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Ronan Garlantézec - One of the best experts on this subject based on the ideXlab platform.
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Exposure to Glycol Ethers among 6-year-old children in France.
International Journal of Hygiene and Environmental Health, 2020Co-Authors: Ronan Garlantézec, Sylvaine Cordier, Luc Multigner, Charline Warembourg, Florence Rouget, Florent Le Gleau, Christine Montfort, Cécile ChevrierAbstract:Abstract Glycol Ethers are an oxygenated solvent family widely present in consumer products. Some of them are recognized reproductive, developmental or hematological toxicants. Although several Glycol ether biomonitoring studies have been performed on adults from working or general populations, no studies have hitherto been carried out on children. The aim of our study was to explore the detection of Glycol ether metabolites in the urinary samples of 6-year-old children, and if any were found, to describe them. The PELAGIE mother-child cohort included 3421 pregnant women from the general population of Brittany, France, between 2002 and 2006. Our biomonitoring study included a random sample of 110 children from the PELAGIE cohort who had participated in a neurodevelopment evaluation at the age of six. First morning voids were collected from all of the children. Eight urinary Glycol ether metabolites were measured using gas chromatography with mass spectrometry. The limit of detection was 0.003 mg/L for all metabolites. Glycol ether metabolites were detected at rates varying from 33.5% of samples for propoxyacetic acid to 100% of samples for phenoxyacetic acid and methoxyacetic acid. The highest median concentration observed was for phenoxyacetic acid (0.141 mg/l). Our study reported the ubiquitous presence of Glycol ether metabolites in children's urinary samples. These results call for larger biomonitoring surveys of the general population and study of the potential sources and determinants of these exposures.
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Prenatal exposure to Glycol Ethers and sex steroid hormones at birth
Environment International, 2018Co-Authors: Charline Warembourg, Sylvaine Cordier, Luc Multigner, Laurence Labat, Christine Monfort, Cécile Chevrier, Anne-claire Binter, Frank Giton, Jean Fiet, Ronan GarlantézecAbstract:Background - Glycol Ethers (GEs) are oxygenated solvents widely found in occupational and consumer water-based products. Some of them are well-known reproductive and developmental toxicants. Objectives - To study the variations in circulating sex steroid hormones, measured in cord blood, according to biomarkers of prenatal GE exposure. Methods - The study population comes from the PELAGIE mother-child cohort, which enrolled pregnant women from Brittany (France, 2002-2006). Maternal urine samples were collected from a random subcohort (n = 338) before 19 weeks' gestation, from which we measured 8 alkoxycarboxylic metabolites of GEs. We subsequently measured 13 sex steroid hormones and sex hormone-binding globulin (SHBG) in cord blood samples. Linear regressions adjusted for potential confounders were used, and nonlinear dose-response associations were investigated. Results - The detection rates of GE metabolites ranged from 4% to 98%; only the 5 most detected (>20%) metabolites were investigated further. Phenoxyacetic acid (detection rate > 95%) was associated with lower levels of SHBG and various steroids (17-alpha-hydroxy-Pregnenolone, delta-5-androstenediol, and dehydroepiandrosterone) among boys and higher SHBG and 16-alpha-hydroxy-dehydroepiandrosterone levels among girls. The two other highly detected metabolites, methoxyetoxyacetic acid and butoxyacetic acid, were associated with variations in estradiol. Butoxyacetic acid was associated with higher delta-5-androstenediol levels while detectable levels of methoxyacetic acid were associated with lower levels of this hormone. Conclusion - Our study suggests that prenatal exposure to GE may affect endocrine response patterns, estimated by determining blood levels of sex steroid hormones in newborns. These results raise questions about the potential role of these changes in the pathways between prenatal GE exposure and previously reported adverse developmental outcomes, including impaired neurocognitive performance.
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Concerning the plausibility of the findings reported in 'Prenatal exposure to Glycol Ethers and cryptorchidism and hypospadias a nested case-control study' by Smet and Kelsey authors' response
Occupational and Environmental Medicine, 2018Co-Authors: Charline Warembourg, Luc Multigner, Ronan GarlantézecAbstract:Reply Letter to Smet and Kelsey: Concerning the plausibility of the findings reported in “Prenatal exposure to Glycol Ethers and cryptorchidism and hypospadias: a nested case–control study”, Warembourg et al, Occup Environ Med 2018;75:59–65
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Prenatal Exposure to Glycol Ethers and Neurocognitive Abilities in 6-Year-Old Children: The PELAGIE Cohort Study
Environmental Health Perspectives, 2017Co-Authors: Rémi Beranger, Charline Warembourg, Florence Rouget, Ronan Garlantézec, Christine Monfort, Gaïd Le Maner-idrissi, Agnès Lacroix, Jessica Trowbridge, Florent Le Gleau, Marylene JourdinAbstract:Background: Glycol Ethers (GE) are widely used organic solvents. Despite the potential neurotoxicity of several families of organic solvents, little is known about the impact of GE on the neurodevelopment of infants and children. Objectives: We investigated the relation between urinary concentrations of GE metabolites in pregnant women and neurocognitive abilities in their 6-year-old children in the PELAGIE mother-child cohort. Methods: Five GE metabolites were measured in first morning void urine samples of 204 French pregnant women in early pregnancy (
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Prenatal Exposure to Glycol Ethers and Male Genital Anomalies
ISEE Conference Abstracts, 2016Co-Authors: Charline Warembourg, Sylvaine Cordier, Jérémie Botton, Nathalie Lelong, Florence Rouget, Babak Koshnood, Rémy Slama, Marie-aline Charles, Ronan GarlantézecAbstract:Introduction: Glycol Ethers (GE) are solvents present in a wide range of occupational and domestic products. Numerous animal studies reported reprotoxic effects of GE and showed that some of them a...
Luc Multigner - One of the best experts on this subject based on the ideXlab platform.
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Exposure to Glycol Ethers among 6-year-old children in France.
International Journal of Hygiene and Environmental Health, 2020Co-Authors: Ronan Garlantézec, Sylvaine Cordier, Luc Multigner, Charline Warembourg, Florence Rouget, Florent Le Gleau, Christine Montfort, Cécile ChevrierAbstract:Abstract Glycol Ethers are an oxygenated solvent family widely present in consumer products. Some of them are recognized reproductive, developmental or hematological toxicants. Although several Glycol ether biomonitoring studies have been performed on adults from working or general populations, no studies have hitherto been carried out on children. The aim of our study was to explore the detection of Glycol ether metabolites in the urinary samples of 6-year-old children, and if any were found, to describe them. The PELAGIE mother-child cohort included 3421 pregnant women from the general population of Brittany, France, between 2002 and 2006. Our biomonitoring study included a random sample of 110 children from the PELAGIE cohort who had participated in a neurodevelopment evaluation at the age of six. First morning voids were collected from all of the children. Eight urinary Glycol ether metabolites were measured using gas chromatography with mass spectrometry. The limit of detection was 0.003 mg/L for all metabolites. Glycol ether metabolites were detected at rates varying from 33.5% of samples for propoxyacetic acid to 100% of samples for phenoxyacetic acid and methoxyacetic acid. The highest median concentration observed was for phenoxyacetic acid (0.141 mg/l). Our study reported the ubiquitous presence of Glycol ether metabolites in children's urinary samples. These results call for larger biomonitoring surveys of the general population and study of the potential sources and determinants of these exposures.
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Prenatal exposure to Glycol Ethers and sex steroid hormones at birth
Environment International, 2018Co-Authors: Charline Warembourg, Sylvaine Cordier, Luc Multigner, Laurence Labat, Christine Monfort, Cécile Chevrier, Anne-claire Binter, Frank Giton, Jean Fiet, Ronan GarlantézecAbstract:Background - Glycol Ethers (GEs) are oxygenated solvents widely found in occupational and consumer water-based products. Some of them are well-known reproductive and developmental toxicants. Objectives - To study the variations in circulating sex steroid hormones, measured in cord blood, according to biomarkers of prenatal GE exposure. Methods - The study population comes from the PELAGIE mother-child cohort, which enrolled pregnant women from Brittany (France, 2002-2006). Maternal urine samples were collected from a random subcohort (n = 338) before 19 weeks' gestation, from which we measured 8 alkoxycarboxylic metabolites of GEs. We subsequently measured 13 sex steroid hormones and sex hormone-binding globulin (SHBG) in cord blood samples. Linear regressions adjusted for potential confounders were used, and nonlinear dose-response associations were investigated. Results - The detection rates of GE metabolites ranged from 4% to 98%; only the 5 most detected (>20%) metabolites were investigated further. Phenoxyacetic acid (detection rate > 95%) was associated with lower levels of SHBG and various steroids (17-alpha-hydroxy-Pregnenolone, delta-5-androstenediol, and dehydroepiandrosterone) among boys and higher SHBG and 16-alpha-hydroxy-dehydroepiandrosterone levels among girls. The two other highly detected metabolites, methoxyetoxyacetic acid and butoxyacetic acid, were associated with variations in estradiol. Butoxyacetic acid was associated with higher delta-5-androstenediol levels while detectable levels of methoxyacetic acid were associated with lower levels of this hormone. Conclusion - Our study suggests that prenatal exposure to GE may affect endocrine response patterns, estimated by determining blood levels of sex steroid hormones in newborns. These results raise questions about the potential role of these changes in the pathways between prenatal GE exposure and previously reported adverse developmental outcomes, including impaired neurocognitive performance.
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Concerning the plausibility of the findings reported in 'Prenatal exposure to Glycol Ethers and cryptorchidism and hypospadias a nested case-control study' by Smet and Kelsey authors' response
Occupational and Environmental Medicine, 2018Co-Authors: Charline Warembourg, Luc Multigner, Ronan GarlantézecAbstract:Reply Letter to Smet and Kelsey: Concerning the plausibility of the findings reported in “Prenatal exposure to Glycol Ethers and cryptorchidism and hypospadias: a nested case–control study”, Warembourg et al, Occup Environ Med 2018;75:59–65
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URINARY BIOMARKERS OF EXPOSURE TO Glycol Ethers AND ADVERSE PREGNANCY OUTCOMES
ISEE Conference Abstracts, 2011Co-Authors: Ronan Garlantézec, Luc Multigner, Florence Rouget, Laurence Labat, Nathalie Bonvallot, Christine Monfort, Cécile Chevrier, Nathalie Costet, Sylvaine CordierAbstract:Background and aims : Glycol Ethers (GE) are widely used solvents present in various products such as paints, cleaning agents or cosmetics. GEs toxic effects are attributed to the production of alk...
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Glycol Ethers and semen quality: a cross‐sectional study among male workers in the Paris Municipality
Occupational and Environmental Medicine, 2007Co-Authors: Luc Multigner, I. Arnaud, J. M. Haguenoer, E. Ben Brik, Pierre Jouannet, Jacques Auger, Francis EustacheAbstract:OBJECTIVES: Apparent increases in human male reproductive disorders, including low sperm production, may have occurred because of increased chemical exposure. Various Glycol ether-based solvents have pronounced adverse effects on sperm production and male fertility in laboratory animals. The authors investigated the effects of past and current exposure to Glycol ether-containing products on semen quality and reproductive hormones among men employed by the Paris Municipality. METHODS: Between 2000 and 2001 the authors recruited 109 men who gave semen, blood and urine samples and underwent an andrological examination. Information on lifestyle, occupation, exposure and medical history was obtained by interview. According to their job and chemical products used during the period 1990-2000, men were classified as either occupationally exposed or non-exposed. Current exposure levels to Glycol Ethers at the time of the study were evaluated by biological monitoring of six urinary metabolites. RESULTS: Previous exposure to Glycol Ethers was associated with an increased risk for sperm concentration, for rapid progressive motility and for morphologically normal sperm below the World Health Organization semen reference values. No effect of previous Glycol ether exposure on hormones levels was observed. By contrast, current Glycol ether exposure levels were low and not correlated with either seminal quality or hormone levels. CONCLUSIONS: This study suggests that most Glycol Ethers currently used do not impact on human semen characteristics. Those that were more prevalent from the 1960s until recently may have long lasting negative effects on human semen quality.
Charline Warembourg - One of the best experts on this subject based on the ideXlab platform.
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Exposure to Glycol Ethers among 6-year-old children in France.
International Journal of Hygiene and Environmental Health, 2020Co-Authors: Ronan Garlantézec, Sylvaine Cordier, Luc Multigner, Charline Warembourg, Florence Rouget, Florent Le Gleau, Christine Montfort, Cécile ChevrierAbstract:Abstract Glycol Ethers are an oxygenated solvent family widely present in consumer products. Some of them are recognized reproductive, developmental or hematological toxicants. Although several Glycol ether biomonitoring studies have been performed on adults from working or general populations, no studies have hitherto been carried out on children. The aim of our study was to explore the detection of Glycol ether metabolites in the urinary samples of 6-year-old children, and if any were found, to describe them. The PELAGIE mother-child cohort included 3421 pregnant women from the general population of Brittany, France, between 2002 and 2006. Our biomonitoring study included a random sample of 110 children from the PELAGIE cohort who had participated in a neurodevelopment evaluation at the age of six. First morning voids were collected from all of the children. Eight urinary Glycol ether metabolites were measured using gas chromatography with mass spectrometry. The limit of detection was 0.003 mg/L for all metabolites. Glycol ether metabolites were detected at rates varying from 33.5% of samples for propoxyacetic acid to 100% of samples for phenoxyacetic acid and methoxyacetic acid. The highest median concentration observed was for phenoxyacetic acid (0.141 mg/l). Our study reported the ubiquitous presence of Glycol ether metabolites in children's urinary samples. These results call for larger biomonitoring surveys of the general population and study of the potential sources and determinants of these exposures.
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Prenatal exposure to Glycol Ethers and sex steroid hormones at birth
Environment International, 2018Co-Authors: Charline Warembourg, Sylvaine Cordier, Luc Multigner, Laurence Labat, Christine Monfort, Cécile Chevrier, Anne-claire Binter, Frank Giton, Jean Fiet, Ronan GarlantézecAbstract:Background - Glycol Ethers (GEs) are oxygenated solvents widely found in occupational and consumer water-based products. Some of them are well-known reproductive and developmental toxicants. Objectives - To study the variations in circulating sex steroid hormones, measured in cord blood, according to biomarkers of prenatal GE exposure. Methods - The study population comes from the PELAGIE mother-child cohort, which enrolled pregnant women from Brittany (France, 2002-2006). Maternal urine samples were collected from a random subcohort (n = 338) before 19 weeks' gestation, from which we measured 8 alkoxycarboxylic metabolites of GEs. We subsequently measured 13 sex steroid hormones and sex hormone-binding globulin (SHBG) in cord blood samples. Linear regressions adjusted for potential confounders were used, and nonlinear dose-response associations were investigated. Results - The detection rates of GE metabolites ranged from 4% to 98%; only the 5 most detected (>20%) metabolites were investigated further. Phenoxyacetic acid (detection rate > 95%) was associated with lower levels of SHBG and various steroids (17-alpha-hydroxy-Pregnenolone, delta-5-androstenediol, and dehydroepiandrosterone) among boys and higher SHBG and 16-alpha-hydroxy-dehydroepiandrosterone levels among girls. The two other highly detected metabolites, methoxyetoxyacetic acid and butoxyacetic acid, were associated with variations in estradiol. Butoxyacetic acid was associated with higher delta-5-androstenediol levels while detectable levels of methoxyacetic acid were associated with lower levels of this hormone. Conclusion - Our study suggests that prenatal exposure to GE may affect endocrine response patterns, estimated by determining blood levels of sex steroid hormones in newborns. These results raise questions about the potential role of these changes in the pathways between prenatal GE exposure and previously reported adverse developmental outcomes, including impaired neurocognitive performance.
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Concerning the plausibility of the findings reported in 'Prenatal exposure to Glycol Ethers and cryptorchidism and hypospadias a nested case-control study' by Smet and Kelsey authors' response
Occupational and Environmental Medicine, 2018Co-Authors: Charline Warembourg, Luc Multigner, Ronan GarlantézecAbstract:Reply Letter to Smet and Kelsey: Concerning the plausibility of the findings reported in “Prenatal exposure to Glycol Ethers and cryptorchidism and hypospadias: a nested case–control study”, Warembourg et al, Occup Environ Med 2018;75:59–65
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Prenatal Exposure to Glycol Ethers and Neurocognitive Abilities in 6-Year-Old Children: The PELAGIE Cohort Study
Environmental Health Perspectives, 2017Co-Authors: Rémi Beranger, Charline Warembourg, Florence Rouget, Ronan Garlantézec, Christine Monfort, Gaïd Le Maner-idrissi, Agnès Lacroix, Jessica Trowbridge, Florent Le Gleau, Marylene JourdinAbstract:Background: Glycol Ethers (GE) are widely used organic solvents. Despite the potential neurotoxicity of several families of organic solvents, little is known about the impact of GE on the neurodevelopment of infants and children. Objectives: We investigated the relation between urinary concentrations of GE metabolites in pregnant women and neurocognitive abilities in their 6-year-old children in the PELAGIE mother-child cohort. Methods: Five GE metabolites were measured in first morning void urine samples of 204 French pregnant women in early pregnancy (
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Prenatal Exposure to Glycol Ethers and Male Genital Anomalies
ISEE Conference Abstracts, 2016Co-Authors: Charline Warembourg, Sylvaine Cordier, Jérémie Botton, Nathalie Lelong, Florence Rouget, Babak Koshnood, Rémy Slama, Marie-aline Charles, Ronan GarlantézecAbstract:Introduction: Glycol Ethers (GE) are solvents present in a wide range of occupational and domestic products. Numerous animal studies reported reprotoxic effects of GE and showed that some of them a...
Sylvaine Cordier - One of the best experts on this subject based on the ideXlab platform.
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Exposure to Glycol Ethers among 6-year-old children in France.
International Journal of Hygiene and Environmental Health, 2020Co-Authors: Ronan Garlantézec, Sylvaine Cordier, Luc Multigner, Charline Warembourg, Florence Rouget, Florent Le Gleau, Christine Montfort, Cécile ChevrierAbstract:Abstract Glycol Ethers are an oxygenated solvent family widely present in consumer products. Some of them are recognized reproductive, developmental or hematological toxicants. Although several Glycol ether biomonitoring studies have been performed on adults from working or general populations, no studies have hitherto been carried out on children. The aim of our study was to explore the detection of Glycol ether metabolites in the urinary samples of 6-year-old children, and if any were found, to describe them. The PELAGIE mother-child cohort included 3421 pregnant women from the general population of Brittany, France, between 2002 and 2006. Our biomonitoring study included a random sample of 110 children from the PELAGIE cohort who had participated in a neurodevelopment evaluation at the age of six. First morning voids were collected from all of the children. Eight urinary Glycol ether metabolites were measured using gas chromatography with mass spectrometry. The limit of detection was 0.003 mg/L for all metabolites. Glycol ether metabolites were detected at rates varying from 33.5% of samples for propoxyacetic acid to 100% of samples for phenoxyacetic acid and methoxyacetic acid. The highest median concentration observed was for phenoxyacetic acid (0.141 mg/l). Our study reported the ubiquitous presence of Glycol ether metabolites in children's urinary samples. These results call for larger biomonitoring surveys of the general population and study of the potential sources and determinants of these exposures.
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Prenatal exposure to Glycol Ethers and motor inhibition function evaluated by functional MRI at the age of 10 to 12 years in the PELAGIE mother-child cohort
Environment International, 2019Co-Authors: Anne-claire Binter, Sylvaine Cordier, Christine Monfort, Cécile Chevrier, Elise Bannier, Grégory Simon, Dave Saint-amour, Jean-christophe Ferré, Christian Barillot, Fabienne PeléAbstract:Background - Pregnant women are ubiquitously exposed to organic solvents, such as Glycol Ethers. Several studies suggest potential developmental neurotoxicity following exposure to Glycol Ethers with a lack of clarity of possible brain mechanisms. Objectives - We investigated the association between urinary levels of Glycol Ethers of women during early pregnancy and motor inhibition function of their 10- to 12-year-old children by behavioral assessment and brain imaging. Methods - Exposure to Glycol Ethers was assessed by measuring six metabolites in urine (
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Prenatal exposure to Glycol Ethers and motor inhibition function evaluated by functional MRI at the age of 10 to 12 years in the PELAGIE mother-child cohort
Environment International, 2019Co-Authors: Anne-claire Binter, Sylvaine Cordier, Christine Monfort, Cécile Chevrier, Elise Bannier, Grégory Simon, Dave Saint-amour, Jean-christophe Ferré, Christian Barillot, Fabienne PeléAbstract:Abstract Background Pregnant women are ubiquitously exposed to organic solvents, such as Glycol Ethers. Several studies suggest potential developmental neurotoxicity following exposure to Glycol Ethers with a lack of clarity of possible brain mechanisms. Objectives We investigated the association between urinary levels of Glycol Ethers of women during early pregnancy and motor inhibition function of their 10- to 12-year-old children by behavioral assessment and brain imaging. Methods Exposure to Glycol Ethers was assessed by measuring six metabolites in urine ( Results Higher maternal butoxyacetic acid (BAA) urinary concentrations were associated with poorer child performance (β = −1.1; 95% CI: −1.9, −0.2 for high vs low). There was also a trend for ethoxyacetic acid (EAA) towards poorer performance (β = −0.3; 95% CI: −0.7, 0.01). Considering inhibition demand, there were increased activity in occipital regions in association with moderate EAA (left cuneus) and moderate methoxyacetic acid (MAA) (right precuneus). When children succeeded to inhibit, high ethoxyethoxyacetic acid (EEAA) and moderate phenoxyacetic acid (PhAA) levels were associated with differential activity in frontal cortex, involved in inhibition network. Discussion Prenatal urinary levels of two Glycol ether metabolites were associated with poorer Go/No-Go task performance. Differential activations were observed in the brain motor inhibition network in relation with successful inhibition, but not with cognitive demand. Nevertheless, there is no consistence between performance indicators and cerebral activity results. Other studies are highly necessary given the ubiquity of Glycol ether exposure.
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Prenatal exposure to Glycol Ethers and sex steroid hormones at birth
Environment International, 2018Co-Authors: Charline Warembourg, Sylvaine Cordier, Luc Multigner, Laurence Labat, Christine Monfort, Cécile Chevrier, Anne-claire Binter, Frank Giton, Jean Fiet, Ronan GarlantézecAbstract:Background - Glycol Ethers (GEs) are oxygenated solvents widely found in occupational and consumer water-based products. Some of them are well-known reproductive and developmental toxicants. Objectives - To study the variations in circulating sex steroid hormones, measured in cord blood, according to biomarkers of prenatal GE exposure. Methods - The study population comes from the PELAGIE mother-child cohort, which enrolled pregnant women from Brittany (France, 2002-2006). Maternal urine samples were collected from a random subcohort (n = 338) before 19 weeks' gestation, from which we measured 8 alkoxycarboxylic metabolites of GEs. We subsequently measured 13 sex steroid hormones and sex hormone-binding globulin (SHBG) in cord blood samples. Linear regressions adjusted for potential confounders were used, and nonlinear dose-response associations were investigated. Results - The detection rates of GE metabolites ranged from 4% to 98%; only the 5 most detected (>20%) metabolites were investigated further. Phenoxyacetic acid (detection rate > 95%) was associated with lower levels of SHBG and various steroids (17-alpha-hydroxy-Pregnenolone, delta-5-androstenediol, and dehydroepiandrosterone) among boys and higher SHBG and 16-alpha-hydroxy-dehydroepiandrosterone levels among girls. The two other highly detected metabolites, methoxyetoxyacetic acid and butoxyacetic acid, were associated with variations in estradiol. Butoxyacetic acid was associated with higher delta-5-androstenediol levels while detectable levels of methoxyacetic acid were associated with lower levels of this hormone. Conclusion - Our study suggests that prenatal exposure to GE may affect endocrine response patterns, estimated by determining blood levels of sex steroid hormones in newborns. These results raise questions about the potential role of these changes in the pathways between prenatal GE exposure and previously reported adverse developmental outcomes, including impaired neurocognitive performance.
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Prenatal Exposure to Glycol Ethers and Male Genital Anomalies
ISEE Conference Abstracts, 2016Co-Authors: Charline Warembourg, Sylvaine Cordier, Jérémie Botton, Nathalie Lelong, Florence Rouget, Babak Koshnood, Rémy Slama, Marie-aline Charles, Ronan GarlantézecAbstract:Introduction: Glycol Ethers (GE) are solvents present in a wide range of occupational and domestic products. Numerous animal studies reported reprotoxic effects of GE and showed that some of them a...
Christine Monfort - One of the best experts on this subject based on the ideXlab platform.
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Prenatal exposure to Glycol Ethers and motor inhibition function evaluated by functional MRI at the age of 10 to 12 years in the PELAGIE mother-child cohort
Environment International, 2019Co-Authors: Anne-claire Binter, Sylvaine Cordier, Christine Monfort, Cécile Chevrier, Elise Bannier, Grégory Simon, Dave Saint-amour, Jean-christophe Ferré, Christian Barillot, Fabienne PeléAbstract:Background - Pregnant women are ubiquitously exposed to organic solvents, such as Glycol Ethers. Several studies suggest potential developmental neurotoxicity following exposure to Glycol Ethers with a lack of clarity of possible brain mechanisms. Objectives - We investigated the association between urinary levels of Glycol Ethers of women during early pregnancy and motor inhibition function of their 10- to 12-year-old children by behavioral assessment and brain imaging. Methods - Exposure to Glycol Ethers was assessed by measuring six metabolites in urine (
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Prenatal exposure to Glycol Ethers and motor inhibition function evaluated by functional MRI at the age of 10 to 12 years in the PELAGIE mother-child cohort
Environment International, 2019Co-Authors: Anne-claire Binter, Sylvaine Cordier, Christine Monfort, Cécile Chevrier, Elise Bannier, Grégory Simon, Dave Saint-amour, Jean-christophe Ferré, Christian Barillot, Fabienne PeléAbstract:Abstract Background Pregnant women are ubiquitously exposed to organic solvents, such as Glycol Ethers. Several studies suggest potential developmental neurotoxicity following exposure to Glycol Ethers with a lack of clarity of possible brain mechanisms. Objectives We investigated the association between urinary levels of Glycol Ethers of women during early pregnancy and motor inhibition function of their 10- to 12-year-old children by behavioral assessment and brain imaging. Methods Exposure to Glycol Ethers was assessed by measuring six metabolites in urine ( Results Higher maternal butoxyacetic acid (BAA) urinary concentrations were associated with poorer child performance (β = −1.1; 95% CI: −1.9, −0.2 for high vs low). There was also a trend for ethoxyacetic acid (EAA) towards poorer performance (β = −0.3; 95% CI: −0.7, 0.01). Considering inhibition demand, there were increased activity in occipital regions in association with moderate EAA (left cuneus) and moderate methoxyacetic acid (MAA) (right precuneus). When children succeeded to inhibit, high ethoxyethoxyacetic acid (EEAA) and moderate phenoxyacetic acid (PhAA) levels were associated with differential activity in frontal cortex, involved in inhibition network. Discussion Prenatal urinary levels of two Glycol ether metabolites were associated with poorer Go/No-Go task performance. Differential activations were observed in the brain motor inhibition network in relation with successful inhibition, but not with cognitive demand. Nevertheless, there is no consistence between performance indicators and cerebral activity results. Other studies are highly necessary given the ubiquity of Glycol ether exposure.
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Prenatal exposure to Glycol Ethers and sex steroid hormones at birth
Environment International, 2018Co-Authors: Charline Warembourg, Sylvaine Cordier, Luc Multigner, Laurence Labat, Christine Monfort, Cécile Chevrier, Anne-claire Binter, Frank Giton, Jean Fiet, Ronan GarlantézecAbstract:Background - Glycol Ethers (GEs) are oxygenated solvents widely found in occupational and consumer water-based products. Some of them are well-known reproductive and developmental toxicants. Objectives - To study the variations in circulating sex steroid hormones, measured in cord blood, according to biomarkers of prenatal GE exposure. Methods - The study population comes from the PELAGIE mother-child cohort, which enrolled pregnant women from Brittany (France, 2002-2006). Maternal urine samples were collected from a random subcohort (n = 338) before 19 weeks' gestation, from which we measured 8 alkoxycarboxylic metabolites of GEs. We subsequently measured 13 sex steroid hormones and sex hormone-binding globulin (SHBG) in cord blood samples. Linear regressions adjusted for potential confounders were used, and nonlinear dose-response associations were investigated. Results - The detection rates of GE metabolites ranged from 4% to 98%; only the 5 most detected (>20%) metabolites were investigated further. Phenoxyacetic acid (detection rate > 95%) was associated with lower levels of SHBG and various steroids (17-alpha-hydroxy-Pregnenolone, delta-5-androstenediol, and dehydroepiandrosterone) among boys and higher SHBG and 16-alpha-hydroxy-dehydroepiandrosterone levels among girls. The two other highly detected metabolites, methoxyetoxyacetic acid and butoxyacetic acid, were associated with variations in estradiol. Butoxyacetic acid was associated with higher delta-5-androstenediol levels while detectable levels of methoxyacetic acid were associated with lower levels of this hormone. Conclusion - Our study suggests that prenatal exposure to GE may affect endocrine response patterns, estimated by determining blood levels of sex steroid hormones in newborns. These results raise questions about the potential role of these changes in the pathways between prenatal GE exposure and previously reported adverse developmental outcomes, including impaired neurocognitive performance.
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Prenatal Exposure to Glycol Ethers and Neurocognitive Abilities in 6-Year-Old Children: The PELAGIE Cohort Study
Environmental Health Perspectives, 2017Co-Authors: Rémi Beranger, Charline Warembourg, Florence Rouget, Ronan Garlantézec, Christine Monfort, Gaïd Le Maner-idrissi, Agnès Lacroix, Jessica Trowbridge, Florent Le Gleau, Marylene JourdinAbstract:Background: Glycol Ethers (GE) are widely used organic solvents. Despite the potential neurotoxicity of several families of organic solvents, little is known about the impact of GE on the neurodevelopment of infants and children. Objectives: We investigated the relation between urinary concentrations of GE metabolites in pregnant women and neurocognitive abilities in their 6-year-old children in the PELAGIE mother-child cohort. Methods: Five GE metabolites were measured in first morning void urine samples of 204 French pregnant women in early pregnancy (
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URINARY BIOMARKERS OF EXPOSURE TO Glycol Ethers AND ADVERSE PREGNANCY OUTCOMES
ISEE Conference Abstracts, 2011Co-Authors: Ronan Garlantézec, Luc Multigner, Florence Rouget, Laurence Labat, Nathalie Bonvallot, Christine Monfort, Cécile Chevrier, Nathalie Costet, Sylvaine CordierAbstract:Background and aims : Glycol Ethers (GE) are widely used solvents present in various products such as paints, cleaning agents or cosmetics. GEs toxic effects are attributed to the production of alk...