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Haidong Zhu - One of the best experts on this subject based on the ideXlab platform.

  • Abstract P234: High Sodium Intake is Associated with Increased Hemoglobin A1C in Young Overweight/Obese African Americans
    Hypertension, 2015
    Co-Authors: Samip Parikh, Jigar Bhagatwala, Gregory A. Harshfield, Yanbin Dong, Anas Raed, Ying Huang, Ishita Kotak, Haidong Zhu
    Abstract:

    Introduction: Whether High Sodium Intake, assessed by 24-hour urinary Sodium excretion (24hrUNaEx), is associated with altered glycemic control, evaluated by hemoglobin A1C (HbA1C), in the African American population remains unknown. We aimed to evaluate the relationship between 24hrUNaEx and HbA1C in young overweight/obese African Americans. Methods: A total of 106 apparently healthy overweight/obese drug-naive African Americans were recruited. Subjects were asked to discard the first morning urine specimen and collect all remaining urine specimens for next 24-hr including a urine specimen of the following morning. HbA1C was measured from venous blood by ion-exchange chromatography. Results: The means (± SE) of age and body mass index (BMI) of subjects (67%, 71/106 females) were 24.30±0.82 years and 35.51±0.70 kg/m2, respectively. Average 24hrUNaEx was 172.17±7.09 mEq/L/d, which corresponded to average Sodium Intake of 3.96±1.63 g/d. Pearson’s correlation analysis revealed a positive correlation between log transformed 24hrUNaEx and HbA1C after adjusting for age, sex, BMI, and systolic blood pressure (r=0.20, p=0.04). In a subgroup analysis involving subjects with HbA1C ≥5.7% (N=40), the correlation between 24hrUNaEx and HbA1C was stronger even with adjustment for the above variables (r=0.35, p=0.04). Conclusions: High Sodium Intake is associated with increased HbA1C independent of traditional risk factors in our study population. This relationship was stronger in subjects with HbA1C ≥5.7%, which by definition represents prediabetes (HbA1C ≥5.7 &

  • abstract p234 High Sodium Intake is associated with increased hemoglobin a1c in young overweight obese african americans
    Hypertension, 2015
    Co-Authors: Samip Parikh, Jigar Bhagatwala, Gregory A. Harshfield, Yanbin Dong, Anas Raed, Ying Huang, Ishita Kotak, Haidong Zhu
    Abstract:

    Introduction: Whether High Sodium Intake, assessed by 24-hour urinary Sodium excretion (24hrUNaEx), is associated with altered glycemic control, evaluated by hemoglobin A1C (HbA1C), in the African American population remains unknown. We aimed to evaluate the relationship between 24hrUNaEx and HbA1C in young overweight/obese African Americans. Methods: A total of 106 apparently healthy overweight/obese drug-naive African Americans were recruited. Subjects were asked to discard the first morning urine specimen and collect all remaining urine specimens for next 24-hr including a urine specimen of the following morning. HbA1C was measured from venous blood by ion-exchange chromatography. Results: The means (± SE) of age and body mass index (BMI) of subjects (67%, 71/106 females) were 24.30±0.82 years and 35.51±0.70 kg/m2, respectively. Average 24hrUNaEx was 172.17±7.09 mEq/L/d, which corresponded to average Sodium Intake of 3.96±1.63 g/d. Pearson’s correlation analysis revealed a positive correlation between log transformed 24hrUNaEx and HbA1C after adjusting for age, sex, BMI, and systolic blood pressure (r=0.20, p=0.04). In a subgroup analysis involving subjects with HbA1C ≥5.7% (N=40), the correlation between 24hrUNaEx and HbA1C was stronger even with adjustment for the above variables (r=0.35, p=0.04). Conclusions: High Sodium Intake is associated with increased HbA1C independent of traditional risk factors in our study population. This relationship was stronger in subjects with HbA1C ≥5.7%, which by definition represents prediabetes (HbA1C ≥5.7 & <6.5%) and diabetes (HbA1C ≥6.5%). Although not fully understood, the possible mechanism by which High Sodium Intake could contribute to glycemic dysregulation involves cellular dysfunction and apoptosis of pancreatic beta cell induced by High Sodium Intakes via inflammation and oxidative stress.

  • High Sodium Intake is associated with short leukocyte telomere length in overweight and obese adolescents
    International journal of obesity (2005), 2015
    Co-Authors: Haidong Zhu, Jigar Bhagatwala, Norman K. Pollock, Samip Parikh, Bernard Gutin, Inger Stallmann-jorgensen, Jeffrey Thomas, Gregory A. Harshfield, Yanbin Dong
    Abstract:

    High Sodium Intake is associated with short leukocyte telomere length in overweight and obese adolescents

Frans H. H. Leenen - One of the best experts on this subject based on the ideXlab platform.

  • Brain “ouabain,” ANG II, and sympathoexcitation by chronic central Sodium loading in rats
    The American journal of physiology, 1998
    Co-Authors: Bing S. Huang, Shereeni J. Veerasingham, Frans H. H. Leenen
    Abstract:

    Both brain ouabain-like activity (“ouabain”) and brain angiotensin II (ANG II) contribute to the sympathoexcitatory and pressor responses to High Sodium Intake in spontaneously hypertensive (SHR) a...

  • Dietary Sodium and central vs. peripheral ouabain-like activity in Dahl salt-sensitive vs. salt-resistant rats.
    American Journal of Physiology-Heart and Circulatory Physiology, 1994
    Co-Authors: Frans H. H. Leenen, E Harmsen
    Abstract:

    To assess the possible contribution of brain ouabain-like activity (OLA) to the pressor effects of High-Sodium Intake in Dahl salt-sensitive (Dahl S) rats, we assessed the effects of High (8%) on b...

  • Brain "ouabain" mediates the sympathoexcitatory and hypertensive effects of High Sodium Intake in Dahl salt-sensitive rats.
    Circulation research, 1994
    Co-Authors: Bing S. Huang, Frans H. H. Leenen
    Abstract:

    To assess whether brain ouabain-like activity (OLA) mediates the hypertensive effects of High Sodium Intake in Dahl salt-sensitive (Dahl S) rats, the effects of blockade of brain OLA on mean arterial pressure (MAP) and renal sympathetic nerve activity (RSNA) were evaluated in conscious Dahl salt-resistant (Dahl R) and Dahl S rats on a regular (120 mumol/g) or High Sodium (1370 mumol/g) diet from 4 to 7 weeks of age. Dahl S rats given High Sodium showed Higher basal MAP and augmented responses of MAP and RSNA to air stress and to intracerebroventricular injection of the alpha 2-adrenergic receptor agonist guanabenz as compared with Dahl R rats or Dahl S rats given regular Sodium. In contrast, the sympathoexcitatory and pressor responses to intracerebroventricular injection of ouabain (0.3 and 1.0 microgram) were markedly attenuated in Dahl S rats given High Sodium. Intracerebroventricular preinjection of 0.3 microgram ouabain significantly enhanced blood pressure and RSNA responses to air stress and intracerebroventricular guanabenz in Dahl S rats given regular Sodium to the levels observed in Dahl S rats given High Sodium. Intracerebroventricular digoxin-specific antibody Fab (DAF) fragments (132 micrograms/8 microL for 5 minutes) did not change basal MAP and RSNA during the first 4 hours after administration in Dahl S rats on a High Sodium diet for 3 weeks. However, 18 hours after the injection of DAF fragments, basal MAP and RSNA were significantly decreased, reaching values for Dahl S rats on a regular Sodium diet. The magnitude of increases or decreases in MAP and RSNA to air stress or intracerebroventricular guanabenz were significantly attenuated by the DAF fragments in Dahl S rats on a High Sodium but not regular Sodium diet. Concomitant intracerebroventricular infusion of DAF fragments (200 micrograms per day) prevented the development of hypertension after a High Sodium diet in Dahl S rats and prevented an augmentation in pressor and sympathoexcitatory responses to air stress. After discontinuing the infusion of DAF fragments, resting MAP gradually increased to the High levels found in Dahl S rats given High Sodium treated with gamma-globulins. These results support the concept that High Sodium Intake may cause hypertension in Dahl S rats by increasing endogenous brain OLA, thereby enhancing sympathetic outflow and basal blood pressure as well as sympathoexcitatory and pressor responses to stress.

  • Role of brain ouabain-like activity in the central effects of Sodium in rats.
    Journal of cardiovascular pharmacology, 1993
    Co-Authors: Frans H. H. Leenen, Bing S. Huang, E Harmsen
    Abstract:

    To evaluate whether changes in central ouabain-like activity (OLA) play a role in the effects of dietary Sodium on sympathetic outflow and blood pressure (BP), the effects of High vs. control Sodium Intake on BP, brain OLA, and responsiveness to exogenous ouabain were studied in young spontaneously hypertensive rats (SHRs) vs. Wistar-Kyoto (WKY) rats. At 4 weeks of age, the BP of SHRs was already significantly increased compared with that of WKY rats, and hypertension developed further with maturation. High Sodium Intake exacerbated the hypertension. Compared with WKY rats, in SHRs OLA in the hypothalamus was already increased at 4 weeks of age. High Sodium Intake increased brain OLA in both SHRs and WKY rats. However, High dietary Sodium decreased pressor and sympathoexcitatory responses to exogenous ouabain only in SHRs. These results may indicate that in WKY rats on control Sodium, endogenous OLA already exerts its maximal central effects and a further increase in OLA by High Sodium Intake does not cause hemodynamic changes, whereas in young SHRs the increase in brain OLA by High Sodium Intake may play a functional role in the pressor and sympathoexcitatory responses to High Sodium.

  • Role of brain ouabain-like activity in the central effects of Sodium in rats.
    Journal of Cardiovascular Pharmacology, 1993
    Co-Authors: Frans H. H. Leenen, Bing S. Huang, E Harmsen
    Abstract:

    To evaluate whether changes in central ouabain-like activity (OLA) play a role in the effects of dietary Sodium on sympathetic outflow and blood pressure (BP), the effects of High vs. control Sodium Intake on BP, brain OLA, and responsiveness to exogenous ouabain were studied in young spontaneously hypertensive rats (SHRs) vs. Wistar-Kyoto (WKY) rats. At 4 weeks of age, the BP of SHRs was already significantly increased compared with that of WKY rats, and hypertension developed further with maturation. High Sodium Intake exacerbated the hypertension. Compared with WKY rats, in SHRs OLA in the hypothalamus was already increased at 4 weeks of age. High Sodium Intake increased brain OLA in both SHRs and WKY rats

Zhiming Liu - One of the best experts on this subject based on the ideXlab platform.

  • age period cohort analysis of stroke mortality attributable to High Sodium Intake in china and japan
    Stroke, 2019
    Co-Authors: Jinhong Cao, Ehab S Eshak, Keyang Liu, Krisztina Gero, Zhiming Liu
    Abstract:

    Background and Purpose- The aim of this study is to assess the long-term trends in stroke mortality attributable to High Sodium Intake in China and Japan during the period 1990 to 2016. Methods- The mortality data were obtained from the GBD study (Global Burden of Disease) 2016 and were analyzed using an age-period-cohort method. Results- The age-standardized mortality rates showed declining trends for High Sodium Intake-related stroke mortality. The overall net drifts per year were -3.1% for Chinese men and -5.0% for Chinese women; and -4.6% for Japanese men and -5.7% for Japanese women. The local drift values were below zero in all age groups for both sexes in both countries, and all local drift values of female participants were below their counterparts of male participants. The longitudinal age curves of High Sodium Intake-attributable stroke mortality increased rapidly for both sexes in China, whereas those of Japanese were slowly rising. The period and cohort rate ratios were found to have similar downward patterns for both sexes in both countries, with a quicker decline for women than for men (significantly with P<0.05 for all). Conclusions- The age-standardized mortality rates, the period effect and the cohort effect of stroke mortality attributable to High Sodium Intake in China and Japan have been declining in both sexes and all age groups from 1990 to 2016. Consequently, Sodium-reduction strategies are of low cost and effective for the prevention of stroke. It is necessary to educate the nation with the correct knowledge on healthy diet and techniques to reduce salt consumption.

  • Age-Period-Cohort Analysis of Stroke Mortality Attributable to High Sodium Intake in China and Japan.
    Stroke, 2019
    Co-Authors: Jinhong Cao, Ehab S Eshak, Keyang Liu, Krisztina Gero, Zhiming Liu
    Abstract:

    Background and Purpose- The aim of this study is to assess the long-term trends in stroke mortality attributable to High Sodium Intake in China and Japan during the period 1990 to 2016. Methods- The mortality data were obtained from the GBD study (Global Burden of Disease) 2016 and were analyzed using an age-period-cohort method. Results- The age-standardized mortality rates showed declining trends for High Sodium Intake-related stroke mortality. The overall net drifts per year were -3.1% for Chinese men and -5.0% for Chinese women; and -4.6% for Japanese men and -5.7% for Japanese women. The local drift values were below zero in all age groups for both sexes in both countries, and all local drift values of female participants were below their counterparts of male participants. The longitudinal age curves of High Sodium Intake-attributable stroke mortality increased rapidly for both sexes in China, whereas those of Japanese were slowly rising. The period and cohort rate ratios were found to have similar downward patterns for both sexes in both countries, with a quicker decline for women than for men (significantly with P

Tahir Hussain - One of the best experts on this subject based on the ideXlab platform.

Masakazu Haneda - One of the best experts on this subject based on the ideXlab platform.

  • Effects of High Sodium Intake and diuretics on the circadian rhythm of blood pressure in type 2 diabetic patients treated with an angiotensin II receptor blocker
    Clinical and Experimental Nephrology, 2009
    Co-Authors: Masayoshi Sakaguchi, Yukiyo Yokomaku, Masami Kanasaki, Toshiro Sugiomoto, Shin-ichi Araki, Daisuke Koya, Keiji Isshiki, Shinji Kume, Masakazu Haneda, Atsunori Kashiwagi
    Abstract:

    Backgrounds The inhibition of the renin-angiotensin system in the diabetic condition was reported to enhance the Sodium sensitivity of blood pressure. In patients with Sodium-sensitive hypertension, High Sodium Intake reduces the nocturnal fall in blood pressure. Therefore, we examined the effects of the amount of Sodium Intake or diuretics in patients with diabetes treated with an angiotensin receptor blocker. Methods We recruited 32 Japanese type 2 diabetic patients with base line blood pressure ≥130/80 mmHg and treated with valsartan (80 mg daily). At baseline, 24-h ambulatory blood pressure and 24-h urinary excretion of Sodium were measured. The patients were then randomly assigned to take either combination therapy with 50 mg of losartan plus 12.5 mg of hydrochlorothiazide or monotherapy with 160 mg of valsartan for 24 weeks. Results At baseline, 22 of 32 (69%) patients were classified as non-dippers, and the night/day ratio of mean arterial pressure was significantly correlated with 24-h urinary Sodium excretion. The combination therapy resulted in a significantly Higher fall than the monotherapy in 24-h mean, daytime, night-time and morning blood pressures. The night/day ratio of mean arterial pressure was significantly reduced from the baseline at the end of the study in the combination therapy group, but not in the monotherapy group. In non-dipper patients, the diminished nocturnal fall in blood pressure was restored by the combination therapy. Conclusions Excessive Intake of salt causes non-dipping and diuretics restored nocturnal BP fall in type 2 diabetic patients treated with angiotensin 2 receptor blockers.

  • Effects of High Sodium Intake and diuretics on the circadian rhythm of blood pressure in type 2 diabetic patients treated with an angiotensin II receptor blocker
    Clinical and experimental nephrology, 2009
    Co-Authors: Takashi Uzu, Yukiyo Yokomaku, Masami Kanasaki, Toshiro Sugiomoto, Shin-ichi Araki, Daisuke Koya, Keiji Isshiki, Shinji Kume, Masayoshi Sakaguchi, Masakazu Haneda
    Abstract:

    Backgrounds The inhibition of the renin-angiotensin system in the diabetic condition was reported to enhance the Sodium sensitivity of blood pressure. In patients with Sodium-sensitive hypertension, High Sodium Intake reduces the nocturnal fall in blood pressure. Therefore, we examined the effects of the amount of Sodium Intake or diuretics in patients with diabetes treated with an angiotensin receptor blocker.