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Xiuzhuang Li - One of the best experts on this subject based on the ideXlab platform.
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allelochemicals from rhizosphere soils of Glycyrrhiza Uralensis fisch discovery of the autotoxic compounds of a traditional herbal medicine
Industrial Crops and Products, 2017Co-Authors: Xiaofeng He, Xiuzhuang LiAbstract:Abstract Autotoxicity is considered as a major factor causing replant problems. As one of the most frequently used herbs in traditional Chinese medicine and industrial crop, Glycyrrhiza Uralensis Fisch. is cultivated extensively in north of China, but it has often been hampered by replant failure. In light of the serious threat of replant failure, the allelochemicals from Glycyrrhiza Uralensis Fisch. and their allelopathic effects were investigated. Extract of Glycyrrhiza Uralensis Fisch. rhizosphere soil showed phytotoxic activity against Lactuca sativa and autotoxic activity on its own seedlings. Six compounds were isolated from the extract and elucidated by spectroscopic analysis. Among them, liquiritin (1), isoliquiritigenin (2) and glycyrrhizic acid (4) showed observably phytotoxicity and autotoxicity. They were further verified and quantified in the rhizosphere soils of Glycyrrhiza Uralensis Fisch. by high-performance liquid chromatography (HPLC), and their concentrations in dry soils were 2.32, 0.09 and 12.5 μg/g, respectively. These allelochemicals, showed remarkably phytotoxic and autotoxic activity, may play an important role in the replant failure of Glycyrrhiza Uralensis Fisch.
Jin-nan Zhang - One of the best experts on this subject based on the ideXlab platform.
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study on the pharmacokinetics drug drug interaction potential of Glycyrrhiza Uralensis a traditional chinese medicine with lidocaine in rats
Phytotherapy Research, 2009Co-Authors: Jing-cheng Tang, Xiao-hong Song, Min Zhu, Jin-nan ZhangAbstract:Drug–drug interaction potentials of an herbal medicine named Glycyrrhiza Uralensis was investigated in rats via in vitro and in vivo pharmacokinetic studies. P450 levels and the metabolic rate of lidocaine in the liver microsomes prepared from different treatment groups were measured. In a separate in vivo pharmacokinetic study, the pharmacokinetic parameters of lidocaine in plasma and urine were estimated. P450 levels in the rats pretreated by Glycyrrhiza Uralensis were significant higher than that in the non-treatment control. The increase in P450 levels was dose-dependent. Glycyrrhiza Uralensis (1 and 3 g/kg) increased P450 levels by 62% and 91%, respectively, compared with the non-treatment control (0.695 nmol/mg protein). The metabolic rate of lidocaine in the liver microsomes was significantly higher in the herb pretreated rats. The pharmacokinetic profile of lidocaine was significantly modified in the rats with the herbal pretreatment. Elimination half-lives were shortened by 39%, and total clearances were increased by 59% with the pretreatment of Glycyrrhiza Uralensis. In conclusion, Glycyrrhiza Uralensis showed induction effect on P450 isozymes. Efficacy and safety profiles of a drug may be affected when the herbal products or herbal prescriptions containing the plant medicine were concomitantly used. Copyright © 2009 John Wiley & Sons, Ltd.
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Study on the pharmacokinetics drug–drug interaction potential of Glycyrrhiza Uralensis, a traditional Chinese medicine, with lidocaine in rats
Phytotherapy research : PTR, 2009Co-Authors: Jing-cheng Tang, Xiao-hong Song, Min Zhu, Jin-nan ZhangAbstract:Drug–drug interaction potentials of an herbal medicine named Glycyrrhiza Uralensis was investigated in rats via in vitro and in vivo pharmacokinetic studies. P450 levels and the metabolic rate of lidocaine in the liver microsomes prepared from different treatment groups were measured. In a separate in vivo pharmacokinetic study, the pharmacokinetic parameters of lidocaine in plasma and urine were estimated. P450 levels in the rats pretreated by Glycyrrhiza Uralensis were significant higher than that in the non-treatment control. The increase in P450 levels was dose-dependent. Glycyrrhiza Uralensis (1 and 3 g/kg) increased P450 levels by 62% and 91%, respectively, compared with the non-treatment control (0.695 nmol/mg protein). The metabolic rate of lidocaine in the liver microsomes was significantly higher in the herb pretreated rats. The pharmacokinetic profile of lidocaine was significantly modified in the rats with the herbal pretreatment. Elimination half-lives were shortened by 39%, and total clearances were increased by 59% with the pretreatment of Glycyrrhiza Uralensis. In conclusion, Glycyrrhiza Uralensis showed induction effect on P450 isozymes. Efficacy and safety profiles of a drug may be affected when the herbal products or herbal prescriptions containing the plant medicine were concomitantly used. Copyright © 2009 John Wiley & Sons, Ltd.
Pei Jiang - One of the best experts on this subject based on the ideXlab platform.
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a protective mechanism of licorice Glycyrrhiza Uralensis isoliquiritigenin stimulates detoxification system via nrf2 activation
Journal of Ethnopharmacology, 2015Co-Authors: Hui Gong, Chunping Hu, Pingfei Fang, Huande Li, Bikui Zhang, Yang Yang, Pei JiangAbstract:Abstract Ethnopharmacological relevance Licorice (Glycyrrhizae radix), the root of Glycyrrhiza Uralensis Fisch. (Leguminosae), is mainly used to moderate the characteristics of toxic herbs in Traditional Chinese Medicine, which could be partly interpreted as detoxification. However, the underlying mechanism is still not fully elucidated. Nuclear factor erythroid 2-related factor 2 (Nrf2) plays a key role in the protection against toxic xenobiotics. In our previous research, we have identified that extracts from Glycyrrhiza Uralensis induced the expression of Nrf2 nuclear protein and its downstream genes. This research aims to screen the most potent Nrf2 inducer isolated from Glycyrrhiza Uralensis and examine its effect on Nrf2 signaling pathway and detoxification system. Materials and methods Four compounds derived from Glycyrrhiza Uralensis (glycyrrhetinic acid, liquiritigenin, isoliquiritigenin and liquiritin) were screened by ARE-luciferase reporter. The most potent ARE-luciferase inducer was chosen to further examine its effect on Nrf2 and detoxification genes in HepG2 cells. The role of Nrf2-dependent mechanism was tested by using Nrf2 knockout mice (Nrf2 KO) and Nrf2 wild-type mice (Nrf2 WT). Results ARE-luciferase reporter assay showed these four compounds were all potent Nrf2 inducers, and isoliquiritigenin was the most potent inducer. Isoliquiritigenin significantly up-regulated the expression of Nrf2 and its downstream detoxification genes UDP-glucuronosyltransferase 1A1 (UGT1A1), glutamate cysteine ligase (GCL), multidrug resistance protein 2 (MRP2) and bile salt export pump (BSEP) in vitro and in vivo. Additionally, isoliquiritigenin showed Nrf2-dependent transactivation of UGT1A1, GCLC and MRP2. Conclusions Isoliquiritigenin, isolated from Glycyrrhiza Uralensis, stimulates detoxification system via Nrf2 activation, which could be a potential protective mechanism of licorice.
Yefei Qian - One of the best experts on this subject based on the ideXlab platform.
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Antithrombotic phenolic compounds from Glycyrrhiza Uralensis.
Fitoterapia, 2012Co-Authors: Wei-wei Tao, Jin-ao Duan, Nian-yun Yang, Yuping Tang, Meng-zhu Liu, Yefei QianAbstract:A new coumestan, named glycyrurol, and nine phenolic compounds were isolated from the ethyl acetate extract of the roots and rhizomes of Glycyrrhiza Uralensis. Their structures were elucidated based on spectroscopic analysis and literature data, and anticoagulative assay found significant antithrombotic activity of compounds 4, 8 and 10.
Xiaofeng He - One of the best experts on this subject based on the ideXlab platform.
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allelochemicals from rhizosphere soils of Glycyrrhiza Uralensis fisch discovery of the autotoxic compounds of a traditional herbal medicine
Industrial Crops and Products, 2017Co-Authors: Xiaofeng He, Xiuzhuang LiAbstract:Abstract Autotoxicity is considered as a major factor causing replant problems. As one of the most frequently used herbs in traditional Chinese medicine and industrial crop, Glycyrrhiza Uralensis Fisch. is cultivated extensively in north of China, but it has often been hampered by replant failure. In light of the serious threat of replant failure, the allelochemicals from Glycyrrhiza Uralensis Fisch. and their allelopathic effects were investigated. Extract of Glycyrrhiza Uralensis Fisch. rhizosphere soil showed phytotoxic activity against Lactuca sativa and autotoxic activity on its own seedlings. Six compounds were isolated from the extract and elucidated by spectroscopic analysis. Among them, liquiritin (1), isoliquiritigenin (2) and glycyrrhizic acid (4) showed observably phytotoxicity and autotoxicity. They were further verified and quantified in the rhizosphere soils of Glycyrrhiza Uralensis Fisch. by high-performance liquid chromatography (HPLC), and their concentrations in dry soils were 2.32, 0.09 and 12.5 μg/g, respectively. These allelochemicals, showed remarkably phytotoxic and autotoxic activity, may play an important role in the replant failure of Glycyrrhiza Uralensis Fisch.