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Ling‐yun Jia - One of the best experts on this subject based on the ideXlab platform.

  • Concentration and separation of Glycyrrhizic Acid by foam separation
    Journal of Chemical Technology & Biotechnology, 2002
    Co-Authors: Zhi-long Xiu, Dai‐jia Zhang, Ling‐yun Jia
    Abstract:

    By the aid of the surface activities of Glycyrrhizic Acid, foam separation can be used to extract and concentrate it. The effects of operating parameters such as flow rate of air, initial feed concentration, pH and ionic strength on the enrichment ratio and recovery yield of Glycyrrhizic Acid are investigated in detail. In addition, the influences of other surface-active substances in solution, such as proteins, on the separation of Glycyrrhizic Acid are also discussed. The experimental results show that foam separation is a simple and effective method to separate and concentrate Glycyrrhizic Acid. © 2002 Society of Chemical Industry

Huizhou Liu - One of the best experts on this subject based on the ideXlab platform.

  • isolation and purification of Glycyrrhizic Acid with solvent extraction
    Separation and Purification Technology, 2005
    Co-Authors: Guoguang Niu, Yuchun Xie, Jianfeng Lou, Huizhou Liu
    Abstract:

    Solvent extraction of Glycyrrhizic Acid (GA) from liquorice leaching solution was studied with tributyl phosphate, trialkylphosphine oxide, n-hexanol and 2-ethyl-hexanol as extractants. The results showed that GA was easily extracted into the organic phase in molecular state by the formation of hydrogen bond. pH was the key factor influencing the selectivity during extraction and stripping. The extraction mechanism was studied with transmitting electron microscopy and analysis of solute distribution. It was deduced that Glycyrrhizic Acid was extracted into the organic solvent in the form of molecular aggregation rather than as single molecules. (C) 2004 Elsevier B.V. All rights reserved.

Yue Gao - One of the best experts on this subject based on the ideXlab platform.

  • Effects of 18β-Glycyrrhizic Acid and 18α-Glycyrrhizic Acid on mRNA and protein expression of cytochrome P450 3A in cultured rat primary hepatocyte.
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2009
    Co-Authors: Yu-guang Wang, Ming-hui Yang, Qiande Liang, Hong-ling Tan, Cheng-rong Xiao, Yue Gao
    Abstract:

    OBJECTIVE To study the effects of 18beta-Glycyrrhizic Acid and 18alpha-Glycyrrhizic Acid on mRNA and protein expression of cytochrome P450 3A in cultured rat primary hepatocyte. METHOD Rat heaptocyte were isolated by two-step in situ collagenase perfusion method; the hepatocytes were seeded in dishes coated with type I rat tail collagen, culture medium was added and changed daily after gelation, the effect of 18beta-Glycyrrhizic Acid and 18alpha-Glycyrrhizic Acid on the expression of CYP3A was determined by reverse transcriptase-polymerase chain reaction (RT-PCR) and western blot respectively. RESULT Treatment with 18beta-Glycyrrhizic Acid of primary rat hepatocytes resulted in marked up-regulation of CYP3A1 expression at both mRNA and protein levels in a concentration dependent manner, while exposure to 18alpha-Glycyrrhizic Acid of primary rat hepatocytes resulted in marked down-regulation of CYP3A1 expression at both mRNA and protein levels in a concentration dependent manmer. CONCLUSION 18beta-Glycyrrhizic Acid and 18alpha-Glycyrrhizic Acid up-regulate and down-regulate CYP3A1 expression at the transcriptive levels.

Gao Y. - One of the best experts on this subject based on the ideXlab platform.

  • Effects of 18β-Glycyrrhizic Acid and 18α-Glycyrrhizic Acid on mRNA and protein expression of cytochrome P450 3A in cultured rat primary hepatocyte.
    China Journal of Chinese Matera Medica, 2009
    Co-Authors: Yitao Wang, Liang Q, Xiao C., Tan H, Ma Z., Mengsu Yang, Gao Y.
    Abstract:

    Objective:To study the effects of 18β-Glycyrrhizic Acid and 18α-Glycyrrhizic Acid on mRNA and protein expression of cytochrome P450 3A in cultured rat primary hepatocyte.Method:Rat heaptocyte were isolated by two-step in situ collagenase perfusion method;the hepatocytes were seeded in dishes coated with type I rat tail collagen,culture medium was added and changed daily after gelation,the effect of 18β-Glycyrrhizic Acid and 18α-Glycyrrhizic Acid on the expression of CYP3A was determined by reverse transcriptase-polymerase chain reaction(RT-PCR) and western blot respectively.Result:Treatment with 18β-Glycyrrhizic Acid of primary rat hepatocytes resulted in marked up-regulationof CYP3A1expression at both mRNA and protein levels in a concentration dependent manner,while exposure to 18α-Glycyrrhizic Acid of primary rat hepatocytes resulted in marked down-regulation of CYP3A1expression at both mRNA and protein levels in a concentration dependent manmer.Conclusion:18β-Glycyrrhizic Acid and 18α-Glycyrrhizic Acid up-regulate and down-regulate CYP3A1 expression at the transcriptive levels.

Joost Dejongh - One of the best experts on this subject based on the ideXlab platform.

  • THE PHARMACOKINETICS OF Glycyrrhizic Acid EVALUATED BY PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING
    Drug metabolism reviews, 2001
    Co-Authors: Bart A. Ploeger, Tjeert T. Mensinga, Adriënne J.a.m. Sips, Willem Seinen, Jan Meulenbelt, Joost Dejongh
    Abstract:

    Glycyrrhizic Acid is widely applied as a sweetener in food products and chewing tobacco. In addition, it is of clinical interest for possible treatment of chronic hepatitis C. In some highly exposed subjects, side effects such as hypertension and symptoms associated with electrolyte disturbances have been reported. To analyze the relationship between the pharmacokinetics of Glycyrrhizic Acid in its toxicity, the kinetics of Glycyrrhizic Acid and its biologically active metabolite glycyrrhetic Acid were evaluated. Glycyrrhizic Acid is mainly absorbed after presystemic hydrolysis as glycyrrhetic Acid. Because glycyrrhetic Acid is a 200–1000 times more potent inhibitor of 11-β-hydroxysteroid dehydrogenase compared to Glycyrrhizic Acid, the kinetics of glycyrrhetic Acid are relevant in a toxicological perspective. Once absorbed, glycyrrhetic Acid is transported, mainly taken up into the liver by capacity-limited carriers, where it is metabolized into glucuronide and sulfate conjugates. These conjugates are tr...