyglactin 910 + Fibrin Sealant
Neurosurgical review, 1996Co-Authors: Mustafa Uzan, Mura Hanci, Cengiz Kuday, Ali A Shamsi, Ziya Akar, Fatma Ozlen, Engin DenizAbstract:Aneurysms experimentally induced by using the silver nitrate coagulation method in 10 Wistar Albino rats are wrapped with Polyglactin 910 and Fibrin Sealant. 6 weeks later the rats are sacrificed and compared with the control group. In the group in which Polyglactin 910 and Fibrin Sealant were used as the wrapping material, non-specific inflammatory granulation tissue development around the ancurysms is observed. We suggest that a Polyglactin 910 and Fibrin Sealant combination can be used as a wrapping material in the treatment of aneurysms where clipping is not possible.
Ali A Shamsi - One of the best experts on this subject based on the ideXlab platform.
-
a new aneurysm wrapping material polyglactin 910 Fibrin Sealant
Neurosurgical Review, 1996Co-Authors: Mustafa Uza, Mura Hanci, Cengiz Kuday, Ziya Aka, Ali A Shamsi, Fatma Ozle, Engi DenizAbstract:Aneurysms experimentally induced by using the silver nitrate coagulation method in 10 Wistar Albino rats are wrapped with Polyglactin 910 and Fibrin Sealant. 6 weeks later the rats are sacrificed and compared with the control group. In the group in which Polyglactin 910 and Fibrin Sealant were used as the wrapping material, non-specific inflammatory granulation tissue development around the ancurysms is observed. We suggest that a Polyglactin 910 and Fibrin Sealant combination can be used as a wrapping material in the treatment of aneurysms where clipping is not possible.
-
A new aneurysm wrapping material : polyglactin 910 + Fibrin Sealant
Neurosurgical review, 1996Co-Authors: Mustafa Uzan, Mura Hanci, Cengiz Kuday, Ali A Shamsi, Ziya Akar, Fatma Ozlen, Engin DenizAbstract:Aneurysms experimentally induced by using the silver nitrate coagulation method in 10 Wistar Albino rats are wrapped with Polyglactin 910 and Fibrin Sealant. 6 weeks later the rats are sacrificed and compared with the control group. In the group in which Polyglactin 910 and Fibrin Sealant were used as the wrapping material, non-specific inflammatory granulation tissue development around the ancurysms is observed. We suggest that a Polyglactin 910 and Fibrin Sealant combination can be used as a wrapping material in the treatment of aneurysms where clipping is not possible.