The Experts below are selected from a list of 7680 Experts worldwide ranked by ideXlab platform
Marta Scorsetti - One of the best experts on this subject based on the ideXlab platform.
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semiautomatic technique for defining the internal Gross Tumor Volume of lung Tumors close to liver spleen cupola by 4d ct
Medical Physics, 2010Co-Authors: Pietro Mancosu, Roberto Sghedoni, Valentino Bettinardi, Mark Anthony Aquilina, Piera Navarria, Giovanni Mauro Cattaneo, Nadia Di Muzio, Luca Cozzi, Marta ScorsettiAbstract:Purpose: It has been shown that in cases of lungTumors close to the liver cupola, the four dimensional (4D)-CT postprocessing maximum intensity projection (MIP) algorithm does not fully recover the radiotherapy internal Gross Tumor Volume (IGTV). In this work, a semiautomatic technique was evaluated by which the residual IGTV that was not included into the IGTV by MIP algorithm was actually added. Methods: A moving phantom and five selected patients were considered. The various IGTVs produced by the semiautomatic approach were compared to those generated by 4D-CT manual contouring. Results: In all cases, the radiation oncologist qualitatively concurred with the semiautomatic IGTV. A quantitative difference in Volume of 2.6% was found in the phantom study, whereas a mean difference of 0.1 ± 4.6 % was obtained in the patient studies. Conclusions: A semiautomatic technique to include the residual part of IGTV covered by liver/spleen cupola when using MIP algorithm was validated on phantom and on selected patients, revealing the possibility of defining the IGTV for patients with lesions located near liver/spleen cupola by performing only the contours on the MIP series.
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Semiautomatic technique for defining the internal Gross Tumor Volume of lung Tumors close to liver/spleen cupola by 4D-CT.
Medical Physics, 2010Co-Authors: Pietro Mancosu, Roberto Sghedoni, Valentino Bettinardi, Mark Anthony Aquilina, Piera Navarria, Giovanni Mauro Cattaneo, Nadia Di Muzio, Luca Cozzi, Marta ScorsettiAbstract:Purpose: It has been shown that in cases of lungTumors close to the liver cupola, the four dimensional (4D)-CT postprocessing maximum intensity projection (MIP) algorithm does not fully recover the radiotherapy internal Gross Tumor Volume (IGTV). In this work, a semiautomatic technique was evaluated by which the residual IGTV that was not included into the IGTV by MIP algorithm was actually added. Methods: A moving phantom and five selected patients were considered. The various IGTVs produced by the semiautomatic approach were compared to those generated by 4D-CT manual contouring. Results: In all cases, the radiation oncologist qualitatively concurred with the semiautomatic IGTV. A quantitative difference in Volume of 2.6% was found in the phantom study, whereas a mean difference of 0.1 ± 4.6 % was obtained in the patient studies. Conclusions: A semiautomatic technique to include the residual part of IGTV covered by liver/spleen cupola when using MIP algorithm was validated on phantom and on selected patients, revealing the possibility of defining the IGTV for patients with lesions located near liver/spleen cupola by performing only the contours on the MIP series.
Yu-pei Chen - One of the best experts on this subject based on the ideXlab platform.
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An integrated model of the Gross Tumor Volume of cervical lymph nodes and pretreatment plasma Epstein–Barr virus DNA predicts survival of nasopharyngeal carcinoma in the intensity-modulated radiotherapy era: a big-data intelligence platform-based ana
Therapeutic Advances in Medical Oncology, 2019Co-Authors: Cheng-long Huang, Ying Sun, Wei-jie Luo, Yuan Zhang, Ling-long Tang, Hao Peng, Yu-pei ChenAbstract:Background:Few studies have evaluated the prognostic value of the integrated model consisting of Gross Tumor Volume of lymph nodes (GTVnd) and pretreatment plasma Epstein–Barr virus DNA (pre-EBV DN...
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an integrated model of the Gross Tumor Volume of cervical lymph nodes and pretreatment plasma epstein barr virus dna predicts survival of nasopharyngeal carcinoma in the intensity modulated radiotherapy era a big data intelligence platform based anal
Therapeutic Advances in Medical Oncology, 2019Co-Authors: Cheng-long Huang, Ying Sun, Wei-jie Luo, Yuan Zhang, Ling-long Tang, Hao Peng, Yu-pei ChenAbstract:Background:Few studies have evaluated the prognostic value of the integrated model consisting of Gross Tumor Volume of lymph nodes (GTVnd) and pretreatment plasma Epstein–Barr virus DNA (pre-EBV DN...
Ying Sun - One of the best experts on this subject based on the ideXlab platform.
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An integrated model of the Gross Tumor Volume of cervical lymph nodes and pretreatment plasma Epstein–Barr virus DNA predicts survival of nasopharyngeal carcinoma in the intensity-modulated radiotherapy era: a big-data intelligence platform-based ana
Therapeutic Advances in Medical Oncology, 2019Co-Authors: Cheng-long Huang, Ying Sun, Wei-jie Luo, Yuan Zhang, Ling-long Tang, Hao Peng, Yu-pei ChenAbstract:Background:Few studies have evaluated the prognostic value of the integrated model consisting of Gross Tumor Volume of lymph nodes (GTVnd) and pretreatment plasma Epstein–Barr virus DNA (pre-EBV DN...
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an integrated model of the Gross Tumor Volume of cervical lymph nodes and pretreatment plasma epstein barr virus dna predicts survival of nasopharyngeal carcinoma in the intensity modulated radiotherapy era a big data intelligence platform based anal
Therapeutic Advances in Medical Oncology, 2019Co-Authors: Cheng-long Huang, Ying Sun, Wei-jie Luo, Yuan Zhang, Ling-long Tang, Hao Peng, Yu-pei ChenAbstract:Background:Few studies have evaluated the prognostic value of the integrated model consisting of Gross Tumor Volume of lymph nodes (GTVnd) and pretreatment plasma Epstein–Barr virus DNA (pre-EBV DN...
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Prognostic value of primary Gross Tumor Volume and standardized uptake value of 18F-FDG in PET/CT for distant metastasis in locoregionally advanced nasopharyngeal carcinoma.
Tumor Biology, 2017Co-Authors: Ya Nan Jin, Ji Jin Yao, Si Yang Wang, Wangjian Zhang, Guan Qun Zhou, Fan Zhang, Zhi Bin Cheng, Ying SunAbstract:Distant metastasis has become the predominant model of treatment failures in patients with locoregionally advanced nasopharyngeal carcinoma. Effort should therefore be made to stratify locoregionally advanced nasopharyngeal carcinoma patients into different groups based on the risk of metastasis to improve prognosis and tailor individualized treatments. This study aims to assess the value of primary Gross Tumor Volume and the maximum standardized uptake value for predicting distant metastasis-free survival of patients with locoregionally advanced nasopharyngeal carcinoma. A total of 294 locoregionally advanced nasopharyngeal carcinoma patients who were identified from prospectively maintained database and underwent fluor-18-fluorodeoxyglucose positron emission tomography/computed tomography imaging before treatment were included. The maximum standardized uptake value was recorded for the primary Tumor (SUVmax-P) and neck lymph nodes (SUVmax-N). Computed tomography-derived primary Gross Tumor Volume was measured using the summation-of-area technique. At 5 years, the distant metastasis-free survival rate was 83.7%. The cut-off of the SUVmax-P, SUVmax-N, and primary Gross Tumor Volume for distant metastasis-free survival was 8.95, 5.75, and 31.3 mL, respectively, by receiver operating characteristic curve. In univariate analysis, only SUVmax-N (hazard ratio: 7.01; 95% confidence interval: 1.70-28.87; p
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prognostic value of primary Gross Tumor Volume and standardized uptake value of 18f fdg in pet ct for distant metastasis in locoregionally advanced nasopharyngeal carcinoma
Tumor Biology, 2017Co-Authors: Ya Nan Jin, Ji Jin Yao, Si Yang Wang, Wangjian Zhang, Guan Qun Zhou, Fan Zhang, Zhi Bin Cheng, Ying SunAbstract:Distant metastasis has become the predominant model of treatment failures in patients with locoregionally advanced nasopharyngeal carcinoma. Effort should therefore be made to stratify locoregionally advanced nasopharyngeal carcinoma patients into different groups based on the risk of metastasis to improve prognosis and tailor individualized treatments. This study aims to assess the value of primary Gross Tumor Volume and the maximum standardized uptake value for predicting distant metastasis-free survival of patients with locoregionally advanced nasopharyngeal carcinoma. A total of 294 locoregionally advanced nasopharyngeal carcinoma patients who were identified from prospectively maintained database and underwent fluor-18-fluorodeoxyglucose positron emission tomography/computed tomography imaging before treatment were included. The maximum standardized uptake value was recorded for the primary Tumor (SUVmax-P) and neck lymph nodes (SUVmax-N). Computed tomography-derived primary Gross Tumor Volume was measured using the summation-of-area technique. At 5 years, the distant metastasis-free survival rate was 83.7%. The cut-off of the SUVmax-P, SUVmax-N, and primary Gross Tumor Volume for distant metastasis-free survival was 8.95, 5.75, and 31.3 mL, respectively, by receiver operating characteristic curve. In univariate analysis, only SUVmax-N (hazard ratio: 7.01; 95% confidence interval: 1.70-28.87; p < 0.01) and clinical stage (hazard ratio: 3.03; 95% confidence interval: 1.67-5.47; p = 0.007) were confirmed as independent predictors of distant metastasis-free survival. A prognostic model was derived by SUVmax-N and clinical stage: low risk (SUVmax-N < 5.75 regardless of clinical stage), medium risk (stage III and SUVmax-N ≥ 5.75), and high risk (stage IV and SUVmax-N ≥ 5.75). Multivariate analysis revealed that SUVmax-N and the prognostic model remained independent prognostic factors for distant metastasis-free survival (p = 0.023 and p < 0.001, respectively), but the clinical stage became insignificant (p = 0.133). Furthermore, the adjusted hazard ratios for the prognostic model were higher than SUVmax-N (hazard ratio = 6.27 vs 5.21, respectively). In summary, compared with SUVmax-P, SUVmax-N may be a better predictor of distant metastasis-free survival for patients with locoregionally advanced nasopharyngeal carcinoma. Combining SUVmax-N with clinical stage gives a more precise picture in predicting distant metastasis.
Sotirios Bisdas - One of the best experts on this subject based on the ideXlab platform.
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18F-Fluorodeoxyglucose-PET/CT to evaluate Tumor, nodal disease, and Gross Tumor Volume of oropharyngeal and oral cavity cancer: comparison with MR imaging and validation with surgical specimen
Neuroradiology, 2009Co-Authors: Oliver Seitz, Nicole Chambron-pinho, Markus Middendorp, Rober Sader, Martin G. Mack, Thomas J. Vogl, Sotirios BisdasAbstract:Introduction The purpose of this paper is to evaluate the impact of adding combined 18F-PET/CT to MRI for T and N staging of the oral and oropharyngeal cancer and calculation of the Gross Tumor Volume (GTV) having histopathology as reference standard.
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18f fluorodeoxyglucose pet ct to evaluate Tumor nodal disease and Gross Tumor Volume of oropharyngeal and oral cavity cancer comparison with mr imaging and validation with surgical specimen
Neuroradiology, 2009Co-Authors: Oliver Seitz, Markus Middendorp, Rober Sader, Martin G. Mack, Thomas J. Vogl, Nicole Chambronpinho, Sotirios BisdasAbstract:Introduction The purpose of this paper is to evaluate the impact of adding combined 18F-PET/CT to MRI for T and N staging of the oral and oropharyngeal cancer and calculation of the Gross Tumor Volume (GTV) having histopathology as reference standard.
Pietro Mancosu - One of the best experts on this subject based on the ideXlab platform.
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semiautomatic technique for defining the internal Gross Tumor Volume of lung Tumors close to liver spleen cupola by 4d ct
Medical Physics, 2010Co-Authors: Pietro Mancosu, Roberto Sghedoni, Valentino Bettinardi, Mark Anthony Aquilina, Piera Navarria, Giovanni Mauro Cattaneo, Nadia Di Muzio, Luca Cozzi, Marta ScorsettiAbstract:Purpose: It has been shown that in cases of lungTumors close to the liver cupola, the four dimensional (4D)-CT postprocessing maximum intensity projection (MIP) algorithm does not fully recover the radiotherapy internal Gross Tumor Volume (IGTV). In this work, a semiautomatic technique was evaluated by which the residual IGTV that was not included into the IGTV by MIP algorithm was actually added. Methods: A moving phantom and five selected patients were considered. The various IGTVs produced by the semiautomatic approach were compared to those generated by 4D-CT manual contouring. Results: In all cases, the radiation oncologist qualitatively concurred with the semiautomatic IGTV. A quantitative difference in Volume of 2.6% was found in the phantom study, whereas a mean difference of 0.1 ± 4.6 % was obtained in the patient studies. Conclusions: A semiautomatic technique to include the residual part of IGTV covered by liver/spleen cupola when using MIP algorithm was validated on phantom and on selected patients, revealing the possibility of defining the IGTV for patients with lesions located near liver/spleen cupola by performing only the contours on the MIP series.
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Semiautomatic technique for defining the internal Gross Tumor Volume of lung Tumors close to liver/spleen cupola by 4D-CT.
Medical Physics, 2010Co-Authors: Pietro Mancosu, Roberto Sghedoni, Valentino Bettinardi, Mark Anthony Aquilina, Piera Navarria, Giovanni Mauro Cattaneo, Nadia Di Muzio, Luca Cozzi, Marta ScorsettiAbstract:Purpose: It has been shown that in cases of lungTumors close to the liver cupola, the four dimensional (4D)-CT postprocessing maximum intensity projection (MIP) algorithm does not fully recover the radiotherapy internal Gross Tumor Volume (IGTV). In this work, a semiautomatic technique was evaluated by which the residual IGTV that was not included into the IGTV by MIP algorithm was actually added. Methods: A moving phantom and five selected patients were considered. The various IGTVs produced by the semiautomatic approach were compared to those generated by 4D-CT manual contouring. Results: In all cases, the radiation oncologist qualitatively concurred with the semiautomatic IGTV. A quantitative difference in Volume of 2.6% was found in the phantom study, whereas a mean difference of 0.1 ± 4.6 % was obtained in the patient studies. Conclusions: A semiautomatic technique to include the residual part of IGTV covered by liver/spleen cupola when using MIP algorithm was validated on phantom and on selected patients, revealing the possibility of defining the IGTV for patients with lesions located near liver/spleen cupola by performing only the contours on the MIP series.
