The Experts below are selected from a list of 153075 Experts worldwide ranked by ideXlab platform
Svetlana Batyrbekova - One of the best experts on this subject based on the ideXlab platform.
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a qsar qstr study on the Human Health Impact of the rocket fuel 1 1 dimethyl hydrazine and its transformation products multicriteria hazard ranking based on partial order methodologies
Environmental Toxicology and Pharmacology, 2009Co-Authors: Lars Carlsen, Bulat Kenessov, Svetlana BatyrbekovaAbstract:The possible Impact of the rocket fuel 1,1-dimethyl hydrazine (heptyl) (1) and its transformation products on Human Health has been studied using (Quantitative) Structure Activity/Toxicity ((Q)SAR/(Q)STR) modelling, including both ADME models and models for acute toxicity, organ specific adverse haematological effects, the cardiovascular and gastrointestinal systems, the kidneys, the liver and the lungs, as well as a model predicting the biological activity of the compounds. It was predicted that all compounds studied are readily bioavailable through oral intake and that significant amounts of the compounds will be freely available in the systemic circulation. In general, the compounds are not predicted to be acutely toxic apart from hydrogen cyanide, whereas several compounds are predicted to cause adverse organ specific Human Health effects. Further, several compounds are predicted to exhibit high probabilities for potential carcinogenicity, mutagenicity, teratogenicity and/or embryotoxicity. The compounds were ranked based on their predicted Human Health Impact using partial order ranking methodologies that highlight which compounds on a cumulative basis should receive the major attention, i.e., N-nitroso dimethyl amine, 1,1,4,4-tetramethyl tetrazene, trimethyl, trimethyl hydrazine, acetaldehyde dimethyl hydrazone, 1, 1-formyl 2,2-dimethyl hydrazine and formaldehyde dimethyl hydrazone, respectively.
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A QSAR/QSTR study on the Human Health Impact of the rocket fuel 1,1-dimethyl hydrazine and its transformation products Multicriteria hazard ranking based on partial order methodologies.
Environmental toxicology and pharmacology, 2009Co-Authors: Lars Carlsen, Bulat Kenessov, Svetlana BatyrbekovaAbstract:The possible Impact of the rocket fuel 1,1-dimethyl hydrazine (heptyl) (1) and its transformation products on Human Health has been studied using (Quantitative) Structure Activity/Toxicity ((Q)SAR/(Q)STR) modelling, including both ADME models and models for acute toxicity, organ specific adverse haematological effects, the cardiovascular and gastrointestinal systems, the kidneys, the liver and the lungs, as well as a model predicting the biological activity of the compounds. It was predicted that all compounds studied are readily bioavailable through oral intake and that significant amounts of the compounds will be freely available in the systemic circulation. In general, the compounds are not predicted to be acutely toxic apart from hydrogen cyanide, whereas several compounds are predicted to cause adverse organ specific Human Health effects. Further, several compounds are predicted to exhibit high probabilities for potential carcinogenicity, mutagenicity, teratogenicity and/or embryotoxicity. The compounds were ranked based on their predicted Human Health Impact using partial order ranking methodologies that highlight which compounds on a cumulative basis should receive the major attention, i.e., N-nitroso dimethyl amine, 1,1,4,4-tetramethyl tetrazene, trimethyl, trimethyl hydrazine, acetaldehyde dimethyl hydrazone, 1, 1-formyl 2,2-dimethyl hydrazine and formaldehyde dimethyl hydrazone, respectively.
Lars Carlsen - One of the best experts on this subject based on the ideXlab platform.
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a qsar qstr study on the Human Health Impact of the rocket fuel 1 1 dimethyl hydrazine and its transformation products multicriteria hazard ranking based on partial order methodologies
Environmental Toxicology and Pharmacology, 2009Co-Authors: Lars Carlsen, Bulat Kenessov, Svetlana BatyrbekovaAbstract:The possible Impact of the rocket fuel 1,1-dimethyl hydrazine (heptyl) (1) and its transformation products on Human Health has been studied using (Quantitative) Structure Activity/Toxicity ((Q)SAR/(Q)STR) modelling, including both ADME models and models for acute toxicity, organ specific adverse haematological effects, the cardiovascular and gastrointestinal systems, the kidneys, the liver and the lungs, as well as a model predicting the biological activity of the compounds. It was predicted that all compounds studied are readily bioavailable through oral intake and that significant amounts of the compounds will be freely available in the systemic circulation. In general, the compounds are not predicted to be acutely toxic apart from hydrogen cyanide, whereas several compounds are predicted to cause adverse organ specific Human Health effects. Further, several compounds are predicted to exhibit high probabilities for potential carcinogenicity, mutagenicity, teratogenicity and/or embryotoxicity. The compounds were ranked based on their predicted Human Health Impact using partial order ranking methodologies that highlight which compounds on a cumulative basis should receive the major attention, i.e., N-nitroso dimethyl amine, 1,1,4,4-tetramethyl tetrazene, trimethyl, trimethyl hydrazine, acetaldehyde dimethyl hydrazone, 1, 1-formyl 2,2-dimethyl hydrazine and formaldehyde dimethyl hydrazone, respectively.
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A QSAR/QSTR study on the Human Health Impact of the rocket fuel 1,1-dimethyl hydrazine and its transformation products Multicriteria hazard ranking based on partial order methodologies.
Environmental toxicology and pharmacology, 2009Co-Authors: Lars Carlsen, Bulat Kenessov, Svetlana BatyrbekovaAbstract:The possible Impact of the rocket fuel 1,1-dimethyl hydrazine (heptyl) (1) and its transformation products on Human Health has been studied using (Quantitative) Structure Activity/Toxicity ((Q)SAR/(Q)STR) modelling, including both ADME models and models for acute toxicity, organ specific adverse haematological effects, the cardiovascular and gastrointestinal systems, the kidneys, the liver and the lungs, as well as a model predicting the biological activity of the compounds. It was predicted that all compounds studied are readily bioavailable through oral intake and that significant amounts of the compounds will be freely available in the systemic circulation. In general, the compounds are not predicted to be acutely toxic apart from hydrogen cyanide, whereas several compounds are predicted to cause adverse organ specific Human Health effects. Further, several compounds are predicted to exhibit high probabilities for potential carcinogenicity, mutagenicity, teratogenicity and/or embryotoxicity. The compounds were ranked based on their predicted Human Health Impact using partial order ranking methodologies that highlight which compounds on a cumulative basis should receive the major attention, i.e., N-nitroso dimethyl amine, 1,1,4,4-tetramethyl tetrazene, trimethyl, trimethyl hydrazine, acetaldehyde dimethyl hydrazone, 1, 1-formyl 2,2-dimethyl hydrazine and formaldehyde dimethyl hydrazone, respectively.
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a preliminary assessment of the potential environmental and Human Health Impact of unsymmetrical dimethylhydrazine as a result of space activities
Chemosphere, 2007Co-Authors: Lars Carlsen, Olga A Kenesova, Svetlana E BatyrbekovaAbstract:A preliminary assessment of the potential environmental and Human Health Impact of UDMH as a result of space activities has been carried out applying a theoretical approach in comparison with selected experimental data. The theoretical framework includes QSAR, ADME and PASS modelling as well as studies on the possible atmospheric dispersion of UDMH as calculated applying the OML-Multi model. The possible Impact on the environment and the Human Health has been elucidated and it has been concluded that UDMH especially inside the fall region of burned-out rocket stages constitute a significant threat to both environmental and Human Health, the latter as a results of the carcinogenic, mutagenic, convulsant, teratogenic and embryotoxic characteristics of UDMH in addition to the general toxic characteristics of the compound.
Yann Denance - One of the best experts on this subject based on the ideXlab platform.
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Wood washing: influence on gaseous and particulate emissions during wood combustion in a domestic pellet stove
Fuel Processing Technology, 2018Co-Authors: Guillaume Schmidt, Gwenaëlle Trouvé, Gontrand Leyssens, Cornelius Schönnenbeck, Paul Genevray, Fabrice Cazier, Dorothée Dewaele, Coralie Vandenbilcke, Elodie Faivre, Yann DenanceAbstract:Nowadays, the use of biomass increasingly replaces the fossil fuels for the domestic heating production. In order to reduce pollutant emissions from biomass combustion, wood was washed at room temperature in order to represent natural rain leaching before burning in a recent pellet stove (2010s) of nominal output of 6.3 kW. Raw and washed woods were combusted for three different types of wood (oak, beech and fir) and the study focused on their particulate and gaseous emissions (Total Suspended Particles (TSP), Particulate Matter with diameter below 2.5 μm (PM2.5), carbon monoxide (CO), nitrogen oxides (NOx) and Total Volatile Organic Compounds (TVOC)). Polycyclic Aromatic Hydrocarbons (PAH), aldehydes and wood tracers as phenols compounds were also measured. In addition, considering the toxic equivalent factor, the Human Health Impact of adsorbed and gaseous PAH is considerably reduced (96%) in the case of washed fir combustion. Emission factors of CO and TSP for washed wood combustion also show a decrease up to 50% depending on the type of wood used. Furthermore, phenolic compounds, Benzene, Toluene, Ethylbenzene, Xylenes and Trimethylbenzene (BTEXT) emissions can also be reduced by the washing of biomass. Washed oak combustion leads to a clear decrease by 60% of the total of BTEXT. In the case of phenols emissions, phenol shows a significant decrease by 91% during the combustion of washed fir wood.
Bulat Kenessov - One of the best experts on this subject based on the ideXlab platform.
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a qsar qstr study on the Human Health Impact of the rocket fuel 1 1 dimethyl hydrazine and its transformation products multicriteria hazard ranking based on partial order methodologies
Environmental Toxicology and Pharmacology, 2009Co-Authors: Lars Carlsen, Bulat Kenessov, Svetlana BatyrbekovaAbstract:The possible Impact of the rocket fuel 1,1-dimethyl hydrazine (heptyl) (1) and its transformation products on Human Health has been studied using (Quantitative) Structure Activity/Toxicity ((Q)SAR/(Q)STR) modelling, including both ADME models and models for acute toxicity, organ specific adverse haematological effects, the cardiovascular and gastrointestinal systems, the kidneys, the liver and the lungs, as well as a model predicting the biological activity of the compounds. It was predicted that all compounds studied are readily bioavailable through oral intake and that significant amounts of the compounds will be freely available in the systemic circulation. In general, the compounds are not predicted to be acutely toxic apart from hydrogen cyanide, whereas several compounds are predicted to cause adverse organ specific Human Health effects. Further, several compounds are predicted to exhibit high probabilities for potential carcinogenicity, mutagenicity, teratogenicity and/or embryotoxicity. The compounds were ranked based on their predicted Human Health Impact using partial order ranking methodologies that highlight which compounds on a cumulative basis should receive the major attention, i.e., N-nitroso dimethyl amine, 1,1,4,4-tetramethyl tetrazene, trimethyl, trimethyl hydrazine, acetaldehyde dimethyl hydrazone, 1, 1-formyl 2,2-dimethyl hydrazine and formaldehyde dimethyl hydrazone, respectively.
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A QSAR/QSTR study on the Human Health Impact of the rocket fuel 1,1-dimethyl hydrazine and its transformation products Multicriteria hazard ranking based on partial order methodologies.
Environmental toxicology and pharmacology, 2009Co-Authors: Lars Carlsen, Bulat Kenessov, Svetlana BatyrbekovaAbstract:The possible Impact of the rocket fuel 1,1-dimethyl hydrazine (heptyl) (1) and its transformation products on Human Health has been studied using (Quantitative) Structure Activity/Toxicity ((Q)SAR/(Q)STR) modelling, including both ADME models and models for acute toxicity, organ specific adverse haematological effects, the cardiovascular and gastrointestinal systems, the kidneys, the liver and the lungs, as well as a model predicting the biological activity of the compounds. It was predicted that all compounds studied are readily bioavailable through oral intake and that significant amounts of the compounds will be freely available in the systemic circulation. In general, the compounds are not predicted to be acutely toxic apart from hydrogen cyanide, whereas several compounds are predicted to cause adverse organ specific Human Health effects. Further, several compounds are predicted to exhibit high probabilities for potential carcinogenicity, mutagenicity, teratogenicity and/or embryotoxicity. The compounds were ranked based on their predicted Human Health Impact using partial order ranking methodologies that highlight which compounds on a cumulative basis should receive the major attention, i.e., N-nitroso dimethyl amine, 1,1,4,4-tetramethyl tetrazene, trimethyl, trimethyl hydrazine, acetaldehyde dimethyl hydrazone, 1, 1-formyl 2,2-dimethyl hydrazine and formaldehyde dimethyl hydrazone, respectively.
Sang-hee Jeong - One of the best experts on this subject based on the ideXlab platform.
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General, Applied and Systems Toxicology - Systems Toxicological Approach to the Risk Assessment of Nanomaterials
General Applied and Systems Toxicology, 2011Co-Authors: Sang-hee JeongAbstract:Nowadays, nanomaterials have come into the spotlight as new materials that have lots of prominent benefits in various fields of Human life. Risk assessment of the nanomaterials requires a multidisciplinary understanding of the differences from their large particles in surface physicochemistry and dosimetry. The size, biological effective dose, surface chemistry, interactions with biological membrane and dispersion media are important factors that make unique characteristics of nanomaterials in their toxicity potency. Conventional methods for the toxicological assessment may have limitations in proper understanding of the dose-response relationships of the diversity of structures and compositions of nanomaterials. Challenges to toxicological testing of nanomaterials will be covered with the strategy of systems toxicology including toxico-genomics, toxico-proteomics and toxico-metabolomics. The data driven from systems toxicology are valuable in the identification and characterization of the mode of action of nanomaterials. Many of toxicogenomic and toxicoproteomic studies have released that the production of reactive oxygen species and inflammation caused by oxidative stress are the key mechanism of toxicity of nanomaterials. However, there is still limited information for the assessment of toxicity thresholds based on dose-response relationships and for the estimation of exposure in risk assessment of nanomaterials. More integrated and systemic studies are required for the risk assessment of Human Health Impact considering various but unique properties of nanomaterials. Keywords: nanomaterials; systems toxicology; toxico-genomics; toxico-proteomics; toxico-metabolomics; risk assessment
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systems toxicological approach to the risk assessment of nanomaterials
General Applied and Systems Toxicology, 2011Co-Authors: Sang-hee Jeong, Wanseob Cho, Jieun Kim, Myunghaing ChoAbstract:Nowadays, nanomaterials have come into the spotlight as new materials that have lots of prominent benefits in various fields of Human life. Risk assessment of the nanomaterials requires a multidisciplinary understanding of the differences from their large particles in surface physicochemistry and dosimetry. The size, biological effective dose, surface chemistry, interactions with biological membrane and dispersion media are important factors that make unique characteristics of nanomaterials in their toxicity potency. Conventional methods for the toxicological assessment may have limitations in proper understanding of the dose-response relationships of the diversity of structures and compositions of nanomaterials. Challenges to toxicological testing of nanomaterials will be covered with the strategy of systems toxicology including toxico-genomics, toxico-proteomics and toxico-metabolomics. The data driven from systems toxicology are valuable in the identification and characterization of the mode of action of nanomaterials. Many of toxicogenomic and toxicoproteomic studies have released that the production of reactive oxygen species and inflammation caused by oxidative stress are the key mechanism of toxicity of nanomaterials. However, there is still limited information for the assessment of toxicity thresholds based on dose-response relationships and for the estimation of exposure in risk assessment of nanomaterials. More integrated and systemic studies are required for the risk assessment of Human Health Impact considering various but unique properties of nanomaterials. Keywords: nanomaterials; systems toxicology; toxico-genomics; toxico-proteomics; toxico-metabolomics; risk assessment
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Risk Assessment of Growth Hormones and Antimicrobial Residues in Meat
Toxicological Research, 2010Co-Authors: Sang-hee Jeong, Daejin Kang, Chang Soo Kang, Ha Jung SungAbstract:Growth promoters including hormonal substances and antibiotics are used legally and illegally in food producing animals for the growth promotion of livestock animals. Hormonal substances still under debate in terms of their Human Health Impacts are estradiol-17β, progesterone, testosterone, zeranol, trenbolone, and melengestrol acetate (MGA). Many of the risk assessment results of natural steroid hormones have presented negligible Impacts when they are used under good veterinary practices. For synthetic hormonelike substances, ADIs and MRLs have been established for food safety along with the approval of animal treatment. Small amounts of antibiotics added to feedstuff present growth promotion effects via the prevention of infectious diseases at doses lower than therapeutic dose. The induction of antimicrobial resistant bacteria and the disruption of normal Human intestinal flora are major concerns in terms of Human Health Impact. Regulatory guidance such as ADIs and MRLs fully reflect the Impact on Human gastrointestinal microflora. However, before deciding on any risk management options, risk assessments of antimicrobial resistance require large-scale evidence regarding the relationship between antimicrobial use in food-producing animals and the occurrence of antimicrobial resistance in Human pathogens. In this article, the risk profiles of hormonal and antibacterial growth promoters are provided based on recent toxicity and Human exposure information, and recommendations for risk management to prevent Human Health Impacts by the use of growth promoters are also presented.