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Maryam Mahmoudi - One of the best experts on this subject based on the ideXlab platform.

  • Comparing effects of low glycemic index/High-fat, High-Calorie Diet and High-fat, High-Calorie Diet on cytokine levels of patients with cystic fibrosis: A randomized controlled clinical trial
    European Cytokine Network, 2020
    Co-Authors: Zahra Gorji, Mohammadreza Modaresi, Saeed Yekanni-nejad, Nima Rezaei, Maryam Mahmoudi
    Abstract:

    The importance of the host inflammatory response, as a central pathological feature of cystic fibrosis, is well recognized. Additionally, hyperglycemia can induce an immune response and consecutively may exacerbate symptoms of this disease. Hence, adherence to a low glycemic index Diet, through normalizing blood glucose levels, may reduce inflammation in patients with this disease. This study aimed to compare effects of a low glycemic index/High-fat, High-Calorie Diet and routine High-fat, High-Calorie Diet on inflammatory biomarkers in patients with cystic fibrosis. In this randomized clinical trial, 44 children and adolescents with cystic fibrosis were randomly assigned to receive for three months either a High-fat, High-Calorie Diet (n = 22) or a low glycemic index/High-fat, High-Calorie Diet (n = 22) with similar Calorie and macronutrients composition to the control Diet. Patients in first arm were allowed to use all sources of carbohydrates with different glycemic indices, whereas those in another arm consumed carbohydrates from low glycemic index sources. Serum levels of the pro-inflammatory cytokines IL-6, IL-17A, and IFNg, and the antiinflammatory cytokine IL-10 were measured at baseline and after the end of the trial. There were significant differences between groups for IL-6 (P = 0.02) and IL-17 (P = 0.01), in favor of the low glycemic Diet, but no between-group differences were detected in IL-10 and IFN-γ. Although serum levels of IL-17 were reduced in both the groups as compared with the baseline values, this reduction was only significant in the group assigned to the low glycemic Diet (P= 0.007), In addition, IL-6 serum levels decreased and those of IL-10 increased significantly as compared with the baseline values in the low glycemic Diet (P= 0.01). It seems that adherence to a low glycemic index/High-fat, High-Calorie Diet for three months can improve some inflammatory biomarkers in children and adolescents with cystic fibrosis compared with the High-fat, High-Calorie Diet.

  • comparing effects of low glycemic index High fat High Calorie Diet and High fat High Calorie Diet on cytokine levels of patients with cystic fibrosis a randomized controlled clinical trial
    European Cytokine Network, 2020
    Co-Authors: Zahra Gorji, Mohammadreza Modaresi, Nima Rezaei, Maryam Mahmoudi, Saeed Yekanninejad
    Abstract:

    The importance of the host inflammatory response, as a central pathological feature of cystic fibrosis, is well recognized. Additionally, hyperglycemia can induce an immune response and consecutively may exacerbate symptoms of this disease. Hence, adherence to a low glycemic index Diet, through normalizing blood glucose levels, may reduce inflammation in patients with this disease. This study aimed to compare effects of a low glycemic index/High-fat, High-Calorie Diet and routine High-fat, High-Calorie Diet on inflammatory biomarkers in patients with cystic fibrosis. In this randomized clinical trial, 44 children and adolescents with cystic fibrosis were randomly assigned to receive for three months either a High-fat, High-Calorie Diet (n = 22) or a low glycemic index/High-fat, High-Calorie Diet (n = 22) with similar Calorie and macronutrients composition to the control Diet. Patients in first arm were allowed to use all sources of carbohydrates with different glycemic indices, whereas those in another arm consumed carbohydrates from low glycemic index sources. Serum levels of the pro-inflammatory cytokines IL-6, IL-17A, and IFNγ, and the anti-inflammatory cytokine IL-10 were measured at baseline and after the end of the trial. There were significant differences between groups for IL-6 (P = 0.02) and IL-17 (P = 0.01), in favor of the low glycemic Diet, but no between-group differences were detected in IL-10 and IFN-γ. Although serum levels of IL-17 were reduced in both the groups as compared with the baseline values, this reduction was only significant in the group assigned to the low glycemic Diet (P= 0.007), In addition, IL-6 serum levels decreased and those of IL-10 increased significantly as compared with the baseline values in the low glycemic Diet (P= 0.01). It seems that adherence to a low glycemic index/High-fat, High-Calorie Diet for three months can improve some inflammatory biomarkers in children and adolescents with cystic fibrosis compared with the High-fat, High-Calorie Diet.

  • Effects of low glycemic index/High-fat, High-Calorie Diet on glycemic control and lipid profiles of children and adolescence with cystic fibrosis: A randomized double-blind controlled clinical trial.
    Diabetes & metabolic syndrome, 2020
    Co-Authors: Zahra Gorji, Mohammadreza Modaresi, Saeed Yekanni-nejad, Maryam Mahmoudi
    Abstract:

    Abstract Purpose Low glycemic index Diets seem to be potentially effective to improve glycemic control and reduce lipid profiles. Hence, this study aimed to evaluate the effect of a low glycemic index/High fat, High-Calorie Diet on glycemic status and lipid profiles of patients with cystic fibrosis. Methods In this randomized clinical trial, 44 children and adolescents with cystic fibrosis were randomized to receive for three months either a High fat, High-Calorie Diet (n = 22) or a low glycemic index/High fat, High-Calorie Diet (n = 22) with similar Calorie and macronutrients composition. Patients in High fat, High-Calorie Diet arm were allowed to use all sources of carbohydrates with different glycaemic indices; whereas those in another arm consumed carbohydrates from low glycemic index sources. Serum levels of lipid profiles (triglyceride, total cholesterol, HDL cholesterol, LDL cholesterol), insulin, fasting blood glucose, and glycated hemoglobin were measured at baseline and after the intervention. Results Between-group differences were significant only for fasting blood glucose (P  Conclusions It seems that adherence to a low glycemic index/High fat, High-Calorie Diet can improve glycemic indices in children and adolescents with cystic fibrosis compared to the High fat, High-Calorie Diet. Trial registration IRCT2017102325267N5.

  • effects of low glycemic index High fat High Calorie Diet on glycemic control and lipid profiles of children and adolescence with cystic fibrosis a randomized double blind controlled clinical trial
    Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 2020
    Co-Authors: Zahra Gorji, Mohammadreza Modaresi, Maryam Mahmoudi, Saeed Yekanninejad
    Abstract:

    Abstract Purpose Low glycemic index Diets seem to be potentially effective to improve glycemic control and reduce lipid profiles. Hence, this study aimed to evaluate the effect of a low glycemic index/High fat, High-Calorie Diet on glycemic status and lipid profiles of patients with cystic fibrosis. Methods In this randomized clinical trial, 44 children and adolescents with cystic fibrosis were randomized to receive for three months either a High fat, High-Calorie Diet (n = 22) or a low glycemic index/High fat, High-Calorie Diet (n = 22) with similar Calorie and macronutrients composition. Patients in High fat, High-Calorie Diet arm were allowed to use all sources of carbohydrates with different glycaemic indices; whereas those in another arm consumed carbohydrates from low glycemic index sources. Serum levels of lipid profiles (triglyceride, total cholesterol, HDL cholesterol, LDL cholesterol), insulin, fasting blood glucose, and glycated hemoglobin were measured at baseline and after the intervention. Results Between-group differences were significant only for fasting blood glucose (P  Conclusions It seems that adherence to a low glycemic index/High fat, High-Calorie Diet can improve glycemic indices in children and adolescents with cystic fibrosis compared to the High fat, High-Calorie Diet. Trial registration IRCT2017102325267N5.

  • Effects of low glycemic index/High-fat, High-Calorie Diet compared to the High-fat, High-Calorie Diet on glycemic control, lipid profile, and inflammatory markers in children and adolescence with cystic fibrosis: A study protocol for a randomized dou
    2019
    Co-Authors: Zahra Gorji, Mohammadreza Modaresi, Saeed Yekanni-nejad, Maryam Mahmoudi
    Abstract:

    Abstract Background: Inflammation plays an important role in pathogenesis of cystic fibrosis, and Diet is considered as an effective factor in controlling inflammation. Low glycemic index Diet seems to be effective for improving glycemic control and reducing the inflammation and lipid profile. Hence, this study was planned to compare the effects of a low glycemic index/High fat, High Calorie Diet with the High fat, High Calorie Diet on glycemic status, lipid profile, and inflammatory markers in patients with cystic fibrosis. Methods: A total of 60 children and adolescence with cystic fibrosis will be randomized to receive a High fat, High Calorie Diet (n=30) or low glycemic index/High fat, High Calorie Diet (n=30) with similar Calorie and macronutrients composition, for three months. Patients in High fat, High Calorie Diet arm will be able to use all sources of carbohydrates with different glycaemic indices; while those in another arm will be received their carbohydrate from low glycemic index sources. Before and after the intervention, serum levels of lipid profile (triglyceride, total cholesterol, HDL cholesterol, LDL cholesterol), insulin, glucose, HbA1c, the homeostasis model assessment-estimated insulin resistance index, and some inflammatory markers (IL-6, IL-10, IL-17A, and IFNγ) will be measured. Discussion: To our knowledge, this study will be the first to examine the effects of a low glycemic index/High fat, High Calorie Diet compared to the High fat, High Calorie Diet in cystic fibrosis patients. The findings of this study might provide evidence to improve the nutritional status and immune system as well as to prevent the disease complications in these patients.

Chih Yang Huang - One of the best experts on this subject based on the ideXlab platform.

  • Heat-killed Lactobacillus Reuteri GMNL-263 Prevents Epididymal Fat Accumulation and Cardiac Injury in High-Calorie Diet-Fed Rats.
    International journal of medical sciences, 2016
    Co-Authors: Po Hsiang Liao, Wei Wen Kuo, Yu Lan Yeh, Ya Hui Chen, Viswanadha Vijaya Padma, Yi Hsing Chen, Dennis Jine Yuan Hsieh, Cecilia Hsuan Day, Sheng Huang Chang, Chih Yang Huang
    Abstract:

    High-Calorie Diet-induced obesity leads to cardiomyocyte dysfunction and apoptosis. Impaired regulation of epididymal fat content in obese patients has been known to increase the risk of cardiac injury. In our study, a lactic acid bacteria, Lactobacillus reuteri GMNL-263, was evaluated for its potential to reduce body weight and body fat ratio and to prevent heart injury in rats with High-fat Diet-induced obesity. Lactic acid bacteria supplementation restored the cardiac function and decreased the physiological changes in the heart of the obese rats. In addition, the Fas/Fas-associated protein pathway-induced caspase 3/e Poly polymerase mediated apoptosis in the cardiomyocytes of the obese rats was reversed in the Lr263-treated rats. These results reveal that fed with Lr-263 reduces body fat ratio, inhibits caspase 3-mediated apoptosis and restores cardiac function in obese rats through recovery of ejection fraction and fractional shortening. Our results indicated that the administration of Lr263 lactic acid bacteria can significantly down-regulate body fat and prevent cardiomyocyte injury in obese rats.

  • Lactobacillus reuteri GMNL-263 reduces hyperlipidaemia and the heart failure process in High-Calorie Diet-fed induced heart dysfunction in rats
    Journal of Functional Foods, 2016
    Co-Authors: Po Hsiang Liao, Wei Wen Kuo, Chia-hua Kuo, Yu Lan Yeh, Chia Yao Shen, Ya Hui Chen, Ray Jade Chen, Viswanadha Vijaya Padma, Yi Hsing Chen, Chih Yang Huang
    Abstract:

    Abstract Probiotics are reported to provide protective health benefits against various disorders. In this study, we established a High-Calorie Diet animal model with a Diet prepared by fortifying normal Diet with soybean oil and condensed milk and the animals were supplemented with different dose of probiotic Lactobacillus reuteri GMNL-263(Lr263) for 8 weeks to investigate the protective function. We measured the lipid levels in plasma, liver and faecal; heart weight, function and collagen accumulation and biochemical markers of cardiac disease. Lr263 reversed High-Calorie Diet-induced cardiac weight gain, systolic malfunction and prevented heart inflammation by decreasing inflammation proteins NF-κB and COX-2. Moreover, Lr263 reduced cardiac eccentric hypertrophy and the levels of cardiac fibrosis markers CTGF and SP1 in High-Calorie Diet-fed rat hearts. Thus, Lr263 is considered as a functional food that provides anti-inflammatory, anti-hypertrophic, anti-fibrotic functions and identified specific biologic effects in reducing the characteristics of the High-Calorie Diet-induced progression to heart failure.

Khalid Abdul Kadir - One of the best experts on this subject based on the ideXlab platform.

  • glycyrrhizic acid prevents High Calorie Diet induced metabolic aberrations despite the suppression of peroxisome proliferator activated receptor γ expression
    Nutrition, 2016
    Co-Authors: Hong Sheng Cheng, Hui Ping Yaw, So Ha Ton, Siew Mei Choy, Joana Magdelene Xiao Fang Kong, Khalid Abdul Kadir
    Abstract:

    Abstract Objective To investigate the effects of glycyrrhizic acid supplementation on glucose and lipid metabolism in rodents consuming a High-fat, High-sucrose Diet. Methods Twenty-four male, 8-week old Sprague Dawley rats with an initial weight of 160 to 200 g were randomised into three groups (n = 6 for each group): groups A (standard rat chow), B (High-fat, High-sucrose Diet), and C (High-fat, High-sucrose Diet + 100 mg/kg/d of glycyrrhizic acid via oral administration). The rats were treated accordingly for 4 wk. Glycaemic parameters, lipid profile, stress hormones, and adiponectin levels were measured after the treatment. Relative gene expressions of peroxisome proliferator-activated receptor α and γ, lipoprotein lipase as well as gluconeogenic enzymatic activities in different tissues were also determined. Results Consumption of High-fat, High-sucrose Diet triggered hyperglycaemia, insulin resistance, and dyslipidemia, which were effectively attenuated by supplementation with glycyrrhizic acid. Glycyrrhizic acid supplementation also effectively reduced circulating adrenaline, alleviated gluconeogenic enzymes overactivity, and promoted the upregulation of lipoprotein lipase expression in the cardiomyocytes and skeletal muscles. A High Calorie Diet also triggered hypoadiponectinaemia and suppression of peroxisome proliferator-activated receptor γ expression, which did not improve with glycyrrhizic acid treatment. Conclusion Supplementation with glycyrrhizic acid could alleviate High Calorie Diet–induced glucose and lipid metabolic dysregulations by reducing circulatory stress hormones, normalizing gluconeogenic enzyme activities, and elevating muscular lipid uptake. The beneficial effects of these bioactivities outweighed the adverse effects caused by Diet-induced repression of peroxisome proliferator-activated receptor γ expression, resulting in the maintenance of lipid and glucose homeostasis.

  • Glycyrrhizic acid prevents High Calorie Diet−induced metabolic aberrations despite the suppression of peroxisome proliferator-activated receptor γ expression
    Nutrition (Burbank Los Angeles County Calif.), 2016
    Co-Authors: Hong Sheng Cheng, Hui Ping Yaw, So Ha Ton, Siew Mei Choy, Joana Magdelene Xiao Fang Kong, Khalid Abdul Kadir
    Abstract:

    Abstract Objective To investigate the effects of glycyrrhizic acid supplementation on glucose and lipid metabolism in rodents consuming a High-fat, High-sucrose Diet. Methods Twenty-four male, 8-week old Sprague Dawley rats with an initial weight of 160 to 200 g were randomised into three groups (n = 6 for each group): groups A (standard rat chow), B (High-fat, High-sucrose Diet), and C (High-fat, High-sucrose Diet + 100 mg/kg/d of glycyrrhizic acid via oral administration). The rats were treated accordingly for 4 wk. Glycaemic parameters, lipid profile, stress hormones, and adiponectin levels were measured after the treatment. Relative gene expressions of peroxisome proliferator-activated receptor α and γ, lipoprotein lipase as well as gluconeogenic enzymatic activities in different tissues were also determined. Results Consumption of High-fat, High-sucrose Diet triggered hyperglycaemia, insulin resistance, and dyslipidemia, which were effectively attenuated by supplementation with glycyrrhizic acid. Glycyrrhizic acid supplementation also effectively reduced circulating adrenaline, alleviated gluconeogenic enzymes overactivity, and promoted the upregulation of lipoprotein lipase expression in the cardiomyocytes and skeletal muscles. A High Calorie Diet also triggered hypoadiponectinaemia and suppression of peroxisome proliferator-activated receptor γ expression, which did not improve with glycyrrhizic acid treatment. Conclusion Supplementation with glycyrrhizic acid could alleviate High Calorie Diet–induced glucose and lipid metabolic dysregulations by reducing circulatory stress hormones, normalizing gluconeogenic enzyme activities, and elevating muscular lipid uptake. The beneficial effects of these bioactivities outweighed the adverse effects caused by Diet-induced repression of peroxisome proliferator-activated receptor γ expression, resulting in the maintenance of lipid and glucose homeostasis.

  • Modulation of lipid metabolism in glycyrrhizic acid-treated rats fed on a High-Calorie Diet and exposed to short or long-term stress.
    International journal of physiology pathophysiology and pharmacology, 2015
    Co-Authors: Hui Ping Yaw, So Ha Ton, Hamish Alexander Fernando, Hsien Fei Chin, Muhammad Kaiser Abdul Karim, Khalid Abdul Kadir
    Abstract:

    Stress and High-Calorie Diets increase the risk of developing metabolic syndrome. Glycyrrhizic acid (GA) has been shown to improve dyslipidaemia in rats fed on a High-Calorie Diet. This study aimed to examine the effects of GA on lipid metabolism in rats exposed to short- or long-term stress and on a High-Calorie Diet. The parameters examined included serum lipid profiles, serum free fatty acids and fatty acid profiles in tissues, and expression of peroxisome proliferator-activated receptors (PPAR), lipoprotein lipase (LPL), elongases and desaturases. Within the 14- or 28-day exposure groups, neither stress nor GA affected the lipid profile and serum free fatty acids. Stress did not affect PPAR-α expression in both the 14- and 28-day exposure groups. However, GA-treated rats from the former group had increased PPAR-α expression only in the kidney while all other tissues from the latter group were unaffected. Stress increased PPAR-γ expression in the heart of the 28-day exposure group but its expression was unaffected in all tissues of the 14-day exposure group. GA elevated PPAR-γ expression in the kidney and the skeletal muscles. Neither stress nor GA affected LPL expressions in all tissues from the 14-day exposure group but its expressions were elevated in the QF of the stressed rats and heart of the GA-treated rats of the 28-day exposure group. As for the elongases and desaturases in the liver, stress down-regulated ELOVL5 in the long-term exposure group while up-regulated ELOVL6 in the short-term exposure group while hepatic desaturases were unaffected by stress. Neither elongase nor desaturase expressions in the liver were affected by GA. This research is the first report of GA on lipid metabolism under stress and High-Calorie Diet conditions and the results gives evidence for the role of GA in ameliorating MetS via site-specific regulation of lipid metabolism gene expressions and modification of fatty acids.

  • Irregularities in glucose metabolism induced by stress and High-Calorie Diet can be attenuated by glycyrrhizic acid.
    International journal of physiology pathophysiology and pharmacology, 2014
    Co-Authors: Hui Ping Yaw, So Ha Ton, Stella Amanda, Irvina Geraldine Xiao Feng Kong, Hong Sheng Cheng, Hamish Alexander Fernando, Hsien Fei Chin, Khalid Abdul Kadir
    Abstract:

    Stress and High-Calorie Diet increase the risk of developing metabolic syndrome. Glycyrrhizic acid (GA) has been shown to improve hyperglycaemia and dyslipidaemia under various physiological conditions. This study was aimed at examining the effects of stress and GA on glucose metabolism under short- or long-term stress. Forty-eight Sprague Dawley rats were divided into two groups with constant stress induced by light (300-400 lux) for either 14 days (short-term stress) or 28 days (long-term stress). Within each group, the rats were subdivided into three treatment groups i.e. Group A (control group): High-Calorie Diet (HCD) only; Group B: HCD + stress (14 or 28 days) and Group C: HCD + stress (14 or 28 days) + GA (100 mg/kg). The blood glucose concentrations of the rats exposed to 14-day stress were elevated significantly and GA lowered blood glucose concentration significantly in the 14-day exposure group. The 28-day exposure group adapted to stress as shown by the lower adrenaline level and gluconeogenic enzymes activities in most of the tissues than the 14-day exposure group. With regards to adrenaline and corticosterone, GA was found to increased adrenaline significantly in the short-term exposure group while lowering corticosterone in the long-term exposure group. GA-treated short- and long-term exposure groups had significant reduction in hexose-6-phosphate dehydrogenase activities in the visceral adipose tissues and quadriceps femoris respectively. The results may indicate the role of GA in improving blood glucose concentration in individuals exposed to short-term stress who are already on a High-Calorie Diet via selective action on gluconeogenic enzymes in different tissues.

E Nassar - One of the best experts on this subject based on the ideXlab platform.

Matthew B. Cooke - One of the best experts on this subject based on the ideXlab platform.