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P A Flecknell - One of the best experts on this subject based on the ideXlab platform.
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sufentanil medetomidine anaesthesia compared with fentanyl Fluanisone midazolam is associated with fewer ventricular arrhythmias and death during experimental myocardial infarction in rats and limits infarct size following reperfusion
Laboratory Animals, 2018Co-Authors: Ellis N Ter Horst, P A Flecknell, Paul A J Krijnen, Klaas W Meyer, K Kramer, Anja M Van Der Laan, Jan J Piek, Hans W M NiessenAbstract:To improve infarct healing following myocardial infarction in humans, therapeutic interventions can be applied during the inflammatory response. Animal models are widely used to study this process....
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preliminary assessment of midazolam fentanyl and Fluanisone combination for the sedation of rhesus macaques macaca mulatta
Laboratory Animals, 2017Co-Authors: Charlotte Sandersen, Henri Bertrand, P A FlecknellAbstract:This study was undertaken to assess the suitability of fentanyl/Fluanisone (‘Hypnorm’, VetaPharma; 0.315 mg/mL of fentanyl citrate and 10 mg/mL of Fluanisone) alone or combined with midazolam in rh...
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effects in laboratory.rodents and rabbits
2015Co-Authors: Lab Anim, M. Mitchell, P A Flecknell, Information ForAbstract:rodents and rabbits Midazolam and fentanyl-Fluanisone: assessment of anaesthetic effects in laborator
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evaluation of auditory evoked potentials to predict depth of anaesthesia during fentanyl Fluanisone midazolam anaesthesia in rats
Veterinary Anaesthesia and Analgesia, 2001Co-Authors: Luis Antunes, Johnny V Roughan, P A FlecknellAbstract:Abstract Objectives To assess a method for monitoring depth of anaesthesia using components of middle latency auditory evoked potential (AEP) waveforms during anaesthesia with fentanyl/Fluanisone and midazolam. Study design Prospective observational study. Animals Five female Wistar rats weighing between 210 and 250 g. Methods Implanted electrodes were used to record AEPs in animals receiving five doses of anaesthetic. Recordings were made at 5 minutes post-injection (deep anaesthesia; no pedal withdrawal response, PWR) and then at 25 minutes (light anaesthesia; strong PWR). Responses showed five characteristic peaks occurring at 11, 14, 23, 42 and 68 ms that were measured for latency of occurrence and peak amplitude. Results Auditory evoked potential peaks P14, N23 and P42 were increased significantly in latency with successive anaesthetic injections [avg. F (1,4) = 12.53, p F (1,4) = 10.6, p F (1,4) = 3.9, p = 0.02, respectively]. Peak N23 showed a significant reduction in latency during the 20 minute recovery period following both the first and second anaesthetic injections ( t (3) = 7.52, p = 0.005; t (4) = 5.17, p = 0.007, respectively). Peak P42 occurred significantly earlier 20 minutes following the second anaesthetic injection ( t (4) = 4.75, p = 0.009). The mean overall depth of anaesthesia assessed using PWR scores was significantly correlated with the mean latency of peak N23, such that as the strength of PWR increased, N23 occurred significantly earlier ( r = −0.99, p = 0.01). The amplitude difference between peaks N23 and P42 increased after the second and third drug administrations [avg. F (1,4) = 10.65, p = 0.031 and avg. F (1,4) = 11.24, p = 0.028, respectively]. Conclusion The characteristics of these peaks, and in particular latency of peak N23, may provide a useful tool for assessing depth of anaesthesia produced by this, and possibly other anaesthetic agents.
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the successful use of fentanyl Fluanisone hypnorm as an anaesthetic for intracranial surgery in neonatal rats
Laboratory Animals, 2000Co-Authors: Gavin J Clowry, P A FlecknellAbstract:This study reports on the successful use of fentanyl citrate and Fluanisone ('Hypnorm') anaesthesia for intracranial surgery in neonatal (7-day-old) rats. Provided the anaesthetic was administered subcutaneously, the animals showed a very high survival rate in the short term (81/85, 95%) and showed no ill effects in the long term. The depth of anaesthesia was sufficient to allow the operation to be carried out without the animal reacting to any painful stimuli. However, the animals did make random movements during the period of surgical anaesthesia which were not related to any painful stimuli. Although these movements did not interfere with the surgery performed here, such movements would interfere with operations requiring greater precision, such as the localized micro-injection of neural tracers.
A.m.l. Coenen - One of the best experts on this subject based on the ideXlab platform.
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Effects of the neuroleptanalgesic fentanyl-Fluanisone (Hypnorm) on spike-wave discharges in epileptic rats
Pharmacology biochemistry and behavior, 1994Co-Authors: Maki Inoue, Nurbay Ates, Jo M.h. Vossen, A.m.l. CoenenAbstract:Abstract Effects of fentanyl-Fluanisone (Hypnorm), a combination often used as a neuroleptanalgesic and anaesthetic, were investigated on spike-wave discharges of epileptic WAG/Rij rats. Fentanyl-Fluanisone has stimulating effects on the amount of spike-wave discharges, but not in a dose-dependent manner. A low dose of 0.01 mg/kg fentanyl with 0.5 mg/kg Fluanisone causes a large increase in epileptic activity. This effect is larger than with a middle dose of 0.1 mg/kg fentanyl and 5 mg/kg Fluanisone and much larger than with a high dose of 0.2 mg/kg fentanyl with 10 mg/kg Fluanisone. The last two doses cause a prolonged anaesthetic state in rats. The frequency of the spikes in the spike-wave discharges was decreased by the mixture of fentanyl-Fluanisone; this decrease was dose-dependent. Administration of fentanyl alone in the same doses as in the combination abolishes spike-wave activity during the anaesthetic phase but causes a moderate increase after this phase. It also causes a lowering in spike frequency, which is of the same order as with fentanyl-Fluanisone. The mechanisms of action of fentanyl are not completely clear, but the opposite effects of μ- and κ -opioid receptors on spike-wave discharges may play a role in this biphasic effect. Fluanisone alone in the same doses as in the mixture induces a large dose-dependent increase in spike-wave activity, with only a small effect on spike frequency. This might be caused by the antagonistic action of this drug at dopamine receptors. The complexity of the stimulatory effects on spike-wave discharges caused by fentanyl-Fluanisone is due to an interaction of the suppressive- stimulatory effects of fentanyl together with the facilitatory effects of Fluanisone.
Maki Inoue - One of the best experts on this subject based on the ideXlab platform.
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Effects of the neuroleptanalgesic fentanyl-Fluanisone (Hypnorm) on spike-wave discharges in epileptic rats
Pharmacology biochemistry and behavior, 1994Co-Authors: Maki Inoue, Nurbay Ates, Jo M.h. Vossen, A.m.l. CoenenAbstract:Abstract Effects of fentanyl-Fluanisone (Hypnorm), a combination often used as a neuroleptanalgesic and anaesthetic, were investigated on spike-wave discharges of epileptic WAG/Rij rats. Fentanyl-Fluanisone has stimulating effects on the amount of spike-wave discharges, but not in a dose-dependent manner. A low dose of 0.01 mg/kg fentanyl with 0.5 mg/kg Fluanisone causes a large increase in epileptic activity. This effect is larger than with a middle dose of 0.1 mg/kg fentanyl and 5 mg/kg Fluanisone and much larger than with a high dose of 0.2 mg/kg fentanyl with 10 mg/kg Fluanisone. The last two doses cause a prolonged anaesthetic state in rats. The frequency of the spikes in the spike-wave discharges was decreased by the mixture of fentanyl-Fluanisone; this decrease was dose-dependent. Administration of fentanyl alone in the same doses as in the combination abolishes spike-wave activity during the anaesthetic phase but causes a moderate increase after this phase. It also causes a lowering in spike frequency, which is of the same order as with fentanyl-Fluanisone. The mechanisms of action of fentanyl are not completely clear, but the opposite effects of μ- and κ -opioid receptors on spike-wave discharges may play a role in this biphasic effect. Fluanisone alone in the same doses as in the mixture induces a large dose-dependent increase in spike-wave activity, with only a small effect on spike frequency. This might be caused by the antagonistic action of this drug at dopamine receptors. The complexity of the stimulatory effects on spike-wave discharges caused by fentanyl-Fluanisone is due to an interaction of the suppressive- stimulatory effects of fentanyl together with the facilitatory effects of Fluanisone.
Peter Bollen - One of the best experts on this subject based on the ideXlab platform.
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the effects of post operative oxygen supply on blood oxygenation and acid base status in rats anaesthetized with fentanyl Fluanisone and midazolam
PLOS ONE, 2021Co-Authors: Leander Gaarde, Stefanie Hansborg Kolstrup, Peter BollenAbstract:In anaesthetic practice the risk of hypoxia and arterial blood gas disturbances is evident, as most anaesthetic regimens depress the respiratory function. Hypoxia may be extended during recovery, and for this reason we wished to investigate if oxygen supply during a one hour post-operative period reduced the development of hypoxia and respiratory acidosis in rats anaesthetized with fentanyl/Fluanisone and midazolam. Twelve Sprague Dawley rats underwent surgery and were divided in two groups, breathing either 100% oxygen or atmospheric air during a post-operative period. The peripheral blood oxygen saturation and arterial acid-base status were analyzed for differences between the two groups. We found that oxygen supply after surgery prevented hypoxia but did not result in a significant difference in the blood acid-base status. All rats developed respiratory acidosis, which could not be reversed by supplemental oxygen supply. We concluded that oxygen supply improved oxygen saturation and avoided hypoxia but did not have an influence on the acid-base status.
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'Public Library of Science (PLoS)', 2021Co-Authors: Leander Gaarde, Stefanie Kolstrup, Peter BollenAbstract:Vital signs with oxygen saturation (a), heart rate (b), respiratory rate (c) and rectal temperature (d) of rats after surgery under fentanyl/Fluanisone and midazolam anaesthesia. T0 represents measurements immediately after surgery. Measurements 30 and 60 minutes after surgery are indicated by T30 or T60 respectively. Oxygen supply is indicated by +O2 (with oxygen supply) and -O2 (without oxygen supply). Symbol shape indicates +O2 group for circle and -O2 group for square. In (a) **** indicates p2) and T60(-O2) versus all other measure points. In (c) * indicates p2) and T30(+O2) versus T60(-O2), and in (d) *** indicates p2). HR: Heart rate, RR: Respiratory rate, Temp: Temperature. Values are means ± standard deviations.
Tor Hofstad - One of the best experts on this subject based on the ideXlab platform.
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the rabbit caused by fentanyl-Fluanisone tranquillization
2015Co-Authors: Lab Anim, V Naess, Richard T Fosse, Tor Hofstad, Information For, V. NiessAbstract:fentanyl-Fluanisone tranquillization A possible inhibitory effect on the Shwartzman reaction in the rabbit caused b