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Masahiro Kurosaka - One of the best experts on this subject based on the ideXlab platform.
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Spontaneous recurrent Hemarthrosis of the knee joint in the elderly: a report of two cases.
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 2011Co-Authors: Kanto Nagai, Seiji Kubo, Tomoyuki Matsumoto, Takehiko Matsushita, Koji Takayama, Daisuke Araki, Hiroshi Sasaki, Shinya Oka, Toshihiro Akisue, Masahiro KurosakaAbstract:Spontaneous recurrent Hemarthrosis of the knee joint usually occurs in elderly patients with osteoarthritis (OA) of the knee joint who have had repeated episodes of Hemarthrosis without associated trauma [1]. When recurrent Hemarthrosis of the knee joint is encountered without trauma, several possibilities should be considered in the differential diagnosis, such as pigmented villonodular synovitis (PVNS), synovial osteochondromatosis, hemangioma, hemophilia, invasion of malignant tumor, leukemia, crystal-induced arthritis, or idiopathic intra-articular hemorrhage [2]. Differential diagnosis is, however, difficult, even with magnetic resonance imaging (MRI), because these diseases are infrequent and clinical presentations sometimes similar. We present two cases of spontaneous recurrent Hemarthrosis of the knee joint in which preoperative diagnosis was not successful because of suspicion of PVNS and synovial osteochondromatosis based on MRI findings. Case report
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isolation and characterization of connective tissue progenitor cells derived from human fracture induced Hemarthrosis in vitro
Journal of Orthopaedic Research, 2008Co-Authors: Sang Yang Lee, Takahiro Niikura, Masahiko Miwa, Yoshitada Sakai, Ryosuke Kuroda, Minoru Doita, Tomoyuki Matsumoto, Hiroyuki Fujioka, Masahiro KurosakaAbstract:In our search for alternative sources of connective tissue progenitor cells that can be obtained with minimal invasion, we studied human intraarticular fracture-induced Hemarthrosis of the knee and attempted to isolate connective tissue progenitors from the Hemarthrosis. Hemarthrosis was aspirated from the knee joints of 13 patients suffering from intraarticular osteochondral fractures of the knee. Mononuclear cells were isolated from the aspirated Hemarthrosis by density gradient separation, and cultured. We were able to obtain fibroblastic adherent cells from the mononuclear cell fractions. Flow cytometry analysis after in vitro expansion on tissue culture plastic revealed that the fibroblastic cells were positive for CD29, CD44, CD105, and CD166, and negative for CD14, CD34, CD45, and CD133. These cells could differentiate in vitro into osteogenic, chondrogenic, and adipogenic cells in the presence of lineage-specific induction factors. These results demonstrate that human intraarticular fracture-induced knee Hemarthrosis contains connective tissue progenitor cells with morphologic features, immunophenotypic markers, and differentiation potential that are similar to bone marrow stromal cells. This suggests that Hemarthrosis, which is easy to harvest without unnecessary invasion to the patient, has possible future clinical applications such as in tissue-engineered therapies for severe osteochondral defects, posttraumatic osteoarthritis, and delayed fracture unions or nonunions.
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in vitro multipotentiality and characterization of human unfractured traumatic Hemarthrosis derived progenitor cells a potential cell source for tissue repair
Journal of Cellular Physiology, 2007Co-Authors: Sang Yang Lee, Masahiko Miwa, Yoshitada Sakai, Ryosuke Kuroda, Minoru Doita, Tomoyuki Matsumoto, Hiroyuki Fujioka, Takashi Iwakura, Masahiro KurosakaAbstract:Mesenchymal progenitor cells (MPCs) are a very attractive tool in the context of repair and regeneration of musculoskeletal tissue damaged by trauma. The most common source of MPCs to date has been the bone marrow, but aspirating bone marrow from the patient is an invasive procedure. In an attempt to search for alternative sources of MPCs that could be obtained with minimal invasion, we looked into traumatic Hemarthrosis of the knee. In this study, we determined whether a population of multipotent MPCs could be isolated from acute traumatic knee Hemarthrosis in the absence of intra-articular fractures. Mononuclear cells were isolated from the aspirated Hemarthrosis by density gradient separation, and cultured. We were able to obtain plastic adherent fibroblast-like cells from the mononuclear cell fractions. Flow cytometry analysis revealed that the adherent fibroblast-like cells were consistently positive for CD29, CD44, CD105, and CD166, and were negative for CD14, CD34, and CD45. These were similar to control bone marrow stromal cells. These cells could differentiate in vitro into osteogenic, adipogenic, and chondrogenic cells in the presence of lineage-specific induction factors. In conclusion, acute unfractured traumatic Hemarthrosis of the knee contains MPCs with multipotentiality. Because knee Hemarthrosis is easy to harvest with minimal pain and without unnecessary invasion, we regard Hemarthrosis-derived cells as an additional progenitor cell source for future tissue engineering and cell-based therapy in knee injuries.
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Human Hemarthrosis-derived progenitor cells can differentiate into osteoblast-like cells in vitro.
Biochemical and biophysical research communications, 2005Co-Authors: Takahiro Niikura, Masahiko Miwa, Yoshitada Sakai, Sang Yang Lee, Ryosuke Kuroda, Takaaki Fujishiro, Seiji Kubo, Minoru Doita, Masahiro KurosakaAbstract:Abstract We hypothesized that intraarticular osteochondral fracture-induced Hemarthrosis could be a useful cell source for bone regeneration, as it is thought to contain osteoprogenitor cells derived from bone marrow. Therefore, we investigated whether human Hemarthrosis-derived cells have the potential to differentiate into osteoblast-like cells in vitro. We aspirated Hemarthrosis from patients suffering from osteochondral fractures of knee joints, and cultured Hemarthrosis-derived cells in a medium supplemented with dexamethasone, β-glycerophosphate, and ascorbic acid, or without them as control. The morphology of the treated cells appeared to be cuboidal shape, differing from spindle-like shape observed in the control. Matrix mineralization was observed only in the treated culture. Alkaline phosphatase activity and gene expression of alkaline phosphatase, parathyroid hormone receptor, osteopontin, and osteocalcin were up-regulated compared with the control. These studies demonstrate that human Hemarthrosis-derived cells can differentiate into osteoblast-like cells, i.e., they contain osteoprogenitor cells and are a useful cell source for bone regeneration.
Clifford W Colwell - One of the best experts on this subject based on the ideXlab platform.
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Recurrent Hemarthrosis following a total knee arthroplasty.
The Journal of arthroplasty, 1995Co-Authors: C S Oishi, M L Elliott, Clifford W ColwellAbstract:The case of a recurrent Hemarthrosis of a total knee arthroplasty after the sixth postoperative month is described. Because of disabling pain, the patient underwent an explorative arthrotomy 18 months after implantation of the total knee arthroplasty. A hypertrophied vascular mass of synovium was discovered in the lateral gutter and excised with an associated synovectomy. Since the arthrotomy, the Hemarthrosis has not recurred. Therefore, in cases of recurrent Hemarthrosis of a total knee arthroplasty that becomes disabling, exploration by arthrotomy should be considered.
Pratik A. Shukla - One of the best experts on this subject based on the ideXlab platform.
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Endovascular Management of Hemarthrosis in Patients with Bleeding Diatheses: Systematic Review
CardioVascular and Interventional Radiology, 2020Co-Authors: Srinidhi Shanmugasundaram, Vishnu Chandra, Marcin Kolber, Abhishek Kumar, Sohail Contractor, Pratik A. ShuklaAbstract:Purpose In this systematic review, we report the safety and efficacy of embolization for treating Hemarthrosis in patients with bleeding diatheses with or without a history of prior arthroplasty. Materials and Methods A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines. A structured search was performed in PubMed, Web of Science, MEDLINE, and SCOPUS databases of patients undergoing embolization for Hemarthrosis. Demographic data, clinical history, angiographic findings, interventions, and outcomes were extracted and tabulated. Results The search identified 97 unique titles of which 15 were deemed relevant comprising 78 patients with coagulopathies undergoing 93 embolization procedures. Mean follow-up time was 29 months (range 3–116.5). In the 29 patients who underwent arthroplasty prior to embolization for Hemarthrosis, there were 11 bleeding recurrences (37.9%). Of these patients who experienced recurrences, 10 underwent repeat embolization as coagulation factor replacement was not sufficient to address the re-bleeding. In the 49 patients with bleeding diatheses who underwent embolization for Hemarthrosis with no history of prior arthroplasty, there were 11 recurrences (22.4%) and 4 of these patients underwent repeat embolization with favorable results. There were four major procedure-related complications. Conclusion Transarterial embolization is safe and effective in addressing recurrent Hemarthrosis in patients with bleeding diatheses with or without a history of arthroplasty of the affected joint.
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Endovascular Management of Hemarthrosis in Patients with Bleeding Diatheses: Systematic Review.
Cardiovascular and interventional radiology, 2019Co-Authors: Srinidhi Shanmugasundaram, Vishnu Chandra, Marcin Kolber, Abhishek Kumar, Sohail Contractor, Pratik A. ShuklaAbstract:In this systematic review, we report the safety and efficacy of embolization for treating Hemarthrosis in patients with bleeding diatheses with or without a history of prior arthroplasty. A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines. A structured search was performed in PubMed, Web of Science, MEDLINE, and SCOPUS databases of patients undergoing embolization for Hemarthrosis. Demographic data, clinical history, angiographic findings, interventions, and outcomes were extracted and tabulated. The search identified 97 unique titles of which 15 were deemed relevant comprising 78 patients with coagulopathies undergoing 93 embolization procedures. Mean follow-up time was 29 months (range 3–116.5). In the 29 patients who underwent arthroplasty prior to embolization for Hemarthrosis, there were 11 bleeding recurrences (37.9%). Of these patients who experienced recurrences, 10 underwent repeat embolization as coagulation factor replacement was not sufficient to address the re-bleeding. In the 49 patients with bleeding diatheses who underwent embolization for Hemarthrosis with no history of prior arthroplasty, there were 11 recurrences (22.4%) and 4 of these patients underwent repeat embolization with favorable results. There were four major procedure-related complications. Transarterial embolization is safe and effective in addressing recurrent Hemarthrosis in patients with bleeding diatheses with or without a history of arthroplasty of the affected joint.
Arina Van Breda - One of the best experts on this subject based on the ideXlab platform.
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Geniculate Artery Embolization in the Management of Spontaneous Recurrent Hemarthrosis of the Knee: Case Series
Journal of vascular and interventional radiology : JVIR, 2013Co-Authors: Sandeep Bagla, Kenneth S. Rholl, Arina Van Breda, Keith M. SterlingAbstract:Abstract Spontaneous recurrent Hemarthrosis after knee arthroplasty is reported to occur in 0.3%–1% of patients, likely secondary to hypertrophic vascular synovium. Five patients who underwent previous arthroplasty presented with spontaneous Hemarthrosis. Selective arterial embolization was performed with spherical embolic particles (diameter range, 100–700 μm). Angiography demonstrated synovial hypervascularity with geniculate artery "tumor blush" appearance in all patients. Average time to resolution of effusion was 2.6 weeks, with no recurrences reported during follow-up (mean, 25.4 mo; range, 16–48 mo). Two patients experienced transient cutaneous ischemia. Selective geniculate artery embolization with spherical embolic particles is an effective treatment for spontaneous recurrent Hemarthrosis of theknee.
Sandeep Bagla - One of the best experts on this subject based on the ideXlab platform.
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Recurrent Hemarthrosis Following Knee Arthroplasty Treated with Arterial Embolization.
The Journal of arthroplasty, 2015Co-Authors: Zachary D. Weidner, William G. Hamilton, John Smirniotopoulos, Sandeep BaglaAbstract:Abstract Recurrent Hemarthrosis is an uncommon but troublesome complication following knee arthroplasty. This study reports the results for 13 patients with spontaneous recurrent Hemarthrosis after knee arthroplasty treated with arterial embolization. The average interval between arthroplasty and embolization was 47 months (range, 2-103 months), and the average time from onset of Hemarthrosis to embolization was 4.1 months (range, 1–11 months). Geniculate arterial embolization lead to resolution of Hemarthrosis in 12 of 13 patients (92.3%). The one clinical failure likely represented a case of misdiagnosed periprosthetic joint infection. Two patients experienced transient cutaneous ischemia related to distal particulate embolization that resolved spontaneously. Selective geniculate arterial embolization is an effective and safe treatment modality for recurrent Hemarthrosis after knee arthroplasty.
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Geniculate Artery Embolization in the Management of Spontaneous Recurrent Hemarthrosis of the Knee: Case Series
Journal of vascular and interventional radiology : JVIR, 2013Co-Authors: Sandeep Bagla, Kenneth S. Rholl, Arina Van Breda, Keith M. SterlingAbstract:Abstract Spontaneous recurrent Hemarthrosis after knee arthroplasty is reported to occur in 0.3%–1% of patients, likely secondary to hypertrophic vascular synovium. Five patients who underwent previous arthroplasty presented with spontaneous Hemarthrosis. Selective arterial embolization was performed with spherical embolic particles (diameter range, 100–700 μm). Angiography demonstrated synovial hypervascularity with geniculate artery "tumor blush" appearance in all patients. Average time to resolution of effusion was 2.6 weeks, with no recurrences reported during follow-up (mean, 25.4 mo; range, 16–48 mo). Two patients experienced transient cutaneous ischemia. Selective geniculate artery embolization with spherical embolic particles is an effective treatment for spontaneous recurrent Hemarthrosis of theknee.