The Experts below are selected from a list of 3192 Experts worldwide ranked by ideXlab platform
Credgington Dan - One of the best experts on this subject based on the ideXlab platform.
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Influence of Heavy Atom Effect on the photophysics of coinage metal carbene-metal-amide emitters
'Wiley', 2021Co-Authors: Feng Jiale, Romanov, Alexander S, Linnolahti Mikko, Bochmann Manfred, Penfold Thomas, Greenham, Neil C, Reponen, Antti‐pekka M., Credgington DanAbstract:The Effect of the Heavy metal Atom on the photophysics of carbene-metal-amide (CMA) photoemitters is explored, where the metal bridge is either Au, Ag, or Cu. Spectroscopic investigations reveal the coupling mechanism responsible for communication between the singlet and triplet manifolds. The photophysical properties do not reflect expected trends based upon the Heavy Atom Effect, as both direct coupling between charge-transfer states and spin-vibronic coupling via a ligand-centered triplet state are present. Direct coupling is weakest for CMA(Ag), increasing the importance of the spin-vibronic pathway and rendering its properties more sensitive to inter-state energy gaps than for the Au and Cu-bridged analogues. The measured activation energy correlates with the expected exchange energy of the charge-transfer state, which is also closely related to the length of the bonds joining the carbene and amide ligands, and decreases in the order CMA(Cu) > CMA(Au) > CMA(Ag). These findings reveal that reducing interference between charge-transfer and ligand-centers excited, and minimizing exchange energy, are required for developing efficient luminescent CMA complexes
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Research data supporting "Influence of Heavy Atom Effect on the Photophysics of Coinage Metal Carbene-Metal-Amide Emitters"
'Organisation for Economic Co-Operation and Development (OECD)', 2020Co-Authors: Feng Jiale, Reponen, Antti-pekka M, Romanov, Alexander S, Linnolahti Mikko, Bochmann Manfred, Greenham Neil, Penfold Thomas, Credgington DanAbstract:This data supports the research work "Influence of Heavy Atom Effect on the Photophysics of Coinage Metal Carbene-Metal-Amide Emitters". The data was collected by using steady-state and transient optical spectroscopy techniques combined with quantum-chemistry calculations
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Influence of Heavy Atom Effect on the Photophysics of Coinage Metal Carbene-Metal-Amide Emitters
'Wiley', 2020Co-Authors: Feng Jiale, Romanov, Alexander S, Linnolahti Mikko, Bochmann Manfred, Penfold Thomas, Reponen Antti-pekka, Greenham, Neil C, Credgington DanAbstract:The Effect of the Heavy metal Atom on the photophysics of carbene‐metal‐amide (CMA) photoemitters is explored, where the metal bridge is either Au, Ag, or Cu. Spectroscopic investigations reveal the coupling mechanism responsible for communication between the singlet and triplet manifolds. The photophysical properties do not reflect expected trends based upon the Heavy Atom Effect, as both direct coupling between charge‐transfer states and spin‐vibronic coupling via a ligand‐centered triplet state are present. Direct coupling is weakest for CMA(Ag), increasing the importance of the spin‐vibronic pathway and rendering its properties more sensitive to inter‐state energy gaps than for the Au and Cu‐bridged analogues. The measured activation energy correlates with the expected exchange energy of the charge‐transfer state, which is also closely related to the length of the bonds joining the carbene and amide ligands, and decreases in the order CMA(Cu) > CMA(Au) > CMA(Ag). These findings reveal that reducing interference between charge‐transfer and ligand‐centers excited, and minimizing exchange energy, are required for developing efficient luminescent CMA complexes.published versionpeerReviewe
Wei Huang - One of the best experts on this subject based on the ideXlab platform.
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highly efficient ultralong organic phosphorescence through intramolecular space Heavy Atom Effect
Journal of Physical Chemistry Letters, 2019Co-Authors: Huifang Shi, Lulu Song, Chen Sun, Kaiwei Huang, He Wang, Suzhi Cai, Wei Yao, Yujian Zhang, Ruilin Zheng, Wei HuangAbstract:Metal-free organic phosphorescent materials have attracted considerable attention in the fields of organic electronics and bioelectronics. However, it remains a great challenge to achieve organic p...
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bodipy derivatives for photodynamic therapy influence of configuration versus Heavy Atom Effect
ACS Applied Materials & Interfaces, 2017Co-Authors: Jianhua Zou, Zhihui Yin, Kaikai Ding, Qianyun Tang, Jinjun Shao, Qi Zhang, Wei Huang, Xiaochen DongAbstract:Heavy Atom Effect and configuration are important for BODIPY derivatives to generate singlet oxygen (1O2) for photodynamic therapy. Herein, a series of BODIPY derivatives with different halogens were synthesized. 1O2 quantum yields (QYs) and MTT assay confirm that incorporation of more Heavy Atoms onto dimeric BODIPY cannot Effectively enhance the 1O2 QYs. Rather, the dark toxicity increases. This phenomenon can be attributed to the competition of Heavy Atom Effect and configuration of dimeric BODIPY. In addition the BODIPY derivative with two iodine Atoms (BDPI) owns the highest 1O2 QYs (73%) and the lowest phototoxicity IC50 (1 μM). Furthermore, an in vivo study demonstrates that BDPI NPs can Effectively inhibit tumor growth and can be used as a promising threanostic agent for photodynamic therapy in clinic.
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BODIPY Derivatives for Photodynamic Therapy: Influence of Configuration versus Heavy Atom Effect
2017Co-Authors: Jianhua Zou, Zhihui Yin, Kaikai Ding, Qianyun Tang, Jinjun Shao, Qi Zhang, Wei Huang, Xiaochen DongAbstract:Heavy Atom Effect and configuration are important for BODIPY derivatives to generate singlet oxygen (1O2) for photodynamic therapy. Herein, a series of BODIPY derivatives with different halogens were synthesized. 1O2 quantum yields (QYs) and MTT assay confirm that incorporation of more Heavy Atoms onto dimeric BODIPY cannot Effectively enhance the 1O2 QYs. Rather, the dark toxicity increases. This phenomenon can be attributed to the competition of Heavy Atom Effect and configuration of dimeric BODIPY. In addition the BODIPY derivative with two iodine Atoms (BDPI) owns the highest 1O2 QYs (73%) and the lowest phototoxicity IC50 (1 μM). Furthermore, an in vivo study demonstrates that BDPI NPs can Effectively inhibit tumor growth and can be used as a promising threanostic agent for photodynamic therapy in clinic
Xiaochen Dong - One of the best experts on this subject based on the ideXlab platform.
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bodipy derivatives for photodynamic therapy influence of configuration versus Heavy Atom Effect
ACS Applied Materials & Interfaces, 2017Co-Authors: Jianhua Zou, Zhihui Yin, Kaikai Ding, Qianyun Tang, Jinjun Shao, Qi Zhang, Wei Huang, Xiaochen DongAbstract:Heavy Atom Effect and configuration are important for BODIPY derivatives to generate singlet oxygen (1O2) for photodynamic therapy. Herein, a series of BODIPY derivatives with different halogens were synthesized. 1O2 quantum yields (QYs) and MTT assay confirm that incorporation of more Heavy Atoms onto dimeric BODIPY cannot Effectively enhance the 1O2 QYs. Rather, the dark toxicity increases. This phenomenon can be attributed to the competition of Heavy Atom Effect and configuration of dimeric BODIPY. In addition the BODIPY derivative with two iodine Atoms (BDPI) owns the highest 1O2 QYs (73%) and the lowest phototoxicity IC50 (1 μM). Furthermore, an in vivo study demonstrates that BDPI NPs can Effectively inhibit tumor growth and can be used as a promising threanostic agent for photodynamic therapy in clinic.
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BODIPY Derivatives for Photodynamic Therapy: Influence of Configuration versus Heavy Atom Effect
2017Co-Authors: Jianhua Zou, Zhihui Yin, Kaikai Ding, Qianyun Tang, Jinjun Shao, Qi Zhang, Wei Huang, Xiaochen DongAbstract:Heavy Atom Effect and configuration are important for BODIPY derivatives to generate singlet oxygen (1O2) for photodynamic therapy. Herein, a series of BODIPY derivatives with different halogens were synthesized. 1O2 quantum yields (QYs) and MTT assay confirm that incorporation of more Heavy Atoms onto dimeric BODIPY cannot Effectively enhance the 1O2 QYs. Rather, the dark toxicity increases. This phenomenon can be attributed to the competition of Heavy Atom Effect and configuration of dimeric BODIPY. In addition the BODIPY derivative with two iodine Atoms (BDPI) owns the highest 1O2 QYs (73%) and the lowest phototoxicity IC50 (1 μM). Furthermore, an in vivo study demonstrates that BDPI NPs can Effectively inhibit tumor growth and can be used as a promising threanostic agent for photodynamic therapy in clinic
Shaohua Wei - One of the best experts on this subject based on the ideXlab platform.
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protonation salt derivative with Heavy Atom Effect on phthalocyanine for enhanced in vitro photodynamic therapy
Dyes and Pigments, 2015Co-Authors: Xianglan Chen, Lin Zhou, Jiahong Zhou, Ao Wang, Yun Lin, Shaohua WeiAbstract:Abstract In order to improve water-solubility and photodynamic activity of 2(3), 9(10), 16(17), 23(24)-tetra-((amino)methyl)phenoxy)phthalocyaninato-zinc (ZnPc) simultaneously, here, we present the first attempt to introduce Heavy Atoms (Br and I) to ZnPc though a simple method by synthesizing the hydrobromide and hydriodate protonation salt derivatives of ZnPc. Researches indicated that these protonation salt derivatives of ZnPc can stably disperse in aqueous system for a long time. Furthermore, the internal Heavy Atom Effect from hydriodate in the ZnPc molecules enhances the intersystem crossing (ISC) efficiency of ZnPc during its photo-exciting process. Therefore, the generation of reactive oxygen species (ROSs), especially singlet oxygen (1O2), is significantly improved, which leads to an improved in vitro photodynamic therapy (PDT).
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internal Heavy Atom Effect of au iii and pt iv on hypocrellin a for enhanced in vitro photodynamic therapy of cancer
Bioorganic & Medicinal Chemistry Letters, 2013Co-Authors: Lin Zhou, Jihua Liu, Jiahong Zhou, Shaohua Wei, Jian ShenAbstract:Hypocrellin A (HA), an a natural perylene quinine photosensitizers (PSs), can chelate with Heavy metal ions, including Au(III) and Pt(IV), to form a 1:2 complex, which exhibits enhanced (1)O2 generation quantum yield through the increased intersystem crossing efficiency mediated by internal Heavy Atom Effect. Besides, the chelate process greatly improved the water solubility of HA. Comparative studies with HA and complexes have demonstrated that the Heavy-Atom Effect on HA molecules enhances the efficiency of in vitro photodynamic (PDT) efficacy.
David R Yarkony - One of the best experts on this subject based on the ideXlab platform.
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on the origin of the Heavy Atom Effect in the fine structure splitting of the 1 2π state of alkali metal 2p rare gas van der waals molecules
Journal of Chemical Physics, 1997Co-Authors: Karl Sohlberg, David R YarkonyAbstract:The fine-structure splitting of the (1 2ΠΩ,ν) levels in Li(1s 22p,2P)Ar and Li(1s 22p,2P)Ne is determined. Analysis of the electronic wave functions demonstrates that the Heavy Atom contribution to the fine-structure splitting results from the antibonding mixture of valence pπ orbitals on the rare gas and metal Atoms. Rydberg orbitals do not contribute significantly to the Heavy Atom Effect.
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new and unusual bonding in open shell van der waals molecules revealed by the Heavy Atom Effect the case of bar
Journal of Physical Chemistry A, 1997Co-Authors: Karl Sohlberg, David R YarkonyAbstract:Calculations are reported for the excited 14Π and C2Δ electronic states of BAr and the (nominally 2s2p2) 4P and 2D states of Atomic boron. It was found necessary to extend an augmented valence triple-zeta orbital basis set to correctly describe the C2Δ state. This enhancement is necessitated by the near degeneracy of the valence 2s2p2 2D and Rydberg 2s23d 2D electron configurations in Atomic boron, both of which are required to describe BAr C2Δ. Unexpectedly strong bonding in the C2Δ state is found. This bonding is shown to have its root in a type of coordinate covalency, dative bonding, that is sensitive to electron correlation Effects and is reflected in a large external Heavy Atom Effect in the spin−orbit coupling of the 14Π and C2Δ states.